Pain mechanisms and their implication for the management of pain in farm and companion animals

Veterinary Journal

Volumn 174, Issue 2, 2007, Pages 227-239

  Viñuela Fernández, Ignacio ^a   Jones, Emma ^a   Welsh, Elizabeth M ^a   Fleetwood Walker, Susan M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Companion animals; Farm animals; Nociception; Pain; Pain assessment

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; BUPIVACAINE; BUPRENORPHINE; FENTANYL; GABAPENTIN; KETAMINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NARCOTIC ANALGESIC AGENT; NERVE GROWTH FACTOR RECEPTOR BLOCKING AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL DISEASE; ANIMAL HUSBANDRY; ANIMAL WELFARE; CAT DISEASE; CHRONIC PAIN; CLINICAL TRIAL; CONTINUOUS INFUSION; DIABETIC NEUROPATHY; DOG DISEASE; DOMESTIC ANIMAL; DRUG POTENTIATION; DRUG TARGETING; FARM ANIMAL; HORSE DISEASE; HUMAN; MCGILL PAIN QUESTIONNAIRE; NEUROPATHIC PAIN; NEUROPATHOLOGY; NEUROPHARMACOLOGY; NEUROPHYSIOLOGY; NOCICEPTION; NONHUMAN; PAIN; PAIN ASSESSMENT; POSTHERPETIC NEURALGIA; RATING SCALE; REVIEW; SENSITIZATION; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; UNSPECIFIED SIDE EFFECT;

ANALGESICS; ANIMALS; ANIMALS, DOMESTIC; BEHAVIOR, ANIMAL; PAIN; PAIN MEASUREMENT; SPECIES SPECIFICITY;

ANIMALIA; MAMMALIA;

EID: 34548769208     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2007.02.002     Document Type: Review

References (186)

1. Anand K.J. Pain, plasticity, and premature birth: a prescription for permanent suffering?. Nature Medicine 6 (2000) 971-973
2. Anand K.J.S., and Craig K.D. New perspectives on the definition of pain. Pain 67 (1996) 3-6
3. Anil S.S., Anil L., and Deen J. Challenges of pain assessment in domestic animals. Journal of the American Veterinary Medical Association 220 (2002) 313-319
4. Anil L., Anil S.S., and Deen J. Pain detection and amelioration in animals on the farm: issues and options. Journal of Applied Animal Welfare Science 8 (2005) 261-278
5. Arner S., and Meyerson B.A. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 33 (1988) 11-23
6. Ashley F.H., Waterman-Pearson A.E., and Whay H.R. Behavioural assessment of pain in horses and donkeys: application to clinical practice and future studies. Equine Veterinary Journal 37 (2005) 565-575
7. Backonja M.-M. Use of anticonvulsants for treatment of neuropathic pain. Neurology 59 (2002) 14-17
8. Basbaum A.I., and Jessell T.M. The perception of pain. In: Kandel E.R., Schwartz J.H., and Jessell T.M. (Eds). Principles of Neural Science (2000), McGraw-Hill, USA 475
9. Bateson P. Assessment of pain in animals. Animal Behaviour 42 (1991) 827-839
10. Bessou P., and Perl E.R. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. Journal of Neurophysiology 32 (1969) 1025-1043
11. Blackburn-Munro G., and Blackburn-Munro R.E. Chronic pain, chronic stress and depression: coincidence or consequence?. Journal of Neuroendocrinology 13 (2001) 1009-1023
12. Borer L.R., Peel J.E., Seewald W., Schawalder P., and Spreng D.E. Effect of carprofen, etodolac, meloxicam or butorphanol in dogs with induced acute synovitis. American Journal of Veterinary Research 64 (2003) 1429-1437
13. Buchner H.H.F., Savelberg H.H.C.M., Schamhardt H.C., and Barneveld A. Limb movement adaptations in horses with experimentally induced fore- or hindlimb lameness. Equine Veterinary Journal 28 (1996) 63-70
14. Budsberg S.C. Long-term temporal evaluation of ground reaction forces during development of experimentally induced osteoarthritis in dogs. American Journal of Veterinary Research 62 (2001) 1207-1211
15. Butkevich I.P., and Vershinina E.A. Maternal stress differently alters nociceptive behaviors in the formalin test in adult female and male rats. Brain Research 961 (2003) 159-165
16. Cain K.C., Jarrett M.E., Burr R.L., Hertig V.L., and Heitkemper M.M. Heart rate variability is related to pain severity and predominant bowel pattern in women with irritable bowel syndrome. Neurogastroenterology and Motility 19 (2007) 110-118
17. Cambridge A.J., Tobias K.M., Newberry R.C., and Sarkar D.K. Subjective and objective measurements of post-operative pain in cats. Journal of the American Medical Association 217 (2000) 685-690
18. Capner C.A., Lascelles B.D.X., and Waterman-Pearson A.E. Current British veterinary attitudes to perioperative analgesia for dogs. The Veterinary Record 145 (1999) 95-99
