Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 4 50-4, 2001, Pages

  Zhang, C ^a   Pate, R ^a   Eiserich, J P ^a   Zhou, F ^a   Kelpke, S ^a   Ma, W ^a   Parks, D A ^a   Darley Usmar, V ^a   White, C R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Endothelium; Nitric oxide; Smooth muscle

Indexed keywords

ACETYLCHOLINE; ARGININE; CALCIMYCIN; DEXTRO ARGININE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; NITRATE; NITRIC OXIDE; NITRITE; NITROPRUSSIDE SODIUM; OXIDIZING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CATTLE; CONTROLLED STUDY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE INJURY; VASCULAR ENDOTHELIUM; VASCULAR RING; VASCULARIZATION; VASODILATATION;

EID: 0034800326     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.4.h1469     Document Type: Article

References (38)

1. The myeloperoxidase system of human phagocytes generates N epsilon-(carboxymethyl) lysine on proteins: A mechanism for producing advanced glycation end products at sites of inflammation
2. NADPH as a co-substrate for studies of the chlorinating activity of myeloperoxidase
3. Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction
4. Dietary L-arginine and alpha-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms
5. Vascular endothelial growth factor attenuates trauma-induced injury in rats
6. Is atherosclerosis an arginine deficiency disease?
7. Proteolytic inactivation of α-1-proteinase inhibitor by a neutrophil metalloproteinase
8. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
9. Oxidation of proteins in rat heart and lungs by polymorphonuclear leukocyte oxidants
10. Kinetics and mechanisms of hypochlorous acid reactions
11. Inhaled nitric oxide prevents pulmonary endothelial dysfunction after mesenteric ischemia-reperfusion
12. Ischemia-reperfusion: Mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease
13. HOCl effects on tight junctions of rabbit tracheal epithelium
14. Nitric oxide prevents neutrophil-mediated pulmonary vasomotor dysfunction in acute lung injury
15. L-Arginine attenuates endothelial dysfunction and prolongs survival in rats subjected to traumatic shock
16. Cellular mechanisms of heparinase III protection in rat traumatic shock
17. Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: A sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation
18. Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize α-amino acids to a family of reactive aldehydes
19. Human neutrophils employ myeloperoxidase to convert α-amino acids to a battery of reactive aldehydes: A pathway for aldehyde generation at sites of inflammation
20. Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis
21. Pathways for oxidation of low density lipoprotein by myeloperoxidase: Tyrosyl radical, reactive aldehydes, hypochlorous acid and molecular chlorine
22. Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
23. Endothelium-dependent coronary flow in ischemia reperfusion
24. Different endothelial mechanisms involved in coronary responses to known vasodilators
25. Nitric oxide and antimicrobial activity of reactive oxygen intermediates
26. Cardiovascular effects of L-arginine
27. Effect of endotoxin-enhanced hepatic reperfusion injury on endothelium-dependent relaxation in rat aorta
28. Endogenous nitric oxide synthase inhibitor. A novel marker of atherosclerosis
29. Insights into myeloperoxidase biosynthesis from its inherited deficiency
30. Lipopolysaccharide impairs endothelial nitric oxide synthesis in rat renal arteries
31. Mechanisms of hypochlorite injury of target cells
32. The oxidative inactivation of tissue inhibitor of metalloproteinase-1 (TIMP-1) by hypochlorous acid (HOCI) is suppressed by anti-rheumatic drugs
33. L-Arginine attenuates endothelial dysfunction in endotoxin-induced lung injury
34. Singlet oxygen inactivates fibrinogen, factor V, factor VIII, factor X, and platelet aggregation of human blood
35. Nitric oxide and the vascular endothelium in myocardial ischemia-reperfusion injury
36. 2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsis
37. Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of α1-antiproteinase by mercaptoethylguanidine
38. Selective modification of apoB-100 in the oxidation of low density lipoproteins by myeloperoxidase in vitro