Baseline viral load and immune activation determine the extent of reconstitution of innate immune effectors in HIV-1-infected subjects undergoing antiretroviral treatment

Journal of Immunology

Volumn 179, Issue 4, 2007, Pages 2642-2650

  Chehimi, Jihed ^a   Azzoni, Livio ^a   Farabaugh, Matthew ^a   Creer, Shenoa A ^a   Tomescu, Costin ^a   Hancock, Aidan ^a   Mackiewicz, Agnes ^a   D'Alessandro, Lara ^a   Ghanekar, Smita ^b   Foulkes, Andrea S ^c   Mounzer, Karam ^d   Kostman, Jay ^e   Montaner, Luis J ^a  

^a WISTAR INSTITUTE   (United States)

^b BD BIOSCIENCES   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

^d Philadelphia Field Initiating Group for HIV Trials (FIGHT)   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL COMPARTMENTALIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INNATE IMMUNITY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; TREATMENT OUTCOME; TREATMENT RESPONSE; VIREMIA; VIRUS LOAD; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; COMPARATIVE STUDY; CONVALESCENCE; DRUG EFFECT; FOLLOW UP; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MULTICENTER STUDY; PLASMA CELL;

ADULT; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, NATURAL; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PLASMA CELLS; RECOVERY OF FUNCTION; VIRAL LOAD; VIREMIA;

EID: 34848880205     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.4.2642     Document Type: Article

References (49)

