-
2
-
-
0010007753
-
-
Robertson JFR, Nicholson RI, Hayes editors. Martin Dunitz, London
-
Endocrine Therapy of Breast Cancer. In: Robertson JFR, Nicholson RI, Hayes editors. Martin Dunitz, London, 2002.
-
(2002)
Endocrine Therapy of Breast Cancer
-
-
-
3
-
-
0036295586
-
Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer
-
Nicholson RI, Hutcheson IR, Harper ME, Knowlden JM, Barrow D, McClelland RA, et al. Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer. Ann N Y Acad Sci 2002;963:104-15.
-
(2002)
Ann N Y Acad Sci
, vol.963
, pp. 104-115
-
-
Nicholson, R.I.1
Hutcheson, I.R.2
Harper, M.E.3
Knowlden, J.M.4
Barrow, D.5
McClelland, R.A.6
-
4
-
-
0033973395
-
Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer
-
Nicholson RI, Gee JM. Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer. Br J Cancer 2000;82:501-13.
-
(2000)
Br J Cancer
, vol.82
, pp. 501-513
-
-
Nicholson, R.I.1
Gee, J.M.2
-
5
-
-
0033838566
-
Function of the IGF-I receptor in breast cancer
-
Surmacz E. Function of the IGF-I receptor in breast cancer. J Mammary Gland Biol Neopl 2000;5:95-105.
-
(2000)
J Mammary Gland Biol Neopl
, vol.5
, pp. 95-105
-
-
Surmacz, E.1
-
6
-
-
0034719406
-
Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer
-
Newman SP, Bates NP, Vernimmen D, Parker MG, Hurst HC. Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer. Oncogene 2000;19:490-7.
-
(2000)
Oncogene
, vol.19
, pp. 490-497
-
-
Newman, S.P.1
Bates, N.P.2
Vernimmen, D.3
Parker, M.G.4
Hurst, H.C.5
-
7
-
-
0036237676
-
Identification and characterization of a negative regulatory element within the epidermal growth factor receptor gene first intron in hormone-dependent breast cancer cells
-
Wilson MA, Chrysogelos SA. Identification and characterization of a negative regulatory element within the epidermal growth factor receptor gene first intron in hormone-dependent breast cancer cells. J Cell Biochem 2002;85:601-14.
-
(2002)
J Cell Biochem
, vol.85
, pp. 601-614
-
-
Wilson, M.A.1
Chrysogelos, S.A.2
-
8
-
-
0034790009
-
Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer
-
Nicholson RI, Hutcheson IR, Harper ME, Knowlden JM, Barrow D, McClelland RA, et al. Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer. Endocr Relat Cancer 2001;8:175-82.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 175-182
-
-
Nicholson, R.I.1
Hutcheson, I.R.2
Harper, M.E.3
Knowlden, J.M.4
Barrow, D.5
McClelland, R.A.6
-
9
-
-
0242721012
-
The anti-epidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves anti-hormone response and prevents development of resistance in breast cancer in vitro
-
Gee JM, Harper ME, Hutcheson IR, Madden TA, Barrow D, Knowlden JM, et al. The anti-epidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves anti-hormone response and prevents development of resistance in breast cancer in vitro. Endocrinology 2003;144:5105-17.
-
(2003)
Endocrinology
, vol.144
, pp. 5105-5117
-
-
Gee, J.M.1
Harper, M.E.2
Hutcheson, I.R.3
Madden, T.A.4
Barrow, D.5
Knowlden, J.M.6
-
10
-
-
0034987631
-
Enhanced epidermal growth factor receptor signalling in MCF-7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex)
-
McClelland RA, Barrow D, Madden TA, Dutkowski CM, Pamment J, Knowlden JM, et al. Enhanced epidermal growth factor receptor signalling in MCF-7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). Endocrinology 2001;142:2776-88.
-
(2001)
Endocrinology
, vol.142
, pp. 2776-2788
-
-
McClelland, R.A.1
Barrow, D.2
Madden, T.A.3
Dutkowski, C.M.4
Pamment, J.5
Knowlden, J.M.6
-
11
-
-
0037373326
-
Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
-
Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, et al. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 2003;144:1032-44.
-
(2003)
Endocrinology
, vol.144
, pp. 1032-1044
-
-
Knowlden, J.M.1
Hutcheson, I.R.2
Jones, H.E.3
Madden, T.4
Gee, J.M.5
Harper, M.E.6
-
12
-
-
0023679801
-
A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo
-
Vickers PJ, Dickson RB, Shoemaker R, Cowan KH. A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo. Mol Endocrinol 1988;2:886-92.
-
(1988)
Mol Endocrinol
, vol.2
, pp. 886-892
-
-
Vickers, P.J.1
Dickson, R.B.2
Shoemaker, R.3
Cowan, K.H.4
-
13
-
-
0026704233
-
Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line
-
Long B, McKibben BM, Lynch M, van den Berg HW. Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line. Br J Cancer 1992;65:865-9.
-
(1992)
Br J Cancer
, vol.65
, pp. 865-869
-
-
Long, B.1
McKibben, B.M.2
Lynch, M.3
Van Den Berg, H.W.4
-
14
-
-
0027074588
-
Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu
-
Benz CC, Scott GK, Sarup JC, Johnson RM, Tripathy D, Coronado E, et al. Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu. Breast Cancer Res Treat 1993;24:85-95.
-
(1993)
Breast Cancer Res Treat
, vol.24
, pp. 85-95
-
-
Benz, C.C.1
Scott, G.K.2
Sarup, J.C.3
Johnson, R.M.4
Tripathy, D.5
Coronado, E.6
-
15
-
-
0026786658
-
Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-1 human breast cancer cells
-
van Agthoven T, van Agthoven TL, Portengen H, Foekens JA, Dorssers LC. Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-1 human breast cancer cells. Cancer Res 1992;52:5082-8.
-
(1992)
Cancer Res
, vol.52
, pp. 5082-5088
-
-
Van Agthoven, T.1
Van Agthoven, T.L.2
Portengen, H.3
Foekens, J.A.4
Dorssers, L.C.5
-
16
-
-
0027973875
-
Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: Evidence for a role of EGFR in breast cancer growth and progression
-
Miller DL, el-Ashry D, Cheville AL, Liu Y, McLeskey SW, Kern FG. Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: evidence for a role of EGFR in breast cancer growth and progression. Cell Growth Differ 1994;5:1263-74.
-
(1994)
Cell Growth Differ
, vol.5
, pp. 1263-1274
-
-
Miller, D.L.1
El-Ashry, D.2
Cheville, A.L.3
Liu, Y.4
McLeskey, S.W.5
Kern, F.G.6
-
17
-
-
0028928063
-
MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo
-
Liu Y, el-Ashry D, Chen D, Ding IY, Kern FG. MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo. Breast Cancer Res Treat 1995;34:97-117.
