Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 9, 2007, Pages 3143-3151

  Balboni, Gianfranco ^a,b   Onnis, Valentina ^a   Congiu, Cenzo ^a   Zotti, Margherita ^b   Sasaki, Yusuke ^c   Ambo, Akihiro ^c   Bryant, Sharon D ^d   Jinsmaa, Yunden ^d   Lazarus, Lawrence H ^d   Lazzari, Ilaria ^b   Trapella, Claudio ^b   Salvadori, Severo ^b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Opioid receptors; Designed multiple ligands; Dmt Tic pharmacophore; Opioid peptides

Indexed keywords

DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; ESTER DERIVATIVE; FUNCTIONAL GROUP; LIGAND; LYSINE; MU OPIATE RECEPTOR; OPIATE;

ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; ISOTOPE LABELING; MALE; MYENTERIC PLEXUS; NONHUMAN; PHARMACOPHORE; RAT; SMALL INTESTINE;

ANIMALS; BINDING SITES; DIPEPTIDES; GUINEA PIGS; LIGANDS; LYSINE; MALE; MOLECULAR CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 33947581997     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.039     Document Type: Article

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