Modulation of the calcium sensitivity of the smooth muscle contractile apparatus: Molecular mechanisms, pharmacological and pathophysiological implications

Fundamental and Clinical Pharmacology

Volumn 11, Issue 4, 1997, Pages 289-299

  Savineau, J P ^a   Marthan, R ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Airway; Anaesthetics; Antihypertensive drugs; Calcium sensitivity; Myosin phosphatase; Pathophysiology; Small G protein; Smooth muscle; Uterus; Vascular smooth muscle

Indexed keywords

ACETYLCHOLINE; ANESTHETIC AGENT; ANTIHYPERTENSIVE AGENT; ARACHIDONIC ACID; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETAXOLOL; CALCIUM; CALDESMON; CALPONIN; CONTRACTILE PROTEIN; CYCLIC GMP DEPENDENT PROTEIN KINASE; DIOSMIN; ENDOTHELIN 1; FLAVONE DERIVATIVE; FORSKOLIN; GLYCERYL TRINITRATE; GUANINE NUCLEOTIDE BINDING PROTEIN; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN KINASE; NORADRENALIN; OXYTOCIN; PINDOLOL; PROPRANOLOL; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; RAS PROTEIN; SEROTONIN; UNINDEXED DRUG; VASODILATOR AGENT;

AIRWAY; ASTHMA; CALCIUM CELL LEVEL; DESENSITIZATION; DRUG MECHANISM; HUMAN; HYPERTENSION; MUSCLE FORCE; NONHUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SECOND MESSENGER; SENSITIZATION; SMOOTH MUSCLE CONTRACTION; SPONTANEOUS ABORTION; THIN FILAMENT; UTERUS; VASCULAR SMOOTH MUSCLE;

EID: 0030744770     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1997.tb00841.x     Document Type: Review

References (103)

