Vitamins, Minerals, and Mood

Psychological Bulletin

Volumn 133, Issue 5, 2007, Pages 747-760

  Kaplan, Bonnie J ^a,b   Crawford, Susan G ^b   Field, Catherine J ^c   Simpson, J Steven A ^d  

^a UNIVERSITY OF CALGARY   (Canada)

^b ALBERTA CHILDREN'S HOSPITAL   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

micronutrients; mood; mood disorders; nutrition

Indexed keywords

MINERAL; TRACE ELEMENT; VITAMIN;

AFFECT; ARTICLE; BRAIN; HUMAN; INBORN ERROR OF METABOLISM; METABOLISM; MOOD DISORDER; NUTRITIONAL DEFICIENCY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT;

AFFECT; BRAIN; DEFICIENCY DISEASES; HUMANS; METABOLISM, INBORN ERRORS; MICRONUTRIENTS; MINERALS; MOOD DISORDERS; VITAMINS;

EID: 34548812841     PISSN: 00332909     EISSN: None     Source Type: Journal    
DOI: 10.1037/0033-2909.133.5.747     Document Type: Article

References (124)

1. Abou-Saleh M.T., and Coppen A. The biology of folate in depression: Implications for nutritional hypotheses of the psychoses. Journal of Psychiatric Research 20 (1986) 91-101
2. Adams J.B., George F., and Audhya T. Abnormally high plasma levels of Vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. Journal of Alternative and Complementary Medicine 12 (2006) 59-63
3. Alpert J.E., Mischoulon D., Nierenberg A.A., and Fava M. Nutrition and depression: Focus on folate. Nutrition 16 (2000) 544-546
4. Ames B.N. A role for supplements in optimizing health: The metabolic tune-up. Archives of Biochemistry and Biophysics 423 (2004) 227-234
5. Ames B., Elson-Schwab I., and Silver E. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): Relevance to genetic disease and polymorphisms. American Journal of Clinical Nutrition 75 (2002) 616-658
6. Arnold L.E., Bozzolo H., Hollway J., Cook A., DiSilvestro R.A., Bozzolo D.R., et al. Serum zinc correlates with parent- and teacher-rated inattention in children with attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology 15 (2005) 628-636
7. Arnold L.E., Pinkham S.M., and Votolato N. Does zinc moderate essential fatty acid and amphetamine treatment of attention-deficit/hyperactivity disorder?. Journal of Child and Adolescent Psychopharmacology 10 (2000) 111-117
8. Baldewicz T.T., Goodkin K., Blaney N.T., Shor-Posner G., Kumar M., Wilkie F.L., et al. Cobalamin level is related to self-reported and clinically rated mood and to syndromal depression in bereaved HIV-1(+) and HIV-1(-) homosexual men. Journal of Psychosomatic Research 48 (2000) 177-185
9. Barringer T., Kirk J., Santaniello A., Foley K., and Michielutte R. Effect of a multivitamin and mineral supplement on infection and quality of life: A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine 138 (2003) 365-371
10. Beard J. Iron deficiency alters brain development and functioning. Journal of Nutrition 133 (2003) 1468S-1472S
11. Bell I., Edman J., Morrow F., Marby B., Perrone G., Kayne H., et al. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction. Journal of the American College of Nutrition 11 (1992) 159-163
12. Bell K.M., Potkin S.G., Carreon D., and Plon L. S-adenosylmethionine blood levels in major depression: Changes with drug treatment. Acta Neurologica Scandinavica Supplement 154 (1994) 15-18
13. Bendich A. The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Journal of the American College of Nutrition 19 (2000) 3-12
14. Benton D., and Cook R. The impact of selenium supplementation on mood. Biological Psychiatry 29 (1991) 1092-1098
15. Benton D., Griffiths R., and Haller J. Thiamine supplementation mood and cognitive functioning. Psychopharmacology 129 (1997) 66-71
16. Benton D., Haller J., and Fordy J. Vitamin supplementation for 1 year improves mood. Neuropsychobiology 32 (1995) 98-105
