메뉴 건너뛰기




Volumn 19, Issue 6, 2007, Pages 598-605

Molecular targeted therapies and chemotherapy in malignant gliomas

Author keywords

Malignant glioma; Targeted therapy; Temozolomide; Vascular endothelial growth factor

Indexed keywords

4 (4 FLUORO 2 METHYL 5 INDOLYLOXY) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY]QUINAZOLINE; 6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AP 23573; BEVACIZUMAB; ENZASTAURIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; EVEROLIMUS; GEFITINIB; HYDROXYUREA; IMATINIB; IRINOTECAN; LAPATANIB; LOMUSTINE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROCARBAZINE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAPAMYCIN; SORAFENIB; TEMOZOLOMIDE; TEMSIROLIMUS; TIPIFARNIB; TYCERB; VASCULOTROPIN RECEPTOR; VATALANIB; VINCRISTINE;

EID: 34848819103     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e3282f0313b     Document Type: Review
Times cited : (46)

References (74)
  • 1
    • 0031964497 scopus 로고    scopus 로고
    • Validation and predictive power of Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis classes for malignant glioma patients: A report using RTOG 90-06
    • Scott CB, Scarantino C, Urtasun R, et al. Validation and predictive power of Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis classes for malignant glioma patients: a report using RTOG 90-06. Int J Radiat Oncol Biol Phys 1998; 40:51-55.
    • (1998) Int J Radiat Oncol Biol Phys , vol.40 , pp. 51-55
    • Scott, C.B.1    Scarantino, C.2    Urtasun, R.3
  • 2
    • 0032945178 scopus 로고    scopus 로고
    • The conditional probability of survival of patients with primary malignant brain tumors: Surveillance, epidemiology, and end results (SEER) data
    • Davis FG, McCarthy BJ, Freels S, et al. The conditional probability of survival of patients with primary malignant brain tumors: surveillance, epidemiology, and end results (SEER) data. Cancer 1999; 85:485-491.
    • (1999) Cancer , vol.85 , pp. 485-491
    • Davis, F.G.1    McCarthy, B.J.2    Freels, S.3
  • 3
    • 0242382624 scopus 로고    scopus 로고
    • Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: Growth factor and Ras signaling pathways
    • Newton HB. Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: growth factor and Ras signaling pathways. Expert Rev Anticancer Ther 2003; 3:595-614.
    • (2003) Expert Rev Anticancer Ther , vol.3 , pp. 595-614
    • Newton, H.B.1
  • 4
    • 1142287357 scopus 로고    scopus 로고
    • Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis
    • Newton HB. Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis. Expert Rev Anticancer Ther 2004; 4:105-128.
    • (2004) Expert Rev Anticancer Ther , vol.4 , pp. 105-128
    • Newton, H.B.1
  • 5
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, Van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352:987-996.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van den Bent, M.J.3
  • 6
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005; 352:997-1003.
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 7
    • 33748043985 scopus 로고    scopus 로고
    • Temozolomide- mediated radiation enhancement in glioblastoma: A report on underlying mechanisms
    • This in-vivo study showsthe synergistic effect ofcombined chemo-irradiation inGBM cell lines and xenografts with MGMT promoter gene methylation. It offers an explanation for the improved outcome of patients treated with combined chemoirradiation with TMZ for GBM with MGMT promoter gene methylation
    • Chakravarti A, Erkkinen MG, Nestler U, et al. Temozolomide- mediated radiation enhancement in glioblastoma: a report on underlying mechanisms. Clin Cancer Res 2006; 12:4738-4746. This in-vivo study showsthe synergistic effect ofcombined chemo-irradiation inGBM cell lines and xenografts with MGMT promoter gene methylation. It offers an explanation for the improved outcome of patients treated with combined chemoirradiation with TMZ for GBM with MGMT promoter gene methylation.
    • (2006) Clin Cancer Res , vol.12 , pp. 4738-4746
    • Chakravarti, A.1    Erkkinen, M.G.2    Nestler, U.3
  • 8
    • 11144349554 scopus 로고    scopus 로고
    • Frequent promotor hypermethylation and low expression of the MGMT gene in oligodendroglial tumors
    • Möllemann M, Wolter M, Felsberg J, et al. Frequent promotor hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Int J Cancer 2004; 113:379-385.
