A double-blind placebo-controlled study of arginmax, a nutritional supplement for enhancement of female sexual function

Journal of Sex and Marital Therapy

Volumn 27, Issue 5, 2001, Pages 541-549

  Ito, Thomas Y ^a   Trant, Aileen S ^b   Polan, Mary Lake ^c  

^a UNIVERSITY OF HAWAII   (United States)

^b Daily Wellness Company   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ARGINMAX; GINKGO BILOBA EXTRACT; MINERAL; MULTIVITAMIN; PLANT EXTRACT; TURNERA APHRODISIACA EXTRACT; UNCLASSIFIED DRUG;

ADULT; CLINICAL ARTICLE; CLINICAL TRIAL; CLITORIS; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG INDUCED DISEASE; FEMALE; GINSENG; HUMAN; NUTRITIONAL SUPPORT; ORGASM; PATIENT SATISFACTION; RANDOMIZED CONTROLLED TRIAL; SEXUAL AROUSAL; SEXUAL BEHAVIOR; SEXUAL FUNCTION; SEXUAL INTERCOURSE; TREATMENT OUTCOME; VAGINA;

ADULT; AGED; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GLYCOSIDES; HUMANS; MIDDLE AGED; MINERALS; PLANT PREPARATIONS; SENSATION; SEVERITY OF ILLNESS INDEX; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; VITAMINS;

EID: 0034861367     PISSN: 0092623X     EISSN: 15210715     Source Type: Journal    
DOI: 10.1080/713846828     Document Type: Article

References (36)

