Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 12, 2003, Pages 2529-2539

  Kang, Ji Hye ^a   Chung, Hye Eun ^a   Kim, Su Yeon ^a   Kim, Yerim ^a   Lee, Jeewoo ^a   Lewin, Nancy E ^b   Pearce, Larry V ^b   Blumberg, Peter M ^b   Marquez, Victor E ^c  

^a Seoul National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (HYDROXYMETHYL) 5 [2 (METHOXYCARBONYL)ETHENYL] 3 (9 OCTADECENYLIDENE)TETRAHYDRO 2 FURANONE; 5 HYDROXYMETHYL 5 PIVALOYLOXYMETHYL 3 (TETRADECYLIDENE)TETRAHYDRO 2 FURANONE; 5 [(ACETYLOXY)METHYL] 5 HYDROXYMETHYL 3 (9 OCTADECENYLIDENE)TETRAHYDRO 2 FURANONE; AMIDE; DIACYLGLYCEROL DERIVATIVE; ESTER; KETONE; LACTONE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; ENZYME BINDING; HYDROGEN BOND; INFRARED SPECTROSCOPY; LIPOPHILICITY; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STEREOSPECIFICITY;

EID: 0038334973     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00156-1     Document Type: Article

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