Leptin and long form of leptin receptor genes expression in the hypothalamus and pituitary during the luteal phase and early pregnancy in pigs

Journal of Physiology and Pharmacology

Volumn 57, Issue 1, 2006, Pages 95-108

  Kaminski, T ^a   Smolinska, N ^a   Gajewska, A ^b   Siawrys, G ^a   Okrasa, S ^a   Kochman, K ^b   Przala, J ^a  

^a UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

^b KIELANOWSKI INSTITUTE OF ANIMAL PHYSIOLOGY AND NUTRITION   (Poland)

Author keywords

Gene expression; Hypothalamus; Leptin; Leptin receptor; Pig; Pituitary

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

ADENOHYPOPHYSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; FIRST TRIMESTER PREGNANCY; GENE EXPRESSION; GENETIC CODE; HYPOPHYSIS; HYPOTHALAMUS; LUTEAL PHASE; MEDIAN EMINENCE; NEUROHYPOPHYSIS; NONHUMAN; PREGNANCY; PREOPTIC AREA; QUANTITATIVE ANALYSIS; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECOND TRIMESTER PREGNANCY; SWINE; THIRD TRIMESTER PREGNANCY;

ANIMALS; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; LEPTIN; LUTEAL PHASE; PITUITARY GLAND; PREGNANCY; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SWINE;

