Evidence for a Susceptibility Locus on Chromosome 10p15 in Early-Onset Obsessive-Compulsive Disorder

Biological Psychiatry

Volumn 62, Issue 8, 2007, Pages 856-862

  Hanna, Gregory L ^a   Veenstra VanderWeele, Jeremy ^b   Cox, Nancy J ^c   Van Etten, Michelle ^a   Fischer, Daniel J ^a   Himle, Joseph A ^a   Bivens, Nancy Chiu ^d   Wu, Xiaolin ^c   Roe, Cheryl A ^c   Hennessy, Kathleen A ^e   Dickel, Diane E ^f   Leventhal, Bennett L ^e   Cook Jr , Edwin H ^e  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Adenosine deaminase acting on RNA 3; genome scan; linkage analysis; microsatellite markers; obsessive compulsive disorder; single nucleotide polymorphisms

Indexed keywords

ADENOSINE DEAMINASE;

ARTICLE; CHROMOSOME; DISEASE PREDISPOSITION; FEMALE; GENE LOCUS; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGE OF ONSET; CHROMOSOMES, HUMAN, PAIR 10; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PEDIGREE; STATISTICS, NONPARAMETRIC;

EID: 34748853081     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2007.01.008     Document Type: Article

References (49)

1. American Psychiatric Association. Diagnostic and Statistical Manual for Mental Disorders. 4th ed, Text Revision (2000), American Psychiatric Association, Washington, DC
2. Arnold P.D., Sicard T., Burroughs E., Richter M.A., and Kennedy J.L. Glutamate transporter gene (SLC1A1) associated with obsessive-compulsive disorder. Arch Gen Psychiatry 63 (2006) 769-776
3. Badner J.A., Gershon E.X., and Goldin L.R. Optimal ascertainment strategies to detect linkage to common disease alleles. Am J Hum Genet 63 (1998) 880-888
4. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
5. Bienvenu O.J., Samuels J.F., Riddle M.A., Hoehn-Saric R., Liang K.Y., Cullen B.A.M., et al. The relationship of obsessive-compulsive disorder to possible spectrum disorders: Results from a family study. Biol Psychiatry 48 (2000) 287-293
6. Bolton P.F., Pickles A., Murphy M., and Rutter M. Autism, affective and other psychiatric disorders: Patterns of familial aggregation. Psychol Med 28 (1998) 385-395
7. Broman K.W., Murray J.C., Sheffield V.C., White R.L., and Weber J.L. Comprehensive human genetic maps: Individual and sex-specific variation in recombination. Am J Hum Genet 632 (1998) 861-869
8. Chen C.X., Dan-Sung C.C., Wang Q., Lai F., Carter K.C., and Nishikura K. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA 6 (2000) 755-767
9. Conne B., Stutz A., and Vassalli J.D. The 3' untranslated region of messenger RNA: A molecular "hotspot" for pathology?. Nat Med 6 (2000) 637-641
10. Dickel D.E., Veenstra-VanderWeele J., Cox N.J., Wu X., Fischer D.J., Van Etten-Lee M., et al. Association testing of the positional and functional candidate gene SLC1A1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry 63 (2006) 778-785
11. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders (1998), New York State Psychiatric Institute, New York
12. Fyer A.J., Lipsitz J.D., Mannuzza S., Aronowitz B., and Chapman T.F. A direct interview family study of obsessive-compulsive disorder. Psychol Med 35 (2005) 1-11
13. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown Obsessive Compulsive Scale I. Development, use, and reliability. Arch Gen Psychiatry 46 (1989) 1006-1011
14. Gudbjartsson D.F., Jonasson K., Frigge M.L., and Kong A. Allegro, a new computer program for multipoint linkage analysis. Nat Genet 25 (2000) 12-13
15. Hanna G.L., Fingerlin T.E., Himle J.A., and Boehnke M. Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Hum Hered 60 (2005) 1-9
16. Hanna G.L., Fischer D.J., Chadha K.R., Himle J.A., and Van Etten M. Familial and sporadic subtypes of early-onset obsessive-compulsive disorder. Biol Psychiatry 57 (2005) 895-900
17. Hanna G.L., Himle J.A., Curtis G.C., and Gillespie B.W. A family study of obsessive-compulsive disorder with pediatric probands. Am J Med Genet 134B (2005) 13-19
18. Hanna G.L., Veenstra-VanderWeele J., Cox N.J., Boehnke M., Himle J.A., Curtis G.C., et al. Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet 114B (2002) 541-552
19. Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., and Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62 (2005) 593-602
20. Kessler R.C., Chiu W.T., Demler O., Merikangas K.R., and Walters E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62 (2005) 617-627
21. Kong A., and Cox N. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61 (1997) 1179-1188
22. Lander E., and Kruglyak L. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11 (1995) 241-247
23. Leckman J.F., Pauls D.L., Zhang H., Rosario-Campos M.C., Katsovich L., Kidd K.K., et al. Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette Syndrome. Am J Med Genet 116 (2003) 60-68
