Oxytocin and its receptor in the process of parturition

Journal of the Society for Gynecologic Investigation

Volumn 8, Issue 3, 2001, Pages 122-133

  Mitchell, B F ^a   Schmid, Birgit ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Oxytocin; Oxytocin receptor; Parturition; Regulation; Sex steroids

Indexed keywords

CYTOKINE; ESTROGEN; ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR; PROGESTERONE RECEPTOR; VASOPRESSIN RECEPTOR;

CHILDBIRTH; DRUG EFFECT; GENE LOCATION; GENE SEQUENCE; HORMONE RESPONSE; HORMONE SYNTHESIS; HUMAN; IMMUNE RESPONSE; PREMATURE LABOR; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REVIEW; UTERUS CONTRACTION;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY; LABOR, OBSTETRIC; OXYTOCIN; PREGNANCY; RECEPTORS, OXYTOCIN; UTERUS;

EID: 0035007020     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-5576(01)00105-8     Document Type: Review

References (125)

1. On some physiological actions of ergot
2. The pituitary body
3. Changes in myometrial sensitivity to oxytocin in man during the last six weeks of pregnancy
4. Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA
5. Is oxytocin an ovarian hormone?
6. Synthesis of oxytocin in amnion, chorion and decidua may influence the timing of human parturition
7. Oxytocin gene expression in rat uterus
8. Oxytocin receptors; Triggers for parturition and lactation?
9. Oxytocin receptors and human parturition; A dual role for oxytocin in the initiation of human labor
10. Neuroendocrine control of the milk ejection reflex
11. Structure and expression of a human oxytocin receptor
12. Estrogen increases renal oxytocin gene expression
13. Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart
14. Fetal and maternal oxytocin in human parturition
15. Oxytocin secretion and human parturition; Pulse frequency and duration increase during spontaneous labor in women
16. Comparison of plasma oxytocin and catecholamine concentrations with uterine activity in pregnant rhesus monkeys
17. Correlation between oxytocin receptor concentration and responsiveness to oxytocin in the pregnant rat myometrium
18. Relationships among sex steroids, oxytocin, and their receptors in the rat uterus during late gestation and at parturition
19. Effects of RU486 on estrogen, progesterone, oxytocin and their receptors in the rat uterus during late gestation
20. Oxytocin is required for nursing but is not essential for parturition or reproductive behavior
21. Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition
22. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements
23. 1D receptor-G-protein coupling; Evidence for constitutive activity and multiple receptor conformations
24. G protein-coupled receptor systems involved in cell growth and oncogenesis
25. Induction of labour by pharmacological and physiological doses of intravenous oxytocin
26. Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy; Effects of the oxytocin antagonist atosiban
27. Design and synthesis of highly selective in vitro and in vivo uterine receptor antagonists of oxytocin; Comparison with atosiban
28. Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study
29. The effects of the oxytocin antagonist atosiban on preterm uterine activity in humans
30. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor; A randomized, double-blind, placebo-controlled trial with tocolytic rescue
31. Effect of the oxytocin antagonist atosiban (1-deamino-2-D-tyr(OET)-4-thr-8-orn-vasotocin/oxytocin) on nocturnal myometrial contractions, maternal cardiovascular function, transplacental passage, and fetal oxygenation in the pregnant baboon during the last third of gestation
32. Oxytocin antagonist inhibitory effect on the rat and baboon uterus may be overcome by prostaglandins
33. Effects of inactivation of oxytocin receptor and gap junction formation on labor in the rat
34. Oxytocin antagonists delay the initiation of parturition and prolong its active phase in rats
35. Role of oxytocin in the initiation of term and preterm labor in rats; Changes in oxytocin receptor density and plasma oxytocin concentration and the effect of an oxytocin antagonist, L-366,509
36. The effect of oxytocin receptor blockade on parturition in guinea pigs
37. A structurally unique, potent and selective oxytocin antagonist derived from Streptomyces silvensis
38. Oxytocin and vasopressin; Distinct receptors in myometrium
39. Vasopressin receptors in human pregnant myometrium and decidua; Interactions with oxytocin and vasopressin agonists and antagonists
40. Oxytocin and vasopressin 1a receptor gene expression in the cycling or pregnant human uterus
41. 1a receptors in uterine contractions in rats; Implications for tocolytic therapy with oxytocin antagonists
42. Placental passage of the oxytocin antagonist atosiban
43. Maternal and fetal cardiovascular effects and placental transfer of the oxytocin antagonist atosiban in late-gestation pregnant sheep
44. Effects of SR 49059, an orally active V1a vasopressin receptor antagonist, on vasopressin-induced uterine contractions
45. Linkage relationships of human arginine vasopressin-neurophysin II and oxytocin-neurophysin I to prodynorphin and other loci on chromosome 20
46. Mapping of the bovine oxytocin gene control region; Identification of binding sites for luteal nuclear proteins in the 5′ non-coding region of the gene
47. Structural organization of the human oxytocin receptor gene
48. Structure, characterization, and expression of the rat oxytocin receptor gene
49. Identification of a GAPBα/β binding site involved in the induction of oxytocin receptor gene expression in human breast cells. Potentiation by c-Fos/c-Jun
50. Cell-specific activity of a GGTCA half-palindromic estrogen-responsive element in the chicken ovalbumin gene promoter
51. Differential biosynthesis and posttranslational processing of vasopressin and oxytocin in rat brain during embryonic and postnatal development
52. Identification of an extracellular segment of the oxytocin receptor producing agonist-specific binding epitopes