    • (2004) Int J Cancer , vol.113 , pp. 379-385
    • Möllemann, M.1    Wolter, M.2    Felsberg, J.3
  • 9
    • 22344447421 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas
    • 6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. Clin Cancer Res 2005; 11:5167-5174.
    • (2005) Clin Cancer Res , vol.11 , pp. 5167-5174
    • Brell, M.1    Tortosa, A.2    Verger, E.3
  • 10
    • 11144355301 scopus 로고    scopus 로고
    • Phase II study of neoadjuvant 1, 3-bis(2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: A North American Brain Tumor Consortium Trial
    • Chang SM, Prados MD, Yung WKA, et al. Phase II study of neoadjuvant 1, 3-bis(2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: a North American Brain Tumor Consortium Trial. Cancer 2004; 100:1712-1716.
    • (2004) Cancer , vol.100 , pp. 1712-1716
    • Chang, S.M.1    Prados, M.D.2    Yung, W.K.A.3
  • 11
    • 33749075532 scopus 로고    scopus 로고
    • Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03
    • Herrlinger U, Rieger J, Koch D, et al. Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03. J Clin Oncol 2006; 24:4412-4417.
    • (2006) J Clin Oncol , vol.24 , pp. 4412-4417
    • Herrlinger, U.1    Rieger, J.2    Koch, D.3
  • 12
    • 34047242618 scopus 로고    scopus 로고
    • Gerber DE, Grossman SA, ZeltzmanM, et al. The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas. Neuro Oncol 2007; 9:47-52. The study emphasizes the potential toxicity of combined chemo-irradiation with TMZ, with severe myelotoxicity in 20% of cases and persistent myelosuppression in 4% of cases.
    • Gerber DE, Grossman SA, ZeltzmanM, et al. The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas. Neuro Oncol 2007; 9:47-52. The study emphasizes the potential toxicity of combined chemo-irradiation with TMZ, with severe myelotoxicity in 20% of cases and persistent myelosuppression in 4% of cases.
  • 13
    • 3543148964 scopus 로고    scopus 로고
    • Immediate postradiotherapy changes in malignant glioma can mimic tumor progression
    • De Wit MCY, De Bruin HG, Eijkenboom WMH, et al. Immediate postradiotherapy changes in malignant glioma can mimic tumor progression. Neurology 2004; 63:535-537.
    • (2004) Neurology , vol.63 , pp. 535-537
    • De Wit, M.C.Y.1    De Bruin, H.G.2    Eijkenboom, W.M.H.3
  • 14
    • 33846955124 scopus 로고    scopus 로고
    • Chamberlain MC, Glantz MJ, Chalmers L, et al. Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma. J Neurooncol 2007; 82:81-83. This study showed a high incidence (14%) of early radionecrosis after concomitant chemo-irradiation in GBM, which in fact were half of the patients that were operated upon for an early recurrence. The clinical importance of this observation is the need to consider second surgery in patients with progressive lesions shortly after radiotherapy, especially if clinically symptomatic.
    • Chamberlain MC, Glantz MJ, Chalmers L, et al. Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma. J Neurooncol 2007; 82:81-83. This study showed a high incidence (14%) of early radionecrosis after concomitant chemo-irradiation in GBM, which in fact were half of the patients that were operated upon for an early recurrence. The clinical importance of this observation is the need to consider second surgery in patients with progressive lesions shortly after radiotherapy, especially if clinically symptomatic.
  • 15
    • 34848825299 scopus 로고    scopus 로고
    • The incidence of pseudoprogression in a cohort of malignant glioma patients treated with chemo-radiation with temozolomide [abstract]
    • Taal W, Brandsma D, De Bruin HG, et al. The incidence of pseudoprogression in a cohort of malignant glioma patients treated with chemo-radiation with temozolomide [abstract]. J Clin Oncol 2007; 25 (18S):2009.