-
(1995)
Breast Cancer Res Treat
, vol.34
, pp. 97-117
-
-
Liu, Y.1
El-Ashry, D.2
Chen, D.3
Ding, I.Y.4
Kern, F.G.5
-
18
-
-
0034667395
-
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
-
Kurokawa H, Lenferink A E, Simpson JF, Pisacane PI, Sliwkowski MX, Forbes JT, et al. Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Res 2000;60:5887-94.
-
(2000)
Cancer Res
, vol.60
, pp. 5887-5894
-
-
Kurokawa, H.1
Lenferink, A.E.2
Simpson, J.F.3
Pisacane, P.I.4
Sliwkowski, M.X.5
Forbes, J.T.6
-
19
-
-
0042232592
-
Enhanced estrogen receptor (ER) alpha, ERBB2 and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term oestrogen deprivation
-
Martin LA, Farmer I, Johnston SR, Ali S, Marshall CJ, Dowsett M. Enhanced estrogen receptor (ER) alpha, ERBB2 and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term oestrogen deprivation. J Biol Chem 2003; 278:30458-68.
-
(2003)
J Biol Chem
, vol.278
, pp. 30458-30468
-
-
Martin, L.A.1
Farmer, I.2
Johnston, S.R.3
Ali, S.4
Marshall, C.J.5
Dowsett, M.6
-
20
-
-
4544352393
-
Increased constitutive activity of PKB/AKT in tamoxifen resistant breast cancer MCF-7 cells
-
Jordan NJ, Gee JM, Barrow D, Wakeling AE, Nicholson RI. Increased constitutive activity of PKB/AKT in tamoxifen resistant breast cancer MCF-7 cells. Breast Cancer Res Treat 2004; 87:167-80.
-
(2004)
Breast Cancer Res Treat
, vol.87
, pp. 167-180
-
-
Jordan, N.J.1
Gee, J.M.2
Barrow, D.3
Wakeling, A.E.4
Nicholson, R.I.5
-
21
-
-
0032530222
-
Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells
-
Coutts AS, Murphy LC. Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells. Cancer Res 1998;58:4071-4.
-
(1998)
Cancer Res
, vol.58
, pp. 4071-4074
-
-
Coutts, A.S.1
Murphy, L.C.2
-
22
-
-
0035971181
-
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
-
Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem 2001;276:9817-24.
-
(2001)
J Biol Chem
, vol.276
, pp. 9817-9824
-
-
Campbell, R.A.1
Bhat-Nakshatri, P.2
Patel, N.M.3
Constantinidou, D.4
Ali, S.5
Nakshatri, H.6
-
23
-
-
0035798683
-
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells
-
Donovan JC, Milic A, Slingerland JM. Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells. J Biol Chem 2001;276:40888-95.
-
(2001)
J Biol Chem
, vol.276
, pp. 40888-40895
-
-
Donovan, J.C.1
Milic, A.2
Slingerland, J.M.3
-
24
-
-
0037240275
-
ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms
-
Kurokawa H, Arteaga CL. ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms. Clin Cancer Res 2003;9:511S-5.
-
(2003)
Clin Cancer Res
, vol.9
-
-
Kurokawa, H.1
Arteaga, C.L.2
-
25
-
-
26944498619
-
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth
-
Frogne T, Jepsen JS, Larsen SS, Fog CK, Brockdorff BL, Lykkesfeldt AE. Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth. Endocr Relat Cancer 2005;12:599-614.
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. 599-614
-
-
Frogne, T.1
Jepsen, J.S.2
Larsen, S.S.3
Fog, C.K.4
Brockdorff, B.L.5
Lykkesfeldt, A.E.6
-
26
-
-
0033765376
-
Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells
-
Jeng MH, Yue W, Eischeid A, Wang JP, Santen RJ. Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells. Breast Cancer Res Treat 2000;62:167-75.
-
(2000)
Breast Cancer Res Treat
, vol.62
, pp. 167-175
-
-
Jeng, M.H.1
Yue, W.2
Eischeid, A.3
Wang, J.P.4
Santen, R.J.5
-
27
-
-
0028020839
-
Induction of estrogen independence of ZR-75-1 human breast cancer cells by epigenetic alterations
-
van Agthoven T, van Agthoven TL, Dekker A, Foekens JA, Dorssers LC. Induction of estrogen independence of ZR-75-1 human breast cancer cells by epigenetic alterations. Mol Endocrinol 1994;8:1474-83.
-
(1994)
Mol Endocrinol
, vol.8
, pp. 1474-1483
-
-
Van Agthoven, T.1
Van Agthoven, T.L.2
Dekker, A.3
Foekens, J.A.4
Dorssers, L.C.5
-
28
-
-
2942652871
-
Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
-
Shou J, Massarweh S, Osborne CK, Wakeling AE, Ali S, Weiss H, et al. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 2004;96:926-35.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 926-935
-
-
Shou, J.1
Massarweh, S.2
Osborne, C.K.3
Wakeling, A.E.4
Ali, S.5
Weiss, H.6
-
29
-
-
0031015394
-
Enhanced anti-proliferative activity of the combination of tamoxifen plus HER-2-neu antibody
-
Witters LM, Kumar R, Chinchilli VM, Lipton A. Enhanced anti-proliferative activity of the combination of tamoxifen plus HER-2-neu antibody. Breast Cancer Res Treat 1997;42:1-5.
-
(1997)
Breast Cancer Res Treat
, vol.42
, pp. 1-5
-
-
Witters, L.M.1
Kumar, R.2
Chinchilli, V.M.3
Lipton, A.4
-
30
-
-
0036835014
-
Restoration of estrogen responsiveness by blocking the HER-2/neu pathway
-
Witters L, Engle L, Lipton A. Restoration of estrogen responsiveness by blocking the HER-2/neu pathway. Oncol Rep 2002;9:1163-6.
-
(2002)
Oncol Rep
, vol.9
, pp. 1163-1166
-
-
Witters, L.1
Engle, L.2
Lipton, A.3
-
31
-
-
0034667395
-
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
-
Kurokawa H, Lenferink AE, Simpson JF, Pisacane PI, Sliwkowski MX, Forbes JT, et al. Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Res 2000;60:5887-94.
-
(2000)
Cancer Res
, vol.60
, pp. 5887-5894
-
-
Kurokawa, H.1
Lenferink, A.E.2
Simpson, J.F.3
Pisacane, P.I.4
Sliwkowski, M.X.5
Forbes, J.T.6
-
32
-
-
33645234316
-
Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth
-
Britton DJ, Hutcheson IR, Knowlden JM, Barrow D, Giles M, McClelland RA, et al. Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat 2006;96:131-46.
-
(2006)
Breast Cancer Res Treat
, vol.96
, pp. 131-146
-
-
Britton, D.J.1
Hutcheson, I.R.2
Knowlden, J.M.3
Barrow, D.4
Giles, M.5
McClelland, R.A.6
-
33
-
-
0035919923
-
Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer
-
Gee JM, Robertson JF, Ellis IO, Nicholson RI. Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer. Int J Cancer 2001;95:247-54.
