메뉴 건너뛰기




Volumn 28, Issue 10, 2007, Pages 1637-1644

Structure-efficacy relationships of immunostimulatory activity of CpG-containing oligodeoxynucleotides on mouse spleen cells

Author keywords

CpG; Immunostimulation; Oligodeoxynucleotides; Structure activity relationship

Indexed keywords

ALPHA INTERFERON; CHROMIUM 51; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOSTIMULATING AGENT; INTERLEUKIN 12; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE DERIVATIVE; THYMIDINE;

EID: 34848882764     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00628.x     Document Type: Article
Times cited : (7)

References (31)
  • 2
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002 20 : 709 60.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-60
    • Krieg, A.M.1
  • 3
    • 0034142182 scopus 로고    scopus 로고
    • Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
    • Hartmann G, Weeratna RD, Ballas ZK, Payette P, Blackwell S, Suparto I, et al. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J Immunol 2000 164 : 1617 24.
    • (2000) J Immunol , vol.164 , pp. 1617-24
    • Hartmann, G.1    Weeratna, R.D.2    Ballas, Z.K.3    Payette, P.4    Blackwell, S.5    Suparto, I.6
  • 4
    • 0030205135 scopus 로고    scopus 로고
    • An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA
    • Krieg AM. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA. J Lab Clin Med 1996 128 : 128 33.
    • (1996) J Lab Clin Med , vol.128 , pp. 128-33
    • Krieg, A.M.1
  • 5
    • 0033536013 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxy-nucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms
    • Walker PS, Scharton-Kersten T, Krieg AM, Love-Homan L, Rowton ED, Udey MC, et al. Immunostimulatory oligodeoxy-nucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms. Proc Natl Acad Sci USA 1999 96 : 6970 5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6970-5
    • Walker, P.S.1    Scharton-Kersten, T.2    Krieg, A.M.3    Love-Homan, L.4    Rowton, E.D.5    Udey, M.C.6
  • 6
    • 34848828226 scopus 로고    scopus 로고
    • Mechanisms and therapeutic applications in DNA vaccines
    • Krieg AM, Yi AK, Hartmann G. Mechanisms and therapeutic applications in DNA vaccines. Trends Microbiol 1999 6 : 23 7.
    • (1999) Trends Microbiol , vol.6 , pp. 23-7
    • Krieg, A.M.1    Yi, A.K.2    Hartmann, G.3
  • 7
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas ZK, Rasmussen WL, Krieg AM. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 1996 157 : 1840 5.
    • (1996) J Immunol , vol.157 , pp. 1840-5
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 8
    • 0031936182 scopus 로고    scopus 로고
    • Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
    • Macfarlane DE, Manzel L. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds. J Immunol 1998 160 : 1122 31.
    • (1998) J Immunol , vol.160 , pp. 1122-31
    • MacFarlane, D.E.1    Manzel, L.2
  • 9
    • 0027325137 scopus 로고
    • Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphos-phonate oligonucleotides
    • Zhao Q, Matson S, Herrera CJ, Fisher E, Yu H, Kreig AM. Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphos-phonate oligonucleotides. Antisense Res Dev 1993 3 : 53 66.
    • (1993) Antisense Res Dev , vol.3 , pp. 53-66
    • Zhao, Q.1    Matson, S.2    Herrera, C.J.3    Fisher, E.4    Yu, H.5    Kreig, A.M.6
  • 10
    • 0036242206 scopus 로고    scopus 로고
    • Phospho-diester CpG oligonucleotides as adjuvants: Polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo
    • Dalpke AH, Zimmermann S, Albrecht I, Heeg K. Phospho-diester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo. Immunology 2002 106 : 102 12.
    • (2002) Immunology , vol.106 , pp. 102-12
    • Dalpke, A.H.1    Zimmermann, S.2    Albrecht, I.3    Heeg, K.4
  • 11
    • 0034667770 scopus 로고    scopus 로고
    • Phosphorothioate backbone modification modulates macrophage activation by CpG DNA
    • Sester DP, Naik S, Beasley SJ, Hume DA, Stacey KJ. Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J Immunol 2000 165 : 4165 73.
