Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hypochlorite

Experimental Biology and Medicine

Volumn 232, Issue 9, 2007, Pages 1204-1212

  Radovits, Tamás ^a,b   Zotkina, Julia ^a   Lin, Li Ni ^a   Bömicke, Timo ^a   Arif, Rawa ^a   Gero, Domokos ^b   Horváth, Eszter M ^b   Karck, Matthias ^a   Szabó, Csaba ^b,c   Szabó, Gábor ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c University of Medicine and Dentistry of New Jersey   (United States)

Author keywords

DNA injury; Endothelial dysfunction; Hypochlorite; Oxidative stress; Poly(ADP ribose) polymerase

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ACETYLCHOLINE; HYPOCHLORITE; INO 1001; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITROPRUSSIDE SODIUM; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DIABETES MELLITUS; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE RESPONSE; ENDOTHELIUM INJURY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; MUSCLE ISOMETRIC CONTRACTION; NICK END LABELING; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; SHOCK; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYPOCHLOROUS ACID; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INDOLES; MALE; OXIDANTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASODILATION;

RATTUS;

EID: 34848921482     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0701-RM-16     Document Type: Article

References (43)

1. Kettle AJ, van Dalen CJ, Winterbourn CC. Peroxynitrite and myeloperoxidase leave the same footprint in protein nitration. Redox Rep 3:257-258, 1997.
2. Schraufstatter IU, Browne K, Harris A, Hyslop PA, Jackson JH, Quehenberger O, Cochrane CG. Mechanisms of hypochlorite injury of target cells. J Clin Invest 85:554-562, 1990.
3. Kawai Y, Kiyokawa H, Kimura Y, Kato Y, Tsuchiya K, Terao J. Hypochlorous acid-derived modification of phospholipids: characterization of aminophospholipids as regulatory molecules for lipid peroxidation. Biochemistry 45:14201-14211, 2006.
4. Panasenko OM. The mechanism of the hypochlorite-induced lipid peroxidation. Biofactors 6:181-190, 1997.
5. Shabani F, McNeil J, Tippett L. The oxidative inactivation of tissue inhibitor of metalloproteinase-1 (TIMP-1) by hypochlorous acid (HOCI) is suppressed by anti-rheumatic drugs. Free Radic Res 28: 115-123, 1998.
6. Vissers MC, Pullar JM, Hampton MB. Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochem J 344:443-449, 1999.
7. Shishido N, Nakamura S, Nakamura M. Dissociation of DNA double strand by hypohalous acids. Redox Rep 5:243-247, 2000.
8. Jenner AM, Ruiz JE, Dunster C, Halliwell B, Mann GE, Siow RC. Vitamin C protects against hypochlorous Acid-induced glutathione depletion and DNA base and protein damage in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 22:574-580, 2002.
9. Schfaufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG, Cochrane CG. Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest 77:1312-1320, 1986.
10. Szabo C, Zingarelli B, O'Connor M, Salzman AL. DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci U S A 93:1753-1758, 1996.
11. Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54:375-429, 2002.
12. Pacher P, Liaudet L, Mabley J, Komjati K, Szabo C. Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. J Am Coll Cardiol 40:1006-1016, 2002.
13. Pacher P, Vaslin A, Benko R, Mabley JG, Liaudet L, Hasko G, Marton A, Batkai S, Kollai M, Szabo C. A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging. J Pharmacol Exp Ther 311:485-491, 2004.
14. Szabo G, Soos P, Mandera S, Heger U, Flechtenmacher C, Bahrle S, Seres L, Cziraki A, Gries A, Zsengeller Z, Vahl CF, Hagl S, Szabo C. INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. Shock 21:426-432, 2004.
15. Soriano FG, Pacher P, Mabley J, Liaudet L, Szabo C. Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 89:684-691, 2001.
16. Beller CJ, Radovits T, Seres L, Kosse J, Krempien R, Gross ML, Penzel R, Berger I, Huber PE, Hagl S, Szabo C, Szabo G. Poly(AD-Pribose) polymerase inhibition reverses vascular dysfunction after gamma-irradiation. Int J Radiat Oncol Biol Phys 65:1528-1535, 2006.
17. Jagtap P, Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 4:421-440, 2005.