-
(2001)
Int J Cancer
, vol.95
, pp. 247-254
-
-
Gee, J.M.1
Robertson, J.F.2
Ellis, I.O.3
Nicholson, R.I.4
-
34
-
-
25844468319
-
Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer
-
Gee JM, Robertson JF, Gutteridge E, Ellis IO, Pinder SE, Rubini M, et al. Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocr Relat Cancer 2005;12:99-111.
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. 99-111
-
-
Gee, J.M.1
Robertson, J.F.2
Gutteridge, E.3
Ellis, I.O.4
Pinder, S.E.5
Rubini, M.6
-
35
-
-
25844467036
-
Overview of tyrosine kinase inhibitors in clinical breast cancer
-
Agrawal A, Gutteridge E, Gee JM, Nicholson RI, Robertson JF. Overview of tyrosine kinase inhibitors in clinical breast cancer. Endocr Relat Cancer 2005;12:135-44.
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. 135-144
-
-
Agrawal, A.1
Gutteridge, E.2
Gee, J.M.3
Nicholson, R.I.4
Robertson, J.F.5
-
37
-
-
25844490498
-
Clinical trials of intracellular signal transductions inhibitors for breast cancer-a strategy to overcome endocrine resistance
-
Johnston SR. Clinical trials of intracellular signal transductions inhibitors for breast cancer-a strategy to overcome endocrine resistance. Endocr Relat Cancer 2005;12:S145-57.
-
(2005)
Endocr Relat Cancer
, vol.12
-
-
Johnston, S.R.1
-
38
-
-
0029877913
-
Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
-
Bunone G, Briand P-A, Miksicek RJ, Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 1996;15:2174-83.
-
(1996)
EMBO J
, vol.15
, pp. 2174-2183
-
-
Bunone, G.1
Briand, P.-A.2
Miksicek, R.J.3
Picard, D.4
-
39
-
-
0031594574
-
Pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167
-
Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol Cell Biol 1998;18:1978-84.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1978-1984
-
-
Joel, P.B.1
Smith, J.2
Sturgill, T.W.3
Fisher, T.L.4
Blenis, J.5
Lannigan, D.A.6
-
40
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995;270:1491-4.
-
(1995)
Science
, vol.270
, pp. 1491-1494
-
-
Kato, S.1
Endoh, H.2
Masuhiro, Y.3
Kitamoto, T.4
Uchiyama, S.5
Sasaki, H.6
-
41
-
-
0037211754
-
Estrogen receptor phosphorylation
-
Lannigan DA. Estrogen receptor phosphorylation. Steroids 2003;68:1-9.
-
(2003)
Steroids
, vol.68
, pp. 1-9
-
-
Lannigan, D.A.1
-
42
-
-
0027435039
-
Measurement of steroid hormone receptors in breast cancer patients on tamoxifen
-
Encarnacion CA, Ciocca DR, McGuire WL, Clark GM, Fuqua SAW, Osborne CK. Measurement of steroid hormone receptors in breast cancer patients on tamoxifen. Breast Cancer Res Treat 1993;26:237-46.
-
(1993)
Breast Cancer Res Treat
, vol.26
, pp. 237-246
-
-
Encarnacion, C.A.1
Ciocca, D.R.2
McGuire, W.L.3
Clark, G.M.4
Fuqua, S.A.W.5
Osborne, C.K.6
-
43
-
-
0027279120
-
MCF7/LCC2: A 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780
-
Brunner N, Frandesen TL, Holst-Hansen C, Bei M, Thompson EW, Wakeling AE, et al. MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780. Cancer Res 1993;53:3229-32.
-
(1993)
Cancer Res
, vol.53
, pp. 3229-3232
-
-
Brunner, N.1
Frandesen, T.L.2
Holst-Hansen, C.3
Bei, M.4
Thompson, E.W.5
Wakeling, A.E.6
-
44
-
-
0028329961
-
Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAM R-1
-
Lykkesfeldt AE, Mogens MW, Briand P. Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAM R-1. Cancer Res 1994;54:1587-95.
-
(1994)
Cancer Res
, vol.54
, pp. 1587-1595
-
-
Lykkesfeldt, A.E.1
Mogens, M.W.2
Briand, P.3
-
45
-
-
0030028024
-
Oestrogen receptor: A stable phenotype in breast cancer
-
Robertson JF. Oestrogen receptor: a stable phenotype in breast cancer. Br J Cancer 1996;73:5-12.
-
(1996)
Br J Cancer
, vol.73
, pp. 5-12
-
-
Robertson, J.F.1
-
46
-
-
0041736202
-
Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells
-
Hutcheson IR, Knowlden JM, Madden TA, Barrow D, Gee JM, Wakeling AE, et al. Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells. Breast Cancer Res Treat 2003;81:81-93.
-
(2003)
Breast Cancer Res Treat
, vol.81
, pp. 81-93
-
-
Hutcheson, I.R.1
Knowlden, J.M.2
Madden, T.A.3
Barrow, D.4
Gee, J.M.5
Wakeling, A.E.6
-
47
-
-
0036702132
-
Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation
-
Chan CM, Martin LA, Johnston SR, Ali S, Dowsett M. Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation. J Steroid Biochem Mol Biol 2002;81:333-41.
-
(2002)
J Steroid Biochem Mol Biol
, vol.81
, pp. 333-341
-
-
Chan, C.M.1
Martin, L.A.2
Johnston, S.R.3
Ali, S.4
Dowsett, M.5
-
48
-
-
16444369651
-
Molecular changes associated with the agonist activity of hydroxy-tamoxifen and the hyper-response to estradiol in hydroxy-tamoxifen- resistant breast cancer cell lines
-
Vendrell JA, Bieche I, Desmetz C, Badia E, Tozlu S, Nguyen C, et al. Molecular changes associated with the agonist activity of hydroxy-tamoxifen and the hyper-response to estradiol in hydroxy-tamoxifen-resistant breast cancer cell lines. Endocr Relat Cancer 2005;12:75-92.
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. 75-92
-
-
Vendrell, J.A.1
Bieche, I.2
Desmetz, C.3
Badia, E.4
Tozlu, S.5
Nguyen, C.6
-
49
-
-
0027358687
-
Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780
-
Hu XF, Veroni M, De Luise M, Wakeling A, Sutherland R, Watts CK, et al. Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780. Int J Cancer 1993;55:873-6.