19. Carroll G.L., and Simonson S.M. Recent developments in Nonsteroidal anti-inflammatory drugs in cats. Journal of the American Animal Hospital Association 41 (2005) 347-354
20. Carroll G.L., Howe L.B., and Peterson K.D. Analgesic efficacy of preoperative administration of meloxicam or butorphanol in onychectomized cats. Journal of the American Veterinary Medical Association 226 (2005) 913-919
21. Caterina M.J., Leffler A., Malmberg A.B., Martin W.J., Trafton J., Petersen-Zeitz K.R., Koltzenburg M., Basbaum A.I., and Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288 (2000) 306-313
22. Caton D. "The poem in the pain". The social significance of pain in western civilization. Anesthesiology 81 (1994) 1044-1052
23. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., and Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. Journal of Neuroscience Methods 53 (1994) 55-63
24. Chapman V., Suzuki R., and Dickenson A.H. Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6. Journal of Physiology 507 (1998) 881-894
25. Chizh B.A., Headley P.M., and Tzschentke T.M. NMDA receptor antagonists as analgesics: focus on the NR2B subtype. Trends in Pharmacological Sciences 22 (2001) 636-642
26. Clements A.C.A., Mellor D.J., and Fitzpatrick J.L. Reporting of sheep lameness conditions to veterinarians in the Scottish Borders. The Veterinary Record 150 (2001) 815-817
27. Coderre T.J., and Melzack R. The contribution of excitatory amino acids to central sensitisation and persistent nociception after formalin-induced tissue injury. Journal of Neuroscience 12 (1992) 3665-3670
28. Conzemius M.G., Hill C.M., Sammarco J.L., and Perkowski S.Z. Correlation between subjective and objective measures used to determine severity of post-operative pain in dogs. Journal of the American Veterinary Medical Association 210 (1997) 1619-1622
29. Conzemius M.G., Aper R.L., and Hill C.M. Evaluation of a canine total-elbow arthroplasty system: a preliminary study in normal dogs. Veterinary Surgery 30 (2001) 11-20
30. Coull J.A., Beggs S., Boudreau D., Boivin D., Tsuda M., Inoue K., Gravel C., Salter M.W., and De Koninck Y. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438 (2005) 1017-1021
31. Degueurce C., Chateau H., Pasqui-Boutard V., Pourcelot P., Audigie F., Crevier-Denoix N., Jerbi H., Geiger D., and Denoix J.M. Concrete use of the joint coordinate system for the quantification of articular rotations in the digital joints of the horse. Veterinary Research 31 (2000) 297-311
32. Dickenson A.H. Mechanisms of the analgesic actions of opiates and opioids. British Medical Bulletin 47 (1991) 690-702
33. Dickenson A.H., and Besson J.-M. Pharmacological control of pain: non-opioid targets. In: Merskey H., Loesser J.D., and Dubner R. (Eds). The Paths of Pain 1975-2005 (2005), IASP Press, Seattle, USA 191-208
34. Dingledine R., Borges K., Bowie D., and Traynelis S.F. The glutamate receptor ion channels. Pharmacological Reviews 51 (1999) 7-61
35. Dinniss A.S., Stafford K.J., Mellor D.J., Bruce R.A., and Ward R.N. behaviour pattern of lambs after castration using a rubber ring and/or castrating clamp with or without local anaesthetic. New Zealand Veterinary Journal 47 (1999) 198-203
36. Dixon M.J., Robertson S.A., and Taylor P.M. A thermal threshold testing device for evaluation of analgesics in cats. Research in Veterinary Science 72 (2002) 205-210
37. Dobromylskyj P., Flecknell P.A., Lascelles B.D., Livingston A., Taylor P., and Waterman-Pearson A. Pain assessment. In: Flecknell P., and Waterman-Pearson A. (Eds). Pain Management in Animals (2000), Harcourt Publishers, London, UK 53-79
38. Dohoo S.E., and Dohoo I.R. Post-operative use of analgesics in dogs and cats by Canadian veterinarians. Canadian Veterinary Journal 37 (1996) 546-551
39. Dohoo S.E., and Dohoo I.R. Factors influencing the post-operative use of analgesics in dogs and cats. Canadian Veterinary Journal 37 (1996) 552-556
40. Dohoo S.E., and Dohoo I.R. Attitudes and concerns of Canadian animal health technologists towards postoperative pain management in dogs and cats. Canadian Veterinary Journal 39 (1998) 491-496
41. Dolan S., Kelly J.G., Monteiro A.M., and Nolan A.M. Up-regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia. Pain 106 (2003) 501-512
42. Earl J. Analgesics in sheep. Proceedings of the Sheep Veterinary Society Meetings 24 (2000) 47-50
