Biochemical and endocrinological preparation for parturition

Best Practice and Research: Clinical Obstetrics and Gynaecology

Volumn 21, Issue 5, 2007, Pages 729-756

  Terzidou, Vasso ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

contractant pathways; NF B; oxytocin; preterm labour; prostaglandins

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 8 QUINOLINOL; ACETYLSALICYLIC ACID; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESALAZINE; OXYTOCIN; OXYTOCIN RECEPTOR; PREDNISOLONE; PROGESTERONE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; SALAZOSULFAPYRIDINE; SALICYLATE SODIUM; SALICYLIC ACID DERIVATIVE; THROMBOCYTE ACTIVATING FACTOR;

AMNION; BIRTH; CHORION; CLINICAL CHEMISTRY; CYTOKINE RELEASE; DECIDUA; DESENSITIZATION; DRUG MECHANISM; DRUG TARGETING; FETOPLACENTAL UNIT; FETUS (ANATOMY); HORMONAL REGULATION; HORMONE ACTION; HUMAN; INFLAMMATION; LABOR ONSET; LABOR STAGE; MYOMETRIUM; NONHUMAN; PATHOPHYSIOLOGY; PLACENTA FUNCTION; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UTERINE CERVIX; UTERUS CONTRACTILITY; UTERUS CONTRACTION; UTERUS FUNCTION; FEMALE; METABOLISM; NEWBORN; PHYSIOLOGY; PREGNANCY;

FEMALE; HUMANS; INFANT, NEWBORN; NF-KAPPA B; OXYTOCIN; PARTURITION; PREGNANCY; PROSTAGLANDINS; RECEPTORS, OXYTOCIN; SIGNAL TRANSDUCTION; UTERINE CONTRACTION;

EID: 35048884231     PISSN: 15216934     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpobgyn.2007.05.001     Document Type: Review

References (148)

1. Wood N.S., Marlow N., Costeloe K., et al. Neurologic and developmental disability after extremely preterm birth. EPICure Study Group [see comments]. N Engl J Med 343 (2000) 378-384
2. Escobar G.J., Littenberg B., and Petitti D.B. Outcome among surviving very low birthweight infants: a meta-analysis. Arch Dis Child 66 (1991) 204-211
3. Hall A., McLeod A., Counsell C., et al. School attainment, cognitive ability and motor function in a total Scottish very-low-birthweight population at eight years: a controlled study. Dev Med Child Neurol 37 (1995) 1037-1050
4. Schothorst P.F., and van Engeland H. Long-term behavioral sequelae of prematurity. J Am Acad Child Adolesc Psychiatry 35 (1996) 175-183
5. McCarton C.M., Brooks-Gunn J., Wallace I.F., et al. Results at age 8 years of early intervention for low-birth-weight premature infants. The Infant Health and Development Program [see comments]. JAMA 277 (1997) 126-132
6. Paneth N., and Pinto J. The epidemiology of germinal matrix/intraventicular hemorrhage. In: Kiely M. (Ed). Reproductive and Perinatal Epidemiology (1990), CRC Press, Boca Raton 371-399
7. Paneth N., Rudelli R., Kazam E., et al. Brain damage in the preterm infant (1994), Mac Keith Press, London
8. Lye S. The initiation and inhibition of labour - toward a molecular understanding. Semin Reprod Endocrinol 12 (1994) 284-294
9. Challis J.R.G., Matthews S.G., Gibb W., et al. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 21 (2000) 514-550
10. Fuchs A.R., Fuchs F., Husslein P., et al. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol 150 (1984) 734-741
11. Sparey C., Robson S.C., Bailey J., et al. The differential expression of myometrial connexin-43, cyclooxygenase-1 and -2, and Gs alpha proteins in the upper and lower segments of the human uterus during pregnancy and labor. J Clin Endocrinol Metab 84 (1999) 1705-1710
12. Stevens M.Y., Challis J.R., and Lye S.J. Corticotropin-releasing hormone receptor subtype 1 is significantly up-regulated at the time of labor in the human myometrium. J Clin Endocrinol Metab 83 (1998) 4107-4115
13. Winkler M., and Rath W. Changes in the cervical extracellular matrix during pregnancy and parturition. J Perinat Med 27 (1999) 45-60