1. Arletti, R., Benelli, A., Cavazzuti, E., Scarpetta, G., & Bertolini, A. (1999). Stimulating properties of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats. Psychopharmacology, 1, 15–19
2. Auguet, M., Delaflotte, S., Hellegouarch, A., & Clostre, F. (1986). Pharmacological bases of the vascular impact of Ginkgo biloba extract. La Presse Medicule, 15, 1524–1528
3. Bayer, R. (1960). Treatment of infertility with vitamin E. International Journal of Fertility, 5, 70-78
4. Berman, J. R., McCarthy, M. M., & Kyprianou, N. (1998). Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina. Urology, 51, 650-656
5. Burnett, A. L. (1995). Nitric oxide control of lower genitourinary tract functions: A review. Urology, 45, 1071–1083
6. Chen, X. (1996). Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clinical & Experimental Pharmacology & Physiology, 23, 728–732
7. Chen, X., & Lee, T. J. (1995). Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. British Journal of Pharmacology, 115, 15–18
8. Chen, X., Salwinski, S., & Lee, T. J. (1997). Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway. Clinical & Experimental Pharmacology & Physiology, 24, 958–959
9. Choi, H. K., Seong, D.H., & Rha, K.H. (1995). Clinical efficacy of Korean red ginseng for erectile dysfunction. International Journal of Impotence Research, 7, 181–186
10. Cohen, A. J., & Bartlik, B. (1998). Ginkgo biloba for antidepressant-induced sexual dysfunction. Journal of Sex & Marital Therapy, 24, 139–143
11. Creager, M. A., Gallagher, S. J., Girerd, X. J., Coleman, S. M., Dzau, V. J., & Cooke, J. P. (1992). L-arginine improves endothelium-dependent vasodilation in hyperc-holesterolemic humans. Journal of Clinical Investigation, 90, 1248–1253
12. Czeizel, A. E. Metneki, J. & Dudas, I. (1996). The effect of preconceptional multivi-tamin supplementation on fertility. International Journal of Vitamin & Nutrition Research, 66, 55–58
13. Foster, S. (1991). Herbs and sex: Separating fact from fantasy. Health Foods Business, 74, 30–33
14. Goldstein, I., & Berman, J. R. (1998). Vasculogenic female sexual dysfunction: Vaginal engorgement and clitoral erectile insufficiency syndromes. International Journal of Impotence Research, 10, S84–S90
15. Han, S. W., & Kim, H. (1996). Ginsenosides stimulate endogenous production of nitric oxide in rat kidney. International Journal of Biochemical & Cell Biology, 28, 573–580
16. Hutchison, S. J., Sudhir, K., Sievers, R. E., Zhu, B. Q., Sun, Y. P., & Chou, T. M. (1999). Effects of L-arginine on atherogenesis and endothelial dysfunction due to secondhand smoke. Hypertension, 34, 44–50
17. Ito, T., Kawahara, K., Das, A. (1998). The effects of ArginMax, a natural dietary supplement for enhancement of male sexual function. Hawaii Medical Journal, 57, 741–744
18. Ito, T., Kawahara, K., Das, A. (1999). A double-blind placebo-controlled clinical study on the effects of ArginMax, a natural dietary supplement for enhancement of male sexual function. Paper presentation at the meeting of the American Urological Association Western Section Meeting, Monterey, CA
19. Jung, H. C., Mun, K. H., Park, T. C., Huh, K., Seong, D. H., & Suh, J. K. (1997). Role of nitric oxide in penile erection. Yonsei Medical Journal, 38, 261–269
20. Kaplan, S. A., Reis, R. B., Kohn, I. J., Ikeguchi, E. F., Laor, E., & Te, A. E. (1999). Safety and efficacy of sildenafil in postmenopausal women with sexual dysfunction. Urology, 53, 481–486
21. Kimura, K., Takahashi, M., Naroda, T., Iriguchi, H., Miyamoto, T., & Kawanishi, Y. (1993). The relaxation of human corpus cavernosum caused by nitric oxide. Nippon Hinyokika Gakkai Zasshi, 84, 1660–1664
22. Kumamoto, Y., Maruta, H., Ishigami, J., Kamidono, S., Orikasa, S., & Kimura, M. (1988). Clinical efficacy of mecobalamin in treatment of oligozoospermia. Acta Urology Japan, 34, 1109–1132
23. Laumann, E. O., Paik, A., & Rosen, R. C. (1999). Sexual dysfunction in the United States. JAMA, 281, 537–544
24. Mohan, H., Verma, J., Singh, I., Mohan, P., Marwah, S., & Singh, P. (1997). Interrelationship of zinc levels in serum and semen in oligospermic infertile patients and fertile males. Indian Journal of Pathology & Microbiology, 40, 451-455
25. Noguchi, T., Sasaki, Y., Seki, J., Giddings, J. C., & Yamamoto, J. (1999). Effects of voluntary exercise and L-arginine on thrombogenesis and microcirculation in stroke-prone spontaneously hypertensive rats. Clinical & Experimental Pharmacology & Physiology 26, 330–335
26. Paick, J. S., & Lee, J. H. (1996). An experimental study of the effect of ginkgo biloba extract on the human and rabbit corpus cavernosum tissue. Journal of Urology, 156, 1876–1880
27. Pau, M. Y., & Milner, J.A. (1982). Dietary arginine and sexual maturation of the female rat. Jounal of Nutrition, 112, 1834–1842
28. Pieper, G. M., & Dondlinger, L. A. (1997). Plasma and vascular tissue arginine are decreased in diabetes: Acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production. Journal of Pharmacology & Experimental Therapeutics, 283, 684–691
29. Robinson, K., Arheart, K., Refsum, H., Brattstrom, L., Boers, G., & Ueland, P. (1998). Low circulating folate and vitamin B6 concentrations: Risk factors for stroke, peripheral vascular disease, and coronary artery disease. Circulation, 10, 437–443
30. Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997). The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology, 49, 822–830
31. Salvati, G., Genovesi, G., Marcellini, L., Paolini, P., De Nuccio, I., Pepe, M., & Re, M. (1996). Effects of Panax ginseng C.A. Meyer saponins on male fertility. Panminerva Medica, 38, 249–254
32. Sandler, B., & Faragher, B. (1984). Treatment of oligospermia with vitamin B12. Infertility, 7, 133–138
33. Thys-Jacobs, S., Starkey, P., Bernstein, D., & Tian, J. (1998). Calcium carbonate and the premenstrual syndrome: Effects on premenstrual and menstrual symptoms. Premenstrual syndrome study group. American Journal of Obstetrics & Gynecology, 179, 444–452
34. Wascher, T. C., Posch, K., Wallner, S., Hermetter, A., Kostner, G. M., & Graier, W. F. (1997). Vascular effects of L-arginine: Anything beyond a substrate for the NO-synthase? Biochemical & Biophysical Research Communications, 234, 35–38
35. Welt, K., Weiss, J., Koch, S., & Fitzl, G. (1999). Protective effects of Ginkgo biloba extract Egb 761 on the myocardium of experimentally diabetic rats. II. Ultra-structural and immunohistochemical investigation on microvessels and interstitium. Experimental & Toxicologic Pathology, 51, 213–222
36. Zava, D. T., Dollbaum, C. M., Blen, M. (1998). Estrogen and progestin bioactivity of foods, herbs, and spices. Proceedings of the Society for Experimental Biology & Medicine, 217, 369–378