Hypochlorite-modified Low Density Lipoprotein Inhibits Nitric Oxide Synthesis in Endothelial Cells via an Intracellular Dislocalization of Endothelial Nitric-oxide Synthase

Journal of Biological Chemistry

Volumn 276, Issue 17, 2001, Pages 14212-14221

  Nuszkowski, Alexander ^a   Gräbner, Rolf ^a   Marsche, Gunther ^b   Unbehaun, Anett ^a   Malle, Ernst ^b   Heller, Regine ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CHOLESTEROL; DISEASES; NITROGEN OXIDES;

LOW DENSITY LIPOPROTEINS (LDL);

ENZYMES;

AMINO ACID; ARGININE; CARBON 14; COMPLEMENTARY DNA; CYCLIC GMP; HYPOCHLORITE; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TETRAHYDROBIOPTERIN; 5,6,7,8-TETRAHYDROBIOPTERIN; ANTIOXIDANT; BIOPTERIN; CITRULLINE; CYCLODEXTRIN; DRUG DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYPOCHLOROUS ACID; IONOMYCIN; IONOPHORE; MESSENGER RNA; MYRISTIC ACID DERIVATIVE; NOS3 PROTEIN, HUMAN; PALMITIC ACID DERIVATIVE; SUCROSE;

ARTICLE; ATHEROSCLEROSIS; CELL FRACTIONATION; CELL LYSATE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; UMBILICAL VEIN; BIOSYNTHESIS; CELL CULTURE; CELL MEMBRANE; CYTOLOGY; DENSITY GRADIENT CENTRIFUGATION; DOSE RESPONSE; ENZYMOLOGY; FLUORESCENCE MICROSCOPY; GOLGI COMPLEX; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; SERODIAGNOSIS; TIME; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ANTIOXIDANTS; ARGININE; BIOPTERIN; BLOTTING, WESTERN; CELL MEMBRANE; CELLS, CULTURED; CENTRIFUGATION, DENSITY GRADIENT; CITRULLINE; CYCLIC GMP; CYCLODEXTRINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIUM, VASCULAR; GOLGI APPARATUS; HUMANS; HYPOCHLOROUS ACID; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IONOMYCIN; IONOPHORES; LIPOPROTEINS, LDL; MICROSCOPY, FLUORESCENCE; MYRISTIC ACIDS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PALMITIC ACIDS; PRECIPITIN TESTS; RNA, MESSENGER; SUBCELLULAR FRACTIONS; SUCROSE; TIME FACTORS; UMBILICAL VEINS;

EID: 0035957931     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007659200     Document Type: Article

References (69)