    • (2009) J Clin Oncol 2007; 25 (18S)
    • Taal, W.1    Brandsma, D.2    De Bruin, H.G.3
  • 16
    • 31844438108 scopus 로고    scopus 로고
    • Perfusion and diffusion MRI of glioblastoma progression in a four year prospective temozolomide clinical trial
    • Leimgruber A, Osterman S, Yeon EJ, et al. Perfusion and diffusion MRI of glioblastoma progression in a four year prospective temozolomide clinical trial. Int J Radiat Oncol Biol Phys 2006; 64:869-875.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 869-875
    • Leimgruber, A.1    Osterman, S.2    Yeon, E.J.3
  • 17
    • 33745532038 scopus 로고    scopus 로고
    • ••], two randomized studies showing that earlyPCV chemotherapy with radiotherapy improves PFS, but not overall survival, and the much better outcome of 1p/19q codeleted oligodendroglial tumors.
    • ••], two randomized studies showing that earlyPCV chemotherapy with radiotherapy improves PFS, but not overall survival, and the much better outcome of 1p/19q codeleted oligodendroglial tumors.
  • 18
    • 33745575716 scopus 로고    scopus 로고
    • ••], two randomized studies showing that earlyPCV chemotherapy with radiotherapy improves PFS, but not overall survival, and the much better outcome of 1p/19q codeleted oligodendroglial tumors.
    • ••], two randomized studies showing that earlyPCV chemotherapy with radiotherapy improves PFS, but not overall survival, and the much better outcome of 1p/19q codeleted oligodendroglial tumors.
  • 19
    • 0032494479 scopus 로고    scopus 로고
    • Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas
    • Cairncross JG, Ueki K, Zlatescu MC, et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 1998; 90:1473-1479.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1473-1479
    • Cairncross, J.G.1    Ueki, K.2    Zlatescu, M.C.3
  • 20
    • 0344863443 scopus 로고    scopus 로고
    • Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features
    • Van den Bent MJ, Looijenga LHJ, Langenberg K, et al. Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features. Cancer 2003; 97:1276-1284.
    • (2003) Cancer , vol.97 , pp. 1276-1284
    • Van den Bent, M.J.1    Looijenga, L.H.J.2    Langenberg, K.3
  • 21
    • 0034307067 scopus 로고    scopus 로고
    • Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendroglioma
    • Bauman GS, Ino Y, Yeki K, et al. Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendroglioma. Int J Radiat Oncol Biol Phys 2000; 48:825-830.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 825-830
    • Bauman, G.S.1    Ino, Y.2    Yeki, K.3
  • 22
    • 0033951824 scopus 로고    scopus 로고
    • Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytoma, and mixed oligoastrocytomas
    • Smith JS, Perry A, Borell TJ, et al. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytoma, and mixed oligoastrocytomas. J Clin Oncol 2000; 18:636-645.
    • (2000) J Clin Oncol , vol.18 , pp. 636-645
    • Smith, J.S.1    Perry, A.2    Borell, T.J.3
  • 23
    • 33749471311 scopus 로고    scopus 로고
    • •], research that identified 1p/19q codeletion to be mediated by a balanced translocation.
    • •], research that identified 1p/19q codeletion to be mediated by a balanced translocation.
  • 24
    • 33750563258 scopus 로고    scopus 로고
    • •], research that identified 1p/19q codeletion to be mediated by a balanced translocation.
    • •], research that identified 1p/19q codeletion to be mediated by a balanced translocation.
  • 25
    • 33749135459 scopus 로고    scopus 로고
    • •], established the correlation between 1p/19q loss and response to temozolomide in oligodendroglial tumors.
    • •], established the correlation between 1p/19q loss and response to temozolomide in oligodendroglial tumors.
  • 26
    • 33750580929 scopus 로고    scopus 로고
    • •], established the correlation between 1p/19q loss and response to temozolomide in oligodendroglial tumors.
    • •], established the correlation between 1p/19q loss and response to temozolomide in oligodendroglial tumors.
  • 27
    • 4644329614 scopus 로고    scopus 로고
    • Response to 2nd line PCV chemotherapy in recurrent oligodendroglioma after 1st line temozolomide
    • Triebels V, Taphoorn MJB, Brandes AA, et al. Response to 2nd line PCV chemotherapy in recurrent oligodendroglioma after 1st line temozolomide. Neurology 2004; 63:904-906.
