Leptin gene and protein expression in the trophoblast and uterine tissues during early pregnancy and the oestrous cycle of pigs

Journal of Physiology and Pharmacology

Volumn 58, Issue 3, 2007, Pages 563-581

  Smolińska, Nina ^a   Siawrys, G ^b   Kaminski, T ^b   Przala, J ^b  

^a UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

^b NONE

Author keywords

Endometrium; Gene expression; Leptin; Myometrium; Pig; Protein concentration; Trophoblast

Indexed keywords

LEPTIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOMETRIUM; ESTRUS CYCLE; FEMALE; FIRST TRIMESTER PREGNANCY; GENE; LEPTIN GENE; LUTEAL PHASE; MYOMETRIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PREGNANCY; PROTEIN EXPRESSION; SWINE; TROPHOBLAST; UTERUS;

ANIMALS; BLOTTING, WESTERN; ENDOMETRIUM; ESTROUS CYCLE; FEMALE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEPTIN; MYOMETRIUM; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUS SCROFA; TIME FACTORS; TROPHOBLASTS; UTERUS;

EID: 34948892135     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
2. Ogawa Y, Masuzaki H, Isse N, et al. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest 1995; 96: 1647-1652.
3. Barash IA, Cheung CC, Weigle DS, et al. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996; 137: 3144-3147.
4. Cheung CC, Thornton JE, Kuijper JL, Weigle DS, Clifton DK, Steiner RA. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 1997; 138: 855-858.
5. Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12: 318-320.
6. Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. Leptin accelerates the onset of puberty in normal female mice. J Clin Invest 1997; 99: 391-395.
7. Butte NF, Hopkinson JM, Nicolson MA. Leptin in human reproduction: serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab 1997; 82: 585-589.
8. Chien EK, Hara M, Rouard M, et al. Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Biochem Biophys Res Commun 1997; 237: 476-480.
9. Gonzalez RR, Caballero-Campo P, Jasper M, et al. Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst. J Clin Endocrinol Metab 2000; 85: 4883-4888.
10. Yoon SJ, Cha KY, Lee KA. Leptin receptors are down-regulated in uterine implantation sites compared to interimplantation sites. Mol Cell Endocrinol 2005; 232: 27-35.
11. Kawamura K, Sato N, Fukuda J, et al. Leptin promotes the development of mouse preimplantation embryos in vitro. Endocrinology 2002; 143: 1922-1931.
12. Masuzaki H, Ogawa Y, Sagawa N, et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 1997; 3: 1029-1033.
13. Senaris R, Garcia-Caballero T, Casabiell X, et al. Synthesis of leptin in human placenta. Endocrinology 1997; 138: 4501-4504.
14. Henson MC, Swan KF, O'Neil JS. Expression of placental leptin and leptin receptor transcripts in early pregnancy and at term. Obstet Gynecol 1998; 92: 1020-1028.
15. Hoggard N, Hunter L, Duncan JS, Williams LM, Trayhurn P, Mercer JG. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc Natl Acad Sci USA 1997; 94: 11073-11078.
16. Dyer CJ, Klemcke HG, Christenson RK, Matteri RL. Porcine placental leptin receptors messenger ribonucleic acid expression: Meishan versus White crossbred. Biol Reprod 1999; 60: 127.
17. Ashworth CJ, Hoggard N, Thomas L, Mercer JG, Wallace JM, Lea RG. Placental leptin. Rev Reprod 2000; 5: 18-24.
18. Smolinska N, Kaminski T, Siawrys G, Przala J. Long form of leptin receptor gene and protein expression in the porcine ovary during the estrous cycle and early pregnancy. Reprod Biol 2007; 7: 17-39.
19. Wong H, Anderson WD, Cheng T, Riabowol KT. Monitoring mRNA expression by polymerase chain reaction: the "primer dropping" method. Anal Biochem 1994; 223: 251-258.
20. Martin RL, Perez E, He YJ, Dawson R Jr, Millard WJ. Leptin resistance is associated with hypothalamic leptin receptor mRNA and protein downregulation. Metabolism 2000; 49: 1479-1484.
21. Hikita M, Bujo H, Hirayama S, Takahashi K, Morisaki N, Saito Y. Differential regulation of leptin receptor expression by insulin and leptin in neuroblastoma cells. Biochem Biophys Res Commun 2000; 271: 703-709.
22. Fernandez-Galaz C, Fernandez-Agullo T, Perez C, et al. Long-term food restriction prevents ageing-associated central leptin resistance in wistar rats. Diabetologia 2002; 45: 997-1003.
23. Bennett PA, Lindell K, Karlsson C, Robinson IC, Carlsson LM, Carlsson B. Differential expression and regulation of leptin receptor isoforms in the rat brain: effects of fasting and oestrogen. Neuroendocrinology 1998; 67: 29-36.
24. Bennett PA, Lindell K, Wilson C, Carlsson LM, Carlsson B, Robinson IC. Cyclical variations in the abundance of leptin receptors, but not in circulating leptin, correlate with NPY expression during the oestrous cycle. Neuroendocrinology 1999; 69: 417-423.