14. Vince G.S., and Johnson P.M. Leucocyte populations and cytokine regulation in human uteroplacental tissues. Biochem Soc Trans 28 (2000) 191-195
15. McLaren J., Malak T.M., and Bell S.C. Structural characteristics of term human fetal membranes prior to labour: identification of an area of altered morphology overlying the cervix. Hum Reprod 14 (1999) 237-241
16. Spaziani E.P., Tsibris J.C., Hunt L.T., et al. The effect of interleukin-1 beta and interleukin-4 on the expression of prostaglandin receptors EP1 and EP3 in amnion WISH cells. Am J Reprod Immunol 38 (1997) 279-285
17. Fuchs A.R., Fuchs F., Husslein P., et al. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science 215 (1982) 1396-1398
18. Haluska G.J., Stanczyk F.Z., Cook M.J., et al. Temporal changes in uterine activity and prostaglandin response to RU486 in rhesus macaques in late gestation. Am J Obstet Gynecol 157 (1987) 1487-1495
19. Critchley H.O., Kelly R.W., Lea R.G., et al. Sex steroid regulation of leukocyte traffic in human decidua. Hum Reprod 11 (1996) 2257-2262
20. McLean M., Bisits A., Davies J., et al. A placental clock controlling the length of human pregnancy [see comments]. Nat Med 1 (1995) 460-463
21. Grammatopoulos D., Stirrat G.M., Williams S.A., et al. The biological activity of the corticotropin-releasing hormone receptor-adenylate cyclase complex in human myometrium is reduced at the end of pregnancy. J Clin Endocrinol Metab 81 (1996) 745-751
22. Petraglia F., De Vita D., Gallinelli A., et al. Abnormal concentration of maternal serum activin-A in gestational diseases. J Clin Endocrinol Metab 80 (1995) 558-561
23. Challis J.R. CRH, a placental clock and preterm labour. Nat Med 1 (1995) 416
24. Mecenas C.A., Giussani D.A., Owiny J.R., et al. Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion. Nat Med 2 (1996) 443-448
25. Romero R., Gomez R., Galasso M., et al. Macrophage inflammatory protein-1 alpha in term and preterm parturition: effect of microbial invasion of the amniotic cavity. Am J Reprod Immunol 32 (1994) 108-113
26. Romero R. Does infection cause premature labor and delivery?. Semin Reprod Endocrinol 12 (1994) 227-239
27. Marvin K.W., Keelan J.A., Eykholt R.L., et al. Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm. Mol Hum Reprod 8 (2002) 399-408
28. Chan E.C., Fraser S., Yin S., et al. Human myometrial genes are differentially expressed in labor: a suppression subtractive hybridization study. J Clin Endocrinol Metab 87 (2002) 2435-2441
29. Charpigny G., Leroy M.J., Breuiller-Fouche M., et al. A functional genomic study to identify differential gene expression in the preterm and term human myometrium. Biol Reprod 68 (2003) 2289-2296
30. Young A., Thomson A.J., Ledingham M., et al. Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term. Biol Reprod 66 (2002) 445-449
31. Allport V.C., Slater D.M., Newton R., et al. NF-kB and AP-1 are required for the cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH). Mol Hum Reprod 6 (2000) 561-565
32. Allport V.C., Pieber D., Slater D.M., et al. Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'. Mol Hum Reprod 7 (2001) 581-586
33. Gorgoni B., Caivano M., Arizmendi C., et al. The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts. J Biol Chem 276 (2001) 40769-40777
34. Romero R., Mazor M., Brandt F., et al. Interleukin-1 alpha and interleukin-1 beta in preterm and term human parturition. Am J Reprod Immunol 27 (1992) 117-123
35. Romero R., Wu Y.K., Sirtori M., et al. Amniotic fluid concentrations of prostaglandin F2 alpha, 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) and 11-deoxy-13,14-dihydro-15-keto-11, 16-cyclo-prostaglandin E2 (PGEM-LL) in preterm labor. Prostaglandins 37 (1989) 149-161