1. Abrahams Z, Tan LLY, Pang MYM, Abrahams B et al. Demonstration of an in vitro vascular relaxant effect of diuretics in the presence of plasma. J Hypertens 1996;14:381-8
2. Adam LP, Hataway DR. Identification of mitogen-activated protein kinase phosphorylation sequences in mammalian h-caldesmon. FEBS Lett 1993;322:56-60
3. Adelstein RS, Hataway DR. Role of calcium and adenosine 3′,5′ monophosphate in regulating smooth muscle contraction. Am J Cardiol 1979;44:783-7
4. 2+ sensitivity during muscarinic receptor stimulation of airway smooth muscle. Am J Physiol 1996;271:L719-25
5. Alessi D, MacDougall LK, Sola MM, Ikebe M, Cohen P. The control of protein phosphatase 1 by targeting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase 1. Eur J Biochem 1992;210:1023-35
6. Allen BG, Walsh MP. The biochemical basis of the regulation of smooth muscle contraction. Trends Biochem Sci 1994;19:362-68
7. Babu YS, Bugg CE, Cook WJ. Structure of calmodulin refined at 2.2A resolution. J Mol Biol 1988;204:191-204
8. Bian K, Bukoski RD. Myofilament calcium sensitivity of normotensive and hypertensive resistance arteries. Hypertension 1995;25:110-6
9. 2+ sensitivity of triton-skinned guinea pig mesenteric microarteries as compared with large arteries. Cir Res 1991;69:989-96
10. Cassidy P, Hoar PE, Kerrick WGL. Irreversible thiophosphorylation and activation of tension in functionally skinned rabbit ileum strips by [35S] ATPγS. J Biol Chem 1979;254:1148-53
11. 2+ sensitivity and partially by repolarization. Am J Physiol 1996;271:H962-8
12. Colburn JC, Michnoff CH, Hsu LC, Slaughter CA, Kamm KE, Stull JT. Sites phosphorylated in myosin light chain in contracting smooth muscle. J Biol Chem 1988;263:19166-73
13. Conti MA, Adelstein RS. The relationship between calmodulin binding and phosphorylation of smooth muscle myosine kinase by the catalytic subunit of 3′,5′ cAMP -dependent protein kinase. J Biol Chem 1981;256:3178-81
14. 2 contractile response on rabbit saphenous vein and femoral artery. In: Raymond-Martinbeau P, Prescott R, Zummo M, eds. Phlébologie. Paris: John Libbey Eurotext, 1992;723-5
15. De Lanerolle P. Airway smooth muscle and asthma. Am J Respir Cell Mol Biol 1992;7:565-6
16. DeFeo TT, Morgan KG. Calcium-force relationships as detected with aequorin in two different vascular smooth muscles of the ferret. J Physiol 1985;369:269-82
17. Endo M, Kitazawa T, Yogi S, Tino M, Karuta Y. Some properties of chemically skinned smooth muscle fibers. In: Casteels R, Godfraind T, Ruegg JC, eds. Excitation-contraction coupling in smooth muscle. Amsterdam: Elsevier Science Publishers, 1977:199-209
18. Filo RB, Bohr DF, Rüegg JC. Glycerinated skeletal and smooth muscle. Calcium and magnesium dependence. Science 1965;147:1581-3
19. 2+ sensitization of skinned muscle of guinea-pig vas deferens. J Pharmacol Exp Ther 1995;274:555-61
20. Gerthoffer WT, Murphy KA, Gunst SJ. Aequorin luminescence, myosin phosphorylation and active stress in tracheal smooth muscle. Am J Physiol 1989;257:C271-7
21. Gong MC, Cohen P, Kitazawa T, Ikebe M et al. Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle. J Biol Chem 1992a;287:14662-8
22. Gong MC, Fulsang A, Alessi D, Kobayashi S et al. Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium. J Biol Chem 1992b;267:21492-8
23. Gong MC, Kinter MT, Somlyo AV, Somlyo AP. Arachidonic acid and diacylglycerol release associated with inhibition of myosin chain dephosphorylation in rabbit smooth muscle. J Physiol 1995;486:113-22
24. 2+ sensitization of smooth muscle. Proc Natl Acad Sci USA 1996;93:1340-45
25. Guerriero V, Russo MA, Olson NJ, Pulkey JA, Means AR. Domain organization of chicken gizzard myosin light chain kinase deduced frm a cloned cDNA. Biochemistry 1986;25:8372-81
26. 2+ level and contraction in the rat aorta. Endothelium-dependent and -independent mechanisms. Cir Res 1995;77:673-8
27. Himpens B, Somlyo AP. Free-calcium and force transients during depolarization and pharmacomechanical coupling in guinea-pig smooth muscle. J Physiol 1988;395:507-30
28. 2+ sensitivity in rabbit pulmonary artery smooth muscle. Pflügers Arch 1990;417:21-8
29. Hirata K, Kikuchi A, Sasaki T, Kuroda S et al. Involvement of rho p21 GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem 1992;267:8719-22
30. 2+-independent contraction in vascular smooth muscle. Am J Physiol 1996;271:C589-94
31. Iino M. Tension responses of chemically skinned fibre bundles of the guinea-pig taenia caeci under varied ionic environments. J Physiol 1981;320:449-67
32. Ikebe M, Hartshorne DJ, Elzinga M. Identification, phosphorylation and dephosphorylation of a second site for myosin light chain kinase on the 20,000 -dalton light chain of smooth muscle myosin. J Biol Chem 1986;261:36-9
33. Ikebe M, Hartshorne DJ, Hidaka H. Phosphorylation of the 20,000 dalton light chain smooth muscle myosin by the calcium-activated phospholipid dependent protein kinase. J Biol Chem 1987;262:9569-73
