Stromelysin 1

Handbook of Proteolytic Enzymes, Second Edition: Volume 1: Aspartic and Metallo Peptidases

Volumn 1, Issue , 2004, Pages 512-523

  Nagase, Hideaki ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34548508517     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-079611-3.50139-7     Document Type: Chapter

References (86)

1. R. Agnihotri, H.C. Crawford, H. Haro, L.M. Matrisian, M.C. Havrda and L. Liaw (2001) Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin). J. Biol. Chem. 276 28261-28267.
2. B. Arza, M.F. Hoylaerts, J. Felez, D. Collen and H.R. Lijnen (2000) Prostromelysin-1 (proMMP-3) stimulates plasminogen activation by tissue-type plasminogen activator. Eur. J. Biochem. 267 6378-6384.
3. W. Azzo and J.F. Woessner Jr. (1986) Purification and characterization of an acid metalloproteinase from human articular cartilage. J. Biol. Chem. 261 5434-5441.
4. J.W. Becker, A.I. Marcy, L.L. Rokosz, M.G. Axel, J.J. Burbaum, P.M. Fitzgerald, P.M. Cameron, C.K. Esser, W.K. Hagmann, J.D. Hermes and J.P. Springer (1995) Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme. Protein Sci. 4 1966-1976.
5. U. Benbow, G. Butticè, H. Nagase and M. Kurkinen (1996) Characterization of the 46-kDa intermediates of matrix metalloproteinase 3 (stromelysin 1) obtained by site-directed mutation of phenylalanine 83. J. Biol. Chem. 271 10715-10722.
6. R. Breathnach, L.M. Matrisian, M.-C. Gesnel, A. Staub and P. Leroy (1987) Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene. Nucleic Acids Res. 15 1139-1151.
7. K.M. Bullard, L. Lund, J.S. Mudgett, T.N. Mellin, T.K. Hunt, B. Murphy, J. Ronan, Z. Werb and M.J. Banda (1999) Impaired wound contraction in stromelysin-1-deficient mice. Ann. Surg. 230 260-265.
8. P.M. Cameron, A.I. Marcy, L.L. Rokosz and J.D. Hermes (1995) Use of an active-site inhibitor of stromelysin to elucidate the mechanism of prostromelysin activation. Bioorg. Chem. 23 415-426.
9. L.C. Chen, M.E. Noelken and H. Nagase (1993) Disruption of the cysteine-75 and zinc ion coordination is not sufficient to activate the precursor of human matrix metalloproteinase 3 (stromelysin 1). Biochemistry 32 10289-10295.
10. L.Y. Chen, T.J. Rydel, F. Gu, C.M. Dunaway, S. Pikul, K.M. Dunham and B.L. Barnett (1999) Crystal structure of the stromelysin catalytic domain at 2.0 angstrom resolution: Inhibitor-induced conformational changes. J. Mol. Biol. 293 545-557.
11. J.R. Chin, G. Murphy and Z. Werb (1985) Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates. J. Biol. Chem. 260 12367-12376.
12. P.K. DenBesten, L.M. Heffernan, B.V. Treadwell and B.J. Awbrey (1989) The presence and possible functions of the matrix metalloproteinase collagenase activator protein in developing enamel matrix. Biochem. J. 264 917-920.
13. J.J. Enghild, G. Salvesen, K. Brew and H. Nagase (1989) Interaction of human rheumatoid synovial collagenase (matrix metalloproteinase 1) and stromelysin (matrix metalloproteinase 3) with human α2 -macroglobulin and chicken ovostatin. Binding kinetics and identification of matrix metalloproteinase cleavage sites. J. Biol. Chem. 264 8779-8785.
14. C.J. Formstone, P.J. Byrd, H.J. Ambrose, J.H. Riley, D. Hernandez, C.M. McConville and A.M. Taylor (1993) The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23. Genomics 16 289-291.
15. M.J. Fray and R.P. Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg. Med. Chem. Lett. 11 571-574.
16. W.A. Galloway, G. Murphy, J.D. Sandy, J. Gavrilovic, T.E. Cawston and J.J. Reynolds (1983) Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components. Biochem. J. 209 741-752.
17. H.A. Goldberg and P.G. Scott (1986) Isolation from cultured porcine gingival explants of a neutral proteinase with collagen telopeptidase activity. Connect. Tissue Res. 15 209-219.
