Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala

Neuropsychopharmacology

Volumn 31, Issue 4, 2006, Pages 739-750

  Narita, Minoru ^a   Kaneko, Chihiro ^a   Miyoshi, Kan ^a   Nagumo, Yasuyuki ^a   Kuzumaki, Naoko ^a   Nakajima, Mayumi ^a   Nanjo, Kana ^a   Matsuzawa, Kiyomi ^a,b   Yamazaki, Mitsuaki ^b   Suzuki, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Amygdala; Anxiety; Opioid; Pain

Indexed keywords

3,4 DICHLORO N METHYL N [1 PHENYL 2 (1 PYRROLIDINYL)ETHYL]BENZENEACETAMIDE; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; DELTA OPIATE RECEPTOR AGONIST; DELTA OPIATE RECEPTOR ANTAGONIST; DYNORPHIN A; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ETIZOLAM; FREUND ADJUVANT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; LIGAND; MU OPIATE RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; OPIATE RECEPTOR;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN MEMBRANE; CHRONIC PAIN; CONTROLLED STUDY; DRUG EFFECT; EMOTION; HYPERALGESIA; LIGHT DARK CYCLE; MALE; MEMBRANE BINDING; MOUSE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SCIATIC NERVE; STRESS;

AMYGDALA; ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BENZAMIDES; CHRONIC DISEASE; DIAZEPAM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DYNORPHINS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FREUND'S ADJUVANT; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INJECTIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; NALTREXONE; NARCOTIC ANTAGONISTS; NARCOTICS; PAIN; PAIN MEASUREMENT; PIPERAZINES; PROTEIN BINDING; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SCIATICA; SOMATOSTATIN; SULFUR ISOTOPES; TIME FACTORS; TRANQUILIZING AGENTS;

EID: 33645025228     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300858     Document Type: Article

References (36)