53. Identification of neurohypophysial hormone receptor domains involved in ligand binding and G-protein coupling
54. Diversity of G-proteins in signal transduction
55. q/11
56. β by G protein α and βγ subunits
57. Inositol trisphosphate and calcium signaling
58. Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells; Involvement of pertussis-sensitive and -insensitive G-proteins
59. Intracellular calcium stores and agonist-induced contractions in isolated human myometrium
60. Oxytocin-stimulated capacitative calcium entry in human myometrial cells
61. Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal myometrial cells
62. Oxytocin activates mitogen-activated protein kinase and up-regulates cyclooxygense-2 and prostaglandin production in human myometrial cells
63. i
64. Signal pathways mediating oxytocin stimulation of prostaglandin synthesis
65. Oxytocin receptors; Triggers for parturition and lactation?
66. Effect of gonadal steroids upon hypothalamic oxytocin expression
67. Estrogen stimulates oxytocin gene expression in human fetal membranes and decidua
68. Uterine oxytocin gene expression. II. Induction by exogenous steroid administration
69. Uterine receptors for oxytocin; Effects of estrogen
70. The regulation of oxytocin receptor expression in human myometrial monolayer culture
71. Regulation of oxytocin receptor concentration in rat uterine explants by estrogen and progesterone
72. The role of sex steroids in the oxytocin hormone system
73. A composite hormone response element mediated the transactivation of the rat oxytocin gene by different classes of nuclear hormone receptors
74. Activation of the mouse oxytocin promoter by the orphan receptor RORα
75. Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary
76. Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols
77. Alteration in the chromatin structure of the distal promoter region of the bovine oxytocin gene correlate with ovarian expression
78. Differential protein-DNA binding analysis identifies a novel enhancer element, US-1, involved in the upregulation of the oxytocin receptor gene in human myometrium at term
79. Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals
80. Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor α and heat shock protein 90 messenger ribonucleic acid in the gravid horn and non-gravid horn in sheep during betamethasone-induced labor
81. A study of the motility of the intact uterus at term
82. Oxytocin deficiency at delivery with epidural analgesia
83. Changes in the electrical properties of supraoptic nucleus oxytocin and vasopressin neurons during lactation
84. Effects of oxytocin antagonists on the activation of human myometrium in vitro; Atosiban prevents oxytocin-induced desensitisation
85. The desensitisation of oxytocin receptors in human myometrial cells is accompanied by down-regulation of oxytocin receptor messenger RNA
86. Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium
87. The separate uterotonic and prostaglandin-releasing actions of oxytocin. Evidence and comparison with angiotensin and methacholine in the isolated rat uterus
88. 2α from human decidual cells
89. Influence of labor and oxytocin on in vitro leukotriene release by human fetal membranes and uterine decidua at term gestation
90. Agonist and antagonist specificities of decidual prostaglandin-releasing oxytocin receptors and myometrial uterotonic oxytocin receptors in pregnant rats
91. Effects of inhibition of prostaglandin synthesis on uterine oxytocin receptor concentration and myometrial gap junction density in parturient rats
92. Myometrial oxytocin receptors and prostaglandins in the parturition process in the rat
93. Flow cytometric characterization of cell populations in human pregnancy decidua and isolation of decidual macrophages
94. Immunologically relevant cells in the uterus
95. Infection and labor. III. Interleukin-1; A signal for the onset of parturition
96. Infection and labor. IV. Cachectin-tumor necrosis factor in the amniotic fluid of women with intraamniotic infection and preterm labor
97. Amniotic interleukin-6 in preterm labor
98. Tumor necrosis factor, interleukin-1, and interleukin-6 in normal human pregnancy
99. Cachectin/tumor necrosis factor-α formation in human decidua
100. Human decidua; A source of interleukin-1
101. Decidual cell biosynthesis of interleukin-6; Regulation by inflammatory cytokines
102. Interleukin stimulates prostaglandin biosynthesis by human amnion
103. Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells
104. Prostaglandin production by chorion laeve cells in response to inflammatory mediators
105. Prostaglandins and parturition
106. ERK2 mediates oxytocin-stimulated PGE2 synthesis
107. Transcriptional regulation of oxytocin receptor by interleukin-1β and interleukin-6
108. Cytokine induced responses of primary and transformed human myometrial cells
109. Interleukin-1β down-regulates the oxytocin receptor in cultured uterine smooth muscle cells
110. Oxytocin signaling in human myometrium is impaired by prolonged exposure to interleukin-1β
111. Effects of LPS and IL-6 on oxytocin receptor in non-pregnant and pregnant rat uterus
112. The course of labor in term patients with chorioamnionitis
113. Chorioamnionitis and uterine function
114. The distribution of enzymes destroying oxytocin and vasopressin in human placentae
115. Inactivation of neurohypophysial peptides by a uterine enzyme. Characterization of the hydrolytic cleavage
116. The origin and distribution of oxytocinase
117. Effect of human pregnancy on metabolic clearance rate of oxytocin
118. Oxytocinase; Placental cystine aminopeptidase or placental leucine aminopeptidase (PLAP)
119. Metabolism of oxytocin in human decidua, chorion and placenta
120. Metabolism of oxytocin in rat uterus and placenta in late gestation
121. An oxytocin precursor intermediate circulates in the plasma of humans and rhesus monkeys administered estrogen
122. The role of carboxy-extended forms of oxytocin in the rat uterus in the process of parturition
123. Inhibition of oxytocin receptor function by direct binding of progesterone