18. F.X. Gomis-Rüth, K. Maskos, M. Betz, A. Bergner, R. Huber, K. Suzuki, N. Yoshida, H. Nagase, K. Brew, G.P. Bourenkov, H. Bartunik and W. Bode (1997) Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature (Lond.) 389 77-81.
19. P.R. Gooley, J.F. O'Connell, A.I. Marcy, G.C. Cuca, S.P. Salowe, B.L. Bush, J.D. Hermes, C.K. Esser, W.K. Hagmann, J.P. Springer, et al. (1994) The NMR structure of the inhibited catalytic domain of human stromelysin-1. Nature Struct. Biol. 1 111-118.
20. Z. Gunja-Smith, H. Nagase and J.F. Woessner Jr. (1989) Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3. Biochem. J. 258 115-119.
21. N. Guex and M.C. Peitsch (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18 2714-2723.
22. R.K. Harrison, B. Chang, L. Niedzwiecki and R.L. Stein (1992) Mechanistic studies on the human matrix metalloproteinase stromelysin. Biochemistry 31 10757-10762.
23. C.M. Holman, C.C. Kan, M.R. Gehring and H.E. Van Wart (1999) Role of His-224 in the anomalous pH dependence of human stromelysin-1. Biochemistry 38 677-681.
24. T.J. Housley, A.P. Baumann, I.D. Braun, G. Davis, P.K. Seperack and S.M. Wilhelm (1993) Recombinant Chinese hamster ovary cell matrix metalloprotease-3 (MMP-3, stromelysin-1). Role of calcium in promatrix metalloprotease-3 (pro-MMP-3, prostromelysin-1) activation and thermostability of the low mass catalytic domain of MMP-3. J. Biol. Chem. 268 4481-4487.
25. S. Humphries, C. Bauters, A. Meirhaeghe, L. Luong, M. Bertrand and P. Amouyel (2002) The 5A6A polymorphism in the promoter of the strimelysin-1 (MMP3) gene as a risk factor for restenosis. Eur. Heart J. 23 721-725.
26. K. Imai, A. Hiramatsu, D. Fukushima, M.D. Pierschbacher and Y. Okada (1997) Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-β1 release. Biochem. J. 322 809-814.
27. E.J. Jacobsen, M.A. Mitchell, S.K. Hendges, K.L. Belonga, L.L. Skaletzky, L.S. Stelzer, T.J. Lindberg, E.L. Fritzen, H.J. Schostarez, T.J. O'Sullivan, L.L. Maggiora, C.W. Stuchly, A.L. Laborde, M.F. Kubicek, R.A. Poorman, J.M. Beck, H.R. Miller, G.L. Petzold, P.S. Scott, S.E. Truesdell, T.L. Wallace, J.W. Wilks, C. Fisher, L.V. Goodman and P.S. Kaytes (1999) Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. J. Med. Chem. 42 1525-1536.
28. L.L. Johnson, D.A. Bornemeier, J.A. Janowicz, J. Chen, A.G. Pavlovsky and D.F. Ortwine (1999) Effect of species differences on stromelysin-1 (MMP-3) inhibitor potency – An explanation of inhibitor selectivity using homology modeling and chimeric proteins. J. Biol. Chem. 274 24881-24887.
29. L.L. Johnson, A.G. Pavlovsky, A.R. Johnson, J.A. Janowicz, C.F. Man, D.F. Ortwine, C.F. Purchase, A.D. White and D.J. Hupe (2000) A rationalization of the acidic pH dependence for stromelysin-1 (matrix metalloproteinase-3) catalysis and inhibition. J. Biol. Chem. 275 11026-11033.
30. C.G. Knight, F. Willenbrock and G. Murphy (1992) A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases. FEBS Lett. 296 263-266.
31. L. Kotajima, S. Aotsuka, M. Fujimani, M. Okawa-Takatsuji, M. Kinoshita, M. Sumiya and K. Obata (1998) Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis. Clin. Exp. Rheumatol. 16 409-415.
32. E.A. Kremer, Y. Chen, K. Suzuki, H. Nagase and J.P. Gorski (1998) Hydroxyapatite induces autolytic degradation and inactivation of matrix metalloproteinase-1 and −3. J. Bone Miner. Res. 13 1890-1902.