    • (2004) Neurology , vol.63 , pp. 904-906
    • Triebels, V.1    Taphoorn, M.J.B.2    Brandes, A.A.3
  • 28
    • 0038157019 scopus 로고    scopus 로고
    • Second line chemotherapy with Temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972
    • Van den Bent MJ, Chinot O, Boogerd W, et al. Second line chemotherapy with Temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972. Ann Oncol 2003; 14:599-602.
    • (2003) Ann Oncol , vol.14 , pp. 599-602
    • Van den Bent, M.J.1    Chinot, O.2    Boogerd, W.3
  • 29
    • 33646061363 scopus 로고    scopus 로고
    • 6-methylguanine DNA methyltransferase protein expression
    • 6-methylguanine DNA methyltransferase protein expression. Cancer 2006; 106:1759-1765.
    • (2006) Cancer , vol.106 , pp. 1759-1765
    • Levin, N.1    Lavon, I.2    Zelikovitsh, B.3
  • 30
    • 2442495498 scopus 로고    scopus 로고
    • Development of novel targeted therapies in the treatment of malignant glioma
    • Rich JN, Bigner DD. Development of novel targeted therapies in the treatment of malignant glioma. Nat Rev Drug Discov 2004; 3:430-446.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 430-446
    • Rich, J.N.1    Bigner, D.D.2
  • 32
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ. Cancer cell cycles. Science 1996; 274:1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 33
    • 0038278706 scopus 로고    scopus 로고
    • Mitogenic signaling cascades in glial tumors
    • Kapoor GS, O'Rourke DM. Mitogenic signaling cascades in glial tumors. Neurosurgery 2003; 52:1425-1434.
    • (2003) Neurosurgery , vol.52 , pp. 1425-1434
    • Kapoor, G.S.1    O'Rourke, D.M.2
  • 34
    • 0030799909 scopus 로고    scopus 로고
    • Somatic mutations of PTEN in glioblastoma multiforme
    • Wang SI, Puc J, Li J, et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 1997; 57:4183-4186.
    • (1997) Cancer Res , vol.57 , pp. 4183-4186
    • Wang, S.I.1    Puc, J.2    Li, J.3
  • 35
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, De la Pompa JL, et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998; 95:29-39.
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    De la Pompa, J.L.3
  • 36
    • 0033604614 scopus 로고    scopus 로고
    • Signaling via vascular endothelial growth factor receptors
    • Petrova TV, Makinen T, Alitalo K. Signaling via vascular endothelial growth factor receptors. Exp Cell Res 1999; 253:117-130.
    • (1999) Exp Cell Res , vol.253 , pp. 117-130
    • Petrova, T.V.1    Makinen, T.2    Alitalo, K.3
  • 37
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Weich HA, et al. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 1992; 359:845-848.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3
  • 38
    • 0034757675 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas
    • Chaudhry IH, O'Donovan DG, Brenchley PE, et al. Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas. Histopathology 2001; 39:409-415.
    • (2001) Histopathology , vol.39 , pp. 409-415
    • Chaudhry, I.H.1    O'Donovan, D.G.2    Brenchley, P.E.3
  • 39
    • 32944479646 scopus 로고    scopus 로고
    • Therapeutic advances in the treatment of glioblastoma: Rationale and potential role of targeted agents
    • Reardon DA, Wen PY. Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents. Oncologist 2006; 11:152-164.
    • (2006) Oncologist , vol.11 , pp. 152-164
    • Reardon, D.A.1    Wen, P.Y.2
  • 40
    • 4944255253 scopus 로고    scopus 로고
    • Genetic pathways to glioblastoma: A population-based study
    • Ohgaki H, Dessen P, Jourde B, et al. Genetic pathways to glioblastoma: a population-based study. Cancer Res 2004; 64:6892-6899.
    • (2004) Cancer Res , vol.64 , pp. 6892-6899
    • Ohgaki, H.1    Dessen, P.2    Jourde, B.3
  • 41
    • 0030017885 scopus 로고    scopus 로고
    • Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
    • Watanabe K, Tachibana O, Sata K, et al. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996; 6:217-223.
