Conformationally restricted macrocyclic analogues of combretastatins

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6316-6320

  Mateo, Carmen ^a   Álvarez, Raquel ^a   Pérez Melero, Concepción ^a   Peláez, Rafael ^a   Medarde, Manuel ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Combretastatins; Conformational restriction; Macrocycles; Tubulin polymerization inhibition

Indexed keywords

AROMATIC COMPOUND; COMBRETASTATIN; COMBRETASTATIN A4; LIGAND; MACROCYCLIC COMPOUND;

ARTICLE; DRUG CONFORMATION; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; MICROTUBULE ASSEMBLY; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

BIBENZYLS; MACROCYCLIC COMPOUNDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 35148825970     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.075     Document Type: Article

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