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Volumn 63, Issue 43, 2007, Pages 10587-10595

Synthesis and antiviral properties of aza-analogues of ganciclovir derived from 5,5-bis(hydroxymethyl)pyrrolidin-2-one

Author keywords

Antiviral agents; Azanucleosides; Ganciclovir; N (Pivaloyloxymethyl)amide; Nucleoside analogues; Pyrrolidinone

Indexed keywords

1,5,5 TRIS(PIVALOYLOXYMETHYL)PYRROLIDIN 2 ONE; 5,5 BIS(HYDROXYMETHYL)PYRROLIDIN 2 ONE; GANCICLOVIR DERIVATIVE; HETEROCYCLIC COMPOUND; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 34548478137     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.08.032     Document Type: Article
Times cited : (12)

References (73)
  • 14
    • 34548510534 scopus 로고    scopus 로고
    • For examples of the pyrrolidin-2-yl analogues, see:
  • 20
    • 34548471707 scopus 로고    scopus 로고
    • For examples of the pyrrolidin-3-yl analogues, see:
  • 28
    • 34548509396 scopus 로고    scopus 로고
    • For examples of the pyrrolidin-1-yl analogues, see:
  • 36
    • 0346672993 scopus 로고
    • ( )
    • (. Zh. Obshch. Khim. 60 (1990) 1390-1395 )
    • (1990) Zh. Obshch. Khim. , vol.60 , pp. 1390-1395
  • 64
    • 34548495513 scopus 로고    scopus 로고
    • note
    • 50) required to reduce virus-induced cytopathogenicity by 50%.
  • 65
    • 34548508617 scopus 로고    scopus 로고
    • note
    • The cytotoxicity was expressed as the minimum cytotoxic concentration (MCC) required to cause a microscopically detectable alteration of normal cell morphology.
  • 66
    • 34548498568 scopus 로고    scopus 로고
    • note
    • 50 of 150 μM.
  • 67
    • 34548511036 scopus 로고    scopus 로고
    • note
    • 50 of 0.0064 μM.
  • 68
    • 34548501479 scopus 로고    scopus 로고
    • note
    • The reference compounds displayed the following MCC values: brivudin and ribavirin (Vero, HEL or HeLa cells, >250 μM); (S)-DHPA (HeLa cells, >250 μM); acyclovir (HEL cells, >250 μM); ganciclovir (HEL cells, >100 μM).
  • 69
    • 34548509154 scopus 로고    scopus 로고
    • note
    • 50) required to reduce virus plaque formation by 50%. Virus input was 100 plaque-forming units (PFU) for cytomegalovirus, or 20 PFU for varicella-zoster virus.
  • 70
    • 34548499024 scopus 로고    scopus 로고
    • note
    • 50) required to reduce cell growth by 50%.
  • 71
    • 34548499263 scopus 로고    scopus 로고
    • note
    • 50=257 μM.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.