33. H.R. Lijnen, F. Ugwu, A. Bini and D. Collen (1998) Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3). Biochemistry 37 4699-4702.
34. H.R. Lijnen, B. Arza, B. van Hoef, D. Collen and P.J. Declerck (2000) Inactivation of plasminogen activator inhibitor-1 by specific proteolysis with stromelysin-1 (MMP-3). J. Biol. Chem. 275 37645-37650.
35. H.R. Lijnen, B.T. Van Hoef and D. Collen (2001) Inactivation of the serpin α2-antiplasmin by stromelysin-1. Biochim. Biophys. Acta – Protein Struct. Mol. Enzymol. 1547 206-213.
36. A. Lochter, S. Galosy, J. Muschler, N. Freedman, Z. Werb and M.J. Bissell (1997) Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J. Cell Biol. 139 1861-1872.
37. A.I. Marcy, L.L. Eiberger, R. Harrison, H.K. Chan, N.I. Hutchinson, W.K. Hagmann, P.M. Cameron, D.A. Boulton and J.D. Hermes (1991) Human fibroblast stromelysin catalytic domain: expression, purification, and characterization of a C-terminally truncated form. Biochemistry 30 6476-6483.
38. L.M. Matrisian, N. Glaichenhaus, M.-C. Gesnel and R. Breathnach (1985) Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J. 4 1435-1440.
39. L.M. Matrisian, G.T. Bowden, P. Krieg, G. Furstenberger, J.-P. Briand, P. Leroy and R. Breathnach (1986) The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors. Proc. Natl. Acad. Sci. USA 83 9413-9417.
40. G.A. McQuibban, H.H. Gong, J.P. Wond, J.L. Wallace, I. Clark-Lewis and C.M. Overall (2002) Matrix metalloproteinase processing of monocyte chemoattractant proteins generated CC chemokine receptor antagonists with anti-inflammatory properties invivo. Blood 100 1160-1167.
41. Q. Meng, V. Malinovskii, W. Huang, Y.J. Hu, L. Chung, H. Nagase, W. Bode, K. Maskos and K. Brew (1999) Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1′ residue of substrate. J. Biol. Chem. 274 10184-10189.
42. Y. Morita, K. Igeta, E. Azumano, T. Kunisawa, K. Iwata, Y. Okada, A. Ito, Y. Mori and H. Nagase (1995) [A two-step sandwich enzyme immunoassay for rabbit proMMP-3 using monoclonal antibodies] [In Japanese]. Connect. Tissue 27 183-190.
43. J.S. Mudgett, N.I. Hutchinson, N.A. Chartrain, A.J. Forsyth, J. McDonnell, I.I. Singer, E.K. Bayne, J. Flanagan, D. Kawka, C.F. Shen, K. Stevens, H. Chen, M. Trumbauer and D.M. Visco (1998) Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum. 41 110-121.
44. D. Muller, B. Quantin, M.C. Gesnel, R. Millon-Collard, J. Abecassis and R. Breathnach (1988) The collagenase gene family in humans consists of at least four members. Biochem. J. 253 187-192.
45. G. Murphy, R.M. Hembry and J.J. Reynolds (1986) Characterization of a specific antiserum to rabbit stromelysin and demonstration of the synthesis of collagenase and stromelysin by stimulated rabbit articular chondrocytes. Coll. Relat. Res. 6 351-363.
46. G. Murphy, J.A. Allan, F. Willenbrock, M.I. Cockett, J.P. O'Connell and A.J.P. Docherty (1992) The role of the C-terminal domain in collagenase and stromelysin specificity. J. Biol. Chem. 267 9612-9618.
47. H. Nagase (1995) Human stromelysins 1 and 2. Methods Enzymol. 248 449-470.
48. H. Nagase (1998) Stromelysins 1 and 2. W.C. Parks, R.P. Mecham (Eds) Matrix Metalloproteinases San Diego: Academic Press 43-84.
49. H. Nagase and G.B. Fields (1996) Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides. Biopolymers 40 399-416.
50. H. Nagase, J.J. Enghild, K. Suzuki and G. Salvesen (1990) Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate. Biochemistry 29 5783-5789.
51. H. Nagase, A.J. Barrett and J.F. Woessner Jr. (1992) Nomenclature and glossary of the matrix metalloproteinases. Matrix Suppl. 1 421-424.
52. H. Nagase, C.G. Fields and G.B. Fields (1994) Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3). J. Biol. Chem. 269 20952-20957.