17. Berdanier C. Advanced nutrition: Micronutrients (1998), CRC, Boca Raton, FL
18. Berwick D.M. Disseminating innovations in health care. Journal of the American Medical Association 289 (2003) 1969-1975
19. Bjelland I., Tell G.S., Vollset S.E., Refsum H., and Ueland P.M. Folate, Vitamin B12, homocysteine, and the MTHFR 677C-T polymorphism in anxiety and depression: The Hordaland homocystein study. Archives of General Psychiatry 60 (2003) 618-626
20. Bottiglieri T. Folate, Vitamin B12, and neuropsychiatric disorders. Nutrition Reviews 54 (1996) 382-390
21. Bottiglieri T., Laundry M., Crellin R., Toone B.K., Carney M.W.P., and Reynolds E.H. Homocysteine, folate, methylation, and monoamine metabolism in depression. Journal of Neurology, Neurosurgery & Psychiatry 69 (2000) 228-232
22. Carney M.W., Ravindran A., Rinsler M.G., and Williams D.G. Thiamine, riboflavin and pyridoxine deficiency in psychiatric in-patients. British Journal of Psychiatry 141 (1982) 271-272
23. Carroll D., Ring C., Suter M., and Willemsen G. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: A double-blind placebo-controlled trial. Psychopharmacology (Berlin) 150 (2000) 220-225
24. Chouinard G., Beauclair L., Geiser R., and Etienne P. A pilot study of magnesium aspartate hydrochloride (Magnesiocard) as a mood stabilizer for rapid cycling bipolar affective disorder patients. Progress in Neuropsychopharmacology Biology and Psychiatry 14 (1990) 171-180
25. Cohen B.M., Lipinski J.F., and Altesman R.I. Lecithin in the treatment of mania: Double-blind, placebo-controlled trials. American Journal of Psychiatry 139 (1982) 1162-1164
26. Connor D.J. Thiamine intake and monoamine oxidase activity. Biological Psychiatry 16 (1981) 869-872
27. Coppen A., and Bailey J. Enhancement of the antidepressant action of fluoxetine by folic acid: A randomised, placebo controlled trial. Journal of Affective Disorders 60 (2000) 121-130
28. Correa A., Botto L., Liu Y., Mulinare J., and Erickson J. Do multivitamin supplements attenuate the risk for diabetes-associated birth defects?. Pediatrics 111 (2003) 1146-1151
29. Cousens G. Depression-free for life (2000), William Morrow, New York
30. Davidson J.R.T., Abraham K., Connor K.M., and McLeod M.N. Effectiveness of chromium in atypical depression: A placebo-controlled trial. Biological Psychiatry 53 (2003) 261-264
31. Deicken R.F., Fein G., and Weiner M.W. Abnormal frontal lobe phosphorous metabolism in bipolar disorder. American Journal of Psychiatry 152 (1995) 915-918
32. Deicken R., Pegues M., Anzalone S., Feiwell R., and Soher B. Lower concentration of hippocampal N-acetylaspartate in familial Bipolar I disorder. American Journal of Psychiatry 160 (2003) 873-882
33. Delle Chiaie R., Pancheri P., and Scapicchio P. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: Comparison with imipramine in two multicenter studies. American Journal of Clinical Nutrition 76 (2002) 1172S-1176S
34. English W.M. Report of the treatment with manganese chloride of 181 cases of schizophrenia, 33 of manic depression, and 16 other defects of psychoses at the Ontario Hospital, Brockville, Ontario. American Journal of Psychiatry 9 (1929) 569-580
35. Fafouti M., Paparrigopoulos T., Liappas J., Mantouvalos V., Typaldou R., and Christodoulou G. Mood disorder with mixed features due to Vitamin B12 and folate deficiency. General Hospital Psychiatry 24 (2002) 106-109
36. Fairfield K.M., and Fletcher R.H. Vitamins for chronic disease prevention in adults: Scientific review. Journal of the American Medicine Association 287 (2002) 3116-3126
37. Fava G.A., Kellner R., Munari F., and Pavan L. The Hamilton Depression Rating Scale in normals and depressives: A cross cultural validation. Acta Psychiatrica Scandinavica 66 (1982) 26-32
