메뉴 건너뛰기




Volumn 59, Issue 3, 2000, Pages 402-409

Neurite outgrowth can be modulated in vitro using a tetracycline- repressible gene therapy vector expressing human nerve growth factor

Author keywords

Gene therapy; NGF; Regeneration; Regulatable expression; Retrovirus; Spinal cord injury; Tetracycline

Indexed keywords

COMPLEMENTARY DNA; DOXYCYCLINE; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; NERVE GROWTH FACTOR; TETRACYCLINE; VIRUS VECTOR;

EID: 0034141674     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(20000201)59:3<402::AID-JNR14>3.0.CO;2-Q     Document Type: Article
Times cited : (32)

References (45)
  • 1
    • 0001361045 scopus 로고    scopus 로고
    • Cellularly delivered GDNF induces robust growth of motor and sensory axons in the injured adult spinal cord
    • Blesch A, Diergardt N, Tuszynski MH. 1998a. Cellularly delivered GDNF induces robust growth of motor and sensory axons in the injured adult spinal cord. Soc Neurosci Abstr 24:555.
    • (1998) Soc Neurosci Abstr , vol.24 , pp. 555
    • Blesch, A.1    Diergardt, N.2    Tuszynski, M.H.3
  • 2
    • 0031771314 scopus 로고    scopus 로고
    • Neurotrophin gene therapy in CNS models of trauma and degeneration
    • Blesch A, Grill RJ, Tuszynski MH. 1998b. Neurotrophin gene therapy in CNS models of trauma and degeneration. Progr Brain Res 117: 473-484.
    • (1998) Progr Brain Res , vol.117 , pp. 473-484
    • Blesch, A.1    Grill, R.J.2    Tuszynski, M.H.3
  • 3
    • 0029548385 scopus 로고
    • Ex vivo gene therapy for Alzheimer's disease and spinal cord injury
    • Blesch A, Tuszynski MH. 1995. Ex vivo gene therapy for Alzheimer's disease and spinal cord injury. Clin Neurosci 3:268-274.
    • (1995) Clin Neurosci , vol.3 , pp. 268-274
    • Blesch, A.1    Tuszynski, M.H.2
  • 4
    • 0033135389 scopus 로고    scopus 로고
    • LIF augments corticospinal axon growth and neurotrophin expression after adult CNS injury
    • Blesch A, Uy HS, Grill RJ, Cheng JG, Patterson PH, Tuszynski MH. 1999. LIF augments corticospinal axon growth and neurotrophin expression after adult CNS injury. J Neurosci 19:3556-3566.
    • (1999) J Neurosci , vol.19 , pp. 3556-3566
    • Blesch, A.1    Uy, H.S.2    Grill, R.J.3    Cheng, J.G.4    Patterson, P.H.5    Tuszynski, M.H.6
  • 5
    • 0031040987 scopus 로고    scopus 로고
    • Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts
    • Bohl D, Naffakh N, Heard JM. 1997. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nat Med 3:299-305.
    • (1997) Nat Med , vol.3 , pp. 299-305
    • Bohl, D.1    Naffakh, N.2    Heard, J.M.3
  • 6
    • 0029997290 scopus 로고    scopus 로고
    • Characterization of antibodies to nerve growth factor: Assay-dependent variability in the cross-reactivity with other neurotrophins
    • Conner JM, Varon S. 1996. Characterization of antibodies to nerve growth factor: assay-dependent variability in the cross-reactivity with other neurotrophins. J Neurosci Meth 65:93-99.
    • (1996) J Neurosci Meth , vol.65 , pp. 93-99
    • Conner, J.M.1    Varon, S.2
  • 7
    • 0029780040 scopus 로고    scopus 로고
    • Intracerebral tetracycline-dependent regulation of gene expression in grafts of neural precursors
    • Corti O, Horellou P, Colin P, Cattaneo E, Mallet J. 1996. Intracerebral tetracycline-dependent regulation of gene expression in grafts of neural precursors. NeuroReport 7:1655-1659.
    • (1996) NeuroReport , vol.7 , pp. 1655-1659
    • Corti, O.1    Horellou, P.2    Colin, P.3    Cattaneo, E.4    Mallet, J.5
  • 8
    • 0029919753 scopus 로고    scopus 로고
    • TAXI/UAS: A molecular switch to control expression of genes in vivo
    • Delort JP, Capecchi MR. 1996. TAXI/UAS: a molecular switch to control expression of genes in vivo. Hum Gene Ther 7:809-820.
    • (1996) Hum Gene Ther , vol.7 , pp. 809-820
    • Delort, J.P.1    Capecchi, M.R.2
  • 9
    • 0027218098 scopus 로고
    • Neurotrophins and their receptors - Current concepts and implications for neurologic disease
    • Eide FF, Lowenstein DH, Reichardt LF. 1993. Neurotrophins and their receptors - current concepts and implications for neurologic disease. Exp Neurol 121:200-214.
    • (1993) Exp Neurol , vol.121 , pp. 200-214
    • Eide, F.F.1    Lowenstein, D.H.2    Reichardt, L.F.3
  • 10
    • 0028126942 scopus 로고
    • In vivo and ex vivo gene transfer to the brain