36. Maymon E., Ghezzi F., Edwin S.S., et al. The tumor necrosis factor alpha and its soluble receptor profile in term and preterm parturition. Am J Obstet Gynecol 181 (1999) 1142-1148
37. Keelan J.A., Marvin K.W., Sato T.A., et al. Cytokine abundance in placental tissues: evidence of inflammatory activation in gestational membranes with term and preterm parturition. Am J Obstet Gynecol 181 (1999) 1530-1536
38. Condon J.C., Jeyasuria P., Faust J.M., et al. Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition. Proc Natl Acad Sci USA 101 (2004) 4978-4983
39. Baeuerle P.A., and Baltimore D. NF-kappaB: ten years after. Cell 87 (1996) 13-20
40. Baldwin Jr. A.S. The NF-kappaB and I kappaB proteins: new discoveries and insights. Annu Rev Immunol 14 (1996) 649-683
41. Sheppard K.A., Rose D.W., Haque Z.K., et al. Transcriptional activation by NF-kappaB requires multiple coactivators. Mol Cell Biol 19 (1999) 6367-6378
42. Lee Y., Allport V., Sykes A., et al. The effects of labour and of interleukin 1 beta upon the expression of nuclear factor kappaB related proteins in human amnion. Mol Hum Reprod 9 (2003) 213-218
43. Condon J.C., Hardy D.B., Kovaric K., et al. Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Mol Endocrinol 20 (2006) 764-775
44. Chapman N.R., Europe-Finner G.N., and Robson S.C. Expression and deoxyribonucleic acid-binding activity of the nuclear factor kappaB family in the human myometrium during pregnancy and labor. J Clin Endocrinol Metab 89 (2004) 5683-5693
45. Kalkhoven E., Wissink S., van der Saag P.T., et al. Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor. J Biol Chem 271 (1996) 6217-6224
46. Mahendroo M.S., Porter A., Russell D.W., et al. The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol 13 (1999) 981-992
47. Condon J.C., Jeyasuria P., Faust J.M., et al. A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. Proc Natl Acad Sci USA 100 (2003) 9518-9523
48. Mesiano S., Chan E.C., Fitter J.T., et al. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab 87 (2002) 2924-2930
49. Pieber D., Allport V.C., and Bennett P.R. Progesterone receptor isoform A inhibits isoform B-mediated transactivation in human amnion. Eur J Pharmacol 427 (2001) 7-11
50. Zakar T., Olson D.M., Teixeira F.J., et al. Regulation of prostaglandin endoperoxide H2 synthase in term human gestational tissues. Acta Physiol Hung 84 (1996) 109-118
51. Romero R., Baumann P., Gonzalez R., et al. Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term. Am J Obstet Gynecol 171 (1994) 1613-1620
52. Mohan A.R., Loudon J.A., and Bennett P.R. Molecular and biochemical mechanisms of preterm labour. Semin Fetal Neonatal Med 9 (2004) 437-444
53. Slater D.M., Berger L.C., Newton R., et al. Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term. Am J Obstet Gynecol 172 (1995) 77-82
54. Slater D., Berger L., Newton R., et al. The relative abundance of type 1 to type 2 cyclo-oxygenase mRNA in human amnion at term. Biochem Biophys Res Commun 198 (1994) 304-308
55. Slater D., Dennes W., Sawdy R., et al. Expression of cyclo-oxygenase types-1 and -2 in human fetal membranes throughout pregnancy. J Mol Endocrinol 22 (1999) 125-130
56. Elliott C.L., Allport V.C., Loudon J.A., et al. Nuclear factor-kappa B is essential for up-regulation of interleukin-8 expression in human amnion and cervical epithelial cells. Mol Hum Reprod 7 (2001) 787-790
57. Loudon J.A., Elliott C.L., Hills F., et al. Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells. Biol Reprod 69 (2003) 331-337
58. Jones S.A., Brooks A.N., and Challis J.R. Steroids modulate corticotropin-releasing hormone production in human fetal membranes and placenta. J Clin Endocrinol Metab 68 (1989) 825-830