53. L. Niedzwiecki, J. Teahan, R.K. Harrison and R.L. Stein (1992) Substrate specificity of the human matrix metalloproteinase stromelysin and the development of continuous fluorometric assays. Biochemistry 31 12618-12623.
54. K. Obata, K. Iwata, Y. Okada, Y. Kohrin, E. Ohuchi, S. Yoshida, M. Shinmei and T. Hayakawa (1992) A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 3 (stromelysin-1) using monoclonal antibodies. Clin. Chim. Acta 211 59-72.
55. Y. Okada, H. Nagase and E.D. Harris Jr. (1986) A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization. J. Biol. Chem. 261 14245-14255.
56. Y. Okada, E.D. Harris Jr. and H. Nagase (1988) The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate. Biochem. J. 254 731-741.
57. Y. Okada, N. Takeuchi, K. Tomita, I. Nakanishi and H. Nagase (1989) Immunolocalization of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis. Ann. Rheum. Dis. 48 645-653.
58. M.W. Olson, M.M. Bernardo, M. Pietila, D.C. Gervasi, M. Toth, L.P. Kotra, I. Massova, S. Mobashery and R. Fridman (2000) Characterization of the monomelic and dimeric forms of latent and active matrix metalloproteinase-9: Differential rates for activation by stromelysin 1. J. Biol. Chem. 275 2661-2668.
59. D. Orgel, W. Schroder, A. Hecker-Kia, K.U. Weithmann, H. Kolkenbrock and N. Ulbrich (1998) The cleavage of pro-urokinase type plasminogen activator by stromelysin-1. Clin. Chem. Lab. Med. 36 697-702.
60. C.M. Overall and J. Sodek (1987) Initial characterization of a neutral metalloproteinase, active on native 3/4-collagen fragments, synthesized by ROS 17/2.8 osteoblastic cells, periodontal fibroblasts, and identified in gingival crevicular fluid. J. Dent. Res. 66 1271-1282.
61. A.G. Pavlovsky, M.G. Williams, Q.Z. Ye, D.F. Ortwine, C.F. Purchase, A.D. White, V. Dhanaraj, B.D. Roth, L.L. Johnson, D. Hupe, C. Humblet and T.L. Blundell (1999) X-ray structure of human stromelysin catalytic domain complexed with non-peptide inhibitors: Implications for inhibitor selectivity. Protein Sci. 8 1455-1462.
62. S.A. Rosenfeld, O.H. Ross, J.I. Corman, M.A. Pratta, D.L. Blessington, W.S. Feeser and B.D. Freimark (1994) Production of human matrix metalloproteinase 3 (stromelysin) in Escherichia coli. Gene 139 281-286.
63. U.K. Saarialho-Kere, A.P. Pentland, H. Birkedal-Hansen, W.C. Parks and H.G. Welgus (1994) Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds. J. Clin. Invest. 94 79-88.
64. R. Sanchez-Lopez, R. Nicholson, M.C. Gesnel, L.M. Matrisian and R. Breathnach (1988) Structure-function relationships in the collagenase family member transin. J. Biol. Chem. 263 11892-11899.
65. A.I. Sapolsky, D.S. Howell and J.F. Woessner Jr. (1974) Neutral proteases and cathepsin D in human articular cartilage. J. Clin. Invest. 53 1044-1053.
66. J. Silence, F. Lupu, D. Collen and H.R. Lijnen (2001) Persistence of atherosclerotic plaque but reduced aneurysm formation in mice with stromelysin-1 (MMP-3) gene inactivation. Arterioscler. Thromb. Vasc. Biol. 21 1440-1445.
67. K.L. Sirum and C.E. Brinckerhoff (1989) Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts. Biochemistry 28 8691-8698.
68. M.D. Sternlicht, A. Lochter, C.J. Sympson, B. Huey, J.P. Rougler, J.W. Gray, D. Pinkel, M.J. Bissell and Z. Werb (1999) The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 98 137-146.
69. B. Stix, T. Kahne, K. Sletten, J. Raynes, A. Roessner and C. Rocken (2001) Proteolysis of AA amyloid fibril proteins by matrix metalloproteinases-1, −2, and-3. Am. J. Pathol. 159 561-570.
