Synthesis of 3′-deoxy-3′-difluoromethyl azanucleosides from trans-4-hydroxy-L-proline

Journal of Organic Chemistry

Volumn 70, Issue 10, 2005, Pages 3826-3837

  Qiu, Xiao Long ^a   Qing, Feng Ling ^a,b  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b DONGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULES; OXIDATION; PHASE TRANSITIONS; REACTION KINETICS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

DIFLUOROMETHYL AZANUCLEOSIDES; PROTECTING GROUPS; STEREOSELECTIVE PREPARATION;

ORGANIC COMPOUNDS;

1 [N TERT BUTYLOXYCARBONYL 3 HYDROXY 4 DIFLUOROMETHYL 5 (HYDROXYMETHYL)PYRROLIDIN 2 YL]THYMINE; 1 [N TERT BUTYLOXYCARBONYL 3 HYDROXY 4 DIFLUOROMETHYL 5 (HYDROXYMETHYL)PYRROLIDIN 2 YL]URACIL; 3' DEOXY 3' DIFLUOROMETHYLAZANUCLEOSIDE DERIVATIVE; ALCOHOL DERIVATIVE; HYDROXYPROLINE; LACTAM DERIVATIVE; METHYL GROUP; N TERT BUTYLOXYCARBONYL 3,4 DIHYDROXY 2 (TERT BUTYLDIPHENYLSILOXYMETHYL)PYRROLIDINE; N TERT BUTYLOXYCARBONYL 4 BENZOYLOXY 3 DIFLUOROMETHYLENYL 2 (TERT BUTYLDIPHENYLSILOXYMETHYL)PYRROLIDINE; N TERT BUTYLOXYCARBONYL 4 TERT BUTYLDIMETHYLSILOXY 3 DIFLUOROMETHYL 2 (TERT BUTYLDIMETHYLSILOXYMETHYL)PYRROLIDINE; N TERT BUTYLOXYCARBONYL 5 TERT BUTYLDIMETHYLSILOXYMETHYL 4 DIFLUOROMETHYL 3 (TERT BUTYLDIMETHYLSILOXY)PYRROLIDIN 2 ONE; N TERT BUTYLOXYCARBONYL 5 TERT BUTYLDIMETHYLSILYLOXYMETHYL 4 DIFLUOROMETHYL 3 (TERT BUTYLDIMETHYLSILYLOXY)PYRROLIDIN 2 ONE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; DEOXYRIBONUCLEOSIDE; FLUORINE; HETEROCYCLIC COMPOUND; NUCLEOSIDE; PYROGLUTAMIC ACID;

ARTICLE; CHEMICAL REACTION; FLUORINATION; HYDROGENATION; OXIDATION; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS; CHEMISTRY;

AZA COMPOUNDS; DEOXYRIBONUCLEOSIDES; FLUORINE; HYDROXYPROLINE; NUCLEOSIDES; PYRROLIDONECARBOXYLIC ACID;

EID: 18744403709     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo050057+     Document Type: Article

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