-
1
-
-
21544448066
-
Gene therapy for the treatment of recurrent glioblastoma multiforme with in vivo tumor transduction with the HSV-tk gene/ganciclovir system
-
NIH approval 04/16/93
-
Van Gilder JC, Berger M, Prados M et al. Gene therapy for the treatment of recurrent glioblastoma multiforme with in vivo tumor transduction with the HSV-tk gene/ganciclovir system. Human Gene Therapy Protocols 9303-037, NIH approval 04/16/93.
-
Human Gene Therapy Protocols 9303-037
-
-
Van Gilder, J.C.1
Berger, M.2
Prados, M.3
-
2
-
-
85046172609
-
A phase I study of direct administration of a replication-deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the prodrug 5-fluorocytosine
-
NIH approval 09/30/95
-
Crystal R, Hershowitz E, Lieberman M. A phase I study of direct administration of a replication-deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the prodrug 5-fluorocytosine. Human Gene Therapy Protocols 9509-125, NIH approval 09/30/95.
-
Human Gene Therapy Protocols 9509-125
-
-
Crystal, R.1
Hershowitz, E.2
Lieberman, M.3
-
3
-
-
0028032719
-
Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene
-
Kim JH, Kim SH, Brown SL et al. Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene. Cancer Res 1994; 54:6053-6056.
-
(1994)
Cancer Res
, vol.54
, pp. 6053-6056
-
-
Kim, J.H.1
Kim, S.H.2
Brown, S.L.3
-
4
-
-
0028805459
-
Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents
-
Kim JH, Kim SH, Kolozsvary A et al. Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents. Int J Radiat Oncol Biol Phys 1995;33:861-868.
-
(1995)
Int J Radiat Oncol Biol Phys
, vol.33
, pp. 861-868
-
-
Kim, J.H.1
Kim, S.H.2
Kolozsvary, A.3
-
5
-
-
0030052050
-
Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene
-
Khil M, Kim JH, Mullen CA et al. Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene. Clin Cancer Res 1996;2:53-57.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 53-57
-
-
Khil, M.1
Kim, J.H.2
Mullen, C.A.3
-
6
-
-
0030906438
-
Preferential radiosensitization of 9L glioma cells transduced with HSV-TK gene by acyclovir
-
Kim SH, Kim JH, Kolozsvary A et al. Preferential radiosensitization of 9L glioma cells transduced with HSV-TK gene by acyclovir. J Neurooncol 1997;33:189-195.
-
(1997)
J Neurooncol
, vol.33
, pp. 189-195
-
-
Kim, S.H.1
Kim, J.H.2
Kolozsvary, A.3
-
7
-
-
0031803611
-
Selective in vivo radiosensitization by 5- fluorocytosine of human colorectal carcinoma cells transduced with the E. coli cytosine deaminase (CD) gene
-
Gabel M, Kim JH, Kolozsvary A et al. Selective in vivo radiosensitization by 5- fluorocytosine of human colorectal carcinoma cells transduced with the E. coli cytosine deaminase (CD) gene. Int J Radiat Oncol Biol Phys 1998;41:883-887.
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.41
, pp. 883-887
-
-
Gabel, M.1
Kim, J.H.2
Kolozsvary, A.3
-
8
-
-
0031024794
-
Glioma cells transduced with an E. coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity
-
Rogulski KR, Kim JH, Kim SH et al. Glioma cells transduced with an E. coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity. Hum Gene Ther 1997; 8:73-85.
-
(1997)
Hum Gene Ther
, vol.8
, pp. 73-85
-
-
Rogulski, K.R.1
Kim, J.H.2
Kim, S.H.3
-
9
-
-
0025108565
-
Low dose rate radiotherapy for transplantable gliosarcoma in the rat brain
-
Kim JH, Alfieri A, Rosenblum M et al. Low dose rate radiotherapy for transplantable gliosarcoma in the rat brain. J Neurooncol 1990;9:9-15.
-
(1990)
J Neurooncol
, vol.9
, pp. 9-15
-
-
Kim, J.H.1
Alfieri, A.2
Rosenblum, M.3
-
10
-
-
0028129499
-
Ectopic expression of the CCAAT/enhancer binding protein a promotes the adipogenic program in a variety of mouse fibroblastic cells
-
Freytag SO, Paielli DL, Gilbert JD. Ectopic expression of the CCAAT/enhancer binding protein a promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev 1994;14:1654-1663.