59. Alvi S.A., Brown N.L., Bennett P.R., et al. Corticotrophin-releasing hormone and platelet-activating factor induce transcription of the type-2 cyclo-oxygenase gene in human fetal membranes. Mol Hum Reprod 5 (1999) 476-480
60. Toyoshima K., Narahara H., Furukawa M., et al. Platelet-activating factor. Role in fetal lung development and relationship to normal and premature labor. Clin Perinatol 22 (1995) 263-280
61. Hoffman D.R., Romero R., and Johnston J.M. Detection of platelet-activating factor in amniotic fluid of complicated pregnancies. Am J Obstet Gynecol 162 (1990) 525-528
62. Dale H.H. On some physiological actions of ergot. J Physiol 34 (1906) 163-206
63. Russell J.A., and Leng G. Sex, parturition and motherhood without oxytocin?. J Endocrinol 157 (1998) 343-359
64. Soloff M.S., Alexandrova M., and Fernstrom M.J. Oxytocin receptors: triggers for parturition and lactation?. Science 204 (1979) 1313-1315
65. Phelan J.P., Guay A.T., and Newman C. Diabetes insipidus in pregnancy: a case review. Am J Obstet Gynecol 130 (1978) 365-366
66. Chibbar R., Miller F.D., and Mitchell B.F. Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition. J Clin Invest 91 (1993) 185-192
67. Mitchell B.F., Fang X., and Wong S. Oxytocin: a paracrine hormone in the regulation of parturition?. Rev Reprod 3 (1998) 113-122
68. Fuchs A.R., Periyasamy S., Alexandrova M., et al. Correlation between oxytocin receptor concentration and responsiveness to oxytocin in pregnant rat myometrium: effects of ovarian steroids. Endocrinology 113 (1983) 742-749
69. Caldeyro-Barcia R., and Theobald G.W. Sensitivity of the pregnant human myometrium to oxytocin. Am J Obstet Gynecol 102 (1968) 1181
70. Jeng Y.J., Soloff S.L., Anderson G.D., et al. Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. Endocrinology 144 (2003) 61-68
71. Breton C., Di Scala-Guenot D., and Zingg H.H. Oxytocin receptor gene expression in rat mammary gland: structural characterization and regulation. J Mol Endocrinol 27 (2001) 175-189
72. Verbalis J.G. The brain oxytocin receptor(s)?. Front Neuroendocrinol 20 (1999) 146-156
73. Chan W.Y., Chen D.L., and Manning M. Oxytocin receptor subtypes in the pregnant rat myometrium and decidua: pharmacological differentiations. Endocrinology 132 (1993) 1381-1386
74. Arpin-Bott M.P., Waltisperger E., Freund-Mercier M.J., et al. Two oxytocin-binding site subtypes in rat kidney: pharmacological characterization, ontogeny and localization by in vitro and in vivo autoradiography. J Endocrinol 153 (1997) 49-59
75. Adan R.A., Van Leeuwen F.W., Sonnemans M.A., et al. Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus: partial sequence and immunocytochemical localization. Endocrinology 136 (1995) 4022-4028
76. Soloff M.S. Uterine receptor for oxytocin: effects of estrogen. Biochem Biophys Res Commun 65 (1975) 205-212
77. Fang X., Wong S., and Mitchell B.F. Relationships among sex steroids, oxytocin, and their receptors in the rat uterus during late gestation and at parturition. Endocrinology 137 (1996) 3213-3219
78. Horn S., Bathgate R., Lioutas C., et al. Bovine endometrial epithelial cells as a model system to study oxytocin receptor regulation. Hum Reprod Update 4 (1998) 605-614
79. Wathes D.C., Mann G.E., Payne J.H., et al. Regulation of oxytocin, oestradiol and progesterone receptor concentrations in different uterine regions by oestradiol, progesterone and oxytocin in ovariectomized ewes. J Endocrinol 151 (1996) 375-393
80. Ivell R., Bathgate R., Kimura T., et al. Molecular biology of the oxytocin receptor: a comparative approach. Biochem Soc Trans 25 (1997) 1058-1066
81. Parry L.J., Bathgate R.A., Shaw G., et al. Evidence for a local1fetal influence on myometrial oxytocin receptors during pregnancy in the tammar wallaby (Macropus eugenii). Biol Reprod 56 (1997) 200-207
