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Volumn 27, Issue 20, 2007, Pages 7291-7301

Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BETA CATENIN; FRIZZLED PROTEIN; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; WNT PROTEIN;

EID: 35148822622     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00773-07     Document Type: Article
Times cited : (61)

References (41)
  • 1
    • 0032575093 scopus 로고    scopus 로고
    • Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts
    • Bafico, A., A. Gazit, S. S. Wu-Morgan, A. Yaniv, and S. A. Aaronson. 1998. Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 16:2819-2825.
    • (1998) Oncogene , vol.16 , pp. 2819-2825
    • Bafico, A.1    Gazit, A.2    Wu-Morgan, S.S.3    Yaniv, A.4    Aaronson, S.A.5
  • 2
    • 7944230668 scopus 로고    scopus 로고
    • An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
    • Bafico, A., G. Liu, L. Goldin, V. Harris, and S. A. Aaronson. 2004. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 6:497-506.
    • (2004) Cancer Cell , vol.6 , pp. 497-506
    • Bafico, A.1    Liu, G.2    Goldin, L.3    Harris, V.4    Aaronson, S.A.5
  • 3
    • 0034933057 scopus 로고    scopus 로고
    • Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
    • Bafico, A., G. Liu, A. Yaniv, A. Gazit, and S. A. Aaronson. 2001. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. 3:683-686.
    • (2001) Nat. Cell Biol , vol.3 , pp. 683-686
    • Bafico, A.1    Liu, G.2    Yaniv, A.3    Gazit, A.4    Aaronson, S.A.5
  • 4
    • 0027067001 scopus 로고
    • Ligand-dependent down-regulation of stably transfected human glucocorticoid receptors is associated with the loss of functional glucocorticoid responsiveness
    • Bellingham, D. L., M. Sar, and J. A. Cidlowski. 1992. Ligand-dependent down-regulation of stably transfected human glucocorticoid receptors is associated with the loss of functional glucocorticoid responsiveness. Mol. Endocrinol. 6:2090-2102.
    • (1992) Mol. Endocrinol , vol.6 , pp. 2090-2102
    • Bellingham, D.L.1    Sar, M.2    Cidlowski, J.A.3
  • 6
    • 33746960721 scopus 로고    scopus 로고
    • A critical role for endocytosis in Wnt signaling
    • Blitzer, J. T., and R. Nusse. 2006. A critical role for endocytosis in Wnt signaling. BMC Cell Biol. 7:28.
    • (2006) BMC Cell Biol , vol.7 , pp. 28
    • Blitzer, J.T.1    Nusse, R.2
  • 7
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan, K. M., and R. Nusse. 1997. Wnt signaling: a common theme in animal development. Genes Dev. 11:3286-3305.
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 9
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers, H. 2006. Wnt/beta-catenin signaling in development and disease. Cell 127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 10
    • 8444223093 scopus 로고    scopus 로고
    • Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
    • Cong, F., L. Schweizer, and H. Varmus. 2004. Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131:5103-5115.
    • (2004) Development , vol.131 , pp. 5103-5115
    • Cong, F.1    Schweizer, L.2    Varmus, H.3
  • 11
    • 28644444440 scopus 로고    scopus 로고
    • Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    • Davidson, G., W. Wu, J. Shen, J. Bilic, U. Fenger, P. Stannek, A. Glinka, and C. Niehrs. 2005. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438:867-872.
    • (2005) Nature , vol.438 , pp. 867-872
    • Davidson, G.1    Wu, W.2    Shen, J.3    Bilic, J.4    Fenger, U.5    Stannek, P.6    Glinka, A.7    Niehrs, C.8
  • 12
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover
    • Di Guglielmo, G. M., C. Le Roy, A. F. Goodfellow, and J. L. Wrana. 2003. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat. Cell Biol. 5:410-421.
    • (2003) Nat. Cell Biol , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 13
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors
    • Gordon, M. D., and R. Nusse. 2006. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J. Biol. Chem. 281: 22429-22433.
    • (2006) J. Biol. Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 14
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way
    • He, X., M. Semenov, K. Tamai, and X. Zeng. 2004. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development 131:1663-1677.
    • (2004) Development , vol.131 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 15
    • 0036902646 scopus 로고    scopus 로고
    • Receptor downregulation and multivesicular-body sorting
    • Katzmann, D. J., G. Odorizzi, and S. D. Emr. 2002. Receptor downregulation and multivesicular-body sorting. Nat. Rev. Mol. Cell. Biol. 3:893-905.
    • (2002) Nat. Rev. Mol. Cell. Biol , vol.3 , pp. 893-905
    • Katzmann, D.J.1    Odorizzi, G.2    Emr, S.D.3
  • 16
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano, Y., and R. Kypta. 2003. Secreted antagonists of the Wnt signalling pathway. J. Cell Sci. 116:2627-2634.
    • (2003) J. Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 17
    • 33847019563 scopus 로고    scopus 로고
    • Multiplicity of the interactions of Wnt proteins and their receptors
    • Kikuchi, A., H. Yamamoto, and S. Kishida. 2007. Multiplicity of the interactions of Wnt proteins and their receptors. Cell. Signal. 19:659-671.
    • (2007) Cell. Signal , vol.19 , pp. 659-671
    • Kikuchi, A.1    Yamamoto, H.2    Kishida, S.3
  • 18
    • 13444263549 scopus 로고    scopus 로고
    • Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling
    • Le Roy, C., and J. L. Wrana. 2005. Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat. Rev. Mol. Cell. Biol. 6:112-126.
    • (2005) Nat. Rev. Mol. Cell. Biol , vol.6 , pp. 112-126
    • Le Roy, C.1    Wrana, J.L.2
  • 19
    • 17644424645 scopus 로고    scopus 로고
    • The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and non-canonical Wnts
    • Liu, G., A. Banco, and S. A., Aaronson. 2005. The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and non-canonical Wnts. Mol. Cell. Biol. 25:3475-3482.
    • (2005) Mol. Cell. Biol , vol.25 , pp. 3475-3482
    • Liu, G.1    Banco, A.2    Aaronson, S.A.3
  • 20
    • 0042131956 scopus 로고    scopus 로고
    • A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor
    • Liu, G., A. Banco, V. K. Harris, and S. A. Aaronson. 2003. A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol. Cell. Biol. 23:5825-5835.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 5825-5835
    • Liu, G.1    Banco, A.2    Harris, V.K.3    Aaronson, S.A.4
  • 21
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao, B., W. Wu, Y. Li, D. Hoppe, P. Stannek, A. Glinka, and C. Niehrs. 2001. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411:321-325.
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 22
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signaling pathway
    • Mao, J., J. Wang, B. Liu, W. Pan, G. H. Farr III, C. Flynn, H. Yuan, S. Takada, D. Kimelman, L. Li, and D. Wu. 2001. Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signaling pathway. Mol. Cell 7:801-809.
    • (2001) Mol. Cell , vol.7 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3    Pan, W.4    Farr III, G.H.5    Flynn, C.6    Yuan, H.7    Takada, S.8    Kimelman, D.9    Li, L.10    Wu, D.11
  • 23
    • 33845352082 scopus 로고    scopus 로고
    • Wnts as ligands: Processing, secretion and reception
    • Mikels, A. J., and R. Nusse. 2006. Wnts as ligands: processing, secretion and reception. Oncogene 25:7461-7468.
    • (2006) Oncogene , vol.25 , pp. 7461-7468
    • Mikels, A.J.1    Nusse, R.2
  • 24
    • 4344584730 scopus 로고    scopus 로고
    • WNT and beta-catenin signalling: Diseases and therapies
    • Moon, R. T., A. D. Kohn, G. V. De Ferrari, and A. Kaykas. 2004. WNT and beta-catenin signalling: diseases and therapies. Nat. Rev. Genet. 5:691-701.
    • (2004) Nat. Rev. Genet , vol.5 , pp. 691-701
    • Moon, R.T.1    Kohn, A.D.2    De Ferrari, G.V.3    Kaykas, A.4
  • 25
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin, P. J., A. B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, and K. W. Kinzler. 1997. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275:1787-1790.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 27
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • Pinson, K. I., J. Brennan, S. Monkley, B. J. Avery, and W. C. Skarnes. 2000. An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407:535-538.
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 28
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis, P. 2000. Wnt signaling and cancer. Genes Dev. 14:1837-1851.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 31
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger, J. 2000. Cell signaling by receptor tyrosine kinases. Cell 103: 211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 32
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • Semenov, M. V., K. Tamai, B. K. Brott, M. Kuhl, S. Sokol, and X. He. 2001. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11:951-961.
    • (2001) Curr. Biol , vol.11 , pp. 951-961
    • Semenov, M.V.1    Tamai, K.2    Brott, B.K.3    Kuhl, M.4    Sokol, S.5    He, X.6
  • 36
    • 34447526784 scopus 로고    scopus 로고
    • R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling
    • Wei, Q., C. Yokota, M. V. Semenov, B. Doble, J. Woodgett, and X. He. 2007. R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling. J. Biol. Chem. 282:15903- 15911.
    • (2007) J. Biol. Chem , vol.282 , pp. 15903-15911
    • Wei, Q.1    Yokota, C.2    Semenov, M.V.3    Doble, B.4    Woodgett, J.5    He, X.6
  • 37
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • Westendorf, J. J., R. A. Kahler, and T. M. Schroeder. 2004. Wnt signaling in osteoblasts and bone diseases. Gene 341:19-39.
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 38
    • 0037429692 scopus 로고    scopus 로고
    • Trafficking of the ErbB receptors and its influence on signaling
    • Wiley, H. S. 2003. Trafficking of the ErbB receptors and its influence on signaling. Exp. Cell Res. 284:78-88.
    • (2003) Exp. Cell Res , vol.284 , pp. 78-88
    • Wiley, H.S.1
  • 39
    • 33746482870 scopus 로고    scopus 로고
    • Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
    • Yamamoto, H., H. Komekado, and A. Kikuchi. 2006. Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev. Cell 11:213-223.
    • (2006) Dev. Cell , vol.11 , pp. 213-223
    • Yamamoto, H.1    Komekado, H.2    Kikuchi, A.3
  • 41
    • 6344228681 scopus 로고    scopus 로고
    • N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21
    • Zhou, Y. B., F. Liu, Z. D. Zhu, H. Zhu, X. Zhang, Z. Q. Wang, J. H. Liu, and Z. G. Han. 2004. N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21. FEBS Lett. 576:401-407.
    • (2004) FEBS Lett , vol.576 , pp. 401-407
    • Zhou, Y.B.1    Liu, F.2    Zhu, Z.D.3    Zhu, H.4    Zhang, X.5    Wang, Z.Q.6    Liu, J.H.7    Han, Z.G.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.