-
(1994)
Genes Dev
, vol.14
, pp. 1654-1663
-
-
Freytag, S.O.1
Paielli, D.L.2
Gilbert, J.D.3
-
11
-
-
0030666029
-
Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy
-
Rogulski K, Zhang K, Kolozsvary A et al. Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy. Clin Cancer Res 1997;3:2081-2088.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 2081-2088
-
-
Rogulski, K.1
Zhang, K.2
Kolozsvary, A.3
-
12
-
-
0032481577
-
Synergistic anticancer effects of ganciclovir/thymidine kinase plus 5-fluorocytosine/cytosine deaminase gene therapies
-
Aghi M, Kramm CM, Chou TC et al. Synergistic anticancer effects of ganciclovir/thymidine kinase plus 5-fluorocytosine/cytosine deaminase gene therapies. J Natl Cancer Inst 1998;90:370-380.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 370-380
-
-
Aghi, M.1
Kramm, C.M.2
Chou, T.C.3
-
13
-
-
0032502844
-
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo
-
Uckert W, Kammertons T, Haack K et al. Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo. Hum Gene Ther 1998;9:855-865.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 855-865
-
-
Uckert, W.1
Kammertons, T.2
Haack, K.3
-
14
-
-
0028019863
-
The role of cell cycle redistribution in radiosensitization: Implications regarding the mechanism of fluorodeoxyuridine radiosensitization
-
McGinn CJ, Miller EM, Lindstrom MJ et al. The role of cell cycle redistribution in radiosensitization: implications regarding the mechanism of fluorodeoxyuridine radiosensitization. Int J Radiat Oncol Biol Phys 1994;30:851-859.
-
(1994)
Int J Radiat Oncol Biol Phys
, vol.30
, pp. 851-859
-
-
McGinn, C.J.1
Miller, E.M.2
Lindstrom, M.J.3
-
16
-
-
0022498513
-
The potentiation of radiation response on murine tumor by fludarabine phosphate
-
Kim JH, Alfieri AA, Kim SH et al. The potentiation of radiation response on murine tumor by fludarabine phosphate. Cancer Lett 1986;31:69-76.
-
(1986)
Cancer Lett
, vol.31
, pp. 69-76
-
-
Kim, J.H.1
Alfieri, A.A.2
Kim, S.H.3
-
17
-
-
0028202066
-
Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo
-
Chen SH, Shine HD, Goodman JC et al. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 1994;91:3054-3057.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3054-3057
-
-
Chen, S.H.1
Shine, H.D.2
Goodman, J.C.3
-
18
-
-
0028795075
-
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine
-
Hirschowitz EA, Ohwada A, Pascal WR et al. In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine. Hum Gene Ther 1995; 6:1055-1063.
-
(1995)
Hum Gene Ther
, vol.6
, pp. 1055-1063
-
-
Hirschowitz, E.A.1
Ohwada, A.2
Pascal, W.R.3
-
19
-
-
0029995247
-
In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine
-
Dong Y, Wen P, Manome Y et al. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther 1996;7:713-720.
-
(1996)
Hum Gene Ther
, vol.7
, pp. 713-720
-
-
Dong, Y.1
Wen, P.2
Manome, Y.3
-
20
-
-
0029743164
-
Regional delivery of an adenovirus vector containing the E. coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver
-
Ohwada A, Hirschowitz EA, Crystal RG. Regional delivery of an adenovirus vector containing the E. coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. Hum Gene Ther 1996;7:1567-1576.
-
(1996)
Hum Gene Ther
, vol.7
, pp. 1567-1576
-
-
Ohwada, A.1
Hirschowitz, E.A.2
Crystal, R.G.3
-
21
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p-53-deficient human tumor cells
-
Bischoff JR, Kiru DH, Williams A et al. An adenovirus mutant that replicates selectively in p-53-deficient human tumor cells. Science 1996;274:373-376.
-
(1996)
Science
, vol.274
, pp. 373-376
-
-
Bischoff, J.R.1
Kiru, D.H.2
Williams, A.3
-
22
-
-
0030917202
-
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor specific cytolysis and antitumor efficacy that can be augmented by standard chemotherapeutic agents
-
Heise C, Sampson-Johannes A, Williams A et al. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor specific cytolysis and antitumor efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 1997;3:639-645.
-
(1997)
Nat Med
, vol.3
, pp. 639-645
-
-
Heise, C.1
Sampson-Johannes, A.2
Williams, A.3
-
23
-
-
0032503659
-
A novel, three-pronged approach to selectively kill cancer cells: Concomitant double suicide gene, viral, and radiotherapy
-
Freytag SO, Rogulski KR, Paielli DL et al. A novel, three-pronged approach to selectively kill cancer cells: concomitant double suicide gene, viral, and radiotherapy. Hum Gene Ther 1998;9:1323-1333.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 1323-1333
-
-
Freytag, S.O.1
Rogulski, K.R.2
Paielli, D.L.3
|