    • (1996) Brain Pathol , vol.6 , pp. 217-223
    • Watanabe, K.1    Tachibana, O.2    Sata, K.3
  • 42
    • 0026521394 scopus 로고
    • Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
    • Ekstrand AJ, Sugawa N, James CD, et al. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci U S A 1992; 89:4309-4313.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 4309-4313
    • Ekstrand, A.J.1    Sugawa, N.2    James, C.D.3
  • 43
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • Huang HS, Nagane M, Klingbeil CK, et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem 1997; 272:2927-2935.
    • (1997) J Biol Chem , vol.272 , pp. 2927-2935
    • Huang, H.S.1    Nagane, M.2    Klingbeil, C.K.3
  • 44
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • Frederick L, Wang XY, Eley G, et al. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 2000; 60:1383-1387.
    • (2000) Cancer Res , vol.60 , pp. 1383-1387
    • Frederick, L.1    Wang, X.Y.2    Eley, G.3
  • 45
    • 3042757984 scopus 로고    scopus 로고
    • Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance
    • Aldape KD, Ballman K, Furth A, et al. Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance. J Neuropathol Exp Neurol 2004; 63:700-707.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 700-707
    • Aldape, K.D.1    Ballman, K.2    Furth, A.3
  • 46
    • 31544474851 scopus 로고    scopus 로고
    • Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma
    • Prados MD, Lamborn KR, Chang S, et al. Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma. Neuro Oncol 2006; 8:67-78.
    • (2006) Neuro Oncol , vol.8 , pp. 67-78
    • Prados, M.D.1    Lamborn, K.R.2    Chang, S.3
  • 47
    • 32944478030 scopus 로고    scopus 로고
    • Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma
    • Reardon DA, Quinn JA, Vredenburgh JJ, et al. Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma. Clin Cancer Res 2006; 12:860-868.
    • (2006) Clin Cancer Res , vol.12 , pp. 860-868
    • Reardon, D.A.1    Quinn, J.A.2    Vredenburgh, J.J.3
  • 48
    • 1842500007 scopus 로고    scopus 로고
    • Phase II trial of gefitinib in recurrent glioblastoma
    • Rich JN, Reardon DA, Peery T, et al. Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 2004; 22:133-142.
    • (2004) J Clin Oncol , vol.22 , pp. 133-142
    • Rich, J.N.1    Reardon, D.A.2    Peery, T.3
  • 49
    • 23944478922 scopus 로고    scopus 로고
    • Phase II study of ZD1839 in patients with newly diagnosed grade 4 astrocytoma [abstract]
    • 14S:1505
    • Uhm JH, Ballman KV, Giannini C, et al. Phase II study of ZD1839 in patients with newly diagnosed grade 4 astrocytoma [abstract]. J Clin Oncol 2004; 22 (14S):1505.
    • (2004) J Clin Oncol , pp. 22
    • Uhm, J.H.1    Ballman, K.V.2    Giannini, C.3
  • 50
    • 16844384784 scopus 로고    scopus 로고
    • A phase II trial of erlotinib (OSI-774) in patients (pts) with recurrent malignant gliomas (MG) not on EIAEDs [abstract]
    • 14S:1502
    • Raizer JJ, Abrey LE, Wen P, et al. A phase II trial of erlotinib (OSI-774) in patients (pts) with recurrent malignant gliomas (MG) not on EIAEDs [abstract]. J Clin Oncol 2004; 22 (14S):1502.
    • (2004) J Clin Oncol , pp. 22
    • Raizer, J.J.1    Abrey, L.E.2    Wen, P.3
  • 51
    • 33750002725 scopus 로고    scopus 로고
    • Phase II study of erlotinib single agent therapy in recurrent glioblastoma multiforme
    • Vogelbaum MA, Peereboom DM, Stevens G, et al. Phase II study of erlotinib single agent therapy in recurrent glioblastoma multiforme. Eur J Cancer Suppl 2005; 3:135.
    • (2005) Eur J Cancer Suppl , vol.3 , pp. 135
    • Vogelbaum, M.A.1    Peereboom, D.M.2    Stevens, G.3
  • 52
    • 27744506881 scopus 로고    scopus 로고
    • Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: Tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
    • Lassman AB, Rossi MR, Raizer JJ, et al. Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01. Clin Cancer Res 2005; 11:7841-7850.
    • (2005) Clin Cancer Res , vol.11 , pp. 7841-7850
    • Lassman, A.B.1    Rossi, M.R.2    Raizer, J.J.3
  • 53
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff IK, Wang MY, Vivanco I, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 2005; 353:2012-2024.