43. Earley B., and Crowe M.A. Effects of ketoprofen alone or in combination with local anesthesia during the castration of bull calves on plasma cortisol, immunological, and inflammatory responses. Journal of Animal Science 80 (2002) 1044-1052
44. Firth A.M., and Haldane S.L. Development of a scale to evaluate post-operative pain in dogs. Journal of the American Veterinary Medical Association 214 (1999) 615-659
45. Fisher A.D., Knight T.W., Cosgrove G.P., Death A.F., Anderson C.B., Duganzich D.M., and Matthews L.R. Effects of surgical and banding castration on stress responses and behaviour of bulls. Australian Veterinary Journal 79 (2001) 279-284
46. Fitzgerald M. The development of nociceptive circuits. Nature Reviews Neuroscience 6 (2005) 507-520
47. Fox S.M., Mellor D.J., Stafford K.J., Lowoko C.R., and Hodge H. The effects of ovariohysterectomy plus different combinations of halothane anaesthesia and butorphanol analgesia on behaviour in the bitch. Research in Veterinary Science 68 (2000) 265-274
48. Franks J.N., Boothe H.W., Taylor L., Geller S., Carroll G.L., Cracas V., and Boothe D.M. Evaluation of transdermal fentanyl patches for analgesia in cats undergoing onychectomy. Journal of the American Veterinary Medical Association 217 (2000) 1013-1020
49. Furlan A.D., Sandoval J.A., Mailis-Gagnon A., and Tunks E. Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. Canadian Medical Association Journal 174 (2006) 1589-1594
50. Garry E.M., Moss A., Delaney A., O'Neill F., Blakemore J., Bowen J., Husi H., Mitchell R., Grant S.G., and Fleetwood-Walker S.M. Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice. Current Biology 13 (2003) 321-328
51. Garry E.M., Jones E., and Fleetwood-Walker S.M. Nociception in vertebrates: key receptors participating in spinal mechanisms of chronic pain in animals. Brain Research Reviews 46 (2004) 216-224
52. Gaynor J.S., and Muir W.W. Handbook of Veterinary Pain Management (2002), Mosby, St. Louis, Missouri, USA
53. Gold M.S., Weinreich D., Kim C.-S., Wang R., Treanor J., Porreca F., and Lai J. Redistribution of NaV1.8 in uninjured axons enables neuropathic pain. Journal of Neuroscience 23 (2003) 158-166
54. Grint N.J., Murison P.J., Coe R.J., and Waterman Pearson A.E. Assessment of the influence of surgical technique on postoperative pain and wound tenderness in cats following ovariohysterectomy. Journal of Feline Medicine and Surgery 8 (2006) 15-21
55. Gupta A., Bodin L., Holmström B., and Berggren L. A systematic review of the peripheral analgesic effects of intraarticular morphine. Anesthesia and Analgesia 93 (2001) 761-770
56. Hansen B. Through a glass darkly: using behaviour to assess pain. Seminars in Veterinary Medicine and Surgery 12 (1997) 61-74
57. Hansen B., and Hardie E. Prescription and use of analgesics in dogs and cats in a veterinary teaching hospital: 258 cases (1983-1989). Journal of the American Medical Association 202 (1993) 1485-1494
58. Hardie E.M. Recognition of pain behaviour in animals. In: Hellebrekers L.J. (Ed). Animal Pain. A Practice-Oriented Approach to an Effective Pain Control in Animals (2000), Van Der Wees, Utrecht, The Netherlands 51-69
59. Hardie E.M., Hansen B.D., and Carroll G.S. Behavior after ovariohysterectomy in the dog: what's normal?. Applied Animal behaviour Science 51 (1997) 111-128
60. Hargreaves K., Dubner R., Brown F., Flores C., and Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32 (1988) 77-88
61. Haussler K.K., and Erb H.N. Mechanical nociceptive thresholds in the axial skeleton of horses. Equine Veterinary Journal 38 (2006) 70-75
62. Haussler K.K., and Erb H.N. Pressure algometry for the detection of induced back pain in horses: a preliminary study. Equine Veterinary Journal 38 (2006) 76-81
63. Hay M., Vulin A., Genin S., Sales P., and Prunier A. Assessment of pain induced by castration in piglets: behavioural and physiological responses over the subsequent 5 days. Applied Animal Behaviour Science 82 (2003) 201-218
64. Hefti F.F., Rosenthal A., Walicke P.A., Wyatt S., Vergara G., Shelton D.L., and Davies A.M. Novel class of pain drugs based on antagonism of NFG. Trends in Pharmacological Sciences 27 (2006) 85-91
65. Hellebrekers L.J. Pathophysiology of pain in animals and its consequence for analgesic therapy. In: Hellebrekers L.J. (Ed). Animal Pain. A Practice-Oriented Approach to an Effective Pain Control in Animals (2000), Van Der Wees, Utrecht, The Netherlands 11-16
