Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Chemistry Letters

Volumn , Issue 7, 2001, Pages 634-635

  Shigeyasu, Masanori ^a   Kuwahara, Masayasu ^a   Sisido, Masahiko ^a   Ishikawa, Teruhiko ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035634151     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2001.634     Document Type: Article

References (13)

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10. Compound 3 (5.8 g, 16 mmol), tert-butyl bromoacetate (6.2 g, 32 mmol), tetrabutylammonium sulfate (1.4 g, 4 mmol) were dissolved into benzene/50% NaOH (3/1) mixture (56 mL). The mixture was stirred at 10 °C for 5 h. The organic layer was washed with 2M HCl, dried over anhydrous magnesium sulfate and evaporated. The crude product was purified by a silica gel column to give 4 (8.8 g, 81%).
11. 3,) δ = 1.52 (9H. s), 1.53 (9H, s), 2.76 (2H, m), 3.62 (1H, m), 3.80 (2H, m), 4.05 (2H, q), 4.21 (1H, br), 4.30 (1H, br), 5.19 (1H, m), 6.05 (2H, s), 8.22 (1H, s), 8.40 (1H, s).
12. 1H NMR of 8 showed unresolved peaks that could not be assigned to individual protons.
13. 19, 2613.2.