82. Gimpl G., and Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev 81 (2001) 629-683
83. Chan W.Y. The separate uterotonic and prostaglandin-releasing actions of oxytocin. Evidence and comparison with angiotensin and methacholine in the isolated rat uterus. J Pharmacol Exp Ther 213 (1980) 575-579
84. Wilson T., Liggins G.C., and Whittaker D.J. Oxytocin stimulates the release of arachidonic acid and prostaglandin F2 alpha from human decidual cells. Prostaglandins 35 (1988) 771-780
85. Pasetto N., Zicari A., Piccione E., et al. Influence of labor and oxytocin on in vitro leukotriene release by human fetal membranes and uterine decidua at term gestation. Am J Obstet Gynecol 166 (1992) 1500-1506
86. Sugimoto Y., Yamasaki A., Segi E., et al. Failure of parturition in mice lacking the prostaglandin F receptor. Science 277 (1997) 681-683
87. Chan W.Y., Berezin I., and Daniel E.E. Effects of inhibition of prostaglandin synthesis on uterine oxytocin receptor concentration and myometrial gap junction density in parturient rats. Biol Reprod 39 (1988) 1117-1128
88. Phaneuf S., Asboth G., Carrasco M.P., et al. Desensitization of oxytocin receptors in human myometrium. Hum Reprod Update 4 (1998) 625-633
89. Lefkowitz R.J., Inglese J., Koch W.J., et al. G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. Cold Spring Harb Symp Quant Biol 57 (1992) 127-133
90. Dawood M.Y. Novel approach to oxytocin induction-augmentation of labor. Application of oxytocin physiology during pregnancy. Adv Exp Med Biol 395 (1995) 585-594
91. Berridge M.J. Calcium signalling and cell proliferation. Bioessays 17 (1995) 491-500
92. Sanborn B.M. Ion channels and the control of myometrial electrical activity. Semin Perinatol 19 (1995) 31-40
93. Bird I.M., Word R.A., Clyne C., et al. Potassium negatively regulates angiotensin II type 1 receptor expression in human adrenocortical H295R cells. Hypertension 25 (1995) 1129-1134
94. Savineau J.P., and Marthan R. Modulation of the calcium sensitivity of the smooth muscle contractile apparatus: molecular mechanisms, pharmacological and pathophysiological implications. Fundam Clin Pharmacol 11 (1997) 289-299
95. Fuchs A., Dagher M.C., and Vignais P.V. Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system. J Biol Chem 270 (1995) 5695-5697
96. Wess J. Molecular basis of receptor/G-protein-coupling selectivity. Pharmacol Ther 80 (1998) 231-264
97. Grammatopoulos D.K., and Hillhouse E.W. Activation of protein kinase C by oxytocin inhibits the biological activity of the human myometrial corticotropin-releasing hormone receptor at term. Endocrinology 140 (1999) 585-594
98. Sanborn B.M. Hormones and calcium: mechanisms controlling uterine smooth muscle contractile activity. The Litchfield Lecture. Exp Physiol 86 (2001) 223-237
99. Sanborn B.M., Dodge K., Monga M., et al. Molecular mechanisms regulating the effects of oxytocin on myometrial intracellular calcium. Adv Exp Med Biol 449 (1998) 277-286
100. Simon M.I., Strathmann M.P., and Gautam N. Diversity of G proteins in signal transduction. Science 252 (1991) 802-808
101. Ku C.Y., Qian A., Wen Y., et al. Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-C activities via coupling to G alpha q/11. Endocrinology 136 (1995) 1509-1515
102. Mitchell B.F., and Schmid B. Oxytocin and its receptor in the process of parturition. J Soc Gynecol Investig 8 (2001) 122-133
103. Ohmichi M., Koike K., Nohara A., et al. Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells. Endocrinology 136 (1995) 2082-2087
104. Dodge K.L., and Sanborn B.M. Evidence for inhibition by protein kinase A of receptor/G alpha(q)/phospholipase C (PLC) coupling by a mechanism not involving PLCbeta2. Endocrinology 139 (1998) 2265-2271
