Imidazoline receptors and agmatine in blood vessels: A novel system inhibiting vascular smooth muscle proliferation

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 3, 1996, Pages 1272-1282

  Regunathan, S ^a   Youngson, C ^a   Raasch, W ^a   Wang, H ^a   Reis, D J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DIOXANE DERIVATIVE; DRUG RECEPTOR; IDAZOXAN; IMIDAZOLE DERIVATIVE; IMIDAZOLINE RECEPTORS;

ANIMAL; AORTA; ARTICLE; CATTLE; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; METABOLISM; RADIOASSAY; RAT; VASCULAR SMOOTH MUSCLE;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; AORTA; CATTLE; CELLS, CULTURED; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; IDAZOXAN; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; MUSCLE, SMOOTH, VASCULAR; RADIOLIGAND ASSAY; RATS; RECEPTORS, DRUG;

EID: 0030098067     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (78)

1. ANGUS, J. A., COCKS, T. M. AND SATOH, K.: The α-adrenoceptors on endothelial cells. Fed. Proc. 45: 2355-2359, 1986.
2. ATLAS, D.: Clonidine-displacing substance (CDS) and its putative imidazoline receptor. New leads for further divergence of α2-adrenergic receptor activity. Biochem. Pharmacol. 41: 1541-1549, 1991.
3. BERDEU, D., GROSS, R., PUECH, R., LOUBATIERES-MARIANI, M.-M. AND BERTRAND, G.: Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur. J. Pharmacol. 275: 91-98, 1995.
4. + transport and intracellular pH in renal proximal tubule cells. Biochem. Biophys. Acta 1024: 173-178, 1990.
5. BOUSQUET, P., FELDMAN, J. AND SCHWARTZ, J.: Central cardiovascular effects of alpha, adrenergic drugs. Differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230: 232-236, 1984.
6. BRICCA, G., DONTENWILL, M., MOLINES, A., FELDMAN, J., BELCOURT, A. AND BOUSQUET, P.. The imidazoline preferring receptor: Binding studies in bovine, rat and human brainstem. Eur. J. Pharmacol. 162: 1-9, 1989.
7. 3H]idazoxan in the human cerebral cortex. Neurochem. Int. 22: 153-163, 1993.
8. 2-adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br. J. Pharmacol. 99: 803-809, 1990.
9. BUCH, J. K AND BOYLE, S. M.: Biosynthetic arginine decarboxylase in escherichia coli is synthesized as a precursor and located in the cell envelope. J. Bacteriol. 163: 522-527, 1985.
10. 2-adrenoceptors and imidazoline-binding sites in the control of insulin secretion. Clin Sci. 85: 671-677, 1993.
11. COUPRY, I., ATLAS, D., PODEVIN, R. A., UZIELLI, I. AND PARINI, A.: Imidazolineguanidinium receptive sites in renal proximal tubule: Asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance. J. Pharmacol. Exp. Ther. 252: 293-299, 1989.
12. 2-subtypes in rat vasculature in vitro and in vivo. Naunyn-Schmiedeberg Arch Pharmacol. 326: 1-6, 1984.
13. EGLEME, C., GODFRAIND, T. AND MILLER, R.. Enhanced responsiveness of isolated rat aorta to clonidine after removal of the endothelial cells. Br. J. Pharmacol. 81: 16-18, 1984.
14. ERLINGE, D., Yoo, H., EDVINSSON, L., REIS, D. J. AND WAHLESTEDT, C.: Mitogenic effects of ATP on vascular smooth muscle cells vs. other growth factors and sympathetic cotransmitters. Am. J. Physiol. 265: H1089-H1097, 1993.
15. ERNSBERGER, P., GIULIANO, R., WILLETTE, R. N. AND REIS, D. J.: Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 253: 408-418, 1990.
16. 1-imidazoline receptors. Definition, characterization, distribution, and transmembrane signaling. Ann. N.Y. Acad. Sci. 763: 22-42, 1995.
17. 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134: 1-14, 1987.
18. ERNSBERGER, P., DAMON, T. H., GRAFF, L. M., SCHAFER, S. G. AND CHRISTEN, M. O.: Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for il-imidazoline sites. J. Pharmacol. Exp. Ther. 264: 172-182, 1993.
