Metallothionein-null mice absorb less Zn from an egg-white diet, but a similar amount from solutions, although with altered intertissue Zn distribution

Journal of Nutrition

Volumn 129, Issue 2, 1999, Pages 372-379

  Coyle, Peter ^a   Philcox, Jeffrey C ^a   Rofe, Allan M ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

Intestinal absorption; Metallothionein; Metallothionein null mice; Zinc

Indexed keywords

EGG WHITE; METALLOTHIONEIN; ZINC;

ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN; DIET SUPPLEMENTATION; DOSE RESPONSE; FEEDING; GENOTYPE; HEART; INTESTINE ABSORPTION; INTESTINE TRANSIT TIME; LIVER; MOUSE; MUSCLE; NONHUMAN; SKIN; TISSUE DISTRIBUTION; ZINC BLOOD LEVEL; ZINC METABOLISM;

ANIMALIA;

EID: 0032915355     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.2.372     Document Type: Article

References (28)

1. Cousins, R. J. (1985) Absorption, transport and hepatic metabolism of copper and zinc: special reference to metallothionein and caeruloplasmin. Physiol. Rev. 65: 238-309.
2. Coyle, P., Philcox, J. C. & Rofe, A. M. (1993) Corticosterone enhances the zinc and interleukin-6-mediated induction of metallothionein in cultured rat hepatocytes. J. Nutr. 123: 1464-1470.
3. Coyle, P., Philcox, J. C. & Rofe, A. M. (1995) Hepatic zinc in metallothionein-null mice following zinc challenge: in vivo and in vitro studies. Biochem. J. 309: 25-31.
4. Davies, N. T. & Olpin, S. E. (1979) Studies on the phytate: zinc molar contents in diets as a determinant of Zn availability to young rats. Br. J. Nutr. 41: 591-603.
5. Davis, S. R., McMahon, R. J. & Cousins, R. J. (1998) Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. J. Nutr. 128: 825-831.
6. Eaton, D. L. & Toal, B. F. (1982) Evaluation of the Cd/hemoglobin assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66: 134-142.
7. Flanagan, P. R., Haist, J. & Valberg, L. S. (1983) Zinc absorption, intraluminal zinc and intestinal metallothionein levels in zinc-deficient and zinc-replete rodents. J. Nutr. 113: 962-973.
8. Fleet, J. C., Tumbull, A. J., Bourcier, M. & Wood, R. J. (1993) Vitamin D-sensitive and quinacrine-sensitive zinc transport in human intestinal cell line Caco-2. Am. J. Physiol. 264: G1037-G1045.
9. Gisbert-Gonzalez, S. L. & Torres-Molina, F. (1996) Zinc uptake in five sectors of the rat gastrointestinal tract: kinetic study in the whole colon. Pharm. Res. 13: 1154-1161.
10. Hallquist, N. A., Khoo, C. & Cousins, R. J. (1996) Lipopolysaccharide regulates cysteine-rich intestinal protein, a zinc-finger protein, in immune cells and plasma. J. Leukoc. Biol. 59: 172-177.
11. Hempe, J. M. & Cousins, R. J. (1992) Cysteine-rich intestinal protein and intestinal metallothionein: an inverse relationship as a conceptual model for zinc absorption in rats. J. Nutr. 122: 89-95.
12. Hoadley, J. E., Leinart, A. S. & Cousins, R. J. (1987) Kinetic analysis of zinc uptake and serosal transfer by vascularly perfused rat intestine. Am. J. Physiol. 252: G825-G831.
13. 65Zn absorption kinetics to intestinal metallothionein in rats: effects of zinc depletion and fasting. J. Nutr. 118: 497-502.
14. Kelly, E. J., Quaife, C. J., Froelick, G. J. & Palmiter, R. D. (1996) Metallothioneim I and II protect against zinc deficiency and zinc toxicity in mice. J. Nutr. 126: 1782-1790.
15. Khoo, C., Blanchard R. K., Sullivan, V. K. & Cousins, R. J. (1997) Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells. Protein Expr. Purif. 9: 379-387.
16. Khoo, C., Hallquist, N. A., Samuelson, D. A. & Cousins, R. J. (1996) Differential expression of cysteine-rich intestinal protein in liver and intestine in CCL4-induced inflammation. Am. J. Physiol. 270: G613-G618.
17. Lönnerdal, B. (1989) Intestinal absorption of zinc. In: Zinc in Human Biology (Mills, C. F., ed.), pp. 33-55. Springer-Verlag, London, UK.
18. McMahon, R. J. & Cousins, R. J. (1998) Regulation of the zinc transporter ZnT-1 by dietary zinc. Proc. Natl. Acad. Sci. U.S.A. 95: 4841-4846.
19. Michalska, A. & Choo, K.H.A. (1993) Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. U.S.A. 90: 8088-8092.
20. Palmiter, R. D., Cole, T. B. & Findley, S. D. (1996) ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 15: 1784-1791.
21. Palmiter, R. D. & Findley, S. D. (1995) Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 14: 639-649.
22. Philcox, J. C., Coyle, P., Michalska, A., Choo, K.H.A. & Rofe, A. M. (1995) Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression. Biochem. J. 308: 543-546.
23. Rofe, A. M., Philcox, J. C. & Coyle, P. (1996) Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice. Biochem. J. 314: 793-797.
24. Rofe, A. M., Philcox, J. C., Sturkenboom, M., & Coyle, P. (1998) Zinc homeostasis during pregnancy in metallothionein-null mice on a low zinc diet. In: Metallothionein IV (Klaassen C.D., ed.), pp. 309-313. Birkenhäuser, Basel, Switzerland.
25. Steel, L. & Cousins, R. J. (1985) Kinetics of zinc absorption by luminally and vascularty perfused rat intestine. Am. J. Physiol. 248: G46-G53.
26. Tukey, J. W. (1949) Comparing individual means in the analysis of variance. Biometrics 5: 99-114.
27. Valee, B. L. & Falchuk, K. H. (1993) The biochemical basis of zinc physiology. Physiol. Rev. 73: 79-118.
28. Whitehead, M. W., Thompson, R.P.H. & Powell, J. J. (1996) Regulation of metal absorption in the gastrointestinal tract. Gut 39: 625-628.