105. Monga M., Campbell D.F., and Sanborn B.M. Oxytocin-stimulated capacitative calcium entry in human myometrial cells. Am J Obstet Gynecol 181 (1999) 424-429
106. Nohara A., Ohmichi M., Koike K., et al. The role of mitogen-activated protein kinase in oxytocin-induced contraction of uterine smooth muscle in pregnant rat. Biochem Biophys Res Commun 229 (1996) 938-944
107. Tahara M., Morishige K., Sawada K., et al. RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction. Endocrinology 143 (2002) 920-929
108. Hoare S., Copland J.A., Strakova Z., et al. The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores. J Biol Chem 274 (1999) 28682-28689
109. Soloff M.S., Jeng Y.J., Copland J.A., et al. Signal pathways mediating oxytocin stimulation of prostaglandin synthesis in select target cells. Exp Physiol 85 Spec No (2000) 51S-58S
110. Jeng Y.J., Liebenthal D., Strakova Z., et al. Complementary mechanisms of enhanced oxytocin-stimulated prostaglandin E2 synthesis in rabbit amnion at the end of gestation. Endocrinology 141 (2000) 4136-4145
111. Wu W.X., Ma X.H., Yoshizato T., et al. Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor alpha and heat shock protein 90 messenger ribonucleic acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor. Endocrinology 140 (1999) 5712-5718
112. Ou C.W., Orsino A., and Lye S.J. Expression of connexin-43 and connexin-26 in the rat myometrium during pregnancy and labor is differentially regulated by mechanical and hormonal signals. Endocrinology 138 (1997) 5398-5407
113. Mohan A.R., Sooranna S.R., Lindstrom T.M., et al. The effect of mechanical stretch on cyclooxygenase type 2 expression and activator protein-1 and nuclear factor-kappaB activity in human amnion cells. Endocrinology 148 (2007) 1850-1857
114. Mitchell J.A., and Lye S.J. Differential activation of the connexin 43 promoter by dimers of activator protein-1 transcription factors in myometrial cells. Endocrinology 146 (2005) 2048-2054
115. Mitchell J.A., Shynlova O., Langille B.L., et al. Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells. Am J Physiol Endocrinol Metab 287 (2004) E439-E445
116. Ou C.W., Chen Z.Q., Qi S., et al. Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals. Biol Reprod 59 (1998) 1055-1061
117. Manabe Y., Sakaguchi M., and Nakajima A. Initiation of uterine contractions by purely mechanical stretching of the uterus at midpregnancy. Int J Biol Res Pregnancy 2 (1981) 63-69
118. Manabe Y., Manabe A., and Sagawa N. Stretch-induced cervical softening and initiation of labor at term. A possible correlation with prostaglandins. Acta Obstet Gynecol Scand 61 (1982) 279-280
119. Shynlova O.P., Oldenhof A.D., Liu M., et al. Regulation of c-fos expression by static stretch in rat myometrial smooth muscle cells. Am J Obstet Gynecol 186 (2002) 1358-1365
120. Mitchell J.A., and Lye S.J. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Biol Reprod 67 (2002) 240-246
121. Oldenhof A.D., Shynlova O.P., Liu M., et al. Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. Am J Physiol Cell Physiol 283 (2002) C1530-C1539
122. Kumar A., Knox A.J., and Boriek A.M. CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. J Biol Chem 278 (2003) 18868-18876
123. Kobayashi S., Nagino M., Komatsu S., et al. Stretch-induced IL-6 secretion from endothelial cells requires NF-kappaB activation. Biochem Biophys Res Commun 308 (2003) 306-312
124. Terzidou V., Lee Y., Lindstrom T., et al. Regulation of the human oxytocin receptor by nuclear factor-kappaB and CCAAT/enhancer-binding protein-beta. J Clin Endocrinol Metab 91 (2006) 2317-2326
125. Sawdy R.J., Slater D.M., Dennes W.J., et al. The roles of the cyclo-oxygenases types one and two in prostaglandin synthesis in human fetal membranes at term. Placenta 21 (2000) 54-57
