A new opioid designed multiple ligand derived from the μ opioid agonist endomorphin-2 and the δ opioid antagonist pharmacophore Dmt-Tic

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6876-6881

  Salvadori, Severo ^a   Trapella, Claudio ^a   Fiorini, Stella ^a   Negri, Lucia ^b   Lattanzi, Roberta ^b   Bryant, Sharon D ^c   Jinsmaa, Yunden ^c   Lazarus, Lawrence H ^c   Balboni, Gianfranco ^a,d  

^a UNIVERSITY OF FERRARA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Opioid receptors; Opioid receptors; Analgesia; Designed multiple ligand; Dmt Tic pharmacophore; Endomorphin 2; Opioid peptides; Physical dependence

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2',6' DIMETHYLTYROSINE; ANALGESIC AGENT; CARBOXYLIC ACID DERIVATIVE; DELTA OPIATE RECEPTOR ANTAGONIST; DELTORPHIN; ENDOMORPHIN 2; MU OPIATE RECEPTOR AGONIST; OPIATE AGONIST; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; GUINEA PIG; ILEUM; MALE; NONHUMAN; PHARMACOPHORE; RAT; SPRAGUE DAWLEY RAT;

DIPEPTIDES; DRUG DESIGN; LIGANDS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 34548825663     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.047     Document Type: Article

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