    • (2000) J Immunol , vol.165 , pp. 4165-73
    • Sester, D.P.1    Naik, S.2    Beasley, S.J.3    Hume, D.A.4    Stacey, K.J.5
  • 12
    • 0034292405 scopus 로고    scopus 로고
    • Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials
    • Lee SW, Song MK, Baek KH, Park Y, Kim JK, Lee CH, et al. Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials. J Immunol 2000 165 : 3631 9.
    • (2000) J Immunol , vol.165 , pp. 3631-9
    • Lee, S.W.1    Song, M.K.2    Baek, K.H.3    Park, Y.4    Kim, J.K.5    Lee, C.H.6
  • 13
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs
    • Verthelyi D, Ishii KJ, Gursel M, Takeshita F, Klinman DM. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J Immunol 2001 166 : 2372 7.
    • (2001) J Immunol , vol.166 , pp. 2372-7
    • Verthelyi, D.1    Ishii, K.J.2    Gursel, M.3    Takeshita, F.4    Klinman, D.M.5
  • 14
    • 0035865228 scopus 로고    scopus 로고
    • Distinct CpG DNA and polyi-nosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c type II dendritic precursor and CD11c+ dendritic cells to produce type I IFN
    • Kadowaki N, Antonenko S, Liu YJ. Distinct CpG DNA and polyi-nosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c type II dendritic precursor and CD11c+ dendritic cells to produce type I IFN. J Immunol 2001 166 : 2291.
    • (2001) J Immunol , vol.166 , pp. 2291
    • Kadowaki, N.1    Antonenko, S.2    Liu, Y.J.3
  • 15
    • 9144238063 scopus 로고    scopus 로고
    • Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities
    • Vollmer J, Weeratna R, Payette P, Jurk M, Schetter C, Laucht M, et al. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol 2004 34 : 251 62.
    • (2004) Eur J Immunol , vol.34 , pp. 251-62
    • Vollmer, J.1    Weeratna, R.2    Payette, P.3    Jurk, M.4    Schetter, C.5    Laucht, M.6
  • 16
    • 32044432614 scopus 로고    scopus 로고
    • Anti-SARS-CoV immunity induced by a novel CpG oligodeoxy-nucleotide
    • Bao MS, Zhang Y, Wan M, Dai L, Hu XP, Wu XL, et al. Anti-SARS-CoV immunity induced by a novel CpG oligodeoxy-nucleotide. Clin Immunol 2006 118 : 180 7.
    • (2006) Clin Immunol , vol.118 , pp. 180-7
    • Bao, M.S.1    Zhang, Y.2    Wan, M.3    Dai, L.4    Hu, X.P.5    Wu, X.L.6
  • 17
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA motif in human primary B cells
    • Hartmann G, Krieg AM. Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J Immunol 2000 164 : 944 53.
    • (2000) J Immunol , vol.164 , pp. 944-53
    • Hartmann, G.1    Krieg, A.M.2
  • 18
    • 0035187324 scopus 로고    scopus 로고
    • CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved
    • Rankin R, Pontarollo R, Ioannou X, Krieg AM, Hecker R, Babiuk LA, et al. CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved. Antisense Nucleic Acid Drug Dev 2001 11 : 333 40.
    • (2001) Antisense Nucleic Acid Drug Dev , vol.11 , pp. 333-40
    • Rankin, R.1    Pontarollo, R.2    Ioannou, X.3    Krieg, A.M.4    Hecker, R.5    Babiuk, L.A.6
  • 19
    • 0032526607 scopus 로고    scopus 로고
    • CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
    • Ashman RF. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. J Immunol 1998 160 : 5898 906.
    • (1998) J Immunol , vol.160 , pp. 5898-906
    • Ashman, R.F.1
  • 20
    • 0034933019 scopus 로고    scopus 로고
    • Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
    • Krug A, Rothenfusser S, Hornung V, Jahrsdorfer B, Blackwell S, Ballas ZK, et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 2001 31 : 2154 63.
    • (2001) Eur J Immunol , vol.31 , pp. 2154-63
    • Krug, A.1    Rothenfusser, S.2    Hornung, V.3    Jahrsdorfer, B.4    Blackwell, S.5    Ballas, Z.K.6
  • 21
    • 4744368053 scopus 로고    scopus 로고
    • Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation
    • Vollmer J, Weeratna R, Jurk M, Samulowitz U, McCluskie MJ, Payette P, et al. Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 2004 113 : 212 23.