66. Hellyer P.W. Treatment of pain in dogs and cats. Journal of the American Veterinary Medical Association 221 (2002) 212-215
67. Hellyer P.W., and Gaynor J.S. Acute post-surgical pain in dogs and cats. Compendium of Continuing Education for the Practicing Veterinarian (Small Animals) 20 (1998) 140-153
68. Hellyer P.W., Frederick C., Lacy M., Salman M.D., and Wagner A.E. Attitudes of veterinary medical students, house officers, clinical faculty, and staff toward pain management in animals. Journal of the American Medical Association 214 (1999) 238-244
69. Hill R. NK1 (substance P) receptor antagonists - why are they not analgesic in humans?. Trends in Pharmacological Sciences 21 (2000) 244-246
70. Hökfelt T., Zhang X., and Wiesenfeld-Hallin Z. Messenger plasticity in primary sensory neurons following axotomy and its functional implications. Trends in Neuroscience 17 (1994) 22-30
71. Holton L.L., Scott E.M., Nolan A.M., Reid J., Welsh E., and Flaherty D. Relationship between physiological factors and clinical pain in dogs scored using a numerical rating scale. Journal of Small Animal Practice 39 (1998) 469-474
72. Holton L.L., Scott E.M., Nolan A.M., Reid J., Welsh E., and Flaherty D. Comparison of three methods used for assessment of pain in dogs. Journal of the American Veterinary Medical Association 212 (1998) 61-66
73. Holton L.L., Reid J., Scott E.M., Pawson P., and Nolan A.M. Development of a behaviour-based scale to measure acute pain in dogs. The Veterinary Record 148 (2001) 525-531
74. Hood D.M., Wagner I.P., Taylor D.D., Brumbaugh G.W., and Chaffin M.K. Voluntary limb-load distribution in horses with acute and chronic laminitis. American Journal of Veterinary Research 62 (2001) 1393-1398
75. Hudson J.T., Slater M.R., Taylor L., Scott M.H., and Kerwin S.C. Assessing repeatability and validity of a visual analogue scale questionnaire for use in assessing pain and lameness in dogs. American Journal of Veterinary Research 65 (2004) 1643
76. Hugonnard M., Leblond A., Keroack S., Cadore J.-L., and Troncy E. Attitudes and concerns of French veterinarians towards pain and analgesia in dogs and cats. Veterinary Anaesthesia and Analgesia 31 (2004) 154-163
77. Hunter E.J., Jones T.A., Guise H.J., Penny R.H., and Hoste S. The relationship between tail biting in pigs, docking procedure and other management practices. The Veterinary Journal 161 (2001) 72-79
78. Husi H., Ward M.A., Choudhary J.S., Blackstock W.P., and Grant S.G. Proteomic analysis of NMDA receptor-adhesion protein signalling complex. Nature Neuroscience 3 (2000) 661-669
79. Huxley J.N., and Whay H.R. Current attitudes of cattle practitioners to pain and the use of analgesics in cattle. The Veterinary Record 159 (2006) 662-668
80. IASP. The need of a taxonomy. Pain 6 (1979) 247-252
81. Ji R.R., and Woolf C.J. Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiology of Disease 8 (2001) 1-10
82. Johansen J.P., Fields H.L., and Manning B.H. The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex. Proceedings of the National Academy of Sciences of the USA 98 (2001) 8077-8082
83. Johnson C.B., Stafford K.J., Sylvester S.P., Ward R.N., Mitchinson S., and Mellor D.J. Effects of age on the electroencephalographic response to castration in lambs anaesthetised using halothane in oxygen. New Zealand Veterinary Journal 53 (2005) 433-437
84. Joris J.L., Dubner R., and Hargreaves K.M. Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation?. Anesthesia and Analgesia 66 (1987) 1277-1281
85. Joubert K.E. The use of analgesic drugs by South African veterinarians. Journal of the South African Veterinary Association 72 (2001) 57-60
86. Julius D., and Basbaum A.I. Molecular mechanisms of nociception. Nature 413 (2001) 203-210
87. Kamerling S.G., Weckman T.J., DeQuick D.J., and Tobin T. A method for studying cutaneous pain perception and analgesia in horses. Journal of Pharmacological Methods 13 (1985) 267-274
88. Keegan K.G., Wilson D.A., Wilson D.J., Smith B., Gaughan E.M., Pleasant R.S., Lillich J.D., Kramer J., Howard R.D., Bacon-Miller C., Davis E.G., May K.A., Cheramie H.S., Valentino W.L., and van Harreveld P.D. Evaluation of mild lameness in horses trotting on a treadmill by clinicians and interns or residents and correlation of their assessment with kinematic gait analysis. American Journal of Veterinary Research 59 (1998) 1370-1377