34. Ikebe M, Reardon S. Binding of caldesmon to smooth muscle myosin. J Biol Chem 1988;263:3055-8
35. Itoh T, Kuriyama H, Suzuki H. Excitation-contraction coupling in smooth muscle cells of the guinea-pig mesenteric artery. J Physiol 1981;321:513-35
36. Izumi H. Changes in the mechanical properties of the longitudinal and circular muscle tissues of the rat myometrium during gestation. Br J Pharmacol 1985;86:247-57
37. Izumi H, Ichihara J, Uchiumi Y, Shirakawa K. Gestational changes in mechanical properties of skinned muscle tissues of human myometrium. Am J Obstet Gynecol 1990;163:638-47
38. Izumi H, Biam-Smith M, Garfield RE. Gestational changes in oxytocin- and endothelin-1-induced contractility of pregnant rat myometrium. Eur J Pharmacol 1995;278:187-94
39. 2+ in pregnant rat myometrium. Am J Obstet Gynecol 1996;175:199-206
40. Jiang H, Rao K, Halayko AJ, Liu X, Stephens NL. Ragweed sensitization -induced increase of myosin light chain kinase content in canine airway smooth muscle. Am J Respir Cell Mol Biol 1992;7:567-73
41. 2+ and myosin phosphorylation but not calmodulin activity in sensitized airway smooth muscle. Am J Physiol 1995;268:L739-46
42. Jones KE, Wong GY, Lorenz RR, Warner DO, Sieck GC. Effects of halothane on the relationship between cytosolic calcium and force in airway smooth muscle. Am J Physiol 1994;266:L199-204
43. 2+ sensitivity of the contractile apparatus in airway smooth muscle. Eur J Pharmacol 1996;315:313-8
44. Kamm KE, Hsu LC, Kubota Y, Stull JT. Phosphorylation of smooth muscle myosin heavy and ligth chains: effects of phorbol dibutyrate and agonists. J Biol Chem 1989;264:21223-9
45. 2+ tension relationship in vascular smooth muscle of rat aorta. Eur J Pharmacol 1988;151:325-8
46. Karaki H, Mitsui M, Nagase H, Ozaki H et al. Inhibitory effect of a toxin okadaic acid isolated from the black spong on smooth muscle and platelets. Br J Pharmacol 1989;98:590-6
47. Katsuyama H, Wang CLA, Morgan KG. Regulation of vascular smooth muscle tone by caldesmon. J Biol Chem 1992;267:14555-8
48. 2+ sensitization in α-toxin-permeabilized vascular smooth muscle. Eur J Pharmacol 1992;214:39-44
49. Khalil RA, Morgan KG. Protein kinase C-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation. Am J Physiol 1993;265:C406-11
50. 2+ -activated contractions in skinned fibers from canine coronary arteries and ventricular muscles. Cardiovasc Drugs Ther 1996;10:581-6
51. 2+ sensitization in smooth muscle. J Biol Chem 1989;264:17997-8004
52. 2+ sensitization. Am J Physiol 1991;260:C364-C370
53. Kozlowski RZ. Ions channels, oxygen sensation and signal transduction in pulmonary arterial smooth muscle. Cardiovasc Res 1995;30:318-25
54. 2+ -sensitivity in pig coronary arterial smooth muscle. Biochem Biophys Res Commun 1995;212:572-9
55. Liu G, Liu X, Rao K, Jiang H, Stephens NL. Increased myosin light chain kinase content in sensitized canine saphenous vein. J Appl Physiol 1996;80:665-9
56. Markuch R, Birukov K, Shirinsky V, Dabrowska R. Functional interrelationship between calponin and caldesmon. Biochem J 1991;280:33-8
57. Marston SB, Redwood CS. The molecular anatomy of caldesmon. Biochem J 1991;278:1-16
58. 2+ -sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase. J Gen Physiol 1994;104:265-86
59. Mitsui T, Inogaki M, Ikebe M. Purification and characterization of smooth muscle myosin-associated phosphatase from chicken gizzards. J Biol Chem 1992;267:16727-35
60. Morgan JP, Morgan KG. Stimulus-specific patterns of intracellular calcium levels in smooth muscle of ferret portal nein. J Physiol 1984;351:155-67
61. Namba H, Tsuchida H. Effect of volatile anesthetics with and without verapamil on intracellular activity in vascular smooth muscle. Anesthesiology 1996;84:1465-74
62. Neering LR, Morgan KG. Use of aequorin to study excitation - contraction coupling in mammalian smooth muscle. Nature 1980;288:585-7
63. Nishimura J, Van Breemen C. Direct regulation of smooth muscle contractile elements by second messengers. Biochem Biophys Res Commun 1989;163:929-35
64. 2+ sensitivity in -toxin-permeabilized rabbit mesenteric artery. Cir Res 1992;71:951-9
65. Noda M, Yasuda-Fukazawa C, Morishi K, Kato T et al. Involvement of rho in GTPγS-induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity. FEBS Lett 1995;367:246-50
66. North AJ, Gimona M, Cross RA, Small JV. Calponin is localized in both the contractile apparatus and the cytoskeleton of smooth muscle. J Cell Biol 1994;107:445-55
67. Ono T, Mita M, Suga O, Hashimoto T et al. Receptor-coupled shortening of -toxin-permeabilized single smooth muscle cells from the guinea-pig stomach. Br J Pharmacol 1992;106:539-43
68. Otto B, Steusloff A, Just I, Aktories K, Pfitzer G. Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea-pig intestinal smooth muscle. J Physiol 1996;496:317-29
69. Ozaki H, Blondfield DP, Hori M, Sanders KM, Publicover NG. Cyclic AMP-mediated regulations of excitation-contraction coupling in canine gastric smooth muscle. J Physiol 1992;447:354-72