    • Fisher LJ, Ray J. 1994. In vivo and ex vivo gene transfer to the brain. Curr Opin Neurobiol 4:735-741.
    • (1994) Curr Opin Neurobiol , vol.4 , pp. 735-741
    • Fisher, L.J.1    Ray, J.2
  • 14
    • 0027501690 scopus 로고
    • Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements
    • Gossen M, Bonin AL, Bujard H. 1993. Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biochem Sci 18:471-475.
    • (1993) Trends Biochem Sci , vol.18 , pp. 471-475
    • Gossen, M.1    Bonin, A.L.2    Bujard, H.3
  • 15
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 17
    • 16944366150 scopus 로고    scopus 로고
    • Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury
    • Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH. 1997a. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci 17:5560-5572.
    • (1997) J Neurosci , vol.17 , pp. 5560-5572
    • Grill, R.1    Murai, K.2    Blesch, A.3    Gage, F.H.4    Tuszynski, M.H.5
  • 18
    • 0031408944 scopus 로고    scopus 로고
    • Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells
    • Grill RJ, Blesch A, Tuszynski MH. 1997b. Robust growth of chronically injured spinal cord axons induced by grafts of genetically modified NGF-secreting cells. Exp Neurol 148:444-452.
    • (1997) Exp Neurol , vol.148 , pp. 444-452
    • Grill, R.J.1    Blesch, A.2    Tuszynski, M.H.3
  • 21
    • 0033151593 scopus 로고    scopus 로고
    • Transplants of fibroblasts genetically modified to express brain-derived neurotrophic factor promote regeneration of adult rat rubrospinal axons and recovery of forelimb function
    • Liu Y, Kim D, Himes BT, Chow SY, Schallert T, Murray M, Tessler A, Fischer I. 1999. Transplants of fibroblasts genetically modified to express brain-derived neurotrophic factor promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J Neurosci 19: 4370-4387.
    • (1999) J Neurosci , vol.19 , pp. 4370-4387
    • Liu, Y.1    Kim, D.2    Himes, B.T.3    Chow, S.Y.4    Schallert, T.5    Murray, M.6    Tessler, A.7    Fischer, I.8
  • 22
    • 0031441285 scopus 로고    scopus 로고
    • Pharmacologic control of a humanized gene therapy system implanted into nude mice
    • Magari SR, Rivera VM, Iuliucci JD, Gilman M, Cerasoli F, Jr. 1997. Pharmacologic control of a humanized gene therapy system implanted into nude mice. J Clin Invest 100:2865-2872.
    • (1997) J Clin Invest , vol.100 , pp. 2865-2872
    • Magari, S.R.1    Rivera, V.M.2    Iuliucci, J.D.3    Gilman, M.4    Cerasoli F., Jr.5
  • 23
    • 0025398116 scopus 로고
    • Retrovirus packaging cells
    • Miller AD. 1990. Retrovirus packaging cells. Hum Gene Ther 1:5-14.
    • (1990) Hum Gene Ther , vol.1 , pp. 5-14
    • Miller, A.D.1
  • 25
  • 26
    • 0029983422 scopus 로고    scopus 로고
    • Graft of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord
    • Nakahara Y, Gage FH, Tuszynski MH. 1996. Graft of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplant 5:191-204.
    • (1996) Cell Transplant , vol.5 , pp. 191-204
    • Nakahara, Y.1    Gage, F.H.2    Tuszynski, M.H.3
  • 27
    • 0029865151 scopus 로고    scopus 로고
    • Ecdysone-inducible gene expression in mammalian cells and transgenic mice
    • No D, Yao TP, Evans RM. 1996. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci USA 93:3346-3351.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3346-3351
    • No, D.1    Yao, T.P.2    Evans, R.M.3
  • 28
    • 0003019169 scopus 로고    scopus 로고
    • Generation of high-titer, helper-free retroviruses by transient transfection
    • Robbins PD, editor. Totowa, New Jersey: Humana Press Inc.
    • Pear WS, Scott ML, Nolan GP. 1997. Generation of high-titer, helper-free retroviruses by transient transfection. In: Robbins PD, editor. Methods in molecular medicine: gene therapy protocols. Totowa, New Jersey: Humana Press Inc. p 41-57.
    • (1997) Methods in Molecular Medicine: Gene Therapy Protocols , pp. 41-57
    • Pear, W.S.1    Scott, M.L.2    Nolan, G.P.3
  • 29
    • 0031105522 scopus 로고    scopus 로고
    • Application of ex vivo gene therapy in the treatment of Parkinson's disease
    • Raymon HK, Thode S, Gage FH. 1997. Application of ex vivo gene therapy in the treatment of Parkinson's disease. Exp Neurol 144:82-91.
    • (1997) Exp Neurol , vol.144 , pp. 82-91
    • Raymon, H.K.1    Thode, S.2    Gage, F.H.3
  • 31
    • 0032192146 scopus 로고    scopus 로고
    • Recent advances in inducible gene expression systems