-
(1993)
Int J Cancer
, vol.55
, pp. 873-876
-
-
Hu, X.F.1
Veroni, M.2
De Luise, M.3
Wakeling, A.4
Sutherland, R.5
Watts, C.K.6
-
50
-
-
0028267222
-
Anti-proliferative and anti-estrogenic effects of ICI 164,384 and ICI 182,780 in 4-OH-tamoxifen-resistant human breast-cancer cells
-
Coopman P, Garcia M, Brunner N, Derocq D, Clarke R, Rochefort H. Anti-proliferative and anti-estrogenic effects of ICI 164,384 and ICI 182,780 in 4-OH-tamoxifen-resistant human breast-cancer cells. Int J Cancer 1994;56:295-300.
-
(1994)
Int J Cancer
, vol.56
, pp. 295-300
-
-
Coopman, P.1
Garcia, M.2
Brunner, N.3
Derocq, D.4
Clarke, R.5
Rochefort, H.6
-
51
-
-
0028965397
-
Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer
-
Howell A, Robertson J. Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer. Lancet 1995;345:989-90.
-
(1995)
Lancet
, vol.345
, pp. 989-990
-
-
Howell, A.1
Robertson, J.2
-
52
-
-
0030016280
-
Pharmacokinetics, pharmacological and anti-tumor effects of the specific anti-estrogen ICI 182,780 in women with advanced breast cancer
-
Howell A, DeFriend DJ, Robertson JF, Blamey RW, Anderson L, Anderson E, et al. Pharmacokinetics, pharmacological and anti-tumor effects of the specific anti-estrogen ICI 182,780 in women with advanced breast cancer. Br J Cancer 1996;74:300-8.
-
(1996)
Br J Cancer
, vol.74
, pp. 300-308
-
-
Howell, A.1
Defriend, D.J.2
Robertson, J.F.3
Blamey, R.W.4
Anderson, L.5
Anderson, E.6
-
53
-
-
25844519113
-
Acquired resistance to oestrogen deprivation: Role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model
-
Staka CM, Nicholson RI, Gee JM. Acquired resistance to oestrogen deprivation: role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model. Endocr Relat Cancer 2005;12:S85-97.
-
(2005)
Endocr Relat Cancer
, vol.12
-
-
Staka, C.M.1
Nicholson, R.I.2
Gee, J.M.3
-
54
-
-
0001392322
-
AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
-
Font de Mora J, Brown M. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol Cell Biol 2000;20:5041-7.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5041-5047
-
-
Font De Mora, J.1
Brown, M.2
-
55
-
-
0035933737
-
Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity
-
Lopez GN, Turck CW, Schaufele F, Stallcup MR, Kushner PJ. Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity. J Biol Chem 2001;276:22177-82.
-
(2001)
J Biol Chem
, vol.276
, pp. 22177-22182
-
-
Lopez, G.N.1
Turck, C.W.2
Schaufele, F.3
Stallcup, M.R.4
Kushner, P.J.5
-
56
-
-
0036242554
-
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
-
Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, et al. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol 2002;22:3549-61.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3549-3561
-
-
Wu, R.C.1
Qin, J.2
Hashimoto, Y.3
Wong, J.4
Xu, J.5
Tsai, S.Y.6
-
57
-
-
0037420192
-
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer
-
Osborne CK, Bardou V, Hopp TA, Chamness GC, Hilsenbeck SG, Fuqua SA, et al. Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. J Natl Cancer Inst 2003;95:353-61.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 353-361
-
-
Osborne, C.K.1
Bardou, V.2
Hopp, T.A.3
Chamness, G.C.4
Hilsenbeck, S.G.5
Fuqua, S.A.6
-
58
-
-
0037237481
-
Breast cancer endocrine resistance: How growth factor signaling and estrogen receptor coregulators modulate response
-
Schiff R, Massarweh S, Shou J, Osborne CK. Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate response. Clin Cancer Res 2003;9:447S-54.
-
(2003)
Clin Cancer Res
, vol.9
-
-
Schiff, R.1
Massarweh, S.2
Shou, J.3
Osborne, C.K.4
-
59
-
-
33751101625
-
Phosphorylation of ERalpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERalpha phosphorylation in breast cancer progression
-
Sarwar N, Kim JS, Jiang J, Peston D, Sinnett HD, Madden P, et al. Phosphorylation of ERalpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERalpha phosphorylation in breast cancer progression. Endocr Relat Cancer 2006;13:851-61.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 851-861
-
-
Sarwar, N.1
Kim, J.S.2
Jiang, J.3
Peston, D.4
Sinnett, H.D.5
Madden, P.6
-
60
-
-
0037441550
-
Membrane receptors for steroid hormones: Signal transduction and physiological significance
-
Nemere I, Pietras RJ, Blackmore PF. Membrane receptors for steroid hormones: signal transduction and physiological significance. J Cell Biochem 2003;88:438-45.
-
(2003)
J Cell Biochem
, vol.88
, pp. 438-445
-
-
Nemere, I.1
Pietras, R.J.2
Blackmore, P.F.3
-
61
-
-
27944468748
-
Adaptation of estrogen-regulated genes in long-term estradiol deprived MCF-7 breast cancer cells
-
Santen RJ, Lobenhofer EK, Afshari CA, Bao Y, Song RX. Adaptation of estrogen-regulated genes in long-term estradiol deprived MCF-7 breast cancer cells. Breast Cancer Res Treat 2005;94:213-23.
-
(2005)
Breast Cancer Res Treat
, vol.94
, pp. 213-223
-
-
Santen, R.J.1
Lobenhofer, E.K.2
Afshari, C.A.3
Bao, Y.4
Song, R.X.5
-
62
-
-
26844487041
-
Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor
-
Knowlden JM, Hutcheson IR, Barrow D, Gee JM, Nicholson RI. Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor. Endocrinology 2005;146:4609-18.
-
(2005)
Endocrinology
, vol.146
, pp. 4609-4618
-
-
Knowlden, J.M.1
Hutcheson, I.R.2
Barrow, D.3
Gee, J.M.4
Nicholson, R.I.5
-
63
-
-
0033001742
-
Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line
-
Parisot JP, Hu XF, DeLuise M, Zalcberg JR. Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line. Br J Cancer 1999;79:693-700.
-
(1999)
Br J Cancer
, vol.79
, pp. 693-700
-
-
Parisot, J.P.1
Hu, X.F.2
Deluise, M.3
Zalcberg, J.R.4
-
64
-
-
0028362024
-
Functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor
-
Coppola D, Ferber A, Miura M, Sell C, D'Ambrosio C, Rubin R, et al. Functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol 1994;14:4588-95.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4588-4595
-
-
Coppola, D.1
Ferber, A.2
Miura, M.3
Sell, C.4
D'Ambrosio, C.5
Rubin, R.6
-
65
-
-
0345826131
-
The mitogenic action of insulin-like growth factor I in normal human mammary epithelial cells requires the epidermal growth factor receptor tyrosine kinase
-
Ahmad T, Farnie G, Bundred NJ, Anderson NG. The mitogenic action of insulin-like growth factor I in normal human mammary epithelial cells requires the epidermal growth factor receptor tyrosine kinase. J Biol Chem 2003;279:1713-9.