70. 2+ regulation of the contractile apparatus in canine smooth muscle. J Physiol 1993;460:33-50
71. Parsons SJW, Summer MJ, Garland CJ. Phospholipase A2 and protein kinase C contribute to myofilament sensitization to 5-HT in the rabbit mesenteric artery. J Physiol 1996;491:447-53
72. Pato MD, Kerc E. Purification and characterization of a smooth muscle myosin phosphatase from turkey gizzards. J Biol Chem 1985;260:12359-66
73. Pfitzer G, Peterson JW, Rüegg JC. Length dependence of calcium activated isometric force and immediate stiffness in living and glycerol extracted vascular smooth muscle. Pflügers Arch 1982;394:174-81
74. Pfitzer G, Merkel L, Ruegg JC, Hofman F. Cyclic-GMP-dependent protein kinase relaxes skinned fibers from guinea pig taenia coli but not from chicken gizzard. Pflügers Arch 1986;407:87-91
75. i oscillations induced by muscarinic stimulation in airway smooth muscle cells: receptor subtypes and correlation with mechanical activity. Br J Pharmacol 1997;120:1299-301
76. Rüegg JC, Sparrow MP and Muva V. Cyclic-AMP mediated relaxation of chemically skinned fibres of smooth muscle. Pflügers Arch 1981;390:198-201
77. Rüegg JC, Paul RJ. Vascular smooth muscle: calmodulin and cyclic AMP-dependent protein kinase alter calcium sensitivity in porcine carotid skinned fibers. Cir Res 1982;50:394-9
78. Sato K, Leposavic R, Publicover NG, Sanders KM, Gerthoffer WT. Sensitization of the contractile system of canine colonic smooth muscle by agonists and phorbol ester. J Physiol 1994;481:677-88
79. 2+ responsiveness of smooth muscle contraction. FEBS Lett 1993;324:211-15
80. 2+ sensitization in rabbit thoracic aorta. Eur J Pharmacol 1994a;265:133-9
81. 2+-sensitization of coronary artery contraction in genetically hypertensive rats. J Clin Invest 1994b;94:1397-403
82. Savineau JP, Mironneau C, Mironneau J. Contractile properties of chemically skinned fibers from pregnant rat myometrium:existence of an internal Ca-store. Pflügers Arch 1988;411:296-303
83. 2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein. Br J Pharmacol 1994a;111:978-80
84. Savineau JP, Marthan R. Activation properties of chemically skinned fibres from human isolated bronchial smooth muscle. J Physiol 1994b;474:433-8
85. Savineau JP, Gonzalez De La Fuente P, Marthan R. Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries. Respir Physiol 1995;99:191-8
86. Seguchi H, Nishimura J, Toyofiku K, Kobayashi S et al. The mechanism of relaxation induced by atrial natriuretic peptide in the porcine renal artery. Br J Pharmacol 1996;118:343-51
87. Shirazi A, Izuka K, Fadden P, Moose C et al. Purification and characterization of the mammalian myosin ligth chain phosphatase enzyme. J Biol Chem 1994;269:31598-606
88. Sparrow MP, Mrwa U, Hofmann F, Rüegg JC. Calmodulin is essential for smooth muscle contraction. FEBS Lett 1981;125:141-5
89. 2+, and cAMP protein kinase on skinned tracheal smooth muscle. Am J Phyisol 1984;246:C308-14
90. Solovier AI, Bershtein SA. The contractile apparatus in vascular smooth muscle cells of spontaneously hypertensive rats posseses increased calcium sensitivity: the possible role of protein kinase C. J Hypertens 1992;10:131-6
91. Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature 1994;372:231-6
92. Stull JT, Hsu LC, Tansey MG, Kamm KE. Myosin light chain kinase phosphorylation in tracheal smooth muscle. J Biol Chem 1990;265:16683-90
93. 2+ requirement for myosin phosphorylation by protaglandin F2 α. Am J Physiol 1991;261:C253-8
94. 2+ dependence of smooth muscle contraction. J Biol Chem 1992;267:11839-45
95. Tansey MG, Word RA, Hidaka H, Singer HA et al. Phosphorylation of myosin ligtht chain kinase by the multifunctional calmodulin-dependent protein kinase II in smooth muscle cells. J Biol Chem 1992;267:12511-6
96. Walsh MP. Calmodulin and the regulation of smooth muscle contraction. Mol Cell Biochem 1994;135:21-41
97. Werth DK, Haeberle JR, Hataway DR. Purification of a myosin phosphatase form bovine aortic smooth muscle. J Biol Chem 1982;257:7306-09
98. Williams DA, Fogarty KE, Tsien RY, Fay F. Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope uring fura 2. Nature 1985;318:558-61
99. Winder SJ, Walsh MP. Calponin: thin-filament linked regulation of smooth muscle contraction. Cell Signaling 1993;5:677-86
100. Word RA, Tang DC, Kamm KE. Activation properties of myosin light chain kinase during contraction/relaxation cycles of tonic and phasic smooth muscles. J Biol Chem 1994;269:21596-602
101. Wu X, Somlyo AV, Somlyo AP. Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphatase. Biochem Biophys Res Commun 1996;220:658-63
102. Yoshida M, Suzuki A, Itoh T. Mechanisms of vasoconstriction induced by endothelin-1 in smooth muscle of rabbit mesenteric artery. J Physiol 1994;477:253-65
103. Zhang XP, List WF. Effect of halothane, isoflurane and sevoflurane on calcium-related contraction in porcine coronary arteries. Acta Anaesthesiol Scand 1996;40:815-9