PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading

Current Biology

Volumn 11, Issue 18, 2001, Pages 1392-1402

  Roberts, Marnie ^a   Barry, Simon ^b   Woods, Alison ^a   Van der Sluijs, Peter ^c   Norman, Jim ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0035908956     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00442-0     Document Type: Article

References (30)

1. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
2. Cells can use their transferrin receptors for locomotion
3. Moving membrane up to the front of migrating cells
4. A tyrosine-based sorting signal in the β2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration
5. PKC-α regulates β1 integrin-dependent cell motility through association and control of integrin traffic
6. Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling
7. In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella
8. Rab11 regulates recycling through the pericentriolar recycling endosome
9. Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes
10. Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network
11. The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions
12. Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11
13. ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway
14. ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements
15. Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments
16. Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism
17. Identification of discrete classes of endosome-derived small vesicles as a major cellular pool for recycling membrane proteins
18. A function for the AP3 coat complex in synaptic vesicle formation from endosomes
19. The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway
20. Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase pin1 during mitosis
21. Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes
22. Recycling of E-cadherin: A potential mechanism for regulating cadherin dynamics
23. The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells
24. Insulin stimulates guanine nucleotide exchange on Rab4 via a wortmannin-sensitive signaling pathway in rat adipocytes
25. Protein kinase B/akt and rab5 mediate Ras activation of endocytosis
26. Integrin affinity modulation
27. T cell receptor-dependent stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to the extracellular matrix
28. Cytohesin-1 regulates β2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1
29. A new method for detecting endocytosed proteins
30. Stage-specific assays for coated pit formation and coated vesicle budding in vitro