Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697)

European Journal of Pharmacology

Volumn 573, Issue 1-3, 2007, Pages 176-183

  Churchman, Adrian ^a   Baydoun, Anwar R ^a   Hoffman, Richard ^a  

^a UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

Angiogenesis; Apoptosis; Cyclo oxygenase 2; DuP 697; Human umbilical vein endothelial cell

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ANGIOGENESIS INHIBITOR; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 9; CELL DNA; CYCLOOXYGENASE 2 INHIBITOR; MATRIGEL; PROSTAGLANDIN E2; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CAPILLARY ENDOTHELIUM; CELL PROLIFERATION; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IC 50; MICROTUBULE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; UMBILICAL VEIN;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 8; CELLS, CULTURED; CHROMATIN ASSEMBLY AND DISASSEMBLY; COLLAGEN; CULTURE MEDIA, SERUM-FREE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROST; DINOPROSTONE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENDOTHELIAL CELLS; FLOW CYTOMETRY; HUMANS; INDOMETHACIN; LAMININ; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGOPEPTIDES; PROTEOGLYCANS; THIOPHENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34648847355     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.057     Document Type: Article

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