3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT2A receptor antagonists

Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2001, Pages 1603-1614

  Rowley, M ^a   Hallett, D J ^a   Goodacre, S ^a   Moyes, C ^a   Crawforth, J ^a   Sparey, T J ^a   Patel, S ^a,a   Marwood, R ^a   Thomas, S ^a   Hitzel, L ^a   O'Connor, D ^a   Szeto, N ^a   Castro, J L ^a   Hutson, P H ^a   Macleod, A M ^a  

^a IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 FLUOROPIPERIDIN 3 YL) 2 PHENYL 1H INDOLE; 3 (4 FLUOROPIPERIDIN 3 YL) 2 PHENYLINDOLE DERIVATIVE; 6 FLUORO 3 (4 FLUOROPIPERIDIN 3 YL) 2 PHENYL 1H INDOLE; FLUORINE; NITROGEN; PIPERIDINE; POTASSIUM CHANNEL; SEROTONIN 2A ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; PKA;

ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; DOGS; FEMALE; HUMANS; INDOLES; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; PIPERIDINES; POTASSIUM CHANNELS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035837068     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0004998     Document Type: Article

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