Gastrointestinal Uptake of Agmatine: Distribution in Tissues and Organs and Pathophysiologic Relevance

Annals of the New York Academy of Sciences

Volumn 1009, Issue , 2003, Pages 44-51

  Molderings, Gerhard J ^a   Heinen, Anja ^a   Menzel, Sigrid ^a   Lübbecke, Friedrich ^b   Homann, Jürgen ^c   Göthert, Manfred ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Kreiskrankenhaus Uelzen ^*  (Germany)

^c EVANGELISCHES KRANKENHAUS   (Germany)

Author keywords

Agmatine distribution; Agmatine transporter; Agmatine uptake; Liver regeneration

Indexed keywords

AGMATINE; POLYCATION;

ABSORPTION; BIOAVAILABILITY; CALORIC RESTRICTION; CONFERENCE PAPER; GASTROINTESTINAL TRACT; HUMAN; LIVER DISEASE; LIVER REGENERATION; ORGAN DISTRIBUTION; PARTIAL HEPATECTOMY; PATHOPHYSIOLOGY; PROTEIN FUNCTION; RADIOACTIVITY; SPECIES COMPARISON; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 1342326715     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1304.005     Document Type: Conference Paper

References (30)

1. RAASCH, W., U. SCHÄFER, J. CHUN, et al. 2001. Biological significance of agmatine, an endogenous ligand at imidazoline binding sites. Br. J. Pharmacol. 133: 755-780.
2. PENAFIEL, R., C. RUZOFA, E. PEDRENO, et al. 1998. Agmatine metabolism in rodent tissues. In Biogenically Active Amines in Food, Vol. 2. S. A. Bardoczs, G. White, G. Hajos, Eds.: 79-85. European Communities. Brussels, Belgium.
3. MOLDERINGS, G.J., M. BURIAN, J. HOMANN, et al. 1999. Potential relevance of agmatine as a virulence factor of Helicobacter pylori. Dig. Dis. Sci. 44: 2397-2404.
4. TABOR, C.W. & H. TABOR. 1984. Polyamines. Ann. Res. Biochem. 53: 749-790.
5. BENAMOUZIG, R., S. MAHÉ, C. LUENGO, et al. 1997. Fasting and postprandial polyamine concentrations in the human digestive lumen. Am. J. Clin. Nutr. 65: 766-770.
6. LORTIE, M.J., W.F. NOVOTNY, O.W. PETERSON, et al. 1996. Agmatine, a bioactive metabolite of arginine. J. Clin. Invest. 97: 413-420.
7. GILAD, G.M., Y. WOLLAM, A. IAINE, et al. 1996. Metabolism of agmatine into urea but not into nitric oxide in rat brain. Neuroreport 7: 1730-1732.
8. SASTRE, M., S. REGUNATHAN, E. GALEA, et al. 1996. Agmatinase activity in rat brain: a metabolic pathway for the degradation of agmatine. J. Neurochem. 67: 1761-1765.
9. SASTRE, M., E. GALEA, D. FEINSTEIN, et al. 1998. Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines. Biochem. J. 330: 1405-1409.
10. CABELLA, C., G. GARDINI, D. CORPILLO, et al. 2001. Transport and metabolism of agmatine in rat hepatocyte cultures. Eur. J. Biochem. 268: 940-947.
11. RAASCH, W., S. REGUNATHEN, et al. 1995. Agmatine, the bacterial amine, is widely distributed in mammalian tissues. Life Sci. 56: 2319-2330.
12. HOLT, A. & G.B. BAKER. 1995. Metabolism of agmatine (clonidine-displacing substance) by diamine oxidase and the possible implications for studies of imidazoline receptors. Progress Brain Res. 106: 187-197.
13. 14C]agmatine: accumulation in the stomach wall and distribution in various tissues. Fundam. Clin. Pharmacol. 16: 219-225.
14. OSBORNE, D.L. & E.R. SEIDEL. 1990. Gastrointestinal luminal polyamines: cellular accumulation and enterohepatic circulation. Am. J. Physiol. 258: G576-G584.
15. YOSHIKAMI, P. 1981. Transmitter sensitivity of neurons assayed by autoradiography. Science 212: 929-930.
16. QUIK, M. 1985. Inhibition of nicotinic receptor mediated ion fluxes in rat sympathetic ganglia by BGT II-S1 a potent phospholipase. Brain Res. 325: 79-88.
17. BABAL, P., M. RUCHKO, J.W. OLSON, et al. 2000. Interactions betwen agmatine and polyamine uptake pathways in rat pulmonary artery endothelial cells. Gen. Pharmacol. 34: 255-261.
18. DEL VALLE, A.E., J.C. PAZ, F. SANCHEZ-JIMENEZ, et al. 2000. Agmatine uptake by cultured hamster kidney cells. Biochem. Biophys. Res. Commun. 280: 307-311.
19. MOLDERINGS, G.J., H. BÖNISCH, M. GÖTHERT, et al. 2001. Agmatine and putrescine uptake in the human glioma cell line SK-MG-1. Naunyn-Schmiedeberg's Arch. Pharmacol. 363: 671-679.
20. SATRIANO, J., M. ISOME, R.A. CASERO, et al. 2001. Polyamine transport system mediates agmatine transport in mammalian cells. Am. J. Physiol. Cell. Physiol. 281: C329-C334.
21. HEINEN, A., M. BRÜSS, H. BÖNISCH, et al. 2003. Pharmacological characteristics of the specific transporter for the endogenous cell growth inhibitor agmatine in six tumor cell lines. Int. J. Colorectal Dis. 18: 314-319.
22. MICHALOPOULOS, G.K. & M.C. DEFRANCES. 1997. Liver regeneration. Science 276: 60-66.
23. HIGAKI, I., I. MATSUI-YUASA, K. HIROHASHI, et al. 1999. The role of polyamines in growth factor induced DNA synthesis in cultured rat hepatocytes. Hepatogastroenterology 46: 1874-1879.
24. ALHONEN, L., T.L. RÄSÄNEN, R. SINERVIRTA, et al. 2002. Polyamines are required for the initiation of rat liver regeneration. Biochem. J. 362: 149-153.
25. BUTTERWORTH, R.F. 2002. Complications of cirrhosis. III. Hepatic encephalopathy. J Hepatology 32(Suppl. 1): 171-180.
26. GERBER, T. & H. SCHOMERUS. 2000. Hepatic encephalopathy in liver cirrhosis. Drugs 60: 1353-1370.
27. RAASCH, W., U. SCHÄFER, F. QADRI, et al. 2002. Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br. J. Pharmacol. 135: 663-672.
28. KAWABATA, T., H. OHSHIMA, M. INO. 1978. Occurrence of methylguanidine and agmatine in foods. IARC Sci. Publ. 19: 415-423.
29. OKAMOTO, A., E. SUGI, Y. KOIZUMI, et al. 1997. Polyamine content of ordinary foodstuffs and various fermented foods. Biosci. Biotech. Biochem. 61: 1582-1584.
30. ERKAN, N., N. HELLE, Ö. ÖZDEN. 2001. Determination of biogenic amines in canned fish of the Turkish market. Berl. Munch. Tierarztl. Wochenschr. 114: 241-245.