1. Bilkei-Gorzo A, Gyertyan I, Levay G (1998). mCPP-induced anxiety in the light-dark box in rats - a new method for screening anxiolytic activity. Psychopharmacology 136: 291-298.
2. Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH (2002). Nonpeptidic δ-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology 26: 744-755.
3. Cahill CM, Morinville A, Lee MC, Vincent JP, Collier B, Beaudet A (2001). Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception. J Neurosci 21: 7598-7607.
4. Chen Y, Mestek A, Liu J, Hurley JA, Yu L (1993). Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol Pharmacol 44: 8-12.
5. Davis M, Rainnie D, Cassell M (1994). Neurotransmission in the rat amygdala related to fear and anxiety. Trends Neurosci 17: 208-214.
6. Dawson GR, Tricklebank MD (1995). Use of the elevated plus maze in the search for novel anxiolytic agents. Trends Pharmacol Sci 16: 33-36.
7. degli Uberti EC, Petraglia F, Bondanelli M, Guo AL, Valentini A, Salvadori S et al (1995). Involvement of mu-opioid receptors in the modulation of pituitary-adrenal axis in normal and stressed rats. J Endocrinol Invest 18: 1-7.
8. Dworkin RH, Gitlin MJ (1991). Clinical aspects of depression in chronic pain patients. Clin J Pain 7: 79-94.
9. Evans CJ, Keith Jr DE, Morrison H, Magendzo K, Edwards RH (1992). Cloning of a delta opioid receptor by functional expression. Science 258: 1952-1955.
10. Filliol D, Ghozland S, Chluba J, Martin M, Matthes HW, Simonin F et al (2000). Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet 25: 195-200.
11. Fukuda K, Kato S, Mori K, Nishi M, Takeshima H (1993). Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. FEBS Lett 327: 311-314.
12. Gallagher RM, Moore P, Chernoff I (1995). The reliability of depression diagnosis in chronic low back pain. Gen Hosp Psychiatry 17: 399-413.
13. Haley MJ, McCormick WG (1957). Pharmacological effects produced by intracerebral injections of drugs in the conscious mouse. Br J Pharmacol 12: 12-15.
14. Katoh A, Nabeshima T, Kameyama T (1990). Behavioral changes induced by stressful situations: effects of enkephalins, dynorphin, and their interactions. J Pharmacol Exp Ther 253: 600-607.
15. Kieffer BL, Befort K, Gaveriaux-Ruff C, Hirth CG (1992). The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci USA 89: 12048-12052.
16. Kiritsy-Roy JA, Appel NM, Bobbitt FG, Van Loon GR (1986). Effects of mu-opioid receptor stimulation in the hypothalamic paraventricular nucleus on basal and stress-induced catecholamine secretion and cardiovascular responses. J Pharmacol Exp Ther 239: 814-822.
17. Manning BH (1998). A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala. J Neurosci 18: 9453-9470.
18. Mansour A, Fox CA, Akil H, Watson SJ (1995). Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci 18: 22-29.
19. Mansour A, Khachaturian H, Lewis ME, Akil H, Watson SJ (1988). Anatomy of CNS opioid receptors. Trends Neurosci 11: 308-314.
20. Meng F, Xie GX, Thompson RC, Mansour A, Goldstein A, Watson SJ et al (1993). Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci USA 90: 9954-9958.
21. Moller C, Wiklund L, Sommer W, Thorsell A, Heilig M (1997). Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Res 760: 94-101.
22. Narita M, Kishimoto Y, Ise Y, Yajima Y, Misawa K, Suzuki T (2005). Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state. Neuropsychopharmacology 30: 111-118.
23. Narita M, Yajima Y, Aoki T, Ozaki S, Narita M, Mizoguchi H et al (2000). Up-regulation of the TrkB receptor in mice injured by the partial ligation of the sciatic nerve. Eur J Pharmacol 401: 187-190.
24. Ohsawa M, Narita M, Mizoguchi H, Suzuki T, Tseng LF (2000). Involvement of spinal protein kinase C in thermal hyperalgesia evoked by partial sciatic nerve ligation, but not by inflammation in the mouse. Eur J Pharmacol 403: 81-85.
25. Ozaki S, Narita M, Narita M, Iino M, Miyoshi K, Suzuki T (2003). Suppression of the morphine-induced rewarding effect and G-protein activation in the lower midbrain following nerve injury in the mouse: involvement of G-protein-coupled receptor kinase 2. Neuroscience 116: 89-97.
26. Ozaki S, Narita M, Narita M, Iino M, Sugita J, Matsumura Y et al (2002). Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in μ-opioid receptor functions in the ventral tegmental area. J Neurochem 82: 1192-1198.
27. Pasternak GW (1988). The Opiate Receptors. The Human Press: Clifton, NJ.
28. Paxinos G, Watson G (1998). The Rat Brain in Stereotaxic Coordinates, 4th edn. Academic Press: New York.
29. Pfeiffer A, Brantl V, Herz A, Emrich HM (1986). Psychotomimesis mediated by kappa opiate receptors. Science 233: 774-776.
30. Schramm NL, McDonald MP, Limbird LE (2001). The alpha-(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. J Neurosci 21: 4875-4882.
31. Suzuki T, Kishimoto Y, Misawa M, Nagase H, Takeda F (1999). Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain. Life Sci 64: PL1-PL7.
32. Von Korff M, Simon G (1996). The relationship between pain and depression. Br J Psychiatry Suppl 30: 101-108.
33. Wang JB, Imai Y, Eppler CM, Gregor P, Spivak CE, Uhl GR (1993). Mu opiate receptor: cDNA cloning and expression. Proc Natl Acad Sci USA 60: 10230-10234.
34. Yajima Y, Narita M, Usui A, Kaneko C, Miyatake M, Narita M et al (2005). Direct evidence for the involvement of brain-derived neurotrophic factor in the development of neuropathic pain-like state in mice. J Neurochem 93: 584-594.
35. Yasuda K, Raynor K, Kong H, Breder CD, Takeda J, Reisine T et al (1993). Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci USA 90: 6736-6740.
36. Zubieta JK, Smith YR, Bueller JA, Xu Y, Kilbourn MR, Jewett DM et al (2001). Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 293: 311-315.