38. Fava M., Borus J.S., Alpert J.E., Nierenberg A.A., Rosenbaum J.F., and Bottiglieri T. Folate, Vitamin B12, and homocysteine in major depressive disorder. American Journal of Psychiatry 154 (1997) 426-428
39. Fletcher R.H., and Fairfield K.M. Vitamins for chronic disease prevention in adults: Clinical applications. Journal of the American Medical Association 287 (2002) 3127-3129
40. Gesch C.B., Hammon S.M., Hampson S.E., Eves A., and Crowder M.J. Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. British Journal of Psychiatry 181 (2002) 22-28
41. Giannini A.J., Nakoneczie A.M., Melemis S.M., Ventresco J., and Condon M. Magnesium oxide augmentation of verapamil maintenance therapy in mania. Psychiatry Research 93 (2000) 83-87
42. Godfrey P., Toone B., Carney M., Flynn T., Bottiglieri T., Laundy M., et al. Enhancement of recovery from psychiatric illness by methylfolate. Lancet 336 (1990, August 18) 392-395
43. Goggans F. A case of mania secondary to Vitamin B12 deficiency. American Journal of Psychiatry 141 (1984) 300-301
44. Goodwin J.S., and Goodwin J.M. The tomato effect: Rejection of highly efficacious therapies. Journal of the American Medical Association 251 (1984) 2387-2390
45. Guy W. ECDEU assessment manual for psychopharmacology (Publication ADM 76-338) (1976), U.S. Department of Health and Human Services, Washington, DC
46. Hasanah C.I., Khan U.A., Musalmah M., and Razali S.M. Reduced red-cell folate in mania. Journal of Affective Disorders 46 (1997) 95-99
47. Heaney R. Long-latency deficiency diseases: Insights from calcium and Vitamin D. American Journal Clinical Nutrition 78 (2003) 912-919
48. Heiden A., Frey R., Presslich O., Blasbichler T., Smetana R., and Kasper S. Treatment of severe mania with intravenous magnesium sulphate as a supplementary therapy. Psychiatry Research 89 (1999) 239-246
49. Helmeste D.M., and Tang S.W. The role of calcium in the etiology of the affective disorders. Japanese Journal of Pharmacology 77 (1998) 107-116
50. Hoobler B.R. Symptomatology of Vitamin B deficiency in infants. Journal of the American Medical Association 91 (1928) 307-310
51. Hutto B.R. Folate and cobalamin in psychiatric illness. Comprehensive Psychiatry 38 (1997) 305-314
52. Ito T.Y., Trant A.S., and Polan M.L. A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. Journal of Sex and Marital Therapy 27 (2001) 541-549
53. Kagan B.L., Sultzer D.L., Rosenlicht N., and Gerner R.H. Oral S-adenosylmethionine in depression: A randomized, double-blind, placebo-controlled trial. American Journal of Psychiatry 147 (1990) 591-595
54. Kamei K., Tabata O., Muneoka K., Muraoka S.I., Tomiyoshi R., and Takigawa M. Electrolytes in erythrocytes of patients with depressive disorders. Psychiatry and Clinical Neurosciences 52 (1998) 529-533
55. Kaplan B.J., Crawford S.G., Gardner B., and Farrelly G. Treatment of mood lability and explosive rage with minerals and vitamins: Two case studies in children. Journal of Child and Adolescent Psychopharmacology 12 (2002) 203-218
56. Kaplan B.J., Fisher J.E., Crawford S.G., Field C.J., and Kolb B. Improved mood and behavior during treatment with a mineral-vitamin supplement: An open-label case series. Journal of Child and Adolescent Psychopharmacology 14 (2004) 115-122
57. Kaplan B.J., Simpson J.S.A., Ferre R.C., Gorman C., McMullen D., and Crawford S.G. Effective mood stabilization in bipolar disorder with a chelated mineral supplement. Journal of Clinical Psychiatry 62 (2001) 936-944
58. Kirov G.K., and Tsachev K.N. Magnesium, schizophrenia and manic-depressive disease. Neuropsychobiology 23 (1990) 79-81
59. Kuby J. Immunology (1994), WH Freeman and Company, New York