24. Maas S., Kawahara Y., Tamburro K.M., and Nishikura K. A-to-I RNA editing and human disease. RNA Biology 3 (2006) 1-9
25. Maas S., Rich A., and Nishikura K. A-to-I RNA editing: Recent news and residual mysteries. J Biol Chem 278 (2003) 1391-1394
26. Mannuza S., Fyer A.J., Endicott J., and Klein D.F. Family Informant Schedule and Criteria (FISC) (1985), New York State Psychiatric Institute, Anxiety Disorders Clinic, New York
27. Mittaz L., Antonarakis S.E., Higuchi M., and Scott H.S. Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15. Hum Genet 100 (1997) 398-400
28. Nestadt G., Samuels J., Riddle M., Bienvenu III O.J., Liang K.Y., LaBuda M., et al. A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 57 (2000) 358-363
29. Nestadt G., Samuels J., Riddle M.A., Liang K.Y., Bienvenu O.J., Hoehn-Saric R., et al. The relationship between obsessive-compulsive disorder and anxiety and affective disorders: Results from the Johns Hopkins OCD Family Study. Psychol Med 31 (2001) 481-487
30. Orvaschel H. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic Version-5 (K-SADS-E-5) (1995), Nova Southeastern University, Center for Psychological Studies, Fort Lauderdale, FL
31. Palladino M., Keegan L.P., O'Connell M.A., and Reenan R.A. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell 102 (2000) 437-499
32. Pauls D.L., Alsobrook J.P., Goodman W., Rasmussen S., and Leckman J.F. A family study of obsessive-compulsive disorder. Am J Psychiatry 152 (1995) 76-84
33. Pauls D.L., and Hurst C.R. Schedule for Tourette and Other Behavioral Syndromes (1991), Child Study Center, Yale University School of Medicine, New Haven, CT
34. Reenan R.A. The RNA world meets behavior: A→ I pre-mRNA processing in animals. Trends Genet 17 (2001) 53-56
35. Rosario-Campos M.C., Leckman J.F., Curi M., Quatrano S., Katsovitch L., Miguel E.C., et al. A family study of early-onset obsessive-compulsive disorder. Am J Med Genet 136B (2005) 92-97
36. Rosario-Campos M.D., Miguel E.C., Quatrano S., Chacon P., Ferrao Y., Findley D., et al. The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): An instrument for assessing obsessive-compulsive symptom dimensions. Mol Psychiatry 11 (2006) 495-504
37. Roy M.A., Lanctot G., Merette C., Cliche D., Fournier J.P., Boutin P., et al. Clinical and methodological factors related to reliability of the best-estimate diagnostic procedure. Am J Psychiatry 154 (1997) 1726-1733
38. Samuels J.F., Riddle M.A., Greenberg B.D., Fyer A.J., McCracken J.T., Rauch S.L., et al. The OCD Collaborative Genetics Study: Methods and sample description. Am J Med Genet 141B (2006) 201-207
39. Shugart Y.Y., Samuels J., Willour V.L., Grados M.A., Greenberg B.D., Knowles J.A., et al. Genomewide linkage scan for obsessive-compulsive disorder: Evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry 11 (2006) 763-770
40. Skoog G., and Skoog I. A 40-year follow-up of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 56 (1999) 121-127
41. Stewart S.E., Geller D.A., Jenike M., Pauls D., Shaw D., Mullin B., et al. Long-term outcome of pediatric obsessive-compulsive disorder: A meta-analysis and qualitative review of the literature. Acta Psychiatr Scand 110 (2004) 4-13
42. Suarez B.K., Hampe C.L., and Van Eerdewegh P. Problems with replicating linkage claims in psychiatry. In: Gershon E.S., and Cloninger C.R. (Eds). Genetic Approaches to Mental Disorders (1994), American Psychiatric Press, Washington, DC 23-46
43. The Tourette Syndrome Association International Consortium for Genetics (2007): Genome scan for Tourette's disorder in affected sib-pair and multigenerational families. Am J Hum Genet 80 (2007) 265-272
44. Thomas D.C. Are we ready for genome-wide association studies?. Cancer Epidemiol Biomarkers Prev 15 (2006) 595-598
45. van Grootheest D.S., Cath D.C., Beekman A.T., and Boomsma D.I. Twin studies on obsessive-compulsive disorder: A review. Twin Res Hum Genet 8 (2005) 450-458
46. Veenstra-VanderWeele J., Kim S.J., Gonen D., Hanna G.L., Leventhal B.L., and Cook E.H. Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder. Mol Psychiatry 6 (2001) 160-167
47. Weissman M.M., Bland R.C., Canino G.J., Greenwald S., Hwu H.G., Lee C.K., et al. The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. J Clin Psychiatry 55 suppl 3 (1994) 5-10
48. Willour V.L., Shugart Y.Y., Samuels J., Grados M., Cullen B., Bienvenu III O.J., et al. Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder. Am J Hum Genet 75 (2004) 508-513
49. Zohar A.H., Ratzoni G., Pauls D.L., Apter A., Bleich A., Kron S., et al. An epidemiological study of obsessive-compulsive disorder and related disorders in Israeli adolescents. J Am Acad Child Adolesc Psychiatry 31 (1992) 1057-1061