Enhancement of the antidepressant action of fluoxetine by folic acid: A randomised, placebo controlled trial

Journal of Affective Disorders

Volumn 60, Issue 2, 2000, Pages 121-130

  Coppen, Alec ^a   Bailey, John ^a  

^a West Park Hospital Epsom   (United Kingdom)

Author keywords

Depression; Fluoxetine; Folic acid; Homocysteine

Indexed keywords

FLUOXETINE; FOLIC ACID; HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG POTENTIATION; FATIGUE; FEMALE; FOLIC ACID BLOOD LEVEL; HAMILTON SCALE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; TREATMENT OUTCOME; VERTIGO; VITAMIN SUPPLEMENTATION;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FLUOXETINE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; SEX FACTORS; TREATMENT OUTCOME; VITAMIN B 12;

EID: 0033858407     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0327(00)00153-1     Document Type: Article

References (22)

1. Abou-Saleh M.T., Coppen A. Subjective side-effects of amitriptyline and lithium in affective disorders. Br. J. Psychiatry. 142:1983;391-397.
2. Abou-Saleh M.T., Coppen A. The biology of folate in depression: implications for nutritional hypotheses of the psychoses. J. Psychiatr. Res. 20:1986;91-101.
3. Abou-Saleh M.T., Coppen A. Serum and red blood cell folate in depression. Acta Psychiatr. Scand. 80:1989;78-82.
4. Agency for Health Care Policy and Research, March, 1999. Treatment of Depression - Newer Pharmacotherapies. Summary, Evidence Report/Technology Assessment: Number 7 http://www.ahcpr.gov/clinic/deprsumm.htm.
5. Diagnostic and Statistical Manual of Mental Disorders. 3rd Revised Edition:1987;American Psychiatric Press, Washington, DC.
6. Angst J. Severity of depression and benzodiazepine co-medication in relationship to efficacy of antidepressants in acute trials. A meta-analysis of moclobemide trials. Human Psychopharmacol. 8:1993;404-407.
7. Carney M.W.P., Chary T.K.N., Laundy M., et al. Red cell folate concentrations in psychiatric patients. J. Affect. Disord. 19:1990;207-213.
8. Coppen A., Chaudhry S., Swade C. Folic acid enhances lithium prophylaxis. J. Affect. Disord. 10:1986;9-13.
9. Coppen A., Swade C., Jones S.A., Armstrong R.A., Blair J.A., Leeming R.J. Depression and tetrahydrobiopterin: the folate connection. J. Affect. Disord. 16:1989;103-107.
10. Everson S.A., Roberts R.E., Goldberg D.E., Kaplan G.A. Depressive symptoms and increased risk of stroke mortality over a 29-year period. Arch. Intern. Med. 158:1998;1133-1138.
11. Fava M., Borus J.S., Alpert J.E., Nierenberg A.A., Rosenbaum J.F., Bottiglieri T. Folate, vitamin B12, and homocysteine in major depressive disorder. Am. J. Psychiatry. 154:1997;426-428.
12. Glassman A.H., Shapiro P.A. Depression and the course of coronary artery disease. Am. J. Psychiatry. 55:1998;4-11.
13. Godfrey P.S., Toone B.K., Carney M.W., et al. Enhancement of recovery from psychiatric illness by methylfolate. Lancet. 336:1990;392-395.
14. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry. 23:1960;56-62.
15. Lowering blood homocysteine with folic acid based supplements: meta analysis of randomised trials. Br. Med. J. 316:1998;894-898.
16. Lelimann M., Gottfries C.G., Regland B. Identification of cognitive impairment in the elderly. Homocysteine is an early marker. Dement. Geriatr. Cogn. Disord. 10:1999;12-20.
17. Morrison H., Schaubel D., Desmeules M., Wigle D.T. Serum folate and risk of fatal coronary heart disease. J. Am. Med. Assoc. 275:1996;1893-1896.
18. Murray O., Lopez A.D. Global mortality, disability, and the contribution of risk factors. Global Burden of Disease Study. Lancet. 349:1997;1436-1442.
19. Refsum H., Ueland P.M., Nygard O., Vollset S.E. Homocysteine and cardiovascular disease. Annu. Rev. 9:1998;31-62.
20. Reynolds E.H., Preece M., Bailey J., Coppen A. Folate deficiency in depressive illness. Br. J. Psychiatry. 117:1970;287-292.
21. Speck C.E., Kukull W.A., Brenner D.E., et al. History of depression as a risk factor for Alzheimer's disease. Epidemiology. 6:1995;366-369.
22. Van der Griend R., Haas M.M., Biesma D.H., Duran M., Meuwissen W.A.T., Banga J.-D. Combination of low-dose folic acid and pyridoxine for treatment of hyperhomocysteinaemia in patients with premature arterial disease and their relatives. Atherosclerosis. 143:1999;177-183.