89. Keegan K.G., Arafat S., Skubic M., Wilson D.A., and Kramer J. Detection of lameness and determination of the affected forelimb in horses by use of a continuous wavelet transformation and neural network classification of kinematic data. American Journal of Veterinary Research 64 (2003) 1376-1381
90. Kidd B.L., and Urban L.A. Mechanisms of inflammatory pain. British Journal of Anaesthesia 87 (2001) 3-11
91. Kingery W.S., Agashe G.S., Sawamura S., Davies M.F., Clark J.D., and Maze M. Glucocorticoid inhibition of neuropathic hyperalgesia and spinal Fos expression. Anesthesia and Analgesia 92 (2001) 476-482
92. KuKanich B., Lascelles B.D.X., and Papich M.G. Assessment of a von Frey device for evaluation of the antinociceptive effects of morphine and its application in pharmacodynamic modelling of morphine in dogs. American Journal of Veterinary Research 66 (2005) 1616-1622
93. Kyles A.E., Waterman A.E., and Livingston A. Antinociceptive effects of combining low doses of neuroleptic drugs and fentanyl in sheep. American Journal of Veterinary Research 54 (1993) 1483-1487
94. Kyles A.E., Hardie E.M., Hansen B.D., and Papich M.G. Comparison of transdermal fentanyl and intramuscular oxymorphone on post-operative behavior after ovariohysterectomy in dogs. Research in Veterinary Science 65 (1998) 245-251
95. LaBuda C.J., and Fuchs P.N. Attenuation of negative pain affect produced by unilateral spinal nerve injury in the rat following anterior cingulate cortex activation. Neuroscience 136 (2005) 311-322
96. Laird J.M., and Bennett G.J. An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. Journal of Neurophysiology 69 (1993) 2072-2085
97. Lascelles B.D.X. Clinical pharmacology of analgesic agents. In: Hellebrekers L.J. (Ed). Animal Pain. A Practice-Oriented Approach to an Effective Pain Control in Animals (2000), Van Der Wees, Utrecht, The Netherlands 85-116
98. Lascelles D., and Waterman A. Analgesia in cats. In Practice 19 (1997) 203-213
99. Lascelles B.D.X., Cripps P.J., Jones A., and Waterman A.E. Post-operative central hypersensitivity and pain: the pre-emptive value of pethidine for ovariohysterectomy. Pain 73 (1997) 461-471
100. Lascelles B.D.X., Cripps P.J., Jones A., and Waterman A.E. Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy. Veterinary Surgery 27 (1998) 568-582
101. Leach D.H., and Crawford W.H. Guidelines for the future of equine locomotion research. Equine Veterinary Journal 15 (1983) 103-111
102. Leem J.W., Choi E.J., Park E.S., and Paik K.S. N-methyl-d-aspartate (NMDA) and non-NMDA glutamate receptor antagonists differentially suppress dorsal horn neuron responses to mechanical stimuli in rats with peripheral nerve injury. Neuroscience Letters 211 (1996) 37-40
103. Lemke K.A. Perioperative use of selective alpha-2-agonists and antagonists in small animals. Canadian Veterinary Journal 45 (2004) 475-480
104. Lester S.J., Mellor D.J., Holmes R.J., Ward R.N., and Stafford K.J. Behavioural and cortisol responses of lambs to castration and tailing using different methods. New Zealand Veterinary Journal 44 (1996) 45-54
105. Ley S.J., Waterman A.E., and Livingston A. Measurement of mechanical thresholds, plasma cortisol and catecholamines in control and lame cattle: a preliminary study. Research in Veterinary Science 61 (1996) 172-173
106. Lindh V., Wiklund U., and Hakansson S. Heel lancing in term new-born infants: an evaluation of pain by frequency domain analysis of heart rate variability. Pain 80 (1999) 143-148
107. McGlone J.J., Nicholson R.I., Hellman J.M., and Herzog D.N. The development of pain in young pigs associated with castration and attempts to prevent castration-induced behavioral changes. Journal of Animal Science 71 (1993) 1441-1446
108. Mellor D.J., Cook C.J., and Stafford K.J. Quantifying some responses to pain as a stressor. In: Moberg G.P., and Mench J.A. (Eds). The Biology of Animal Stress (2000), CAB International, Wallingford, Oxon, UK 171-198
109. Melzack R., and Torgerson W.S. On the language of pain. Anesthesiology 34 (1971) 50-59
110. Mogil J.S. The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proceedings of the National Academy of Sciences of the USA 96 (1999) 7744-7751
111. Mogil J.S., Richards S.P., O'Toole L.A., Helms M.L., Mitchell S.R., and Belknap J.K. Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by delta2-opioid receptors. Pain 70 (1997) 267-277
112. Møiniche S., Kehlet H., and Dahl J.B. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief- the role of timing of analgesia. Anesthesiology 96 (2002) 725-741
