-
1
-
-
0037260139
-
Cancer statistics, 2003
-
Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics, 2003. CA Cancer J Clin 2003;53:5-26.
-
(2003)
CA Cancer J Clin
, vol.53
, pp. 5-26
-
-
Jemal, A.1
Murray, T.2
Samuels, A.3
Ghafoor, A.4
Ward, E.5
Thun, M.J.6
-
2
-
-
0027571473
-
Small cell lung cancer: Etiology, biology, clinical features, staging, and treatment
-
Cook RM, Miller YE, Bunn PA, Jr. Small cell lung cancer: etiology, biology, clinical features, staging, and treatment. Curr Probl Cancer 1993;17:69-141.
-
(1993)
Curr Probl Cancer
, vol.17
, pp. 69-141
-
-
Cook, R.M.1
Miller, Y.E.2
Bunn Jr., P.A.3
-
3
-
-
0031934761
-
Molecular abnormalities in lung cancer
-
Salgia R, Skarin AT. Molecular abnormalities in lung cancer. J Clin Oncol 1998;16:1207-17.
-
(1998)
J Clin Oncol
, vol.16
, pp. 1207-1217
-
-
Salgia, R.1
Skarin, A.T.2
-
4
-
-
0037352170
-
Involvement of P13K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
-
Chang F, Lee JT, Navolanic PM, et al. Involvement of P13K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 2003;17:590-603.
-
(2003)
Leukemia
, vol.17
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
-
5
-
-
0037069932
-
In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways
-
Kraus AC, Ferber I, Bachmann SO, et al. In vitro chemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways. Oncogene 2002;21:8683-95.
-
(2002)
Oncogene
, vol.21
, pp. 8683-8695
-
-
Kraus, A.C.1
Ferber, I.2
Bachmann, S.O.3
-
6
-
-
0036729867
-
Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
-
Krystal GW, Sulanke G, Litz J. Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol Cancer Ther 2002;1:913-22.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 913-922
-
-
Krystal, G.W.1
Sulanke, G.2
Litz, J.3
-
7
-
-
0035872199
-
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
-
Brognard J, Clark AS, Ni Y, Dennis PA. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 2001;61:3986-97.
-
(2001)
Cancer Res
, vol.61
, pp. 3986-3997
-
-
Brognard, J.1
Clark, A.S.2
Ni, Y.3
Dennis, P.A.4
-
8
-
-
0033018109
-
Mechanism of protein kinase B activation by insulin/insulin-like growth factor-I revealed by specific inhibitors of phosphoinositide 3-kinase-significance for diabetes and cancer
-
Galetic I, Andjelkovic M, Meier R, Brodbeck D, Park J, Hemmings BA. Mechanism of protein kinase B activation by insulin/insulin-like growth factor-I revealed by specific inhibitors of phosphoinositide 3-kinase-significance for diabetes and cancer. Pharmacol Ther 1999;82:409-25.
-
(1999)
Pharmacol Ther
, vol.82
, pp. 409-425
-
-
Galetic, I.1
Andjelkovic, M.2
Meier, R.3
Brodbeck, D.4
Park, J.5
Hemmings, B.A.6
-
9
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
Bellacosa A, Testa JR, Staal SP, Tsichlis PN. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science (Wash DC) 1991;254:274-7.
-
(1991)
Science (Wash DC)
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
11
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-68.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
-
12
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-I
-
Alessi DR, Andjelkovic M, Caudwell B, et al. Mechanism of activation of protein kinase B by insulin and IGF-I. EMBO J 1996;15:6541-51.
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
-
13
-
-
0033517244
-
Akt is more than just a Bad kinase
-
Khwaja A. Akt is more than just a Bad kinase. Nature (Lond) 1999;401:33-4.
-
(1999)
Nature (Lond)
, vol.401
, pp. 33-34
-
-
Khwaja, A.1
-
14
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 1994;269:5241-8.
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
15
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science (Wash DC) 2002;296:1655-7.
-
(2002)
Science (Wash DC)
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
16
-
-
0035990924
-
Inhibition of protein kinase B/Akt. Implications for cancer therapy
-
Hill MM, Hemmings BA. Inhibition of protein kinase B/Akt. implications for cancer therapy. Pharmacol Ther 2002;93:243-51.
-
(2002)
Pharmacol Ther
, vol.93
, pp. 243-251
-
-
Hill, M.M.1
Hemmings, B.A.2
-
17
-
-
0023931559
-
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist
-
Portoghese PS, Sultana M, Takemori AE. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur Pharmacol 1988;146:185-6.