-
(2003)
J Biol Chem
, vol.279
, pp. 1713-1719
-
-
Ahmad, T.1
Farnie, G.2
Bundred, N.J.3
Anderson, N.G.4
-
66
-
-
0037008761
-
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
-
Gilmore AP, Valentijn AJ, Wang P, Ranger AM, Bundred N, O'Hare MJ, et al. Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. J Biol Chem 2002;277:27643-50.
-
(2002)
J Biol Chem
, vol.277
, pp. 27643-27650
-
-
Gilmore, A.P.1
Valentijn, A.J.2
Wang, P.3
Ranger, A.M.4
Bundred, N.5
O'Hare, M.J.6
-
67
-
-
0034698096
-
Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells
-
Roudabush FL, Pierce KL, Maudsley S, Khan KD, Luttrell LM. Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. J Biol Chem 2000;275:22583-9.
-
(2000)
J Biol Chem
, vol.275
, pp. 22583-22589
-
-
Roudabush, F.L.1
Pierce, K.L.2
Maudsley, S.3
Khan, K.D.4
Luttrell, L.M.5
-
68
-
-
0037147108
-
Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines
-
Hurbin A, Dubrez L, Coll JL, Favrot MC. Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines. J Biol Chem 2002;277:49127-33.
-
(2002)
J Biol Chem
, vol.277
, pp. 49127-49133
-
-
Hurbin, A.1
Dubrez, L.2
Coll, J.L.3
Favrot, M.C.4
-
69
-
-
85047699864
-
Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells
-
Wang D, Patil S, Li W, Humphrey LE, Brattain MG, Howell GM. Activation of the TGFalpha autocrine loop is downstream of IGF-I receptor activation during mitogenesis in growth factor dependent human colon carcinoma cells. Oncogene 2002;21:2785-96.
-
(2002)
Oncogene
, vol.21
, pp. 2785-2796
-
-
Wang, D.1
Patil, S.2
Li, W.3
Humphrey, L.E.4
Brattain, M.G.5
Howell, G.M.6
-
70
-
-
0028902772
-
Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1
-
Vardy DA, Kari C, Lazarus GS, Jensen PJ, Zilberstein A, Plowman GD, et al. Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. J Cell Biol 1995;163:257-65.
-
(1995)
J Cell Biol
, vol.163
, pp. 257-265
-
-
Vardy, D.A.1
Kari, C.2
Lazarus, G.S.3
Jensen, P.J.4
Zilberstein, A.5
Plowman, G.D.6
-
71
-
-
0035804218
-
Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells
-
Balana ME, Labriola L, Salatino M, Movsichoff F, Peters G, Charreau EH, et al. Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells. Oncogene 2001;20:34-47.
-
(2001)
Oncogene
, vol.20
, pp. 34-47
-
-
Balana, M.E.1
Labriola, L.2
Salatino, M.3
Movsichoff, F.4
Peters, G.5
Charreau, E.H.6
-
72
-
-
0033583220
-
C-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function
-
Biscardi JS, Maa MC, Tice DA, Cox ME, Leu TH, Parsons SJ. c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J Biol Chem 1999;274:8335-43.
-
(1999)
J Biol Chem
, vol.274
, pp. 8335-8343
-
-
Biscardi, J.S.1
Maa, M.C.2
Tice, D.A.3
Cox, M.E.4
Leu, T.H.5
Parsons, S.J.6
-
74
-
-
36549089022
-
Heregulin β1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells
-
(submitted).
-
Hutcheson IR, Knowlden JM, Hiscox SE, Barrow D, Gee JMW, Robertson JF, Ellis IO, Nicholson RI: Heregulin β1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells. Breast Cancer Res (submitted).
-
Breast Cancer Res
-
-
Hutcheson, I.R.1
Knowlden, J.M.2
Hiscox, S.E.3
Barrow, D.4
Gee, J.M.W.5
Robertson, J.F.6
Ellis, I.O.7
Nicholson, R.I.8
-
75
-
-
0034899503
-
Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells
-
Oh AS, Lorant LA, Holloway JN, Miller DL, Kern FG, El-Ashry D: Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells. Mol Endocrinol 2001;15:1344-59.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1344-1359
-
-
Oh, A.S.1
Lorant, L.A.2
Holloway, J.N.3
Miller, D.L.4
Kern, F.G.5
El-Ashry, D.6
-
76
-
-
2542454563
-
A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: The role of nuclear factor-kappaB
-
Holloway JN, Murthy S, El-Ashry D. A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: the role of nuclear factor-kappaB. Mol Endocrinol 2004;18:1396-410.
-
(2004)
Mol Endocrinol
, vol.18
, pp. 1396-1410
-
-
Holloway, J.N.1
Murthy, S.2
El-Ashry, D.3
-
77
-
-
4344626023
-
Extreme growth factor signalling can promote oestrogen receptor-alpha loss: Therapeutic implications in breast cancer
-
Gee JM, Giles MG, Nicholson RI. Extreme growth factor signalling can promote oestrogen receptor-alpha loss: therapeutic implications in breast cancer. Breast Cancer Res 2004;6:162-3.
-
(2004)
Breast Cancer Res
, vol.6
, pp. 162-163
-
-
Gee, J.M.1
Giles, M.G.2
Nicholson, R.I.3
-
78
-
-
25844458526
-
Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: The use of anti-growth factor therapies to treat or delay endocrine resistance in breast cancer
-
Nicholson RI, Hutcheson IR, Hiscox SE, Knowlden JM, Giles M, Barrow D, et al. Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: the use of anti-growth factor therapies to treat or delay endocrine resistance in breast cancer. Endocr Relat Cancer 2005;12:S29-36.
-
(2005)
Endocr Relat Cancer
, vol.12
-
-
Nicholson, R.I.1
Hutcheson, I.R.2
Hiscox, S.E.3
Knowlden, J.M.4
Giles, M.5
Barrow, D.6
-
79
-
-
84944274901
-
Loss of estrogen receptor (ER) expression in Mcf-7 cells following long-term exposure to Fulvesterant (Abstract)
-
Giles MG, Fiegl H, Widschwendter M, Gee JM, Wakeling A, Nicholson RI. Loss of estrogen receptor (ER) expression in Mcf-7 cells following long-term exposure to Fulvesterant (Abstract). Breast Cancer Res Treat 2005;94:S243.
-
(2005)
Breast Cancer Res Treat
, vol.94
, pp. 243
-
-
Giles, M.G.1
Fiegl, H.2
Widschwendter, M.3
Gee, J.M.4
Wakeling, A.5
Nicholson, R.I.6
-
80
-
-
33846888637
-
Array profiling of survival and resistance genes in anti-hormone-treated breast cancer cells (Abstract)
-
Gee J, Shaw V, Burmi R, McClelland R, Morgan H, Harper M, et al. Array profiling of survival and resistance genes in anti-hormone-treated breast cancer cells (Abstract). Intl J Mol Med 2004;14:S81.