EID: 33645558326     PISSN: 08675910     EISSN: 08675910     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway: a link between adipose tissue mass and central neural networks. Horm Metab Res 1996; 28: 619-632
2. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000; 62: 413-437.
3. Amstalden M, Garcia MR, Williams SW, Stanko RL, Nizielski SE, Morrison CD, Keisler DH, Williams GL. Leptin gene expression, circulating leptin, and luteinizing hormone pulsatility are acutely responsive to short-term fasting in prepubertal heifers: relationship to circulating insulin and insulin-like growth factor I. Biol Reprod 2000; 63: 127-133.
4. Foster DL, Nagatani S. Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty. Biol Reprod 1999; 60: 205-215.
5. Barb CR, Yan X, Azain MJ, Kraeling RR, Rampacek GB, Ramsay TG. Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine. Dom Anim Endocrinol 1998; 15: 77-86.
6. Barb CR, Kraeling RR, Barrett JB, Rampacek GB. Role of leptin in modulating neuroendocrine function: a metabolic link between the brain-pituitary and adipose tissue. Reprod Dom Anim 1999; 34: 111-125.
7. Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272: 6093-6096.
8. Lin J, Barb CR, Matteri RL, Kraeling RR, Chen X, Meinersman RJ, Rampacek GB. Long for leptin receptor mRNA expression in the brain, pituitary and other tissues in the pig. Dom Anim Endocrinol 2000; 19: 53-61.
9. Lin J, Barb R, Kraeling RK, Rampacek GB. Developmental changes in the long form leptin receptor and related neuropeptide gene expression in the pig brain. Biol Reprod 2001; 64: 1614-1618.
10. Smolinska N, Przala J, Kamiński T, Siawrys G, Gajewska A, Kochman K, Okrasa S. Leptin gene expression in the hypothalamus and pituitary of pregnant pigs. Neuroendocrinol Lett 2004; 25: 191-195.
11. Siawrys G, Przala, Kaminski T, Smolinska N, Gajewska A, Kochman K, Skowronski M, Staszkiewicz J. Long form leptin receptor mRNA expression in the hypothalamus and pituitary during early pregnancy in the pig. Neuroendocrinol Lett 2005; 26:305-309.
12. Sesti LAC, Britt JH. Relationship of secretion of GnRH in vitro to changes in pituitary concentrations of LH and FSH and serum concentrations of LH during lactation in sows. J Reprod Fertil 1993; 98: 393-400.
13. Wong H, Anderson WD, Cheng T, Riabowol KT. Monitoring mRNA expression by polymerase chain reaction: the "primer dropping" method. Anal Biochem 1994; 223: 251-258.
14. Caprio M, Fabbrini E, Isidori AM, Aversa A, Fabbri A. Leptin in reproduction. Trend Endocrinol Metab 2001; 12: 65-72.
15. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
16. Morash B, Li SA, Murphy PR, Wilkinson M, Ur E. Leptin gene expression in the brain and pituitary gland. Endocrinology 1999; 140: 5995-5998.
17. Wilkinson M, Morash B, Ur E. The brain is the source of leptin. Front Horm Res 2000; 26: 106-125.
18. Jin L, Zhang S, Burguera BG, Couce ME, Osamura RY, Kulig E, Lloyd RV. Leptin and leptin receptor expression in rat and mouse pituitary cells. Endocrinology 2000; 142: 333-339.
19. Ehrhardt RA, Bell AW, Boisclair YR. Spatial and developmental regulation of leptin in fetal sheep. Am J Physiol Regul Integr Comp Physiol 2002; 282: R1628-1635.
20. Burguera B, Couce ME, Long J, Lamsam J, Laakso K, Jensen MD, Parisi JE, Lloyd RV. The long form of the leptin receptor (OB-Rb) is widely expressed in human brain. Neuroendocrinology 2000; 71: 187-195.
21. Ur E, Wilkinson D, Morash BA, Wilkinson M. Leptin immunoreactivity is localized to neurons in rat brain. Neuroendocrinology 2002; 75: 264-272.
22. Iqbal J, Pompolo S, Murakami T, Grouzmann E, Sakurai T, Meister B, Clarke LJ. Immunohistochemical characterization of localization of long form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus. Brain Res 2001; 920: 55-64.
23. Morash BA, Imran A, Wilkinson D, Ur E, Wilkinson D. Leptin receptors are developmentally regulated in rat pituitary and hypothalamus. Mol Cell Endocrinol 2003; 210: 1-8.
24. Czaja K, Łakomy M, Sienkiewicz W, Kaleczyc J, Pisudko Z, Barb CR, Rampacek GB, Kraeling RR. Distribution of neurons containing leptin receptors in the hypothalamus of the pig. Biochem Biophys Res Commun 2002; 298: 333-337.
25. Meli R, Pacilio M, Raso GM, Esposito E, Coppola A, Nasti A, Di Carlo C, Nappi C, Di Carlo R. Estrogen and raloxifen modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Endocrinology 2004; 145: 3115-3121.
26. Bennett PA, Lindell K, Karlsson C, Robinson ICAF, Carlsson LMS, Carlsson B. Differential expression and regulation of leptin receptor isoforms in the rat brain: effects of fasting and oestrogen. Neuroendocrinology 1998; 67: 29-36.
27. Yu WH, Kimura M, Walczewska A, Karanth S, Mc Cann SM. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997; 94: 1023-1028.
28. Magni P, Vettor R, Pagano C, Calcagno A, Beretta E, Messi E, Zanisi M, Martini L, Motta M. Expression of a leptin receptor in immortalized GnRH-secreting neurons. Endocrinology 1999; 140: 1581-1585.
29. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ, Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol 1996; 8: 733-735.
30. Kalra SP, Kalra PS. Nutritional infertility: the role of interconnected hypothalamic neuropeptide Y-galanin-opioid network. Front Neuroendocrinol 1996; 17: 371-401.
31. Gonzales MI, Baker BI, Wilson CA. Stimulatory effect of melanin-concentrating hormone on luteinizing hormone release. Neuroendocrinology 1997; 66: 254-262.
32. Sahu A. Evidence that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT) proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets for leptin signalling in the hypothalamus. Endocrinology 1998; 139: 3331-3336.
33. Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997; 138: 4489-4492.
34. Watanabe H, Yoneda M, Kakizaki Y, Kohsaka A, Suda T, Shioti HB. Further evidence for a significant participation of the melanocortin 4 receptor in the preovulatory prolactin surge in the rat. Brain Res Bull 2001; 54:521-525.
35. Caballero C, Celis ME. The effect of the blockade of alpha-melanocyte stimulating hormone on LH release in the rat. J Endocrinol 1993; 137: 197-202.
36. Iqbal J, Pompolo S, Considine R, Clarke I. Localization of receptor-like immunoreactivity in the corticotropes, somatotropes and gonadotropes in the ovine anterior pituitary. Endocrinology 2000; 141: 1515-1520.
37. Jin L, Burguera BG, Couce ME, Scheithauer BW, Lamsan J, Eberhardt NL, Kulig E, Lloyd RV. Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab 1999; 84: 2903-2911.
38. Bagnasco M, Kalra PS, Kalra SP. Plasma leptin levels are pulsatile in adult rats: effects of gonadectomy. Neuroendocrinology 2002; 75: 257-263.
39. Vidal S, Cohen S, Horvath E, Kovacs K, Scheithauer B, Burguera B, Lloyd R. Subcellular localization of leptin in non-tumorous and adenomatous human pituitaries: An immunoultrastructural study. J Histochem Cytochem 2000; 48: 1147-1152.
40. Licinio J, Negrao AB, Mantzoros Ch, Kaklamani V, Wong M-L, Bongiorno PB, Mulla A, Cearnal L, Veldhuis JD, Flier JS, McCann SM, Gold PW. Synchronicity of frequently sampled 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Proc Natl Acad Sci USA 1998; 95: 2541-2546.
41. Tena-Sempere M, Pinilla L, Zhang F-P, Gonzales LC, Huhtaniemi I, Casanueva FF, Dieguez C, Aguilar E. Developmental and hormonal regulation of leptin receptor (Ob-R) messenger ribonucleic acid expression in rat testis. Biol Reprod 2001; 64: 634-643.
42. del Carmen Garcia M, Casanueva FF, Dieguez C, Senaris RM. Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of mRNA levels of the leptin receptor subtypes in the hypothalamus during pregnancy and lactation. Biol Reprod 2000; 62: 698-703.
43. Tena-Sempere M, Pinilla L, Gonzales LC, Casanueva FF, Dieguez C, Aguilar E. Homologues and heterologues down-regulation of leptin receptor messenger ribonucleic acid in rat adrenal gland. J Endocrinol 2000; 167: 479-486.
44. Lin J, Barb CR, Kraeling RR, Rampacek GB. Growth hormone releasing factor decreases long form leptin receptor expression in porcine anterior pituitary cells. Dom Anim Endocrinol 2003; 24: 95-101.