Optimal ascertainment strategies to detect linkage to common disease alleles

American Journal of Human Genetics

Volumn 63, Issue 3, 1998, Pages 880-888

  Badner, Judith A ^a   Gershon, Elliot S ^a,b   Goldin, Lynn R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; GENE LOCUS; GENETIC DISORDER; GENETIC LINKAGE; GENETIC MODEL; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; PEDIGREE; PRIORITY JOURNAL;

EID: 0032231878     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302007     Document Type: Article

References (20)

1. Baron M, Endicott J, Lerer B, Loth JE, Alexander JR, Simon R, Sharpe L, et al (1994) A pedigree series for mapping disease genes in bipolar affective disorder: sampling, assessment, and analytic considerations. Psychiatr Genet 4: 43-55
2. Cottingham RW Jr, Idury RM, Schäffer AA (1993) Faster sequential genetic linkage computations. Am J Hum Genet 53: 252-263
3. Davis S, Weeks DE (1997) Comparison of nonparametric statistics for detection of linkage in nuclear families: single-marker evaluation. Am J Hum Genet 61:1431-1444
4. Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, et al (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325: 783-787
5. Greenberg DA, Hodge SE (1989) Linkage analysis under $random$ and $genetic$ reduced penetrance. Genet Epidemiol 6:259-264
6. Hasstedt SJ (1994) Pedigree analysis package, version 4.02. Department of Human Genetics, University of Utah, Salt Lake City
7. Hauser ER, Boehnke M, Guo SW, Risch N (1996) Affected sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet Epidemiol 13: 117-137
8. Holmans P (1993) Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet 52:362-374
9. James JW (1971) Frequency in relatives for an all-or-none trait. Ann Hum Genet 35:47-48
10. Kong A, Cox NJ (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61:1179-1188
11. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified approach. Am J Hum Genet 58:1347-1363
12. Kruglyak L, Lander ES (1995) Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454
13. Neuman RJ, Rice JP (1992) Two-locus models of disease. Genet Epidemiol 9:347-365
14. Ott J (1989) Computer-simulation methods in human linkage analysis. Proc Natl Acad Sci USA 86:4175-4178
15. Risch N (1987) Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 40:1-14
16. _ (1990a) Linkage strategies for genetically complex traits. I. Multilocus models [see comments]. Am J Hum Genet 46:222-228
17. _ (1990b) Linkage strategies for genetically complex traits. II. The power of affected relative pairs [see comments]. Am J Hum Genet 46:229-241
18. SAGE (1994) Statistical analysis for genetic epidemiology, version 2.2. Department of Biometry and Biostatistics, Rammelkamp Center for Education and Research, Metro Health Campus, Case Western Reserve University, Cleveland
19. Weeks DE, Ott J, Lathrop GM (1990) SLINK: a general simulation program for linkage analysis. Am J Hum Genet Suppl 47:A204
20. Wijsman EM, Amos CI (1997) Genetic analysis of simulated oligogenic traits in nuclear families and extended pedigrees: summary of GAW10 contributions. Genet Epidemiol 14: 719-735