19. EVINGER, M. J., ERNSBERGER, P., REGUNATHAN, S. AND REIS, D. J.: Regulation of PNMT gene expression by imidazoline receptors in adrenal chromaffin cells. J. Neurochem. 65: 988-997, 1995.
20. FLAVAHAN, N. A., SHIMOKAWA, H. AND VANHOUTTE, P. M.: Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries. J. Physiol (Lond.) 408: 549-560, 1989.
21. GALEA, E., RECUNATHAN, S., ELIOPOULOS, V., FEINSTEIN, D. L., AND REIS, D. J.: Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine Biochem. J., in press, 1996
22. GAO, Y., GUMUSEL, B , KOVES, G., PRASAD, A., HAO, Q., HYMAN, A. AND LIPPTON, H.: Agmatine: A novel endogenous vasodilator substance. Life Sci. 57: PL83-86, 1995.
23. GOMEZ, R. E., ERNSBERGER, P., FEINLAND, G. AND REIS, D. J.: Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area. Eur. J. Pharmacol. 195: 181-191, 1991.
24. 3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes. Eur. J. Pharmacol. 146: 345-348, 1988.
25. HSU, S. M., RAINE, L. AND FANGER, H.: Use of avidin-biotin-peroxidase complec (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29: 557-580, 1981.
26. 2-adrenergic inhibitory control of transmitter release in the rabbit mesentric artery. Eur J. Pharmacol. 143: 151-161, 1987.
27. JACKSON, C. L. AND SCHWARTZ, S. M.: Pharmacology of smooth muscle cell replication. Hypertension 20: 713-736, 1992
28. 3H]p-aminoclonidine to two sites, alpha 2-adrenoceptors and imidazoline binding sites: Distribution of imidazoline binding sites in rat brain. Brain Res. 514: 15-21, 1990.
29. KATSUTA, H., TAKAOKA, T., NOSE, K. AND NAGAI, Y.: Effects of polyamines on the proliferation of mammalian cells in tissue culture. Jpn J. Exp. Med. 45: 345-354, 1975.
30. LACOMBE, C., VIALLARD, V. AND PARIS, H.: Identification of α2-adrenceptors and non-adrenergic idazoxan binding sites in pancreatic islets from young and adult hamsters. Int. J. Biochem. 25: 1077-1084, 1993
31. LANGER, S Z AND HICKS, P. E.: Alpha-adrenoceptor subtypes in blood vessels: Physiology and pharmacology. J. Cardiovasc. Pharmacol. 6:(Suppl. 4), S547-S558, 1984.
32. 3H-idazoxan binding at α-adrenoceptors in rabbit adipocyte membranes. Eur. J. Pharmacol. 159: 199-203, 1989.
33. LI, G., REGUNATHAN, S., BARROW, C. J., ESHRACHI, J., COOPER, R. AND REIS, D. J : Agmatine: An endogenous clonidine-displacing substance in the brain. Science 263: 966-969, 1994.
34. LI, G., REGUNATHAN, S. AND REIS, D. J.: Agmatine is synthesized by a mitochondrial arginine decarboxylase in rat brain. Ann. N.Y. Acad. Sci. 763: 325-329, 1995.
35. LORING, R. H.: Agmatine acts as an antagonist of neuronal nicotinic receptors. Br. J. Pharmacol. 99(1): 207-211, 1990.
36. MAJUMDER, S., WIRTH, J. J., BITONTI, A J., McCANN, P. P. AND KIERSZENBAUM, F.: Biochemical evidence for the presence of arginine decarboxylase activity in trypanosoma cruzi. J. Parasitol. 78: 371-374, 1992.
37. MALMBERG, R. L. AND CELLINO, M. L.: Arginine decarboxylase of oats is activated by enzymatic cleavage into two polypeptides. J. Biol. Chem. 269: 2703-2706, 1994.
38. MEYER-LEHNERT, H. AND SCHRIER, R. W.: Potential mechanism of cyclosporin A-induced vascular smooth muscle contraction. Hypertension 13: 350-361, 1989.
39. MICHEL, M. C AND INSEL, P. A.: Are there multiple imidazoline binding sites? Trends Pharmacol. Sci 10: 342-344, 1989.