70. K. Suzuki, J.J. Enghild, T. Morodomi, G. Salvesen and H. Nagase (1990) Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry 29 10261-10270.
71. M. Suzuki, G. Raab, M.A. Moses, C.A. Fernandez and M. Klagsbrun (1997) Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site. J. Biol. Chem. 272 31730-31737.
72. K. Suzuki, C.C. Kan, W. Hung, M.R. Gehring, K. Brew and H. Nagase (1998) Expression of human pro-matrix metalloproteinase 3 that lacks the N-terminal 34 residues in Escherichia coli – autoactivation and interaction with tissue inhibitor of metalloproteinase 1 (TIMP-1). Biol. Chem. 379 185-191.
73. B.V. Treadwell, J. Neidel, M. Pavia, C.A. Towle, M.E. Trice and H.J. Mankin (1986) Purification and characterization of collagenase activator protein synthesized by articular cartilage. Arch. Biochem. Biophys. 251 715-723.
74. F. Ugwu, B. van Hoef, A. Bini, D. Collen and H.R. Lijnen (1998) Proteolytic cleavage of urokinase-type plasminogen activator by stromelysin-1 (MMP-3). Biochemistry 37 7231-7236.
75. S.R. Van Doren, A.V. Kurochkin, W. Hu, Q.Z. Ye, L.L. Johnson, D.J. Hupe and E.R. Zuiderweg (1995) Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor. Protein Sci. 4 2487-2498.
76. J. van Meurs, P. van Lent, R. Stoop, A. Holthuysen, I. Singer, E. Bayne, J. Mudgett, R. Poole, C. Billinghurst, P. van der Kraan, P. Buma and W. van den Berg (1999) Cleavage of aggrecan at the Asn(341)-Phe(342) site coincides with the initiation of collagen damage in murine antigen-induced arthritis – A pivotal role for stromelysin 1 in matrix metalloproteinase activity. Arthritis Rheum. 42 2074-2084.
77. C.A. Vater, H. Nagase and E.D. Harris Jr. (1983) Purification of an endogenous activator of procollagenase from rabbit synovial fibroblast culture medium. J. Biol. Chem. 258 9374-9382.
78. M. Wang, X. Qin, J.S. Mudgett, T.A. Ferguson, R.M. Senior and H.G. Welgus (1999) Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Proc. Natl. Acad. Sci. USA 96 6885-6889.
79. Z. Werb and J.J. Reynolds (1974) Stimulation by endocytosis of the secretion of collagenase and neutral proteinase from rabbit synovial fibroblasts. J. Exp. Med. 140 1482-1497.
80. S.M. Wilhelm, I.E. Collier, A. Kronberger, A.Z. Eisen, B.L. Marmer, G.A. Grant, E.A. Bauer and G.I. Goldberg (1987) Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells. Proc. Natl. Acad. Sci. USA 84 6725-6729.
81. S.M. Wilhelm, Z.H. Shao, T.J. Housley, P.K. Seperack, A.P. Baumann, Z. Gunja-Smith and J.F. Woessner Jr. (1993) Matrix metalloproteinase-3 (stromelysin-1). Identification as the cartilage acid metalloprotease and effect of pH on catalytic properties and calcium affinity. J. Biol. Chem. 268 21906-21913.
82. L.J. Windsor, H. Grenett, B. Birkedal-Hansen, M.K. Bodden, J.A. Engler and H. Birkedal-Hansen (1993) Cell type-specific regulation of SL-1 and SL-2 genes. Induction of the SL-2 gene but not the SL-1 gene by human keratinocytes in response to cytokines and phorbolesters. J. Biol. Chem. 268 17341-17347.
83. H. Yamanaka, Y. Matsuda, M. Tanaka, W. Sendo, H. Nakajima, A. Taniguchi and N. Kamatani (2000) Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum. 43 852-858.
84. Q.Z. Ye, L.L. Johnson, D.J. Hupe and V. Baragi (1992) Purification and characterization of the human stromelysin catalytic domain expressed in Escherichia coli. Biochemistry 31 11231-11235.
85. S. Ye, G.F. Watts, S. Mandalia, S.E. Humphries and A.M. Henney (1995) Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis. Br. Heart J. 73 209-215.
86. S. Ye, P. Eriksson, A. Hamsten, M. Kurkinen, S.E. Humphries and A.M. Henney (1996) Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. J. Biol. Chem. 271 13055-13060.