113. Molony V. Comments on Anand and Craig (Letters to the Editor). Pain 70 (1997) 293
114. Molony V., and Kent J.E. Assessment of acute pain in farm animals using behavioral and physiological measurements. Journal of Animal Science 75 (1997) 266-272
115. Molony V., Kent J.E., and Robertson I.S. Assessment of acute and chronic pain after different methods of castration of calves. Applied Animal Behaviour Science 46 (1995) 33-48
116. Molony V., Kent J.E., and McKendrick I.J. Validation of a method for assessment of an acute pain in lambs. Applied Animal Behaviour Science 76 (2002) 215-238
117. Morton D.B., and Griffiths P.H.M. Guidelines on the recognition of pain distress and discomfort in experimental animals and a hypothesis of assessment. The Veterinary Record 116 (1985) 431-436
118. Morton C.M., Reid J., Scott E.M., Holton L.L., and Nolan A.M. Application of a scaling model to establish and validate an interval level pain scale for assessment of acute pain in dogs. American Journal of Veterinary Research 66 (2005) 2154-2166
119. Muir W.W., Wiese A.J., and Wittum T.E. Prevalence and characteristics of pain in dogs and cats examined as outpatients at a veterinary teaching hospital. Journal of the American Veterinary Medical Association 224 (2004) 1459-1463
120. Nandigama P., and Borszcz G. Affective analgesia following the administration of morphine into the amygdala of rats. Brain Research 959 (2003) 343-354
121. Narita M., Kaneko C., Miyoshi K., Nagumo Y., Kuzumaki N., Nakajima M., Nanjo K., Matsuzawa K., Yamazaki M., and Suzuki T. Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology 31 (2006) 739-750
122. Nolan A.M., and Hall L.W. Combined use of sedatives and opiates in horses. The Veterinary Record 114 (1984) 63-67
123. Noonan G.J., Rand J.S., Priest J., Ainscow J., and Blackshaw J.K. Behavioural observations of piglets undergoing tail docking, teeth clipping and ear notching. Applied Animal Behaviour Science 39 (1994) 203-213
124. Obel N. Studies on the Histopathology of Acute Laminitis (1948), Almqvist and Wiksells Boktryckteri AK, Uppsala, Sweden
125. O'Callaghan K. Lameness and associated pain in cattle - challenging traditional perceptions. In Practice 24 (2002) 212-219
126. O'Callaghan K.A., Cripps P.J., Downham D.Y., and Murray R.D. Subjective and objective assessment of pain and discomfort due to lameness in dairy cattle. Animal Welfare 12 (2003) 605-610
127. Owens J.G., Kamerling S.G., Stanton S.R., and Keowen M.L. Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. Equine Veterinary Journal 27 (1995) 296-300
128. Paul-Murphy J., Ludders J.W., Robertson S.A., Gaynor J.S., Hellyer P.W., and Wong P.L. The need for a cross-species approach to the study of pain in animals. Journal of the American Veterinary Medical Association 224 (2004) 692-697
129. Peham C., Licka T., Girtler D., and Scheidl M. Supporting forelimb lameness: clinical judgment vs. computerised symmetry measurement. Equine Veterinary Journal 31 (1999) 417-421
130. Peloso J.G., Stick J.A., Soutas-Little R.W., Caron J.C., DeCamp C.E., and Leach D.H. Computer-assisted three-dimensional gait analysis of amphotericin-induced carpal lameness in horses. American Journal of Veterinary Research 54 (1993) 1535-1543
131. Polgar E., Hughes D.I., Riddell J.S., Maxwell D.J., Puskar Z., and Todd A.J. Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain. Pain 104 (2003) 229-239
132. Potthoff A., and Carithers R.W. Pain and analgesia in dogs and cats. Compendium of Continuing Education for the Practicing Veterinarian 11 (1989) 887-896
133. Price J., Marques J.M., Welsh E.M., and Waran N.K. Pilot epidemiological study of attitudes towards pain in horses. The Veterinary Record 151 (2002) 570-575
134. Price J., Catriona S., Welsh E.M., and Waran N.K. Preliminary evaluation of a behaviour-based system for assessment of post-operative pain in horses following arthroscopic surgery. Veterinary Anaesthesia and Analgesia 30 (2003) 124-137
135. Pypendop B.H., Ilkiew J.E., and Robertson S.A. Effect of intravenous administration of lidocaine on the thermal threshold in cats. American Journal of Veterinary Research 67 (2006) 16-20
136. Raekallio M., Taylor P.M., and Bennett R.C. Preliminary investigations of pain and analgesia assessment in horses administered phenylbutazone or placebo after arthroscopic surgery. Veterinary Surgery 26 (1997) 150-155