-
(2004)
Intl J Mol Med
, vol.14
, pp. 81
-
-
Gee, J.1
Shaw, V.2
Burmi, R.3
McClelland, R.4
Morgan, H.5
Harper, M.6
-
81
-
-
33846890652
-
Deciphering antihormone-induced compensatory mechanisms in breast cancer and their therapeutic implications
-
Gee JM, Shaw VE, Hiscox SE, McClelland RA, Rushmere NK, Nicholson RI. Deciphering antihormone-induced compensatory mechanisms in breast cancer and their therapeutic implications. Endocr Rel Cancer 2006;13 Suppl 1:577-88.
-
(2006)
Endocr Rel Cancer
, vol.13
, Issue.SUPPL. 1
, pp. 577-588
-
-
Gee, J.M.1
Shaw, V.E.2
Hiscox, S.E.3
McClelland, R.A.4
Rushmere, N.K.5
Nicholson, R.I.6
-
82
-
-
13944282293
-
The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; Fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells
-
Riggins RB, Zwart A, Nehra R, Clarke R. The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells. Mol Cancer Ther 2005;4:33-41.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 33-41
-
-
Riggins, R.B.1
Zwart, A.2
Nehra, R.3
Clarke, R.4
-
83
-
-
25844460747
-
Development of strategies for the use of anti-growth factor treatments
-
Jones HE, Gee JM, Taylor KM, Barrow D, Williams HD, Rubini M, et al. Development of strategies for the use of anti-growth factor treatments. Endocr Relat Cancer 2005;12:173-82.
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. 173-182
-
-
Jones, H.E.1
Gee, J.M.2
Taylor, K.M.3
Barrow, D.4
Williams, H.D.5
Rubini, M.6
-
84
-
-
19944427176
-
Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells
-
Jones HE, Goddard L, Gee JM, Hiscox S, Rubini M, Barrow D, et al. Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells. Endocr Relat Cancer 2004;11:793-814.
-
(2004)
Endocr Relat Cancer
, vol.11
, pp. 793-814
-
-
Jones, H.E.1
Goddard, L.2
Gee, J.M.3
Hiscox, S.4
Rubini, M.5
Barrow, D.6
-
85
-
-
33750719158
-
Maintenance of EGFR phosphorylation by the IGF-1R in the presence of gefitinib in lung cancer cells: Co-targeting the EGFR and IGF-1R maximises anti-tumour effects
-
Jones HE, Gee JMW, Barrow D, Holloway B, Tonge D, Nicholson RI. Maintenance of EGFR phosphorylation by the IGF-1R in the presence of gefitinib in lung cancer cells: co-targeting the EGFR and IGF-1R maximises anti-tumour effects. Proc. 4th International Symposium on Signal Transduction Modulators in Cancer Therapy A210 2006.
-
(2006)
Proc. 4th International Symposium on Signal Transduction Modulators in Cancer Therapy A210
-
-
Jones, H.E.1
Gee, J.M.W.2
Barrow, D.3
Holloway, B.4
Tonge, D.5
Nicholson, R.I.6
-
86
-
-
0036141447
-
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signalling
-
Chakravati A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signalling. Cancer Res 2002;62:200-7.
-
(2002)
Cancer Res
, vol.62
, pp. 200-207
-
-
Chakravati, A.1
Loeffler, J.S.2
Dyson, N.J.3
-
87
-
-
0035810044
-
Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody
-
Liu B, Fang M, Lu Y, Mendelsohn J, Fan Z. Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. Oncogene 2001;20:1913-22.
-
(2001)
Oncogene
, vol.20
, pp. 1913-1922
-
-
Liu, B.1
Fang, M.2
Lu, Y.3
Mendelsohn, J.4
Fan, Z.5
-
88
-
-
31644439702
-
Herceptin: Mechanisms of action and resistance
-
Nahta R, Esteva FJ. Herceptin: mechanisms of action and resistance. Cancer Lett 2006;232:123-38.
-
(2006)
Cancer Lett
, vol.232
, pp. 123-138
-
-
Nahta, R.1
Esteva, F.J.2
-
89
-
-
28244432561
-
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
Nahta R, Yuan LX, Zhang B, Kobayashi R, Esteva FJ. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005;65:11118-28.
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.X.2
Zhang, B.3
Kobayashi, R.4
Esteva, F.J.5
-
90
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
-
Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001;93:1852-7.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1852-1857
-
-
Lu, Y.1
Zi, X.2
Zhao, Y.3
Mascarenhas, D.4
Pollak, M.5
-
91
-
-
0036606779
-
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides
-
Motoyama AB, Hynes NE, Lane HA. The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides. Cancer Res 2002;62:3151-8.
-
(2002)
Cancer Res
, vol.62
, pp. 3151-3158
-
-
Motoyama, A.B.1
Hynes, N.E.2
Lane, H.A.3
-
93
-
-
11244257032
-
The dual EErbB1/ErbB2 inhibitor, lapatinib (GW572016), co-operates with tamoxifen to inhibit both cell proliferation and estrogen-dependent gene expression in antiestrogen-resistant breast cancer
-
Chu I, Blackwell K, Chen S, Slingerland J. The dual EErbB1/ErbB2 inhibitor, lapatinib (GW572016), co-operates with tamoxifen to inhibit both cell proliferation and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res 2005;65:18-25.
-
(2005)
Cancer Res
, vol.65
, pp. 18-25
-
-
Chu, I.1
Blackwell, K.2
Chen, S.3
Slingerland, J.4
-
94
-
-
32944466881
-
Clinical efforts to combine endocrine agents with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of rapamycin in breast cancer
-
Johnston SR. Clinical efforts to combine endocrine agents with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of rapamycin in breast cancer. Clin Cancer Res 2006;12:S1061-8.
-
(2006)
Clin Cancer Res
, vol.12
-
-
Johnston, S.R.1
-
95
-
-
19944408390
-
Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor- positive primary breast cancer: A double-blind placebo-controlled phase II randomised trial
-
Polychronis A, Sinnett HD, Hadjiminas D, Singhal H, Mansi JL, Shivapatham D, et al. Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial. Lancet Oncol 2005;6: 383-91
-
(2005)
Lancet Oncol
, vol.6
, pp. 383-391
-
-
Polychronis, A.1
Sinnett, H.D.2
Hadjiminas, D.3
Singhal, H.4
Mansi, J.L.5
Shivapatham, D.6
-
96
-
-
34948859553
-
Identification of anti-hormone induced genes as potential therapeutic targets in breast cancer (Abstract)
-
Shaw VE, Gee JMW, McClelland RA, Morgan H, Rushmere N, Nicholson RI. Identification of anti-hormone induced genes as potential therapeutic targets in breast cancer (Abstract). Proc Amer Assoc Cancer Res 2005;46:A3706.