    • (2005) N Engl J Med , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 54
    • 34848820863 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib (E) versus temozolomide (TMZ) or BCNU in recurrent glioblastoma multiforme (GBM): EORTC 26034 [abstract]
    • Van den Bent MJ, Brandes A, Rampling R, et al. Randomized phase II trial of erlotinib (E) versus temozolomide (TMZ) or BCNU in recurrent glioblastoma multiforme (GBM): EORTC 26034 [abstract]. J Clin Oncol 2007; 25 (18S):2005.
    • (2005) J Clin Oncol 2007; 25 (18S)
    • Van den Bent, M.J.1    Brandes, A.2    Rampling, R.3
  • 55
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 56
    • 3042823868 scopus 로고    scopus 로고
    • The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
    • Chakravarti A, Zhai G, Suzuki Y, et al. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol 2004; 22:1926-1933.
    • (2004) J Clin Oncol , vol.22 , pp. 1926-1933
    • Chakravarti, A.1    Zhai, G.2    Suzuki, Y.3
  • 57
    • 17944377486 scopus 로고    scopus 로고
    • Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
    • Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A 2001; 98:10314-10319.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10314-10319
    • Neshat, M.S.1    Mellinghoff, I.K.2    Tran, C.3
  • 58
    • 23944453425 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
    • Galanis E, Buckner JC, Maurer MJ, et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 2005; 23:5294-5304.
    • (2005) J Clin Oncol , vol.23 , pp. 5294-5304
    • Galanis, E.1    Buckner, J.C.2    Maurer, M.J.3
  • 59
    • 21044431575 scopus 로고    scopus 로고
    • Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
    • Chang SM, Wen P, Cloughesy T, et al. Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest New Drugs 2005; 23:357-361.
    • (2005) Invest New Drugs , vol.23 , pp. 357-361
    • Chang, S.M.1    Wen, P.2    Cloughesy, T.3
  • 60
    • 33847402740 scopus 로고    scopus 로고
    • A pilot study to assess the tolerability and efficacy of RAD-001 (everolimus) with gefitinib in patients with recurrent glioblastoma multiforme (GBM)
    • 18S:1507
    • Nguyen TD, Lassman AB, Lis E, et al. A pilot study to assess the tolerability and efficacy of RAD-001 (everolimus) with gefitinib in patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol 2006; 24 (18S):1507.
    • (2006) J Clin Oncol , pp. 24
    • Nguyen, T.D.1    Lassman, A.B.2    Lis, E.3
  • 61
    • 2942670180 scopus 로고    scopus 로고
    • PDGF receptors - mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
    • Ostman A. PDGF receptors - mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev 2004; 15:275-286.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 275-286
    • Ostman, A.1
  • 62
    • 0036645057 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    • Lokker NA, Sullivan CM, Hollenbach SJ, et al. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res 2002; 62:3729-3735.
    • (2002) Cancer Res , vol.62 , pp. 3729-3735
    • Lokker, N.A.1    Sullivan, C.M.2    Hollenbach, S.J.3
  • 63
    • 0037421971 scopus 로고    scopus 로고
    • A human brain tumor-derived PDGFR-alpha deletion mutant is transforming
    • Clarke ID, Dirks PB. A human brain tumor-derived PDGFR-alpha deletion mutant is transforming. Oncogene 2003; 22:722-733.
    • (2003) Oncogene , vol.22 , pp. 722-733
    • Clarke, I.D.1    Dirks, P.B.2
  • 64
    • 16844382189 scopus 로고    scopus 로고
    • Multicenter phase II study of imatinib mesylate in patients with recurrent glioblastoma: An EORTC: NDDG/BTG Intergroup Study [abstract]
    • 14S:1501
    • Raymond E, Brandes A, Van Oosterom A, et al. Multicenter phase II study of imatinib mesylate in patients with recurrent glioblastoma: an EORTC: NDDG/BTG Intergroup Study [abstract]. J Clin Oncol 2004; 22 (14S):1501.