    • Rossi FM, Blau HM. 1998. Recent advances in inducible gene expression systems. Current Opin Biotechnol 9:451-456.
    • (1998) Current Opin Biotechnol , vol.9 , pp. 451-456
    • Rossi, F.M.1    Blau, H.M.2
  • 32
    • 0020684210 scopus 로고
    • The quantitative bioassay of nerve growth factor: Use of frozen 'primed' PC12 pheochromocytoma cells
    • Rukenstein A, Greene LA. 1983. The quantitative bioassay of nerve growth factor: use of frozen 'primed' PC12 pheochromocytoma cells. Brain Res 263:177-180.
    • (1983) Brain Res , vol.263 , pp. 177-180
    • Rukenstein, A.1    Greene, L.A.2
  • 33
    • 0029021083 scopus 로고
    • A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
    • Shockett P, Difilippantonio M, Hellman N, Schatz DG. 1995. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci USA 92:6522-6526.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6522-6526
    • Shockett, P.1    Difilippantonio, M.2    Hellman, N.3    Schatz, D.G.4
  • 34
    • 0027525494 scopus 로고
    • Gene therapy for neurologic disease
    • Suhr ST, Gage FH. 1993. Gene therapy for neurologic disease. Arch Neurol 50:1252-1268.
    • (1993) Arch Neurol , vol.50 , pp. 1252-1268
    • Suhr, S.T.1    Gage, F.H.2
  • 35
    • 0032493446 scopus 로고    scopus 로고
    • High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor
    • Suhr ST, Gil EB, Senut MC, Gage FH. 1998. High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor. Proc Natl Acad Sci USA 95:7999-8004.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7999-8004
    • Suhr, S.T.1    Gil, E.B.2    Senut, M.C.3    Gage, F.H.4
  • 37
    • 0030054303 scopus 로고    scopus 로고
    • Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury
    • Tuszynski MH, Gabriel K, Gage FH, Suhr S, Meyer S, Rosetti A. 1996. Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp Neurol 137:157-173.
    • (1996) Exp Neurol , vol.137 , pp. 157-173
    • Tuszynski, M.H.1    Gabriel, K.2    Gage, F.H.3    Suhr, S.4    Meyer, S.5    Rosetti, A.6
  • 38
    • 0028232803 scopus 로고
    • Neurotrophic factors and diseases of the nervous system
    • Tuszynski MH, Gage FH. 1994. Neurotrophic factors and diseases of the nervous system. Ann Neurol 35(suppl):S9-12.
    • (1994) Ann Neurol , vol.35 , Issue.SUPPL.
    • Tuszynski, M.H.1    Gage, F.H.2
  • 39
    • 0030330850 scopus 로고    scopus 로고
    • Somatic gene therapy for nervous system disease
    • Tuszynski MH, Gage FH. 1996. Somatic gene therapy for nervous system disease. CIBA Found Symp 196:85-94.
    • (1996) CIBA Found Symp , vol.196 , pp. 85-94
    • Tuszynski, M.H.1    Gage, F.H.2
  • 40
    • 0030973478 scopus 로고    scopus 로고
    • Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord
    • Tuszynski MH, Murai K, Blesch A, Grill R, Miller I. 1997. Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord. Cell Transplant 6:361-368.
    • (1997) Cell Transplant , vol.6 , pp. 361-368
    • Tuszynski, M.H.1    Murai, K.2    Blesch, A.3    Grill, R.4    Miller, I.5
  • 41
    • 0028218083 scopus 로고
    • Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord
    • Tuszynski MH, Peterson DA, Ray J, Baird A, Nakahara Y, Gage FH. 1994a. Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp Neurol 126:1-14.
    • (1994) Exp Neurol , vol.126 , pp. 1-14
    • Tuszynski, M.H.1    Peterson, D.A.2    Ray, J.3    Baird, A.4    Nakahara, Y.5    Gage, F.H.6
  • 42
    • 0028535645 scopus 로고
    • Somatic gene transfer to the adult primate central nervous system: In vitro and in vivo characterization of cells genetically modified to secrete nerve growth factor
    • Tuszynski MH, Senut MC, Ray J, Roberts J. 1994b. Somatic gene transfer to the adult primate central nervous system: in vitro and in vivo characterization of cells genetically modified to secrete nerve growth factor. Neurobiol Dis 1:67-78.
    • (1994) Neurobiol Dis , vol.1 , pp. 67-78
    • Tuszynski, M.H.1    Senut, M.C.2    Ray, J.3    Roberts, J.4
  • 43
    • 0033232045 scopus 로고    scopus 로고
    • Nerve growth factor-hypersecreting schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1
    • Weidner N, Blesch A, Grill R, Tuszynski M. 1999. Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1. J Comp Neurol 413:495-506.
    • (1999) J Comp Neurol , vol.413 , pp. 495-506
    • Weidner, N.1    Blesch, A.2    Grill, R.3    Tuszynski, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.