-
(2005)
Proc Amer Assoc Cancer Res
, vol.46
, pp. 3706
-
-
Shaw, V.E.1
Gee, J.M.W.2
McClelland, R.A.3
Morgan, H.4
Rushmere, N.5
Nicholson, R.I.6
-
98
-
-
15444344415
-
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain
-
Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, et al. 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. J Biol Chem 1997;272:25267-74.
-
(1997)
J Biol Chem
, vol.272
, pp. 25267-25274
-
-
Ogihara, T.1
Isobe, T.2
Ichimura, T.3
Taoka, M.4
Funaki, M.5
Sakoda, H.6
-
99
-
-
0035890044
-
Functional conservation of 14-3-3 isoforms in inhibiting Bad-induced apoptosis
-
Subramanian RR, Masters SC, Zhang H, Fu H. Functional conservation of 14-3-3 isoforms in inhibiting Bad-induced apoptosis. Exp Cell Res 2001;271:142-51.
-
(2001)
Exp Cell Res
, vol.271
, pp. 142-151
-
-
Subramanian, R.R.1
Masters, S.C.2
Zhang, H.3
Fu, H.4
-
100
-
-
3042644634
-
Identification of 14-3-3ζ as an EGF receptor interacting protein
-
Oksvold MP, Huitfeldt HS, Langdon WY. Identification of 14-3-3ζ as an EGF receptor interacting protein. FEBS Lett 2004;569:207-10.
-
(2004)
FEBS Lett
, vol.569
, pp. 207-210
-
-
Oksvold, M.P.1
Huitfeldt, H.S.2
Langdon, W.Y.3
-
102
-
-
0041802782
-
Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation
-
Qi W, Martinez JD. Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation. Radiation Res 2003;160:217-23.
-
(2003)
Radiation Res
, vol.160
, pp. 217-223
-
-
Qi, W.1
Martinez, J.D.2
-
103
-
-
11844251170
-
The NF-kappaB/IkappaB signaling system: A molecular target in breast cancer therapy
-
Wu JT, Kral JG. The NF-kappaB/IkappaB signaling system: a molecular target in breast cancer therapy. J Surg Res 2005;123:158-69.
-
(2005)
J Surg Res
, vol.123
, pp. 158-169
-
-
Wu, J.T.1
Kral, J.G.2
-
104
-
-
0141619401
-
Estrogen withdrawal-induced NF-kappaB activity and bcl-3 expression in breast cancer cells: Roles in growth and hormone independence
-
Pratt MA, Bishop TE, White D, Yasvinski G, Menard M, Niu MY, et al. Estrogen withdrawal-induced NF-kappaB activity and bcl-3 expression in breast cancer cells: roles in growth and hormone independence. Mol Cell Biol 2003;23:6887-900.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6887-6900
-
-
Pratt, M.A.1
Bishop, T.E.2
White, D.3
Yasvinski, G.4
Menard, M.5
Niu, M.Y.6
-
106
-
-
33746908103
-
Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome
-
Frasor J, Chang EC, Komm B, Lin CY, Vega VB, Liu ET, et al. Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res 2006;66:7334-40.
-
(2006)
Cancer Res
, vol.66
, pp. 7334-7340
-
-
Frasor, J.1
Chang, E.C.2
Komm, B.3
Lin, C.Y.4
Vega, V.B.5
Liu, E.T.6
-
107
-
-
3442901974
-
NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen
-
deGraffenried LA, Chandrasekar B, Friedrichs WE, Donzis E, Silva J, Hidalgo M, et al. NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen. Ann Oncol. 2004;15:885-90.
-
(2004)
Ann Oncol
, vol.15
, pp. 885-890
-
-
De Graffenried, L.A.1
Chandrasekar, B.2
Friedrichs, W.E.3
Donzis, E.4
Silva, J.5
Hidalgo, M.6
-
108
-
-
33846885216
-
Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy
-
Hutcheson IR, Knowlden JM, Jones HE, Burmi RS, McClelland RA, Barrow D, et al. Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy. Endocr Rel Cancer 2006;13:S89-97.
-
(2006)
Endocr Rel Cancer
, vol.13
-
-
Hutcheson, I.R.1
Knowlden, J.M.2
Jones, H.E.3
Burmi, R.S.4
McClelland, R.A.5
Barrow, D.6
-
111
-
-
33745924420
-
Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells
-
Jones HE, Gee JM, Barrow D, Tonge D, Holloway B, Nicholson RI. Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells. Br J Cancer 2006;95:172-80.
-
(2006)
Br J Cancer
, vol.95
, pp. 172-180
-
-
Jones, H.E.1
Gee, J.M.2
Barrow, D.3
Tonge, D.4
Holloway, B.5
Nicholson, R.I.6
-
112
-
-
0842289982
-
Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
-
Ciardiello F, Bianco R, Caputo R, Caputo R, Damiano V, Troiani T, et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res 2004;10:784-93.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 784-793
-
-
Ciardiello, F.1
Bianco, R.2
Caputo, R.3
Caputo, R.4
Damiano, V.5
Troiani, T.6
-
113
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006;66:1500-8.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
-
114
-
-
33846889291
-
Growth factor receptor interplay and resistance in cancer
-
Jones HE, Gee JMW, Hutcheson IR, Knowlden JM, Barrow D, Nicholson RI. Growth factor receptor interplay and resistance in cancer. Endocr Rel Cancer 2006;13:S45-51.
-
(2006)
Endocr Rel Cancer
, vol.13
-
-
Jones, H.E.1
Gee, J.M.W.2
Hutcheson, I.R.3
Knowlden, J.M.4
Barrow, D.5
Nicholson, R.I.6
-
115
-
-
0036581222
-
The GDNF family: Signalling, biological functions and therapeutic value
-
Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002;3:383-94.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 383-394
-
-
Airaksinen, M.S.1
Saarma, M.2
-
116
-
-
34948852801
-
Microarray studies reveal novel genes associated with endocrine resistance in breast cancer (Abstract)
-
Burmi RS, McClelland RA, Barrow D, Ellis IO, Robertson JFR, Nicholson RI, et al. Microarray studies reveal novel genes associated with endocrine resistance in breast cancer (Abstract). Breast Cancer Res 2006;8:S11.
-
(2006)
Breast Cancer Res
, vol.8
, pp. 11
-
-
Burmi, R.S.1
McClelland, R.A.2
Barrow, D.3
Ellis, I.O.4
Robertson, J.F.R.5
Nicholson, R.I.6
-
117
-
-
27944477029
-
Inhibition of insulin-like growth factor-1 receptor signaling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa) in human breast cancer cells
-
Camirand A, Zakikhani M, Young F, Pollak M. Inhibition of insulin-like growth factor-1 receptor signaling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa) in human breast cancer cells. Breast Cancer Res 2005;7:R570-9.