25. Ryan NK, Van der Hoek KH, Robertson SA, Norman RJ. Leptin and leptin receptor expression in the rat ovary. Endocrinology 2003; 144: 5006-5013.
26. Kaminski T, Smolinska N, Gajewska A, et al. Leptin and long form of leptin receptor genes expression in the hypothalamus and pituitary during the luteal phase and early pregnancy in pigs. J Physiol Pharmacol 2006; 57: 95-108.
27. Lin J, Barb CR, Matteri RL, et al. Long form leptin receptor mRNA expression in the brain, pituitary and other tissues in the pig. Domest Anim Endocrinol 2000; 19: 53-61.
28. Lin J, Barb CR, Kraeling RR, Rampacek GB. Developmental changes in the long form leptin receptor and related neuropeptide gene expression in the pig brain. Biol Reprod 2001; 64: 1614-1618.
29. Siawrys G, Przala J, Kaminski T, et al. Long form leptin receptor mRNA expression in the hypothalamus and pituitary during early pregnancy in the pig. Neuroendocrinol Lett 2005; 26: 305-309.
30. Smolinska N, Przala J, Kaminski T, et al. Leptin gene expression in the hypothalamus and pituitary of pregnant pigs. Neuroendocrinol Lett 2004; 25: 191-195.
31. Bogacka I, Przala J, Siawrys G, Kaminski T, Smolinska N. The expression of short form of leptin receptor gene during early pregnancy in the pig examined by quantitative real time RT-PCR. J Physiol Pharmacol 2006; 57: 479-489.
32. Terada Y, Yamakawa K, Sugaya A, Toyoda N. Serum leptin levels do not rise during pregnancy in age-matched rats. Biochem Biophys Res Commun 1998; 253: 841-844.
33. Hoggard N, Hunter L, Lea RG, Trayhurn P, Mercer JG. Ontogeny of the expression of leptin and its receptor in the murine fetus and placenta. Br J Nutr 2000; 83: 317-326.
34. Trayhurn P, Hoggard N, Mercer JG, Rayner DV. Hormonal and neuroendocrine regulation of energy balance - the role of leptin. Arch Tierernahr 1998; 51: 177-185.
35. Shimizu H, Shimomura Y, Nakanishi Y, et al. Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol 1997; 154: 285-292.
36. Hardie L, Trayhurn P, Abramovich D, Fowler P. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol (Oxf) 1997; 47: 101-106.
37. Lukaszuk K, Liss J, Kusiak E, Wojcikowski C. Serum leptin concentration increase during luteal phase in healthy premenopausal women. Horm Metab Res 1998; 30: 172-173.
38. Guay F, Palin MF, Matte JJ, Laforest JP. Effects of breed, parity and folic acid supplement on the expression of leptin and its receptors genes in embryonic and endometrial tissues from pigs at day 25 of gestation. Biol Reprod 2001; 65: 921-927.
39. Lea RG, Hannah L, Blades J, Howe D, Hoggard N. Placental leptin in normal and abnormal pregnancies. J Reprod Fertil 1998; Abstract Series 21: Abstract 41.
40. Lea RG, Howe D, Hannah LT, Bonneau O, Hunter L, Hoggard N. Placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol Hum Reprod 2000; 6: 763-769.
41. Gonzalez RR, Leavis P. Leptin upregulates beta3-integrin expression and interleukin-1beta, upregulates leptin and leptin receptor expression in human endometrial epithelial cell cultures. Endocrine 2001; 16: 21-28.
42. Gonzalez RR, Rueda BR, Ramos MP, Littell RD, Glasser S, Leavis PC. Leptin-induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interleukin 1 receptor signaling. Endocrinology 2004; 145: 3850-3857.
43. Ramos MP, Rueda BR, Leavis PC, Gonzalez RR. Leptin serves as an upstream activator of an obligatory signaling cascade in the embryo-implantation process. Endocrinology 2005; 146: 694-701.
44. Kaufmann P, Castellucci M. Extravillous trophoblst in the human placenta. Trophoblast Res 1997; 10: 21-65.
45. Gonzalez RR, Devoto L, Campana A, Bischof P. Effects of leptin, interleukin-1 alpha, interleukin-6, and transforming growth factor-beta on integrin expression and metalloproteinase secretion by human cytotrophoblastic cells. Fertil Steril 1999; 72: S136.
46. Castellucci M, De Matteis R, Meisser A, et al. Leptin modulates extracellular matrix molecules and metalloproteinases: possible implications for trophoblast invasion. Mol Hum Reprod 2000; 6: 951-958.
47. Sierra-Honigmann MR, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science 1998; 281: 1683-1686.
48. Craig JA, Zhu H, Dyce PW, Wen L, Li J. Leptin enhances porcine preimplantation embryo development in vitro. Mol Cell Endocrinol 2005; 229: 141-147.
49. Malik NM, Carter ND, Murray JF, Scaramuzzi RJ, Wilson CA, Stock MJ. Leptin requirement for conception, implantation and gestation in the mouse. Endocrinology 2001; 142: 5198-5202.
50. Kawamura K, Sato N, Fukuda J, et al. Leptin promotes the development of mouse preimplantation embryos in vitro. Endocrinology 2002; 143: 1922-1931.