1. Mayer, B., and Hemmens, B. (1997) Trends Biochem. Sci. 22, 477-481
2. Busse, R., and Mülsch, A. (1990) FEBS Lett. 265, 133-136
3. Fulton, D., Gratton, J.-P., McCabe, T. J., Fontana, J., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., and Sessa, W. C. (1999) Nature 399, 597-601
4. Heller, R., Unbehaun, A., Schellenberg, B., Mayer, B., Werner-Felmayer, G., and Werner, E. R. (2001) J. Biol. Chem. 276, 40-47
5. Stroes, E., Kastelein, J., Cosentino, F., Erkelens, W., Wever, R., Koomans, H., Lüscher, T., and Rabelink, T. (1997) J. Clin. Invest. 99, 41-46
6. Feron, O. (1999) Curr. Opin. Nephrol. Hypertens 8, 55-59
7. Sessa, W. C., Garcia-Cardena, G., Liu, J., Keh, A., Pollock, J. S., Bradley, J., Thiru, S., Braverman, I. M., and Desai, K. M. (1995) J. Biol. Chem. 270, 17641-17644
8. Liu, J., Hughes, T. E., and Sessa, W. C. (1997) J. Cell Biol. 137, 1525-1535
9. Sowa, G., Liu, J., Papapetropoulos, A., Rex-Haffner, M., Hughes, T. E., and Sessa, W. C. (1999) J. Biol. Chem. 274, 22524-22531
10. Garcia-Cardena, G., Oh, P., Liu, J., Schnitzer, J. E., and Sessa, W. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6448-6453
11. Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y., Anderson, R. G. W., and Michel, T. (1996) J. Biol. Chem. 271, 6518-6522
12. Liu, J., Garcia-Cardena, G., and Sessa, W. C. (1996) Biochemistry 35, 13227-13281
13. Michel, J. B., Feron, O., Sacks, D., and Michel, T. (1997) J. Biol. Chem. 272, 15583-15586
14. Ju, H., Zou, R., Venema, V. J., and Venema, R. C. (1997) J. Biol. Chem. 272, 18522-18525
15. Michel, J. B., Feron, O., Sase, K., Prabhakar, P., and Michel, T. (1997) J. Biol. Chem. 272, 25907-25912
16. Garcia-Cardena, G., Martasek, P., Masters, B. S. S., Skidd, P. M., Couet, J., Li, S., Lisanti, M. P., and Sessa, W. C. (1997) J. Biol. Chem. 272, 25437-25440
17. Feron, O., Michel, J. B., Sase, K., and Michel, T. (1998) Biochemistry 37, 193-200
18. Feron, O., Saldana, F., Michel, J. B., and Michel, T. (1998) J. Biol. Chem. 273, 3125-3128
19. Ghosh, S., Gachhui, R., Crooks, C., Wu, C., Lisanti, M. P., and Stuehr, D. J. (1998) J. Biol. Chem. 273, 22267-22271
20. Gratton, J.-P., Fontana, J., O'Connor, D. S., Garcia-Cardena, G., McCabe, T. J., and Sessa, W. C. (2000) J. Biol. Chem. 275, 22268-22272
21. Robinson, L.-J., and Michel, T. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11776-11780
22. Ignarro, L. J., Cirino, G., Casini, A., and Napoli, C. (1999) J. Cardiovasc. Pharmacol. 34, 879-886
23. Bult, H., Herman, A. G., and Matthys, K. E. (1999) Eur. J. Pharmacol. 375, 157-176
24. Cooke, J. P., and Dzau, V. J. (1997) Annu. Rev. Med. 48, 489-509
25. Heinecke, J. W. (1998) Atherosclerosis 141, 1-15
26. Kugiyama, K., Kerns, S. A., Morrisett, J. D., Roberts, R., and Henry, P. D. (1990) Nature 344, 160-162
27. Galle, J., Bauersachs, J., Busse, R., and Bassenge, E. (1992) Arterioscler. Thromb. 12, 180-186
28. Hein, T. W., Liao, J. C., and Kuo, L. (2000) Am. J. Physiol. 278, H175-H183
29. Liao, J. K., and Clark, S. L. (1995) J. Clin. Invest. 95, 1457-1463
30. Galle, J., Mulsch, A., Busse, R., and Bassenge, E. (1991) Arterioseler. Thromb. 11, 198-203
31. Chin, J. H., Azhar, S., and Hoffmann, B. B. (1992) J. Clin. Invest. 89, 10-18
32. Hein, T. W., and Kuo, L. (1998) Circ. Res. 83, 404-414
33. Vergnani, L., Hatrik, S., Ricci, F., Passaro, A., Manzoli, N., Zulianin, G., Brovkovych, V., Fellin, R., and Malinski, T. (2000) Circulation 101, 1261-1266
34. Liao, J. K., Shin, W. S., Lee, W. Y., and Clark, S. L. (1995) J. Biol. Chem. 270, 319-324
35. Hernandez-Perera, O., Perez-Sala, D., Navarro-Antolin, J., Sanchez-Pascuala, R., Hernandez, G., Diaz, C., and Lamas, S. (1998) J. Clin. Invest. 101, 2711-2719