137. Raekallio M., Taylor P.M., and Bloomfield M. A comparison of methods for evaluation of pain and distress after orthopaedic surgery in horses. Journal of Veterinary Anaesthesia 24 (1997) 17-20
138. Raekallio M., Heinonen K.M., Kuussaari J., and Vainio O. Pain alleviation in animals: attitudes and practices of Finnish Veterinarians. The Veterinary Journal 165 (2003) 131-135
139. Ramachandran V.S., and Rogers-Ramachandran D. Phantom limbs and neural plasticity. Archives of Neurology 57 (2000) 317-320
140. Redua M.A., Valadao C.A., Duque J.C., and Balestrero L.T. The pre-emptive effect of epidural ketamine on wound sensitivity in horses tested by Von Frey filaments. Veterinary Anaesthesia and Analgesia 29 (2002) 200-206
141. Rietmann T.R., Stauffacher M., Bernasconi P., Auer J.A., and Weishaupt M.A. The association between heart rate, heart rate variability, endocrine and behavioural pain measures in horses suffering from laminitis. Journal of Veterinary Medicine A 51 (2004) 218-225
142. Robertson S.A. What is pain?. Journal of the American Veterinary Medical Association 221 (2002) 202-205
143. Robertson S.A. How do we know if they hurt? Pain assessment in small animals. Veterinary Medicine 98 (2003) 700-709
144. Robertson S.A. Assessment and management of acute pain in cats. Journal of Veterinary Emergency and Critical Care 15 (2005) 261-272
145. Robertson S.A., and Taylor P.M. Pain management in cats - past, present and future. Part 2. Treatment of pain-clinical pharmacology. Journal of Feline Medicine and Surgery 6 (2004) 321-333
146. Robertson I.S., Kent J.E., and Molony V. Effects of different methods of castration on behaviour and plasma cortisol in calves of three ages. Research in Veterinary Medicine Science 56 (1994) 8-17
147. Romans C.W., Conzemius M.G., Horstman C.L., Gordon W.J., and Evans R.B. Use of pressure platform gait analysis in cats with and without bilateral onychectomy. American Journal of Veterinary Research 65 (2004) 1276-1278
148. Romans C.W., Gordon W.J., Robinson D.A., Evans R., and Conzemius M.G. Effect of postoperative analgesic protocol on limb function following onychectomy in cats. Journal of the American Veterinary Medical Association 227 (2005) 89-93
149. Rowbotham M., Harden N., Stacey B., Bernstein P., and Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. Journal of the American Medical Association 280 (1998) 1837-1842
150. + channel NaV1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. Journal of Physiology 550 (2003) 921-926
151. Sanford J., Ewbank R., Molony V., Tavernor W.D., and Uvarov O. Guidelines for the recognition and assessment of pain in animals. The Veterinary Record 118 (1986) 334-338
152. Short C.E. The management of animal pain. Where have we been, where are now and where are we going?. The Veterinary Journal 165 (2003) 101-103
153. Siao Tick Chong P., and Cros D.P. Technology literature review: quantitative sensory testing. Muscle Nerve 29 (2004) 734-747
154. Simonsen H.B., Klinken L., and Bindseil E. Histopathology of intact and docked pigtails. The British Veterinary Journal 147 (1991) 407-412
155. Slingsby L.S., and Waterman-Pearson A.E. Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat. The Veterinary Record 143 (1998) 185-189
156. Slingsby L.S., Jones A., and Waterman-Pearson A.E. Use of a finger-mounted device to compare mechanical nociceptive thresholds in cats given pethidine or no medication after castration. Research in Veterinary Science 70 (2001) 243-246
157. Sotgiu M.L., and Biella G. Differential effects of MK-801, a N-methyl-d-aspartate non-competitive antagonist, on the dorsal horn neuron hyperactivity and hyperexcitability in neuropathic rats. Neuroscience Letters 283 (2000) 153-156
158. Stafford K.J., and Mellor D.J. The welfare significance of the castration of cattle: a review. New Zealand Veterinary Journal 53 (2005) 271-278
159. Stashak T.S. Diagnosis of lameness. In: Stashak T.S. (Ed). Adam's Lameness in Horses. fifth ed. (2002), Lea and Febiger, Philadelphia
160. Sugimoto T., Bennett G.J., and Kajander K.C. Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine. Pain 42 (1990) 205-213
161. Suzuki R., Rygh L.J., and Dickenson A.H. Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends in Pharmacological Sciences 25 (2004) 613-617
