Herpes simplex virus-thymidine kinase-based suicide gene therapy as a "molecular switch off" for nerve growth factor production in vitro

Tissue Engineering

Volumn 13, Issue 9, 2007, Pages 2357-2365

  Dhar, Sanjay ^a   McConnell, Michael P ^a   Gharibjanian, Nareg A ^a   Young, Christine M ^a   Rogers, Jason M ^a   Nguyen, Thang D ^b   Evans, Gregory R D ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Aesthetic and Plastic Surgery Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DELIVERY; GENES; GROWTH KINETICS; PATIENT TREATMENT; VIRUSES;

HUMAN EMBRYONIC KIDNEY (HEK-293) CELLS; NERVE GROWTH FACTOR (NGF); POSTBOOSTER DOSE;

TISSUE ENGINEERING;

COMPLEMENTARY DNA; GANCICLOVIR; NERVE GROWTH FACTOR; PONASTERONE A; THYMIDINE KINASE;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MOLECULAR CLONING; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; SUICIDE GENE THERAPY; TISSUE ENGINEERING;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GANCICLOVIR; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; HUMANS; NERVE GROWTH FACTOR; PC12 CELLS; PERIPHERAL NERVES; RATS; SIMPLEXVIRUS; THYMIDINE KINASE;

RATTUS; SIMPLEXVIRUS;

EID: 34548658438     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2006.0316     Document Type: Article

References (49)