-
(1988)
Eur Pharmacol
, vol.146
, pp. 185-186
-
-
Portoghese, P.S.1
Sultana, M.2
Takemori, A.E.3
-
18
-
-
0026776660
-
The immunosuppressive effect of delta-opioid receptor antagonist on rat renal allograft survival
-
Arakawa K, Akami T, Okamoto M, Oka T, Nagase H, Matsumoto S. The immunosuppressive effect of delta-opioid receptor antagonist on rat renal allograft survival. Transplantation 1992;53:951-3.
-
(1992)
Transplantation
, vol.53
, pp. 951-953
-
-
Arakawa, K.1
Akami, T.2
Okamoto, M.3
Oka, T.4
Nagase, H.5
Matsumoto, S.6
-
19
-
-
0031658880
-
The delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [correction of 7-benzylspiroindanylnaltrexone], prolongs renal allograft survival in a rat model
-
Linner KM, Stickney BJ, Quist HE, Sharp BM, Portoghese PS. The delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [correction of 7-benzylspiroindanylnaltrexone], prolongs renal allograft survival in a rat model. Eur Pharmacol 1998;354:R3-5.
-
(1998)
Eur Pharmacol
, vol.354
-
-
Linner, K.M.1
Stickney, B.J.2
Quist, H.E.3
Sharp, B.M.4
Portoghese, P.S.5
-
20
-
-
0022006760
-
Establishment and identification of small cell lung cancer cell lines having classic and variant features
-
Carney DN, Gazdar AF, Bepler G, et al. Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res 1985;45:2913-23.
-
(1985)
Cancer Res
, vol.45
, pp. 2913-2923
-
-
Carney, D.N.1
Gazdar, A.F.2
Bepler, G.3
-
21
-
-
0031756961
-
Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease
-
Chen Y. Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease. Cancer Lett 1998;131:191-200.
-
(1998)
Cancer Lett
, vol.131
, pp. 191-200
-
-
Chen, Y.1
-
22
-
-
0022606830
-
Small cell carcinoma cell lines contain opioid peptides and receptors
-
Roth KA, Barchas JD. Small cell carcinoma cell lines contain opioid peptides and receptors. Cancer (Phila) 1986;57:769-73.
-
(1986)
Cancer (Phila)
, vol.57
, pp. 769-773
-
-
Roth, K.A.1
Barchas, J.D.2
-
23
-
-
0025341202
-
Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines
-
Maneckjee R, Minna JD. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci USA 1990;87:3294-8.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 3294-3298
-
-
Maneckjee, R.1
Minna, J.D.2
-
24
-
-
0029913445
-
Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand
-
Campa MJ, Schreiber G, Bepler G, et al. Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand. Cancer Res 1996;56:1695-1701.
-
(1996)
Cancer Res
, vol.56
, pp. 1695-1701
-
-
Campa, M.J.1
Schreiber, G.2
Bepler, G.3
-
25
-
-
0024511825
-
Beta-endorphin and neurotensin stimulate in vitro clonal growth of human SCLC cells
-
Davis TP, Burgess HS, Crowell S, Moody TW, Culling-Berglund A, Liu RH. Beta-endorphin and neurotensin stimulate in vitro clonal growth of human SCLC cells. Eur Pharmacol 1989;161:283-5.
-
(1989)
Eur Pharmacol
, vol.161
, pp. 283-285
-
-
Davis, T.P.1
Burgess, H.S.2
Crowell, S.3
Moody, T.W.4
Culling-Berglund, A.5
Liu, R.H.6
-
26
-
-
0032534025
-
The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway
-
Moore SM, Rintoul RC, Walker TR, Chilvers ER, Haslett C, Sethi T. The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway. Cancer Res 1998;58:5239-47.
-
(1998)
Cancer Res
, vol.58
, pp. 5239-5247
-
-
Moore, S.M.1
Rintoul, R.C.2
Walker, T.R.3
Chilvers, E.R.4
Haslett, C.5
Sethi, T.6
-
27
-
-
0033545393
-
Intracellular signalling: PDK1-a kinase at the hub of things
-
Belham C, Wu S, Avruch J. Intracellular signalling: PDK1-a kinase at the hub of things. Curr Biol 1999;9:R93-96.
-
(1999)
Curr Biol
, vol.9
-
-
Belham, C.1
Wu, S.2
Avruch, J.3
-
28
-
-
0030998441
-
CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein
-
Prasad KV, Ao Z, Yoon Y, et al. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc Natl Acad Sci USA 1997;94:6346-51.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 6346-6351
-
-
Prasad, K.V.1
Ao, Z.2
Yoon, Y.3
-
29
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (Lond) 2001;411:494-8.
-
(2001)
Nature (Lond)
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
30
-
-
0038624395
-
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
-
Peng XD, Xu PZ, Chen ML, et al. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 2003;17:1352-65.