40. MICHEL, M. C. AND ERNSBERGER, P. R.: Keeping an eye on the I site: imidazolinepreferring receptors. Trends Pharmacol. Sci. 13: 369-370, 1992.
41. 2-adrenergic drugs also binds with high affinity to a nonadrenergic site Mol. Pharmacol. 35: 324-330, 1989.
42. 2-adrenoceptor effects of substituted catecholimidazole and catecholimidazoline analogs in human platelets. J. Med. Chem. 33: 1138-1147, 1990.
43. MONCADA, S., PALMER, R. M. AND HIGGS, E. A: Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
44. PARINI, A , COUPRY, I., GRAHAM, R. M., UZIELLI, I., ATLAS, D. AND LANIER, S. M.: Characterization of an imidazoline guanidinium receptive site distinct from the α2-adrenergic receptor. J. Biol. Chem. 264: 11874-11878, 1989.
45. PATCHETT, M. L , MONK, C. R , DANIEL, R. M. AND MORGAN, H. W.: Determination of agmatine, arginine, citrulline and ornithine by reversed-phase liquid chromatography using automated pre-column derivatization with o-phthalaldehyde. J. Chromatogr. 425: 269-276, 1988.
46. 2-adrenergic receptors. Eur. J. Pharmacol. 76: 461-464, 1981.
47. PICKEL, V, M.. Immunocytochemical methods. In Neuroanatomical Tract Tracing Methods, ed. by L Heimer and M. J Robards, pp. 483-509, Plenum Publishing, New York, 1981.
48. PILETZ, J E., CIUKKALA, D. N. AND ERNSBERGER, P.: Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. J. Pharmacol. Exp. Ther. 272: 581-587, 1995.
49. 2-adrenoceptor sites plus a non-adrenergic site on human platelet plasma membranes. Biochem. Pharmacol 42: 569-584, 1991.
50. 2-adrenoceptors. Naunyn Schmiedeberg Arch. Pharmacol. 351: 10-16, 1995.
51. RAASCH, W., REGUNATHAN, S., Li, G. AND REIS, D. J.: Agmatine, the bacterial amine, is widely distributed in mammalian tissues. Life Sci. 56: 2319-2330, 1995.
52. RAMAKRISHNA, S. AND ADIGA, P. R : Arginine decarboxylase from lathyrus sativus seedlings. purification and properites. Eur. J. Biochem. 59: 377-386, 1975.
53. REGUNATHAN, S., MEELEY, M. P. AND REIS, D. J.: Expression of nonadrenergic imidazoline sites in chrornaffin cells and mitochondrial membranes of bovine adrenal medulla. Biochem Pharmacol. 45: 1667-1675, 1993a.
54. REGUNATHAN, S., YOUNGSON, C., WANG, H. AND REIS, D. J.: Imidazoline receptors in vascular smooth muscle and endothelial cells Ann. N Y. Acad. Sci. 763: 580-590, 1995.
55. REGUNATHAN, S., FEINSTEIN, D. L. AND REIS, D. J.: Expression of non-adrenergic imidazoline sites in rat cerebral cortical astrocytes. J. Neurosci. Res 34: 681-688, 1993b.
56. REGUNATHAN, S., MEELEY, M. P. AND REIS, D. J.: Clonidine-displacing substance from bovine brain binds to imidazoline receptors and releases catecholamines m adrenal chromaffin cells. Mol. Pharmacol. 40: 884-888, 1991.
57. REIS, D J., Li, G. AND REGUNATHAN, S.: Endogenous ligands of imidazoline receptors: Classic and immunoreactive clonidine displacing substance (CDS) and agmatine. Ann. N.Y. Acad. Sci. 763: 295-313, 1995.
58. RUGGIERO, D. A., REGUNATHAN, S., WANG, H., MILNER, T. A. AND REIS, D. J.: Distribution of imidazoline receptor binding protein in the central nervous system. Ann. N.Y Acad. Sci. 763: 208-221, 1995.
59. SENER, A., LEBRUN, P., BLACHIER, F AND MALAISSE, W. J.: Stimulus-secretion coupling of arginine-induced insulin release. Insulinotropic action of agmatine. Biochem. Pharmacol. 38: 327-330, 1989.
