Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis

Cancer Letters

Volumn 129, Issue 1, 1998, Pages 1-6

  Barotto, Nelso N ^a,b   López, Cristina B ^a,b   Eynard, Aldo R ^a,b,c   Fernández Zapico, Martín E ^a,b   Valentich, Mirta A ^a,b,c  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^b FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Nitrosomethylurea; Pancreatic carcinogenesis; Progression; Promotion; Quercetin

Indexed keywords

METHYLNITROSOUREA; QUERCETIN;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CARCINOMA IN SITU; CONTROLLED STUDY; MITOSIS; NONHUMAN; PANCREAS CANCER; PANCREAS ISLET CELL HYPERPLASIA; PRECANCER; PRIORITY JOURNAL; RAT; UTERINE CERVIX CARCINOMA;

ANIMALS; BODY WEIGHT; CARCINOGENS; COCARCINOGENESIS; FEMALE; MALE; METHYLNITROSOUREA; ORGAN SIZE; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS; PREGNANCY; QUERCETIN; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0345451003     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00033-0     Document Type: Article

References (21)

1. Steinmetz K.A., Potter J.D. Vegetables, fruits, and cancer. I. Epidemiology. Cancer Causes Control. 2:1991;325-357.
2. Singleton V.L. Naturally occurring food toxicants: phenolic substances of plant origin common in risk foods. Adv. Food Res. 27:1981;149-242.
3. Jones E., Hughes R.E. Quercetin, flavonoids, and the life span of mice. Exp. Gerontol. 117:1982;213-217.
4. International Agency for Research on Cancer, Quercetin, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Some Food Additives and Naturally Occurring Substances, Vol. 31, IARC, Lyon, 1983, pp. 213-229.
5. Zhu B.T., Liehr J.G. Quercetin increases the severity of estradiol-induced tumorigenesis in hamster kidney. Toxicol. Appl. Pharmacol. 125:1994;149-158.
6. Pereira M.A., Grubbs C.J., Barnes L.H., Li H., Olson G.R., Eto I., Juliana M., Whitaker L.M., Kelloff G.J., Steele V.E., Lubet R.A. Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats. Carcinogenesis. 17:1996;1305-1311.
7. Stavric B. Quercetin in our diet: from potent mutagen to probable anticarcinogen. Clin. Biochem. 27:1994;245-248.
8. Shimoi K., Masuda S., Furugori M., Esaki S., Kinae N. Radioprotective effect of antioxidative flavonoids in γ-ray irradiated mice. Carcinogenesis. 15:1994;2669-2672.
9. Ip C., Ganther H.E. Combination of blocking agents and suppressing agents in cancer prevention. Carcinogenesis. 12:1991;365-367.
10. Monis B., Valentich M.A. Promoting effects of mancozeb on pancreas of nitrosomethylurea-treated rats. Carcinogenesis. 14:1993;929-933.
11. Monis B., Valentich M.A., Urrutia R., Rivolta M. Multicentric focal acinar cell hyperplasia and hepatocyte-like cell metaplasia are induced by nitrosomethylurea in rat pancreas. Int. J. Pancreatol. 8:1991;119-131.
12. Longnecker D.S., Millar P.M. Tumors of the pancreas. IARC Sci. Publ. 99:1990;241-257.
13. Suda K., Hosokawa Y., Kuroda J., Yuminamochi T., Ishii Y., Nakazawa K. Pancreatic acinar cells in adult human islets of Langerhans. Pancreas. 9:1994;563-565.
14. Valentich M.A., Monis B. Effect of dietary administration of sodium diethyldithiocarbamate on proliferation phenotypes and on gamma glutamyltranspeptidase activity of pancreas of nitrosomethylurea-treated rats. J. Exp. Clin. Cancer Res. 14:1995;283-285.
15. Valentich M.A., Monis B., Chesta C.S., Spinsanti L.I. Effect on the pancreas of dietary administration of the pesticides folithion or bayleton to rats treated with nitrosomethylurea (NMU). Com. Biol. 12:1994;371-382.
16. Urrutia R.A., Rivolta M.N., Valentich M.A., Monis B. A Feulgen microspectrophotometric study of the DNA content of essential fatty acid-deficient rat pancreas treated with nitrosomethylurea. Cell. Mol. Biol. 36:1990;547-555.
17. Valentich M.A., Monis B. Gamma glutamyltranspeptidase, glutathione S-transferase and glutathione peroxidase on pancreas of rats treated with nitrosomethylurea. J. Exp. Clin. Cancer Res. 12:1992;59-63.
18. Valentich M.A., Cook T., Urrutia R. Expression of dynamin immunoreactivity in experimental pancreatic tumors induced in rat by mancozeb-nitrosomethylurea. Cancer Lett. 102:1996;23-29.
19. Longnecker D.S. Rats models of carcinoma of the pancreas. Int. J. Pancreatol. 16:1994;287-288.
20. Kishi K., Nakamura K., Yoshimori M., Tajiri H., Ozaki H., Kinoshita T., Kosuge T., Hayakawa M. Morphology and pathological significance of focal acinar cell dysplasia of the human pancreas. Pancreas. 7:1992;177-182.
21. Longnecker D.S. Experimental pancreatic cancer: role of species, sex and diet. Bull. Cancer. 77:1990;27-37.