60. Lindenbaum J., Healton E.B., Savage D.G., Brust J.C.M., Garrett T.J., Podell E.R., et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. New England Journal of Medicine 318 (1988) 1720-1728
61. Linder J., Brimar K., Granberg P.O., Wetterberg L., and Werner S. Characteristic changes in psychiatric symptoms, cortisol and melatonin but not prolactin in primary hyperparathyroidism. Acta Psychiatrica Scandinavica 78 (1988) 32-40
62. Lozoff B., Brittenham G.M., Wolf A.W., McClish D.K., Kuhnert P.M., Jimenez E., et al. Iron deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics 79 (1987) 981-995
63. Maes M., De Vos N., Pioli R., Demedts P., Wauters A., Neels H., et al. Lower serum Vitamin E concentrations in major depression: Another marker of lowered antioxidant defenses in that illness. Journal of Affective Disorders 58 (2000) 241-246
64. Maes M., Van de Vyvere J., Vandoolaeghe E., Bril T., Demedts P., Wauters A., et al. Alterations in iron metabolism and the erythron in major depression: Further evidence for a chronic inflammatory process. Journal of Affective Disorders 40 (1996) 23-33
65. Maes M., Vandoolaeghe E., Neels H., Demedts P., Wauters A., Meltzer H.Y., et al. Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness. Biological Psychiatry 42 (1997) 349-358
66. McCarty M.F. High-dose pyridoxine as an "anti-stress" strategy. Medical Hypotheses 54 (2000) 803-807
67. McLeod M.N., Gaynes B.N., and Golden R.N. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. Journal of Clinical Psychiatry 60 (1999) 237-240
68. McLeod M.N., and Golden R.N. Chromium treatment of depression. International Journal of Neuropsychopharmacology 3 (2000) 311-314
69. McNair D.A., Lorr M., and Droppelman L.F. Profile of Mood States (1971), Educational and Industrial Testing Service, San Diego, CA
70. Meador K., Nichols M., Franke P., Durkin M., Oberzan R., Moore E., et al. Evidence for a central cholinergic effect of high-dose thiamine. Annals of Neurology 34 (1993) 724-726
71. Mertz W. A balanced approach to nutrition for health: The need for biologically essential minerals and vitamins. Journal of the American Dietetic Association 94 (1994) 1259-1262
72. Michelson D., Stratakis C., Hill L., Reynolds J., Galliven E., Chrousos G., et al. Bone mineral density in women with depression. New England Journal of Medicine 335 (1996) 1176-1181
73. Milne D.B. Laboratory assessment of trace element and mineral status (2000), Humana Press, Totowa, NJ
74. Mischoulon D., and Fava M. Role of S-adenosyl-L-methionine in the treatment of depression: A review of the evidence. American Journal of Clinical Nutrition 76 (2002) 1158S-1161S
75. Mitchell B.L., Ulrich C.M., and McTiernan A. Supplementation with vitamins or minerals and immune function: Can the elderly benefit?. Nutrition Research 23 (2003) 1117-1139
76. Moore C.M., Breeze J.L., Gruber S.A., Babb S.M., Frederick B.D., Villafuerte R.A., et al. Choline, myo-inositol and mood in bipolar disorder: A proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar Disorders 2 (2000) 207-216
77. Morris M.S., Fava M., Jacques P.F., Selhub J., and Rosenberg I.H. Depression and folate status in the U.S. population. Psychotherapy and Psychosomatics 72 (2003) 80-87
78. Munoz F., Sole M., and Coma M. The protective role of Vitamin E in vascular amyloid beta-mediated damage. Sub-Cellular Biochemistry 38 (2005) 147-165
79. Murphy S., and Poos M. Dietary reference intakes: Summary of applications in dietary assessment. Public Health Nutrition 5 (2002) 843-849
80. Mussolino M. Depression and hip fracture risk: The NHANES I epidemiologic follow-up study. Public Health Reports 120 (2005) 71-75
81. Nowak G., and Schlegel-Zawadzka M. Alterations in serum and brain trace element levels after antidepressant treatment: Part I. Zinc. Biological Trace Element Research 67 (1999) 85-92