36. Blair, A., Shaul, P. W., Yuhanna, I. S., Conrad, P. A., and Smart, E. J. (1999) J. Biol. Chem. 274, 32512-32519
37. Klebanoff, S. J. (1999) Proc. Assoc. Am. Physicians 111, 383-389
38. Hazell, L. J., and Stocker, R. (1993) Biochem. J. 290, 165-172
39. Kopprasch, S., Leonhardt, W., Pietzsch, J., and Kuhne, H. (1998) Atherosclerosis 136, 315-324
40. Woenckhaus, C., Kaufmann, A., Bußfeld, D., Gemsa, D., Sprenger, H., and Gröne, H.-J. (1998) Clin. Immunol. Immunopathol. 86, 27-33
41. Opper, C., Schüssler, G., Sattler, W., and Malle, E. (1998) Platelets 9, 339-341
42. Daugherty, A., Dunn, J. L., Rateri, D. L., and Heinecke, J. W. (1994) J. Clin. Invest. 94, 437-444
43. Hazell, L. J., Arnold, L., Flowers, D., Waeg, G., Malle, E., and Stocker, R. (1996) J. Clin. Invest. 97, 1535-1544
44. Malle, E., Waeg, G., Schreiber, R., Gröne, E. F., Sattler, W., and Gröne, H. J. (2000) Eur. J. Biochem. 276, 4495-4503
45. Hazen, S. L., and Heinecke, J. W. (1997) J. Clin. Invest. 99, 2075-2081
46. Fu, S., Davies, M. J., Stocker, R., and Dean, R. T. (1998) Biochem. J. 333, 519-525
47. Leeuwenburgh, C., Rasmussen, J. E., Hsu, F. F., Mueller, D. M., Pennatur, S., and Heinecke, J. W. (1997) J. Biol. Chem. 272, 3520-3526
48. Kettle, A. J. (1996) FEBS Lett. 379, 103-106
49. Malle, E., Woenckhaus, C., Waeg, G., Esterbauer, H., Gröne, E. F., and Gröne, H. J. (1997) Am. J. Pathol. 150, 603-615
50. Malle, E., Hazell, L., Stocker, R., Sattler, W., Esterbauer, H., and Waeg, G. (1995) Arterioscler. Thromb. Vasc. Biol. 15, 982-989
51. Erber, W. N., Mynheer, L. C., and Mason, D. Y. (1986) Lancet 1, 761-765
52. Bredt, D. S., and Snyder, S. H. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 9030-9033
53. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. M., and Rutter, W. J. (1979) Biochemistry 18, 5294-5299
54. Enouf, J., Bredoux, R., Boizard, B., Wautier, J.-L., Chap, H., Thomas, J., de Metz, M., and Levy-Toledano, S. (1984) Biochem. Biophys. Res. Commun. 123, 50-58
55. Avruch, J., and Wallach, D. F. H. (1971) Biochim. Biophys. Acta 233, 334-347
56. Nichol, C. A., Smith, G. K., and Duch, D. S. (1985) Annu. Rev. Biochem. 54, 729-764
57. Linstedt, A. D., and Hauri, H. P. (1993) Mol. Biol. Cell 4, 679-693
58. Uittenbogaard, A., Shaul, P. W., Yuhanna, I. S., Blair, A., and Smart, E. J. (2000) J. Biol. Chem. 275, 11278-11283
59. Furuchi, T., and Anderson, R. G. W. (1998) J. Biol. Chem. 273, 21099-21104
60. Adachi, H., Tsujimoto, M., Arai, H., and Inoue, K. (1997) J. Biol. Chem. 272, 31217-31220
61. Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T., and Masaki, T. (1997) Nature 386, 73-77
62. Marsche, G., Levak-Frank, S., Quehenberger, O., Heller, R., Sattler, W., and Malle, E. (2001) FASEB J., 10.1096/fj.00-0532fje
63. Hazell, L. J., van den Bergt, J. J. M., and Stocker, R. (1994) Biochem. J. 302, 297-304
64. Hazell, L. J., Davies, M. J., and Stocker, R. (1999) Biochem. J. 339, 489-495
65. Kritharides, L., Upston, J., Jessup, W., and Dean, R. T. (1998) J. Lipid Res. 39, 2394-2405
66. Deckert, V., Persegol, L., Viens, L., Lizard, G., Athias, A., Lallemant, C., Gambert, P., and Lagrost, L. (1997) Circulation 95, 723-731
67. Deckert, V., Brunet, A., Lantoine, F., Lizard, G., Millanvoye-van Brussel, S. M., Lagrost, L., David-Dufilho, M., Gambert, P., and Devynck, M.-A. (1998) Arterioscler. Thromb. Vasc. Biol. 18, 1054-1060
68. Thorin, E., Hamilton, C., Dominiczak, A., Dominiczak, M. H., and Reid, J. L. (1995) Atherosclerosis 114, 185-195
69. Peterson, T. E., Poppa, V., Ueba, H., Wu, A., Yan, C., and Berk, B. C. (1999) Circ. Res. 85, 29-37