1. Otto, D., Unsicker, K., and Grothe, C. Pharmacologic effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia. Neurosci. Lett. 83, 156, 1987.
2. Sjoberg, J., and Kanje, M. Insulin like growth factor (IGF-I) as a stimulator of regeneration in the freeze-injured rat sciatic nerve. Brain Res. 485, 102, 1989.
3. He, C., Chen, Z., and Chen, Z. Enhancement of motor nerve regeneration by nerve growth factor. Microsurgery 13, 151, 1992.
4. Derby, A., Wayne, E.V., Frierdich, G.E., Neises, G., Rapp, S.R., and Roua, D.G. Nerve growth factor facilitates regeneration across nerve gaps: morphological and behavioral studies in rat sciatic nerve. Exp. Neurol. 119, 176, 1993.
5. Reichert, F., Levitzky, R., and Rotzhenker, S. Interleukin 6 in intact and injured mouse peripheral nerve. Eur. J. Neurosci. 8, 530, 1996.
6. Sterne, G.D., Brown, R.A., Green, C.J., and Terenghi, G. Neurotrophin-3 delivered locally via fibronectin mats enhances peripheral nerve regeneration. Eur. J. Neurosci. 9, 1388, 1997.
7. Fu, S.Y., and Gordon, T. The cellular and molecular basis of peripheral nerve regeneration. Mol. Neurobiol. 14, 67, 1997.
8. Pu, L.L.Q., Syed, S.A., Reid, M., Patwa, H., Goldstein, J.M., Forman, D.L., and Thomson, J.G. Effects of nerve growth factor on nerve regeneration through a vein graft across a gap. Plast. Reconstr. Surg. 104, 1379, 1999.
9. Winn, S.R., Lindner, A.L., Haggett, G., Francis, J.M., and Emerich, D.F. Polymer-encapsulated genetically modified cells continue to secrete human nerve growth factor for over a year in rat ventricles: behavioral and anatomic consequences. Exp. Neurol. 140, 126, 1996.
10. Patrick, C.W., Zheng, B., Schmidt, M., Hermann, S., Chauvin, P., Fan, Z., Stark, B., and Evans, G.R. Dermal fibroblasts genetically engineered to release NGF. Ann. Plast. Surg. 47, 660, 2001.
11. Patrick, C.W., Zheng, B., Schmidt, M., Wu, X., Gurtner, G., Borden, M., Koutz, C., Chang, D., and Evans, G.R. Muristerone A induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering. Tissue Eng. 7, 303, 2001.
12. Jimenez, J.C., Tyson, D.R., Dhar, S., Nguyen, T., Hamai, Y., Bradshaw, R.A., and Evans, G.R. Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration. Plast. Reconstr. Surg. 113, 605, 2004.
13. McConnell, M.P., Dhar, S., Nguyen, T., Naran, S., Calvert, J.W., Sundine, M.J., Bradshaw, R.A., and Evans, G.R. Nerve growth factor expression response to induction agent booster dosing in transfected human embryonic kidney cells. Plast. Reconstr. Surg. 115, 506, 2005.
14. McConnell, M.P., Dhar, S., Naran, S., Nguyen, T., Bradshaw, R.A., and Evans, G.R. In vivo induction and delivery of nerve growth factor, using HEK-293 cells. Tissue Eng. 10, 1492, 2004.
15. Miller, A.D. Human gene therapy comes to age. Nature 357, 455, 1992.
16. Black, M.E., Newcomb, T.G., Wilson, H.M., and Loeb, L.A. Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy. Proc. Natl. Acad. Sci. USA 93, 3525, 1996.
17. Boucher, P.D., Ruch, R.J., and Shewach, D.S. Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase. Hum. Gene Ther. 9, 801, 1998.
18. Tischler, A.S., and Greene, L.A. Phenotypic plasticity of pheochromocytoma and normal adrenal medullary cells. Adv. Biochem. Psychopharmocol. 25, 61, 1980.
19. Doupe, A.J., Landis, S.C., and Patterson, P.H. Environmental influences in the development of neural crest derivatives: glucocorticoids, growth factors, and chromaffin cell plasticity. J. Neurosci. 5, 2119, 1985.
20. Fisher, L.J., and Ray, J. In vivo and ex vivo gene transfer to the brain. Curr. Opin. Neurobiol. 4, 735, 1994.
21. Snyder, E.Y., and Fisher, L.J. Gene therapy in neurology. Curr. Opin. Pediatr. 8, 558, 1996.
22. Gage, F.H., Wolff, J.A., Rosenberg, M.B., Xu, L., Yee, J.E., Shults, C., and Friedmann, T. Grafting genetically modified cells to the brain. Possibilities for the future. Neuroscience 19, 795, 1987.
23. Tornatore, C., Baker-Cairns, B., Yadid, G., Hamilton, R., Meyers, K., Atwood, W., Cummins, A., Tanner, V., and Major, E. Expression of tyrosine hydroxylase in an immortalized human fetal astrocyte cell line, in vitro characterization and engraftment into rodent striatum. Cell Transplant. 5, 145, 1996.
24. Shimohama, S., Rosenberg, M.B., Fagan, A.M., Wolff, J.A., Short, M.P., Breakefield, X.O., Friedmann, T., and Gage, F.H. Grafting genetically modified cells into the rat brain: characteristic of E. coli beta-galactosidase as a reporter gene. Brain Res. Mol. Brain Res. 5, 271, 1989.
25. Horellou, P., Brundin, P., Kalen, P., Mallet, J., and Bjorklund, A. In vivo release of DOPA and dopamine from genetically engineered cells grafted to the denervated rat striatum. Neuron 5, 393, 1990.