82. Okamoto T., Gerstein H.C., and Obara T. Psychiatric symptoms, bone density and non-specific symptoms in patients with mild hypercalcemia due to primary hyperparathyroidism: A systematic overview of the literature. Endocrine Journal 44 (1997) 367-374
83. Palti H., Pevsner B., and Adler B. Does anemia in infancy affect achievement on developmental and intelligence tests?. Human Biology 55 (1983) 189-194
84. Popper C.W. Do vitamins or minerals (apart from lithium) have mood-stabilizing effects? [Commentary]. Journal of Clinical Psychiatry 62 (2001) 933-935
85. Pufulete M., Al-Ghnaniem R., Khushal A., Appleby P., Harris N., Gout S., et al. Effect of folic acid supplementation on genomic DNS methylation in patients with colorectal adenoma. Gut 54 (2005) 648-653
86. Raine A., Mellingen K., Liu J., Venables P., and Mednick S.A. Effects of environmental enrichment at ages 3-5 years on schizotypal personality and antisocial behavior at ages 17 and 23 years. American Journal of Psychiatry 160 (2003) 1627-1635
87. Reed G.E. Use of manganese chloride in dementia praecox. Canadian Medical Association Journal 21 (1929) 46-49
88. Ritter T. The people's home medical book 1 (1910), Barnum, Cleveland, OH
89. Sandstead H. A brief history of the influence of trace elements on brain function. American Journal of Clinical Nutrition 43 (1986) 293-298
90. Sato Y., Honda Y., Iwamoto J., Kanoko T., and Satoh K. Effect of folate and mecobalamin on hip fractures in patients with stroke: A randomized controlled trial. Journal of the American Medical Association 293 (2005) 1082-1088
91. Schlebusch L., Bosch B.A., Polglase G., Kleinschmidt I., Pillay B.J., and Cassimjee M.H. A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combination on stress. South African Medical Journal 90 (2000) 1216-1223
92. Schoenthaler S.J., and Bier I.D. The effect of vitamin-mineral supplementation on juvenile delinquency among American schoolchildren: A randomized, double-blind placebo-controlled trial. Journal of Alternative and Complementary Medicine 6 (2000) 7-17
93. Scott J.M., Molloy A.M., Kennedy D.G., Kennedy S., and Weir D.G. Effects of the disruption of transmethylation in the central nervous system: An animal model. Acta Neurologica Scandinavica 154 (1994) 27-31
94. Selhub J., Bagley L., Miller J., and Rosenberg I. B vitamins, homocysteine, and neurocognitive function in the elderly. American Journal of Clinical Nutrition 71 (2000) 614S-620S
95. Shiloh R., Weizman A., Weizer N., Dorman-Etrog P., and Munitz H. Antidepressive effect of pyridoxine (Vitamin B6) in neuroleptic-treated schizophrenic patients with comorbid minor depression-Preliminary open label trial. Harefuah 140 (2001) 369-373
96. Simmons M. Nutritional approach to bipolar disorder [Letter to the editor]. Journal of Clinical Psychiatry 64 (2002) 338
97. Stevens L., Zhang W., Peck L., Kuczek T., Grevstad N., Mahon A., et al. EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 38 (2003) 1007-1021
98. Stewart J.W., Harrison W., Quitkin F., and Baker H. Low B6 levels in depressed outpatients. Biological Psychiatry 19 (1984) 613-616
99. Stoll A.L., Cohen B.M., Snyder M.B., and Hanin I. Erythrocyte choline concentration in bipolar disorder: A predictor of clinical course and medication response. Biological Psychiatry 29 (1991) 1171-1180
100. Stoll A.L., Sachs G.S., Cohen B.M., Lafer B., Christensen J.D., and Renshaw P.F. Choline in the treatment of rapid-cycling bipolar disorder: Clinical and neurochemical findings in lithium-treated patients. Biological Psychiatry 40 (1996) 382-388
101. Strakowski S.M., DelBello M.P., Adler C., Cecil D.M., and Sax K.W. Neuroimaging in bipolar disorder. Bipolar Disorders 2 (2000) 148-164