162. Takaishi K., Eisele Jr. J.H., and Carstens E. Behavioural and electrophysiological assessment of hyperalgesia and changes in dorsal horn responses following partial sciatic nerve ligation in rats. Pain 66 (1996) 297-306
163. Taylor P.M., and Robertson S.M. Pain management in cats-past, present and future. Part 1. The cat is unique. Journal of Feline Medicine and Surgery 6 (2004) 313-320
164. Taylor B.K., Akana S.F., Peterson M.A., Dallman M.F., and Basbaum A.I. Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: endogenous corticosterone does not reduce nociception in the formalin test. Endocrinology 139 (1998) 2407-2413
165. Taylor D., Hood D.M., and Wagner I.P. Short-term effect of therapeutic shoeing on severity of lameness in horses with chronic laminitis. American Journal of Veterinary Research 63 (2002) 1629-1633
166. Tsuda M., Shigemoto-Mogami Y., Koizumi S., Mizokoshi A., Kohsaka S., Salter M.W., and Inoue K. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424 (2003) 778-783
167. Tsuda M., Mizokoshi A., Shigemoto-Mogami Y., Koizumi S., and Inoue K. Activation of p38 mitogenen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia 45 (2004) 89-95
168. Underwood W.J. Pain and distress in agricultural animals. Journal of the American Veterinary Medical Association 221 (2002) 208-211
169. Vanegas H., and Schaible H.-G. Descending control of persistent pain: inhibitory or facilitatory?. Brain Research Reviews 46 (2004) 295-309
170. Veissier I., Rushen J., Colwell D., and de Passillé A.M. A laser-based method for measuring thermal nociception of cattle. Applied Animal Behaviour Science 66 (2000) 289-304
171. Visser E., and Schug S.A. The role of ketamine in pain management. Biomedicine and Pharmacotherapy 60 (2006) 341-348
172. Watkins L.R., Hutchinson M.R., Ledeboer A., Wieseler-Frank J., Milligan E.D., and Maier S.F. Glia as the "bad guys: implications for improving clinical pain control and the clinical utility of opioids. Brain, Behavior, and Immunity 21 (2007) 131-146
173. Watson A.D., Nicholson A., Church D.B., and Pearson M.R. Use of anti-inflammatory and analgesic drugs in dogs and cats. Australian Veterinary Journal 74 (1996) 201-210
174. Welsh E.M., and Nolan A.M. Effect of flunixin meglumine on the thresholds to mechanical stimulation in healthy and lame sheep. Research in Veterinary Science 58 (1995) 61-66
175. Whay H.R., Waterman A.E., Webster A.J.F., and O'Brien J.K. The influence of lesion type on the duration of hyperalgesia associated with hindlimb lameness in dairy cattle. The Veterinary Journal 156 (1998) 23-29
176. Wiese A.J., Muir W.W., and Wittum T.E. Characteristics of pain and response to analgesic treatment in dogs and cats examined at a veterinary teaching hospital emergency service. Journal of the American Veterinary Medical Association 226 (2005) 2004-2009
177. Williams V.M., Lascelles B.D.X., and Robson M.C. Current attitudes to, and use of, peri-operative analgesia in dogs and cats by veterinarians in New Zealand. New Zealand Veterinary journal 53 (2005) 193-202
178. Wilson S.G., Chesler E.J., Hain H., Rankin A.J., Schwarz J.Z., Call S.B., Murray M.R., West E.E., Teuscher C., Rodriguez-Zas S., Belknap J.K., and Mogil J.S. Identification of quantitative trait loci for chemical/inflammatory nociception in mice. Pain 96 (2002) 385-391
179. Wiseman M.L., Nolan A.M., Reid J., and Scott E.M. Preliminary study on owner-reported behaviour changes associated with chronic pain in dogs. The Veterinary Record 149 (2001) 423-424
180. Woolf C.J. Evidence for a central component of post-injury pain hypersensitivity. Nature 306 (1983) 686-688
181. Woolf C.J., and Chong M.S. Pre-emptive analgesia - treating postoperative pain by preventing the establishment of central sensitization. Anesthesia and Analgesia 77 (1993) 362-379
182. Woolf C.J., and Costigan M. Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proceedings of the National Academy of Sciences of the United States of America 96 (1998) 7723-7730
183. Woolf C.J., and Mannion R.J. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 353 (1999) 1959-1964
184. Woolf C.J., and Salter M.W. Neuronal plasticity: increasing the gain in pain. Science 288 (2000) 1765-1768
185. Woolf C.J., and Thompson S.W. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 44 (1991) 293-299
186. Zhuo M. NMDA receptor-dependent long term hyperalgesia after tail amputation in mice. European Journal of Pharmacology 349 (1998) 211-220