-
(2005)
Breast Cancer Res
, vol.7
-
-
Camirand, A.1
Zakikhani, M.2
Young, F.3
Pollak, M.4
-
118
-
-
21244441508
-
A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity
-
Lu D, Zhang H, Koo H, Tonra J, Balderes P, Prewett M, et al. A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity. J Biol Chem 2005;280:19665-72.
-
(2005)
J Biol Chem
, vol.280
, pp. 19665-19672
-
-
Lu, D.1
Zhang, H.2
Koo, H.3
Tonra, J.4
Balderes, P.5
Prewett, M.6
-
119
-
-
4344705051
-
Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib ('Iressa', ZD1839)
-
Hiscox S, Morgan L, Barrow D, Dutkowski C, Wakeling A, Nicholson RI. Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ('Iressa', ZD1839). Clin Exp Metastasis 2004;21:201-12.
-
(2004)
Clin Exp Metastasis
, vol.21
, pp. 201-212
-
-
Hiscox, S.1
Morgan, L.2
Barrow, D.3
Dutkowski, C.4
Wakeling, A.5
Nicholson, R.I.6
-
120
-
-
1642420739
-
Inhibition of the metastatic potential the of tamoxifen-resistant breast cancer cells by gefitinib ('Iressa', ZD1839)
-
Hiscox SE, Wakeling A, Nicholson RI. Inhibition of the metastatic potential the of tamoxifen-resistant breast cancer cells by gefitinib ('Iressa', ZD1839) Abstract. Proc Am Ass Cancer Res 2003;44:4863.
-
(2003)
Proc Am Ass Cancer Res
, vol.44
, pp. 4863
-
-
Hiscox, S.E.1
Wakeling, A.2
Nicholson, R.I.3
-
121
-
-
28844494352
-
Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation
-
Hiscox S, Jiang WG, Obermeier K, Taylor K, Morgan L, Burmi R, Barrow D, et al. Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation. Int J Cancer 2006;118:290-301.
-
(2006)
Int J Cancer
, vol.118
, pp. 290-301
-
-
Hiscox, S.1
Jiang, W.G.2
Obermeier, K.3
Taylor, K.4
Morgan, L.5
Burmi, R.6
-
122
-
-
33745402375
-
Elevated Src activity promotes cellular invasion and motility in tamoxifen-resistant breast cancer cells
-
Hiscox S, Morgan L, Green T, Barrow D, Gee JM, Nicholson RI. Elevated Src activity promotes cellular invasion and motility in tamoxifen-resistant breast cancer cells. Breast Cancer Res Treat 2005;97:263-74.
-
(2005)
Breast Cancer Res Treat
, vol.97
, pp. 263-274
-
-
Hiscox, S.1
Morgan, L.2
Green, T.3
Barrow, D.4
Gee, J.M.5
Nicholson, R.I.6
-
123
-
-
0035127466
-
Selection of primary breast cancer patients for adjuvant endocrine therapy-is oestrogen receptor alone adequate
-
Cheung KL, Nicholson RI, Blamey RW, Robertson JF. Selection of primary breast cancer patients for adjuvant endocrine therapy-is oestrogen receptor alone adequate? Breast Cancer Res Treat 2001;65:155-62.
-
(2001)
Breast Cancer Res Treat
, vol.65
, pp. 155-162
-
-
Cheung, K.L.1
Nicholson, R.I.2
Blamey, R.W.3
Robertson, J.F.4
-
124
-
-
1642461800
-
Clinical response and resistance to SERMS
-
Martin Dunitz Ltd London
-
Gee JMW, Madden TA, Robertson JFR, Nicholson RI, Clinical response and resistance to SERMS. In: Robertson JFR, Nicholson RI, Hayes DF, editors Endocrine Therapy in Breast Cancer. Martin Dunitz Ltd: London; 2002. p. 155-90.
-
(2002)
Endocrine Therapy in Breast Cancer
, pp. 155-190
-
-
Gee, J.M.W.1
Madden, T.A.2
Robertson, J.F.R.3
Nicholson, R.I.4
Robertson, J.F.R.5
Nicholson, R.I.6
Hayes, D.F.7
-
126
-
-
26844455578
-
Clinical value of epidermal growth factor receptor expression in primary breast cancer
-
Rampaul RS, Pinder SE, Nicholson RI, Gullick WJ, Robertson JF, Ellis IO. Clinical value of epidermal growth factor receptor expression in primary breast cancer. Adv Anat Pathol 2005;12:271-3.
-
(2005)
Adv Anat Pathol
, vol.12
, pp. 271-273
-
-
Rampaul, R.S.1
Pinder, S.E.2
Nicholson, R.I.3
Gullick, W.J.4
Robertson, J.F.5
Ellis, I.O.6
-
127
-
-
79959586534
-
Increased matrix metalloproteinase (MMP) expression in anti-oestrogen resistant breast carcinoma cell lines
-
Khirwadkar Y, Jordan NJ, Hiscox SE, Nicholson RI. Increased matrix metalloproteinase (MMP) expression in anti-oestrogen resistant breast carcinoma cell lines. Eur J Cancer 2005;3 Suppl P19.
-
(2005)
Eur J Cancer
, Issue.3 SUPPL. P19
-
-
Khirwadkar, Y.1
Jordan, N.J.2
Hiscox, S.E.3
Nicholson, R.I.4
-
128
-
-
34948870439
-
Upregulation of CD44s and variants in anti-hormone resistant breast cancer cells
-
Harper ME, Smith C, Nicholson RI. Upregulation of CD44s and variants in anti-hormone resistant breast cancer cells. Eur J Cancer 2005;3:Suppl 25 38.
-
(2005)
Eur J Cancer
, vol.3
, Issue.SUPPL. 25
, pp. 38
-
-
Harper, M.E.1
Smith, C.2
Nicholson, R.I.3
-
129
-
-
33749236179
-
Impact of altered growth factor signalling on endocrine response in breast cancer and the transition from ER+ to ER-disease
-
Nicholson RI, Giles MG, Hutcheson IR, Madden TA, Gee JMW. Impact of altered growth factor signalling on endocrine response in breast cancer and the transition from ER+ to ER-disease. Breast Cancer Online 2004;7:issue 10.
-
(2004)
Breast Cancer Online
, vol.7
, Issue.10
-
-
Nicholson, R.I.1
Giles, M.G.2
Hutcheson, I.R.3
Madden, T.A.4
Gee, J.M.W.5
-
130
-
-
33846811714
-
Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: Implications for tumour-stroma interactions
-
Hiscox S, Jordan NJ, Jiang WG, Harper ME, McClelland R, Smith C, et al. Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: implications for tumour-stroma interactions. Endocr Relat Cancer 2006;13:1085-99.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 1085-1099
-
-
Hiscox, S.1
Jordan, N.J.2
Jiang, W.G.3
Harper, M.E.4
McClelland, R.5
Smith, C.6
|