    • (2004) J Clin Oncol , pp. 22
    • Raymond, E.1    Brandes, A.2    Van Oosterom, A.3
  • 65
    • 33748376520 scopus 로고    scopus 로고
    • Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08
    • Wen PY, Yung WK, Lamborn KR, et al. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 2006; 12:4899-4907.
    • (2006) Clin Cancer Res , vol.12 , pp. 4899-4907
    • Wen, P.Y.1    Yung, W.K.2    Lamborn, K.R.3
  • 66
    • 26444621412 scopus 로고    scopus 로고
    • Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: A patient series
    • Dresemann G. Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: a patient series. Ann Oncol 2005; 16:1702-1708.
    • (2005) Ann Oncol , vol.16 , pp. 1702-1708
    • Dresemann, G.1
  • 67
    • 33644830094 scopus 로고    scopus 로고
    • Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme
    • Reardon DA, Egorin MJ, Quinn JA, et al. Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol 2005; 23:9359-9368.
    • (2005) J Clin Oncol , vol.23 , pp. 9359-9368
    • Reardon, D.A.1    Egorin, M.J.2    Quinn, J.A.3
  • 68
    • 34247476830 scopus 로고    scopus 로고
    • Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas
    • Desjardins A, Quinn JA, Vredenburgh JJ, et al. Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas. J Neurooncol 2007; 83:53-60.
    • (2007) J Neurooncol , vol.83 , pp. 53-60
    • Desjardins, A.1    Quinn, J.A.2    Vredenburgh, J.J.3
  • 69
    • 16844382092 scopus 로고    scopus 로고
    • A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM) [abstract]
    • 14S:1512
    • Conrad C, Friedman H, Reardon D, et al. A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM) [abstract]. J Clin Oncol 2004; 22 (14S):1512.
    • (2004) J Clin Oncol , pp. 22
    • Conrad, C.1    Friedman, H.2    Reardon, D.3
  • 70
    • 16844371774 scopus 로고    scopus 로고
    • A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM) [abstract]
    • 14S:1513
    • Reardon D, Friedman H, Yung WKA, et al. A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM) [abstract]. J Clin Oncol 2004; 22 (14S):1513.
    • (2004) J Clin Oncol , pp. 22
    • Reardon, D.1    Friedman, H.2    Yung, W.K.A.3
  • 71
    • 33947191055 scopus 로고    scopus 로고
    • Vredenburgh JJ, Desjardins A, Herndon JE, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 2007; 13:1253-1259. Results of the first phase II study showing high response rates and improved survival for the combination of bevacizumab and irinotecan in recurrent gliomas.
    • Vredenburgh JJ, Desjardins A, Herndon JE, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 2007; 13:1253-1259. Results of the first phase II study showing high response rates and improved survival for the combination of bevacizumab and irinotecan in recurrent gliomas.
  • 72
    • 33846149645 scopus 로고    scopus 로고
    • Batchelor TT, Sorensen AG, Di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007; 11:83-95. Phase II study with extensive neuro-imaging research indicating a strong antiedema effect of AZD2171 in glioblastoma patients, with an interesting 6-month PFS showing that antiangiogenic agents are indeed likely to play a major role in the management of high grade gliomas.
    • Batchelor TT, Sorensen AG, Di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007; 11:83-95. Phase II study with extensive neuro-imaging research indicating a strong antiedema effect of AZD2171 in glioblastoma patients, with an interesting 6-month PFS showing that antiangiogenic agents are indeed likely to play a major role in the management of high grade gliomas.
  • 73
    • 27244439817 scopus 로고    scopus 로고
    • Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: A North American Brain Tumor Consortium Study
    • Cloughesy TF, Kuhn J, Robins HI, et al. Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study. J Clin Oncol 2005; 23:6647-6656.
    • (2005) J Clin Oncol , vol.23 , pp. 6647-6656
    • Cloughesy, T.F.1    Kuhn, J.2    Robins, H.I.3
  • 74
    • 33747058029 scopus 로고    scopus 로고
    • Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: A North American Brain Tumor Consortium Study
    • Cloughesy TF, Wen PY, Robins HI, et al. Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study. J Clin Oncol 2006; 24:3651-3656.
    • (2006) J Clin Oncol , vol.24 , pp. 3651-3656
    • Cloughesy, T.F.1    Wen, P.Y.2    Robins, H.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.