102. Suboticanec K., Folnegovic-Smalc V., Korbar M., Mestrovic B., and Buzina R. Vitamin C status in chronic schizophrenia. Biological Psychiatry 28 (1990) 959-966
103. Sydenstricker V.P., and Cleckley H.M. The effect of nicotinic acid in stupor, lethargy and various other psychiatric disorders. American Journal of Psychiatry 98 (1941) 83-92
104. Szeszko P.R., Betensky J.D., Mentschel C., Gunduz-Bruce H., Lencz T., Ashtari M., et al. Increased stress and smaller anterior hippocampal volume. NeuroReport 17 (2006) 1825-1828
105. Takeda A. Zinc homeostasis and functions of zinc in the brain. Biometals 14 (2001) 343-351
106. Thys-Jacobs S., Starkey P., Bernstein D., and Tian J. Calcium carbonate and the premenstrual syndrome: Effects on premenstrual and menstrual symptoms. American Journal of Obstetrics and Gynecology 179 (1998) 444-452
107. Tolmunen T., Voutilainen S., Hintikka J., Rissanen T., Tanskanen A., Viinamaki H., et al. Dietary folate and depressive symptoms are associated in middle-aged Finnish men. Journal of Nutrition 133 (2003) 3233-3236
108. Toren P., Eldar S., Sela B.-A., Wolmer L., Weitz R., Inbar D., et al. Zinc deficiency in attention-deficit/hyperactivity disorder. Biological Psychiatry 40 (1996) 1308-1310
109. Ueland P.M., Hustad S., Schneede J., Refsum H., and Vollset S.E. Biological and clinical implications of the MTHFR C677T polymorphism. TRENDS in Pharmacological Sciences 22 (2001) 195-201
110. Velez-Pardo C., Jimenez del Rio M., Ebinger G., and Vauquelin G. Manganese and copper promote the binding of dopamine to "serotonin binding proteins" in bovine frontal cortex. Neurochemistry International 26 (1995) 615-622
111. Vieth R. Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults. Journal of Steroid Biochemistry and Molecular Biology 89-90 (2004) 575-579
112. Walsh W., Glab L., and Haakenson M. Reduced violent behavior following biochemical therapy. Physiology & Behavior 82 (2004) 835-839
113. Walsh W.J., Isaacson H.R., Rehman F., and Hall A. Elevated blood copper/zinc ratios in assaultive young males. Physiology & Behavior 62 (1997) 327-329
114. Waterland R.A., and Jirtle R.L. Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Molecular and Cellular Biology 23 (2003) 5293-5300
115. Weinberg J., Dallman P., and Levine S. Iron deficiency during early development in the rat: Behavioral and physiological consequences. Pharmacology Biochemistry and Behavior 12 (1980) 493-502
116. Weir D.G., and Scott J.M. Brain function in the elderly: Role of Vitamin B12 and folate. British Medical Bulletin 55 (1999) 669-682
117. Weiser M., Levkowitch Y., Neuman M., and Yehuda S. Decrease of serum iron in acutely psychotic schizophrenic patients. International Journal of Neuroscience 78 (1994) 49-52
118. Wester P.O. Magnesium. American Journal of Clinical Nutrition 45 (1987) 1305-1312
119. Weston P., and Howard M. The determination of sodium, potassium, calcium and magnesium in the blood and spinal fluid of patients suffering from manic depressive insanity. Archives of Neurology and Psychiatry 8 (1922) 179-183
120. Williams R. Biochemical individuality (1956), University of Texas Press, Austin, TX
121. Wyatt K.M., Dimmock P.W., Jones P.W., and O'Brien P.M.S. Efficacy of Vitamin B-6 in the treatment of premenstrual syndrome: Systematic review. British Medical Journal 318 (1999) 1375-1381
122. Yang P.C., Jury J., Soderholm J.D., Sherman P.M., McKay D.M., and Perdue M.H. Chronic psychological stress in rats induces intestinal sensitization to luminal antigens. American Journal of Pathology 168 (2006) 104-114
123. Youdim M. Deficiency and excess of iron in brain function and dysfunction. Nutrition Reviews 59 (2001) S83-S85
124. Zeisel S. Choline: An essential nutrient for humans. Nutrition 16 (2000) 669-671