    • (2004) Immunology , vol.113 , pp. 212-23
    • Vollmer, J.1    Weeratna, R.2    Jurk, M.3    Samulowitz, U.4    McCluskie, M.J.5    Payette, P.6
  • 22
    • 0036384444 scopus 로고    scopus 로고
    • Potent CpG oligodeoxynucleotides containing phosphodiester linkages: In vitro and in vivo immunostimulatory properties
    • Yu D, Zhu FG, Bhagat L, Wang H, Kandimalla ER, Zhang R, et al. Potent CpG oligodeoxynucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties. Biochem Biophys Res Commun 2002 297 : 83 90.
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 83-90
    • Yu, D.1    Zhu, F.G.2    Bhagat, L.3    Wang, H.4    Kandimalla, E.R.5    Zhang, R.6
  • 23
    • 0030071007 scopus 로고    scopus 로고
    • Effect of different chemically modified oligodeoxynucleotides on immune stimulation
    • Zhao Q, Temsamani J, Iadarola PL, Jiang Z, Agrawal S. Effect of different chemically modified oligodeoxynucleotides on immune stimulation. Biochem Pharmacol 1996 51 : 173 82.
    • (1996) Biochem Pharmacol , vol.51 , pp. 173-82
    • Zhao, Q.1    Temsamani, J.2    Iadarola, P.L.3    Jiang, Z.4    Agrawal, S.5
  • 24
    • 0034606443 scopus 로고    scopus 로고
    • Accessible 5′-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity
    • Yu D, Zhao Q, Kandimalla ER, Agrawal S. Accessible 5′-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity. Bioorg Med Chem Lett 2000 10 : 2585 8.
    • (2000) Bioorg Med Chem Lett , vol.10 , pp. 2585-8
    • Yu, D.1    Zhao, Q.2    Kandimalla, E.R.3    Agrawal, S.4
  • 25
    • 0036738536 scopus 로고    scopus 로고
    • Conjugation of ligands at the 5′-end of CpG DNA affects immuno-stimulatory activity
    • Kandimalla ER, Bhagat L, Yu D, Cong Y, Tang J, Agrawal S. Conjugation of ligands at the 5′-end of CpG DNA affects immuno-stimulatory activity. Bioconjug Chem 2002 13 : 966 74.
    • (2002) Bioconjug Chem , vol.13 , pp. 966-74
    • Kandimalla, E.R.1    Bhagat, L.2    Yu, D.3    Cong, Y.4    Tang, J.5    Agrawal, S.6
  • 26
    • 0037109211 scopus 로고    scopus 로고
    • ′immunomer′-novel 3′-3′-linked CpG oligodeoxynucleotides as potent immunomodulatory agents
    • Yu D, Kandimalla ER, Bhagat L, Tang JY, Cong Y, Tang J, et al. ′Immunomer′-novel 3′-3′-linked CpG oligodeoxynucleotides as potent immunomodulatory agents. Nucleic Acids Res 2002 30 : 4460 9.
    • (2002) Nucleic Acids Res , vol.30 , pp. 4460-9
    • Yu, D.1    Kandimalla, E.R.2    Bhagat, L.3    Tang, J.Y.4    Cong, Y.5    Tang, J.6
  • 28
    • 0035501012 scopus 로고    scopus 로고
    • Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs
    • Ballas ZK, Kreig AM, Warren T, Rasmussen W, Davis HL, Waldschmidt M, et al. Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs. J Immunol 2001 167 : 4878 86.
    • (2001) J Immunol , vol.167 , pp. 4878-86
    • Ballas, Z.K.1    Kreig, A.M.2    Warren, T.3    Rasmussen, W.4    Davis, H.L.5    Waldschmidt, M.6
  • 29
    • 9144238063 scopus 로고    scopus 로고
    • Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities
    • Vollmer J, Weeratna R, Payette P, Jurk M, Schetter C, Laucht M, et al. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol 2004 34 : 251 62.
    • (2004) Eur J Immunol , vol.34 , pp. 251-62
    • Vollmer, J.1    Weeratna, R.2    Payette, P.3    Jurk, M.4    Schetter, C.5    Laucht, M.6
  • 30
    • 0037443644 scopus 로고    scopus 로고
    • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    • Hemmi H, Kaisho T, Takeda K, Akira S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 2003 170 : 3059 64.
    • (2003) J Immunol , vol.170 , pp. 3059-64
    • Hemmi, H.1    Kaisho, T.2    Takeda, K.3    Akira, S.4
  • 31
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda K, Ohba Y, Yanai H, Negishi H, Mizutani T, Takaoka A, et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 2005 434 : 1035 40.
    • (2005) Nature , vol.434 , pp. 1035-40
    • Honda, K.1    Ohba, Y.2    Yanai, H.3    Negishi, H.4    Mizutani, T.5    Takaoka, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.