-
(2003)
Genes Dev
, vol.17
, pp. 1352-1365
-
-
Peng, X.D.1
Xu, P.Z.2
Chen, M.L.3
-
31
-
-
0027985282
-
Opioids induce while nicotine suppresses apoptosis in human lung cancer cells
-
Maneckjee R, Minna JD. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ 1994;5:1033-40.
-
(1994)
Cell Growth Differ
, vol.5
, pp. 1033-1040
-
-
Maneckjee, R.1
Minna, J.D.2
-
32
-
-
0036682055
-
Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth
-
Gupta K, Kshirsagar S, Chang L, et al. Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res 2002;62:4491-8.
-
(2002)
Cancer Res
, vol.62
, pp. 4491-4498
-
-
Gupta, K.1
Kshirsagar, S.2
Chang, L.3
-
33
-
-
0034641936
-
Apoptosis in the nervous system
-
Yuan J, Yankner BA. Apoptosis in the nervous system. Nature (Lond) 2000;407:802-9.
-
(2000)
Nature (Lond)
, vol.407
, pp. 802-809
-
-
Yuan, J.1
Yankner, B.A.2
-
34
-
-
0036570241
-
Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma
-
Wischhusen J, Jung G, Radovanovic I, et al. Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Cancer Res 2002;62:2592-9.
-
(2002)
Cancer Res
, vol.62
, pp. 2592-2599
-
-
Wischhusen, J.1
Jung, G.2
Radovanovic, I.3
-
35
-
-
0029126581
-
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-I during Fas-mediated apoptosis
-
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-I during Fas-mediated apoptosis. J Exp Med 1995;182:865-74.
-
(1995)
J Exp Med
, vol.182
, pp. 865-874
-
-
Tian, Q.1
Taupin, J.2
Elledge, S.3
Robertson, M.4
Anderson, P.5
-
36
-
-
0030962139
-
The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins
-
Sladeczek F, Camonis JH, Burnol AF, Le Bouffant F. The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins. Mol Gen Genet 1997;254:571-7.
-
(1997)
Mol Gen Genet
, vol.254
, pp. 571-577
-
-
Sladeczek, F.1
Camonis, J.H.2
Burnol, A.F.3
Le Bouffant, F.4
-
37
-
-
0034725690
-
Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation
-
Shao J, Sheng H, DuBois RN, Beauchamp RD. Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation. J Biol Chem 2000l275:22916-24.
-
(2000)
J Biol Chem
, vol.275
, pp. 22916-22924
-
-
Shao, J.1
Sheng, H.2
DuBois, R.N.3
Beauchamp, R.D.4
-
38
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (Wash DC) 2004;304:1497-500.
-
(2004)
Science (Wash DC)
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
39
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
40
-
-
0037330953
-
Molecular and cellular biology of small cell lung cancer
-
Sattler M, Salgia R. Molecular and cellular biology of small cell lung cancer. Semin Oncol 2003;30:57-71.
-
(2003)
Semin Oncol
, vol.30
, pp. 57-71
-
-
Sattler, M.1
Salgia, R.2
-
41
-
-
0030614842
-
[D-Arg1,D-Trp5,7,9,Leu11]substance P: A novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells
-
Seckl MJ, Higgins T, Widmer F, Rozengurt E. [D-Arg1,D-Trp5,7,9,Leu11] substance P: a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells. Cancer Res 1997;57:51-4.
-
(1997)
Cancer Res
, vol.57
, pp. 51-54
-
-
Seckl, M.J.1
Higgins, T.2
Widmer, F.3
Rozengurt, E.4
-
42
-
-
0034105966
-
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord
-
Honore P, Luger NM, Sabino MA, et al. Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med 2000;6:521-8.
-
(2000)
Nat Med
, vol.6
, pp. 521-528
-
-
Honore, P.1
Luger, N.M.2
Sabino, M.A.3
-
43
-
-
0004329625
-
-
Philadelphia, PA: J.B. Lippincott Company
-
Patt RB, editor. Cancer pain. Philadelphia, PA: J.B. Lippincott Company; 1993. p. 1-650.
-
(1993)
Cancer Pain
, pp. 1-650
-
-
Patt, R.B.1
-
44
-
-
0033198831
-
Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice
-
Zhu Y, King MA, Schuller AG. et al. Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice. Neuron 1999;24:243-52.
-
(1999)
Neuron
, vol.24
, pp. 243-252
-
-
Zhu, Y.1
King, M.A.2
Schuller, A.G.3
-
45
-
-
0025827095
-
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice
-
Abdelhamid EE, Sultana M, Portoghese PS, Takemori AE. Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice. J Pharmacol Exp Ther 1991;258:299-303.
-
(1991)
J Pharmacol Exp Ther
, vol.258
, pp. 299-303
-
-
Abdelhamid, E.E.1
Sultana, M.2
Portoghese, P.S.3
Takemori, A.E.4
|