Improved glycemic control in subjects with atypical diabetes results from restored insulin secretion, but not improved insulin sensitivity

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 12, 2004, Pages 6331-6335

  Rasouli, Neda ^a   Elbein, Steven C ^b  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; FRUCTOSAMINE; GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADULT; AFRICAN AMERICAN; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; INSULIN TREATMENT; INTRAVENOUS GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ADULT; AFRICAN AMERICANS; BLOOD GLUCOSE; DIABETIC KETOACIDOSIS; FEMALE; FRUCTOSAMINE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; MIDDLE AGED;

EID: 10344241985     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1016     Document Type: Article

References (19)

1. Banerji MA, Chaiken RL, Huey H, Tuomi T, Norin AJ, Mackay IR, Rowley MJ, Zimmet PZ, Lebovitz HE 1994 GAD antibody negative NIDDM in adult black subjects with diabetic ketoacidosis and increased frequency of human leukocyte antigen DR3 and DR4. Flatbush diabetes. Diabetes 43:741-745
2. Umpierrez GE, Woo W, Hagopian WA, Isaacs SD, Palmer JP, Gaur LK, Nepom GT, Clark WS, Mixon PS, Kitabchi AE 1999 Immunogenetic analysis suggests different pathogenesis for obese and lean African-Americans with diabetic ketoacidosis. Diabetes Care 22:1517-1523
3. Tan KC, Mackay IR, Zimmet PZ, Hawkins BR, Lam KS 2000 Metabolic and immunologic features of Chinese patients with atypical diabetes mellitus. Diabetes Care 23:335-338
4. Tanaka K, Moriya T, Kanamori A, Yajima Y 1999 Analysis and a long-term follow up of ketosis-onset Japanese NIDDM patients. Diabetes Res Clin Pract 44:137-146
5. Pinero-Pilona A, Raskin P 2001 Idiopathic type 1 diabetes. J Diabetes Complications 15:328-335
6. Maldonado M, Hampe CS, Gaur LK, D'Amico S, Iyer D, Hammerle LP, Bolgiano D, Rodriguez L, Rajan A, Lernmark A, Balasubramanyam A 2003 Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and β-cell functional classification, prospective analysis, and clinical outcomes. J Clin Endocrinol Metab 88:5090-5098
7. Kitabchi AE 2003 Ketosis-prone diabetes: a new subgroup of patients with atypical type 1 and type 2 diabetes? J Clin Endocrinol Metab 88:5087-5089
8. Umpierrez GE, Clark WS, Steen MT 1997 Sulfonylurea treatment prevents recurrence of hyperglycemia in obese African-American patients with a history of hyperglycemic crises. Diabetes Care 20:479-483
9. McFarlane SI, Chaiken RL, Hirsch S, Harrington P, Lebovitz HE, Banerji MA 2001 Near-normoglycaemic remission in African-Americans with type 2 diabetes mellitus is associated with recovery of β cell function. Diabet Med 18:10-16
10. Banerji MA, Chaiken RL, Lebovitz HE 1995 Prolongation of near-normoglycemic remission in black NIDDM subjects with chronic low-dose sulfonylurea treatment. Diabetes 44:466-470
11. Umpierrez GE, Casals MM, Gebhart SP, Mixon PS, Clark WS, Phillips LS 1995 Diabetic ketoacidosis in obese African-Americans. Diabetes 44:790-795
12. Bergman RN, Ider YZ, Bowden CR, Cobelli C 1979 Quantitative estimation of insulin sensitivity. Am J Physiol 236:E667-E677
13. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP 1993 Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42:1663-1672
14. Bergman RN 1989 Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes 38:1512-1527
15. Turner RC 1998 The U.K. Prospective Diabetes Study. A review. Diabetes Care 21(Suppl 3):C35-C38
16. Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, Charpentier G, Guillausseau PJ, Vexiau P, Gautier JF 2004 Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of β-cell dysfunction and insulin resistance. Diabetes 53:645-653
17. Garvey WT, Olefsky JM, Griffin J, Hamman RF, Kolterman OG 1985 The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes 34:222-234
18. Henry RR 1996 Glucose control and insulin resistance in non-insulin-dependent diabetes mellitus. Ann Intern Med 124:97-103
19. Hani EH, Stoffers DA, Chevre JC, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P1999 Defective mutations in the insulin promoter factor-1 (1PF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest 104:R41-R48