Mechanism of interaction of niflumic acid with heterologously expressed kidney CLC-K chloride channels

Journal of Membrane Biology

Volumn 216, Issue 2-3, 2007, Pages 73-82

  Picollo, Alessandra ^a   Liantonio, Antonella ^b   Babini, Elena ^a   Camerino, Diana Conte ^b   Pusch, Michael ^a  

^a CNR   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

CLC K channel; Flufenamic acid; Niflumic acid

Indexed keywords

3 PHENYL 2 (4 CHLOROPHENOXY)PROPIONIC ACID; CHLORIDE CHANNEL; CHLORIDE ION; CLC PROTEIN; FLUFENAMIC ACID; NIFLUMIC ACID; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG MECHANISM; HUMAN; HUMAN CELL; INHIBITION KINETICS; KIDNEY CELL; NONHUMAN; RAT; VOLTAGE CLAMP;

ANIMALS; CHLORIDE CHANNELS; DRUG SYNERGISM; FLUFENAMIC ACID; HUMANS; KIDNEY; MODELS, BIOLOGICAL; NIFLUMIC ACID; PHENYLPROPIONATES; RATS; XENOPUS LAEVIS;

RATTUS;

EID: 34748814891     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-007-9034-z     Document Type: Article

References (22)

1. Adachi S, Uchida S, Ito H, Hata M, Hiroe M, Marumo F, Sasaki S (1994) Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney. J Biol Chem 269:17677-17683
2. Birkenhäger R, Otto E, Schurmann MJ, Vollmer M, Ruf EM, Maier-Lutz I, Beekmann F, Fekete A, Omran H, Feldmann D, Milford DV, Jeck N, Konrad M, Landau D, Knoers NV, Antignac C, Sudbrak R, Kispert A, Hildebrandt F (2001) Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure. Nat Genet 29:310-314
3. Brandt S, Jentsch TJ (1995) ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family. FEBS Lett 377:15-20
4. + secretion. Nature 414:558-561
5. Fong P (2004) CLC-K channels: if the drug fits, use it. EMBO Rep 5:565-566
6. Gögelein H, Dahlem D, Englert HC, Lang HJ (1990) Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas. FEBS Lett 268:79-82
7. Kalgutkar AS, Crews BC, Rowlinson SW, Marnett AB, Kozak KR, Remmel RP, Marnett LJ (2000) Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc Natl Acad Sci USA 97:925-930
8. Kieferle S, Fong P, Bens M, Vandewalle A, Jentsch TJ (1994) Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Proc Natl Acad Sci USA 91:6943-6947
9. + channel, by meclofenamic acid. Eur J Pharmacol 378:349-356
10. Liantonio A, Picollo A, Babini E, Carbonara G, Fracchiolla G, Loiodice F, Tortorella V, Pusch M, Camerino DC (2006) Activation and inhibition of kidney CLC-K chloride channels by fenamates. Mol Pharmacol 69:165-173
11. Liantonio A, Pusch M, Picollo A, Guida P, De Luca A, Pierno S, Fracchiolla G, Loiodice F, Tortorella P, Conte Camerino D (2004) Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers. J Am Soc Nephrol 15:13-20
12. Matsumura Y, Uchida S, Kondo Y, Miyazaki H, Ko SB, Hayama A, Morimoto T, Liu W, Arisawa M, Sasaki S, Marumo F (1999) Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Nat Genet 21:95-98
13. - channel by two closely related arylaminobenzoates. J Gen Physiol 102:1-23
14. Picollo A, Liantonio A, Didonna MP, Elia L, Camerino DC, Pusch M (2004) Molecular determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO Rep 5:584-589
15. Pusch M, Jentsch TJ (2005) Unique structure and function of chloride transporting CLC proteins. IEEE Trans Nanobiosci 4:49-57
16. Pusch M, Liantonio A, Bertorello L, Accardi A, De Luca A, Pierno S, Tortorella V, Camerino DC (2000) Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives. Mol Pharmacol 58:498-507
17. - channels. J Gen Physiol 116:825-844
18. Simon DB, Bindra RS, Mansfield TA, Nelson-Williams C, Mendonca E, Stone R, Schurman S, Nayir A, Alpay H, Bakkaloglu A, Rodriguez-Soriano J, Morales JM, Sanjad SA, Taylor CM, Pilz D, Brem A, Trachtman H, Griswold W, Richard GA, John E, Lifton RP (1997) Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet 17:171-178
19. Uchida S, Sasaki S (2005) Function of chloride channels in the kidney. Annu Rev Physiol 67:759-778
20. Vandewalle A, Cluzeaud F, Bens M, Kieferle S, Steinmeyer K, Jentsch TJ (1997) Localization and induction by dehydration of ClC-K chloride channels in the rat kidney. Am J Physiol 272:F678-F688
21. Vane JR, Botting RM (1998) Mechanism of action of nonsteroidal anti-inflammatory drugs. Am J Med 104:2S-8S, discussion 21S-22S
22. - channels in Xenopus oocytes. Mol Pharmacol 37:720-724