60. SHAMS, G., VENKATARAMAN, B. V., HAMADA, A., MILLER, D. D., PATIL, P. N. AND FELLER, D. R.: Diversity of the pharmacological actions of some tolazoline analogues in human platelets and rat aorta. Eur. J. Pharmacol. 199: 315-323, 1991.
61. STALON, V. AND MERCENIER, A.: L-arginine utilization by pseudomonas species. J. Gen. Microbiol. 130(Pt 1): 69-76, 1984.
62. SUN, M.-K., REGUNATHAN, S. AND REIS, D. J.: Cardiovascular responses to agmatinc, a clonidine-displacing substance, in anesthetized rats. Clin. Exp. Hypertens. 17: 115-128, 1995.
63. TABOR, C. W. AND TABOR, H.: Polyamines. Annu. Rev. Biochem. 53: 749-790, 1984.
64. TESSON, F. AND PARINI, A.: Identification of an imidazoline-guanidinium receptive site in mitochondria from rabbit cerebral cortex. Eur. J. Pharmacol. 208: 81-83, 1991.
65. TESSON, F., PRIP-BUUS, C., LEMOINE, A., PEGORIER, J-P. AND PARNI, A.: Subcellular distribution of imidazoline-guanidinium-receptive sites in human and rabbit liver: Major localization to the mitochandrial outer membrane. J Biol Chem 260: 155-160, 1991.
66. THYBERG, J. AND FREDHOLM, B. B.. Modulation of arterial smooth muscle cells from contractile to synthetic phenotype requires induction of ornithine decarboxylase activity and polyamine synthesis. Exp. Cell Res. 270: 153-159, 1987.
67. TIBIRICA, E., FELDMAN, J., MERMET, C., GONON, F. AND BOUSQUET, P.: An imidazoline specific mechanism for the hypotensive effect of clonidine: A study with yohimbine and idazoxan. J. Pharmacol Exp. Ther. 256: 606-613, 1991.
68. VENKATARAMAN, B. V., HAMADA, H., SHAMS, G., FELLER, D. E., MILLER, D. D. AND PATIL, P. N.. Paradoxical effects of a isothiocyanate analogue of tolazoline on rat aorta and human platelets. Blood Vessels 26: 335-346, 1989.
69. WANG, H., REGUNATHAN, S., MEELEY, M. P. AND REIS, D. J.: Isolation and characterization of imidazoline receptor proteins from bovine adrenal chromaffin cells. Mol. Pharmacol. 42: 792-801, 1992.
70. WANG, H., REGUNATHAN, S., RUGGIERO, D. A. AND REIS, D. J.: Production and characterization of antibodies specific for the imidazoline receptor protein. Mol. Pharmacol. 43: 509-515, 1993.
71. WANG, H., REGUNATHAN, S., YOUNGSON, C. AND REIS, D. J.: An antibody to agmatine localizes the amine in bovine adrenal chromaffin cells. Neurosci Lett. 183: 1-5, 1995.
72. WEITZEL, G., PFEIFFER, B. AND STOCK, W.: Insulin-like partial effects of agmatine derivatives in adipocytes. Hoppe Seyler's Z. Physiol. Chem. 361: 51-60, 1980.
73. WIKBERG, J. E. S. AND UHLEN, S.: Further characterization of the guinea pig cerebral cortex idazoxan receptor: Solubilization, distinction from the imidazole site and demonstration of cirazoline as an idazoxan receptor-selective drug J. Neurochem. 55: 192-203, 1990.
74. 3H]-idazoxan binding sites (I-receptors) occurs to interacting or interconvertible affinity forms of the receptor. Pharmacol. Toxicol. 70: 208-219, 1992.
75. Wu, W. H. AND MORRIS, D. R.: Biosynthetic arginine decarboxylase from Escherichia coli: Purification and properties. J. Biol. Chem. 248: 1687-1695, 1973.
76. 3]idazoxan in the rabbit urethral smooth muscle. Biochem. Pharmacol. 41: 701-707, 1991.
77. YAU, K. M., FONG, W. F AND NG, S. F : Putrescine biosynthesis in tetrahymena thermophila. Biochem. J. 222: 679-684, 1984.
78. 2-adrenoceptors? Eur. J. Pharmacol 190: 203-215, 1990.