126. Belt A.R., Baldassare J.J., Molnar M., et al. The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells. Am J Obstet Gynecol 181 (1999) 359-366
127. Yan X., Wu Xiao C., Sun M., et al. Nuclear factor kappa B activation and regulation of cyclooxygenase type-2 expression in human amnion mesenchymal cells by interleukin-1beta. Biol Reprod 66 (2002) 1667-1671
128. Soloff M.S., Cook Jr. D.L., Jeng Y.J., et al. In situ analysis of interleukin-1-induced transcription of cox-2 and il-8 in cultured human myometrial cells. Endocrinology 145 (2004) 1248-1254
129. Hansen W.R., Marvin K.W., Potter S., et al. Tumour necrosis factor-alpha regulation of prostaglandin H synthase-2 transcription is not through nuclear factor-kappaB in amnion-derived AV-3 cells. Placenta 21 (2000) 789-798
130. Potter S., Mitchell M.D., Hansen W.R., et al. NF-IL6 and CRE elements principally account for both basal and interleukin-1 beta-induced transcriptional activity of the proximal 528bp of the PGHS-2 promoter in amnion-derived AV3 cells: evidence for involvement of C/EBP beta. Mol Hum Reprod 6 (2000) 771-778
131. Lee Y.S., Terzidou V., Lindstrom T., et al. The role of CCAAT/enhancer-binding protein beta in the transcriptional regulation of COX-2 in human amnion. Mol Hum Reprod 11 (2005) 853-858
132. Stein B., and Baldwin Jr. A.S. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B. Mol Cell Biol 13 (1993) 7191-7198
133. Matsusaka T., Fujikawa K., Nishio Y., et al. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90 (1993) 10193-10197
134. Yoo H.G., Shin B.A., Park J.S., et al. IL-1beta induces MMP-9 via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells. Biochem Biophys Res Commun 298 (2002) 251-256
135. Lappas M., Permezel M., and Rice G.E. N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleicacid-binding activity in human fetal membranes in vitro. J Clin Endocrinol Metab 88 (2003) 1723-1729
136. Dodd J.M., Flenady V., Cincotta R., et al. Prenatal administration of progesterone for preventing preterm birth. Cochrane Database Syst Rev (2006) CD004947
137. De Bosscher K., Vanden Berghe W., and Haegeman G. The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 24 (2003) 488-522
138. Auphan N., DiDonato J.A., Rosette C., et al. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270 (1995) 286-290
139. Wahl C., Liptay S., Adler G., et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest 101 (1998) 1163-1174
140. Egan L.J., Mays D.C., Huntoon C.J., et al. Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J Biol Chem 274 (1999) 26448-26453
141. Lappas M., Permezel M., Georgiou H.M., et al. Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro. Biol Reprod 67 (2002) 668-673
142. Yin M.J., Yamamoto Y., and Gaynor R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396 (1998) 77-80
143. Kopp E., and Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265 (1994) 956-959
144. Olivier S., Robe P., and Bours V. Can NF-kappaB be a target for novel and efficient anti-cancer agents?. Biochem Pharmacol 72 (2006) 1054-1068
145. Saunders M.A., Sansores-Garcia L., Gilroy D.W., et al. Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. J Biol Chem 276 (2001) 18897-18904
146. Kim Y.H., Woo K.J., Lim J.H., et al. 8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and C/EBPbeta in Raw 264.7 cells. Biochem Biophys Res Commun 329 (2005) 591-597
147. Aouadi M., Laurent K., Prot M., et al. Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages. Diabetes 55 (2006) 281-289
148. Lindstrom T.M., and Bennett P.R. 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. J Clin Endocrinol Metab 90 (2005) 3534-3543