Effect of species differences on stromelysin-1 (MMP-3) inhibitor potency. An explanation of inhibitor selectivity using homology modeling and chimeric proteins

Journal of Biological Chemistry

Volumn 274, Issue 35, 1999, Pages 24881-24887

  Johnson, Linda L ^a   Bornemeier, Dirk A ^a   Janowicz, Jeffrey A ^a   Chen, Jing ^a   Pavlovsky, Alexander G ^a   Ortwine, Daniel F ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIPHENYL DERIVATIVE; DIBENZOFURAN DERIVATIVE; STROMELYSIN; STROMELYSIN INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; CHIMERA; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; ENZYME INHIBITORS; HUMANS; KINETICS; MATRIX METALLOPROTEINASE 3; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN ISOFORMS; RABBITS; RECOMBINANT FUSION PROTEINS; SPECIES SPECIFICITY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0033609820     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.35.24881     Document Type: Article

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