26. Pagnotta, A., Tos, P., Fornaro, M., Gigante, A., Geuna, S., and Battitson, B. Neurotrophins and their receptors in early axonal regeneration along muscle-vein-combined graft. Microsurgery 22, 300, 2002.
27. Menderes, A., Yilmaz, M., Vayvada, H., Ozer, E., and Barutcu, A. Effects of nerve growth factor on the neurotization of denervated muscles. Ann. Plast. Surg. 48, 415, 2002.
28. Skaper, S.D. Nerve growth factor: a neurokine orchestrating neuroimmune-endocrine functions. Mol. Neurobiol. 24, 183, 2001.
29. Everill, B., and Kocsis, J.D. Nerve growth factor maintains potassium conductance after nerve injury in adult cutaneous afferent dorsal root ganglion neurons. Neuroscience 100, 417, 2000.
30. Rahimi, O., and Juliano, S.L. Transplants of NGF secreting fibroblasts restore stimulus-evoked activity in barrel cortex of basal-forebrain-lesioned rats. J. Neurophysiol. 86, 2081, 2000.
31. Shoemaker, S.E., Kudwa, A.E., and Isaacson, L.G. Sympathetic ingrowth to the trigeminal ganglion following intracerebroventricular infusion of nerve growth factor. Brain Res. 956, 136, 2002.
32. Nakahara, Y., Gage, F.H., and Tuszynski, M.H. Grafts of fibroblast genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplant. 5, 191, 1996.
33. Tuszynski, M.H., Gabriel, K., Gage, F.H., Suhr, S.T., Meyer, S., and Rosetti, A. Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp. Neurol. 137, 157, 1996.
34. Tuszynski, M.H., Peterson, D.A., Ray, J., Baird, A., Nakahara, Y., and Gage, F.H. Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp. Neurol. 126, 1, 1994.
35. Sakiyama-Elbert, S.E, and Hubbell, J.A. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell in growth matrix. J. Control. Release 69, 149, 2000.
36. Blesch, A., Uy, H.S., Diergardt, N., and Tuszynski, M.H. Neurite outgrowth can be modulated in vitro using a tetracycline-repressible gene therapy vector expressing human nerve growth factor. J. Neurosci. Res. 59, 402, 2000.
37. Kim, J.H., Kolozsvary, A., Rogulski, K., Khil, M.S., Brown, S.L., and Freytag, S.O. Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene. Cancer J. Sci. Am. 4, 349, 1998.
38. Beltinger, C., Fulda, S., Kammertoens, T., Meyer, E., Uckert, W., and Debatin, K.M. Herpes simplex virus thymidine kinase/ganciclovir induced apoptosis involves ligand independent death receptor aggregation and activation of caspases. Proc. Natl. Acad. Sci. USA 96, 8699, 1999.
39. Wei, S.J., Chao, Y., Hung, Y.M., Lin, W.C., Yand, D.M., Ch'ang, L.Y., Whang-Peng, J., and Yang, W.K. S- and G2-phase cell cycle arrest and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase. Exp. Cell Res. 241, 66, 1998.
40. Hall, S.J., Sanford, M.A., Atkinson, G., and Chen, S.H. Induction of potent antitumor natural killer cell activity by herpes simplex virus thymidine kinase and ganciclovir therapy in an orthotopic mouse model of prostate cancer. Cancer Res. 58, 3221, 1998.
41. Gao, D.C., An, W., and Dai, J. Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy. Cell Res. 9, 225, 1999.
42. Li, P.X., Ngo, D., Brade, A.M., and Klamut, H.J. Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus mediated herpes simplex virus thymidine kinase gene transfer. Cancer Gene Ther. 6, 179, 1999.
43. Anderson, L.M., Swaminathan, S., Zackon, I., Tajuddin, A.K., Thimmapaya, B., and Wetizman, S.A. Adenovirus-mediated tissue targeted expression of the HSV-TK gene for the treatment of breast cancer. Gene Ther. 6, 854, 1999.
44. Howard, B.D., Kalthoff, H., and Fong, T.C. Ablation of tumor cells in vivo by direct injection of HSV-thymidine kinase retroviral vector and ganciclovir therapy. Ann. N. Y. Acad. Sci. 880, 352, 1999.
45. Seto, M., Wakabayashi, H., Yamazaki, T., Sonoda, J., Shinto, Y., and Uchida, A. Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene. Int. J. Oncol. 14, 1137, 1999.
46. Sant, S.M., Suarez, T.M., Moalli, M.R., Wu, B.Y., Blaivas, M., Laing, T.J., and Roessler, B.J. Molecular lysis of synovial lining cells by in vivo herpes simplex virus thymidine kinase gene transfer. Hum. Gene Ther. 9, 2735, 1998.
47. Shand, N., Weber, F., Marinai, L., Bernstein, M., Gianella-Borradori, A., Long, Z., Sorensen, A.G., and Barbier, N. A phase 1-2 clinical trail of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. Hum. Gene Ther. 10, 2325, 1999.
48. Driesse, M.J., Vincent, A.J., Sillevis-Smith, P.A., Kros, J.M., Hoogerbrugge, P.M., Avezaat, C.J., and Valerio, D. Intracerebral injection of adenovirus harboring the HSV-TK gene combined with ganciclovir administration: toxicity study in nonhuman primates. Gene Ther. 5, 1122, 1998.
49. Kunishige, I., Samejima, Y., Shiki, Y., Moriyama, A., Meruelo, D., Saji, F., and Murata, Y. Suicide gene therapy for human uterine adenocarcinoma cells using herpes simplex virus thymidine. Gynecol. Oncol. 72, 16, 1999.