18. Van Rensburg CE, Van Staden AM, Anderson R. Inactivation of poly (ADP-ribose) polymerase by hypochlorous acid. Free Radic Biol Med 11:285-291, 1991.
19. Stocker R, Huang A, Jeranian E, Hou JY, Wu TT, Thomas SR, Keaney JF Jr. Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism. Arterioscler Thromb Vasc Biol 24:2028-2033, 2004.
20. Candeias LP, Patel KB, Stratford MR, Wardman P. Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid. FEBS Lett 333:151-153, 1993.
21. Shen Z, Wu W, Hazen SL. Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halide-dependent formation of hydroxyl radical. Biochemistry 39:5474-5482, 2000.
22. Hawkins CL, Davies MJ. Hypochlorite-induced damage to DNA, RNA, and polynucleotides: formation of chloramines and nitrogen-centered radicals. Chem Res Toxicol 15:83-92, 2002.
23. Whiteman M, Rose P, Halliwell B. Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: is nitrite an antioxidant? Biochem Biophys Res Commun 303:1217-1224, 2003.
24. Sand C, Peters SL, Pfaffendorf M, van Zwieten PA. Effects of hypochlorite and hydrogen peroxide on cardiac autonomic receptors and vascular endothelial function. Clin Exp Pharmacol Physiol 30:249-253, 2003.
25. Zhang C, Patel R, Eiserich JP, Zhou F, Kelpke S, Ma W, Parks DA, Darley-Usmar V, White CR. Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid. Am J Physiol Heart Circ Physiol 281:H1469-H1475, 2001.
26. Zhang C, Reiter C, Eiserich JP, Boersma B, Parks DA, Beckman JS, Barnes S, Kirk M, Baldus S, Darley-Usmar VM, White CR. L-arginine chlorination products inhibit endothelial nitric oxide production. J Biol Chem 276:27159-27165, 2001.
27. Leipert B, Becker BF, Gerlach E. Different endothelial mechanisms involved in coronary responses to known vasodilators. Am J Physiol 262:H1676-H1683, 1992.
28. Jaimes EA, Sweeney C, Raij L. Effects of the reactive oxygen species hydrogen peroxide and hypochlorite on endothelial nitric oxide production. Hypertension 38:877-883, 2001.
29. Yang J, Ji R, Cheng Y, Sun JZ, Jennings LK, Zhang C. L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor. J Pharmacol Exp Ther 318:1044-1049, 2006.
30. Vissers MC, Lee WG, Hampton MB. Regulation of apoptosis by vitamin C. Specific protection of the apoptotic machinery against exposure to chlorinated oxidants. J Biol Chem 276:46835-46840, 2001.
31. Liaudet L, Soriano FG, Szabo E, Virag L, Mabley JG, Salzman AL, Szabo C. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase. Proc Natl Acad Sci U S A 97:10203-10208, 2000.
32. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840-844, 2000.
33. Witting PK, Wu BJ, Raftery M, Southwell-Keely P, Stocker R. Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate. J Biol Chem 280:15612-15618, 2005.
34. Lau D, Baldus S. Myeloperoxidase and its contributory role in inflammatory vascular disease. Pharmacol Ther 111:16-26, 2006.
35. Nuszkowski A, Grabner R, Marsche G, Unbehaun A, Malle E, Heller R. Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase. J Biol Chem 276:14212-14221, 2001.
36. Candeias LP, Stratford MR, Wardman P. Formation of hydroxyl radicals on reaction of hypochlorous acid with ferrocyanide, a model iron(II) complex. Free Radic Res 20:241-249, 1994.
37. Van Rensburg CE, van Staden AM, Anderson R, Van Rensburg EJ. Hypochlorous acid potentiates hydrogen peroxide-mediated DNA-strand breaks in human mononuclear leucocytes. Mutat Res 265:255-261, 1992.
38. Pero RW, Sheng Y, Olsson A, Bryngelsson C, Lund-Pero M. Hypochlorous acid/N-chloramines are naturally produced DNA repair inhibitors. Carcinogenesis 17:13-18, 1996.
39. Eiserich JP, Hristova M, Cross CE, Jones AD, Freeman BA, Halliwell B, van der Vliet A. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 391:393-397, 1998.
40. Soriano FG, Virag L, Szabo C. Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation. J Mol Med 79:437-448, 2001.
41. Szabo G, Bahrle S. Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury. Curr Vasc Pharmacol 3:215-220, 2005.
42. Szabo C, Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J Clin Invest 100:723-735, 1997.
43. Radovits T, Lin LN, Zotkina J, Gero D, Szabo C, Karck M, Szabo G. Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol 564:158-166, 2007.