1. Fauci, A. S. 1993. Immunopathogenesis of HIV infection. J. Acquir. Immune Defic. Syndr. 6: 655-662.
2. Levy, J. A. 1993. HIV and host immune responses in AIDS pathogenesis. J. Clin. Apher. 8: 19-28.
3. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47: 187-376.
4. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
5. Moretta, A. 2002. Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat. Rev. Immunol. 2: 957-964.
6. Moretta, A. 2005. The dialogue between human natural killer cells and dendritic cells. Curr. Opin. Immunol. 17: 306-311.
7. Ferlazzo, G., M. L. Tsang, L. Moretta, G. Melioli, R. M. Steinman, and C. Munz. 2002. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp. Med. 195: 343-351.
8. Gerosa, F., B. Baldani-Guerra, C. Nisii, V. Marchesini, G. Carra, and G. Trinchieri. 2002. Reciprocal activating interaction between natural killer cells and dendritic cells. J. Exp. Med. 195: 327-333.
9. Gerosa, F., A. Gobbi, P. Zorzi, S. Burg, F. Briere, G. Carra, and G. Trinchieri. 2005. The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions. J. Immunol. 174: 727-734.
10. Asselin-Paturel, C., and G. Trinchieri. 2005. Production of type I interferons: plasmacytoid dendritic cells and beyond. J. Exp. Med. 202: 461-465.
11. Fortis, C., and G. Poli. 2005. Dendritic cells and natural killer cells in the pathogenesis of HIV infection. Immunol. Res. 33: 1-21.
12. Muller-Trutwin, M., and A. Hosmalin. 2005. Role for plasmacytoid dendritic cells in anti-HIV innate immunity. Immunol. Cell. Biol. 83: 578-583.
13. Fauci, A. S., D. Mavilio, and S. Kottilil. 2005. NK cells in HIV infection: paradigm for protection or targets for ambush. Nat. Rev. Immunol. 5: 835-843.
14. Lanier, L. L. 2005. NK cell recognition. Annu. Rev. Immunol. 23: 225-274.
15. Kaisho, T., and S. Akira. 2006. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117: 979-987.
16. Beutler, B., Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du, and K. Hoebe. 2006. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24: 353-389.
17. Lopez, C., P. A. Fitzgerald, F. P. Siegal, S. Landesman, J. Gold, and S. E. Krown. 1984. Deficiency of interferon-α generating capacity is associated with susceptibility to opportunistic infections in patients with AIDS. Ann. NY Acad. Sci. 437: 39-48.
18. Chehimi, J., S. E. Starr, I. Frank, M. Rengaraju, S. J. Jackson, C. Llanes, M. Kobayashi, B. Perussia, D. Young, E. Nickbarg, et al. 1992. Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients. J. Exp. Med. 175: 789-796.
19. Chehimi, J., J. D. Marshall, O. Salvucci, I. Frank, S. Chehimi, S. Kawecki, D. Bacheller, S. Rifat, and S. Chouaib. 1997. IL-15 enhances immune functions during HIV infection. J. Immunol. 158: 5978-5987.
20. Siegal, F. P., P. Fitzgerald-Bocarsly, B. K. Holland, and M. Shodell. 2001. Interferon-α generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection. AIDS 15: 1603-1612.
21. Soumelis, V., I. Scott, F. Gheyas, D. Bouhour, G. Cozon, L. Cotte, L. Huang, J. A. Levy, and Y. J. Liu. 2001. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood 98: 906-912.
22. Chehimi, J., D. E. Campbell, L. Azzoni, D. Bacheller, E. Papasavvas, G. Jerandi, K. Mounzer, J. Kostman, G. Trinchieri, and L. J. Montaner. 2002. Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J. Immunol. 168: 4796-4801.
23. Finke, J. S., M. Shodell, K. Shah, F. P. Siegal, and R. M. Steinman. 2004. Dendritic cell numbers in the blood of HIV-1 infected patients before and after changes in antiretroviral therapy. J. Clin. Immunol. 24: 647-652.
24. + cell counts in treated HIV-1-infected children. J. Infect. Dis. 191: 1451-1459.
25. Killian, M. S., S. H. Fujimura, F. M. Hecht, and J. A. Levy. 2006. Similar changes in plasmacytoid dendritic cell and CD4 T-cell counts during primary HIV-1 infection and treatment. AIDS 20: 1247-1252.
26. Azzoni, L., J. Chehimi, L. Zhou, A. S. Foulkes, R. June, V. C. Maino, A. Landay, C. Rinaldo, L. P. Jacobson, and L. J. Montaner. 2007. Early and delayed benefits of HIV-1 suppression: timeline of recovery of innate immunity effector cells. AIDS 21: 293-305.
27. Biancotto, A., J. C. Grivel, S. J. Iglehart, C. Vanpouille, A. Lisco, S. F. Sieg, R. Debernardo, K. Garate, B. Rodriguez, L. B. Margolis, and M. M. Lederman. 2007. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood 109: 4272-4279.
28. Siegal, F. 2003. Interferon-producing plasmacytoid dendritic cells and the pathogenesis of AIDS. Res. Initiat. Treat. Action 8: 10-13.
29. Flores-Villanueva, P. O., E. J. Yunis, J. C. Delgado, E. Vittinghoff, S. Buchbinder, J. Y. Leung, A. M. Uglialoro, O. P. Clavijo, E. S. Rosenberg, S. A. Kalams, et al. 2001. Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. Proc. Natl. Acad. Sci. USA 98: 5140-5145.
30. Martin, M. P., X. Gao, J. H. Lee, G. W. Nelson, R. Detels, J. J. Goedert, S. Buchbinder, K. Hoots, D. Vlahov, J. Trowsdale, et al. 2002. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat. Genet. 31: 429-434.
31. Chehimi, J., N. M. Valiante, A. D'Andrea, M. Rengaraju, Z. Rosado, M. Kobayashi, B. Perussia, S. F. Wolf, S. E. Starr, and G. Trinchieri. 1993. Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur. J. Immunol. 23: 1826-1830.
32. Strohlein, M. A., K. U. Grutzner, F. W. Schildberg, and M. M. Heiss. 2002. Induction of cytotoxicity against autologous tumour cells by interleukin-12: evidence for intrinsic anti-tumor immune capacity in curatively resected gastrointestinal tumour patients. Cancer Immunol. Immunother. 51: 505-512.
33. + cell subsets in human peripheral blood. Immunology 68: 486-490.
34. Tarwater, P. M., J. B. Margolick, J. Jin, J. P. Phair, R. Detels, C. Rinaldo, J. Giorgi, and A. Munoz. 2001. Increase and plateau of CD4 T-cell counts in the 3(1/2) years after initiation of potent antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 27: 168-175.
35. Smith, C. J., C. A. Sabin, F. C. Lampe, S. Kinloch-de-Loes, H. Gumley, A. Carroll, B. Prinz, M. Youle, M. A. Johnson, and A. N. Phillips. 2003. The potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapy. AIDS 17: 963-969.
36. + T cells in untreated HIV-infected individuals. Proc. Natl. Acad. Sci. USA 101: 2464-2469.
37. Barbaro, G., A. Scozzafava, A. Mastrolorenzo, and C. T. Supuran. 2005. Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome. Curr. Pharm. Des. 11: 1805-1843.
38. - cells with low lytic activity. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. 10: 331-340.
39. Mavilio, D., J. Benjamin, M. Daucher, G. Lombardo, S. Kottilil, M. A. Planta, E. Marcenaro, C. Bottino, L. Moretta, A. Moretta, and A. S. Fauci. 2003. Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc. Natl. Acad. Sci. USA 100: 15011-15016.
40. Alter, G., J. M. Malenfant, R. M. Delabre, N. C. Burgett, X. G. Yu, M. Lichterfeld, J. Zaunders, and M. Altfeld. 2004. Increased natural killer cell activity in viremic HIV-1 infection. J. Immunol. 173: 5305-5311.
41. + natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc. Natl. Acad. Sci. USA 102: 2886-2891.
42. Pacanowski, J., L. Develioglu, I. Kamga, M. Sinet, M. Desvarieux, P. M. Girard, and A. Hosmalin. 2004. Early plasmacytoid dendritic cell changes predict plasma HIV load rebound during primary infection. J. Infect. Dis. 190: 1889-1892.
43. Herbeuval, J. P., A. Boasso, J. C. Grivel, A. W. Hardy, S. A. Anderson, M. J. Dolan, C. Chougnet, J. D. Lifson, and G. M. Shearer. 2005. TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells. Blood 105: 2458-2464.
44. Herbeuval, J. P., J. Nilsson, A. Boasso, A. W. Hardy, M. J. Kruhlak, S. A. Anderson, M. J. Dolan, M. Dy, J. Andersson, and G. M. Shearer. 2006. Differential expression of IFN-α and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients. Proc. Natl. Acad. Sci. USA 103: 7000-7005.
45. Herbeuval, J. P., and G. M. Shearer. 2007. HIV-1 immunopathogenesis: how good interferon turns bad. Clin. Immunol. 123: 121-128.
46. Rodriguez, B., M. M. Lederman, W. Jiang, D. A. Bazdar, K. Garate, C. V. Harding, and S. F. Sieg. 2006. Interferon-α differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection. AIDS 20: 1379-1389.
47. + T cells. J. Immunol. 177: 6227-6237.
48. Brenchley, J. M., D. A. Price, T. W. Schacker, T. E. Asher, G. Silvestri, S. Rao, Z. Kazzaz, E. Bornstein, O. Lambotte, D. Altmann, et al. 2006. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12: 1365-1371.
49. Kottilil, S., K. Shin, J. O. Jackson, K. N. Reitano, M. A. O'Shea, J. Yang, C. W. Hallahan, R. Lempicki, J. Arthos, and A. S. Fauci. 2006. Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions. J. Immunol. 176: 1107-1114.