CNS proteomes in alcohol and drug abuse and dependence

Expert Review of Proteomics

Volumn 4, Issue 4, 2007, Pages 539-552

  Matsumoto, Izuru ^a   Alexander Kaufman, Kimberley ^a   Iwazaki, Takeshi ^a   Kashem, Mohammed Abul ^a   Matsuda Matsumoto, Haruka ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Alcohol; Animal model; CNS; Drug of abuse; Human brain; Proteomics

Indexed keywords

ACONITATE HYDRATASE; BETA TUBULIN; ENOLASE; GLUTAMATE AMMONIA LIGASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE SYNTHASE; NUCLEAR RECEPTOR RELATED FACTOR 1; PEROXIREDOXIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVATE DEHYDROGENASE; TRANSALDOLASE; TRANSKETOLASE;

ALCOHOLISM; BRAIN DAMAGE; BRAIN REGION; CENTRAL NERVOUS SYSTEM; COGNITIVE DEFECT; DNA MICROARRAY; DRUG ABUSE; DRUG DEPENDENCE; HUMAN; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; REVIEW; TWO DIMENSIONAL ELECTROPHORESIS;

ALCOHOLISM; BRAIN; COGNITION DISORDERS; DNA, COMPLEMENTARY; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POSTMORTEM CHANGES; PROTEOME; SUBSTANCE-RELATED DISORDERS;

ANIMALIA;

EID: 34548460374     PISSN: 14789450     EISSN: 17448387     Source Type: Journal    
DOI: 10.1586/14789450.4.4.539     Document Type: Review

References (125)

1. Bates ME, Bowden SC, Barry D. Neurocognitive impairment associated with alcohol use disorders: implications for treatment. Exp. Clin. Psychopharmacol. 10(3), 193-212 (2002). • Excellent paper introducing US alcohol-induced cognitive dysfunction and its relation to prognosis.
2. Harper C, Matsumoto I. Ethanol and brain damage. Curr. Opin. Pharmacol. 5(1), 73-78 (2005).
3. Pishkin V, Lovallo WR, Bourne LE Jr. Chronic alcoholism in males: cognitive deficit as a function of age of onset, age, and duration. Alcohol. Clin. Exp. Res. 9(5), 400-406 (1985).
4. Glenn SW, Errico AL, Parsons OA, King AC, Nixon SJ. The role of antisocial, affective, and childhood behavioral characteristics in alcoholics' neuropsychological performance. Alcohol. Clin. Exp. Res. 162-169 (1993).
5. O'Neill JO, Cardenas VA, Meyerhoff DJ. Effects of abstinence on the brain: quantitative magnetic resonance imaging and magnetic resonance spectroscopic imaging in chronic alcohol abuse. Alcohol. Clin. Exp. Res. 25(11), 1673-1682 (2001).
6. Pfefferbaum A, Adalsteinsson E, Sullivan EV. Dysmorphology and microstructural degradation of the corpus callosum: interaction of age and alcoholism. Neurobiol. Aging 27(7), 994-1009 (2006).
7. Pfefferbaum A, Adalsteinsson E, Sullivan EV. Supratentorial profile of white matter microstructural integrity in recovering alcoholic men and women. Biol. Psychiatry 59(4), 364-372 (2006). •• Very interesting paper describing alcohol-related white matter damage in association with cognitive dysfunction.
8. Harper CG, Kril JJ. Neuropathology of alcoholism. Alcohol Alcohol. 25(2-3), 207-216 (1990).
9. Harper C, Kril J. An introduction to alcohol-induced brain damage and its causes. Alcohol Alcohol. (Suppl. 2), 237-243 (1994). •• Excellent review paper overviewing alcohol-related neuropathological changes.
10. Pfefferbaum A, Lim KO, Zipursky RB et al. Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol. Clin. Exp. Res. 16(6), 1078-1089 (1992). • First neuroimaging data demostrating alcohol-induced brain shrinkage.
11. Pfefferbaum A, Rosenbloom M, Crusan K, Jernigan TL. Brain CT changes in alcoholics: effects of age and alcohol consumption. Alcohol. Clin. Exp. Res. 12(1), 81-87 (1988).
12. de la Monte SM. Disproportionate atrophy of cerebral white matter in chronic alcoholics. Arch. Neurol. 45(9), 990-992 (1988).
13. Harper C, Kril J. Brain atrophy in chronic alcoholic patients: a quantitative pathological study. J. Neurol. Neurosurg. Psychiatry 48(3), 211-217 (1985).
14. Kril JJ, Halliday GM, Svoboda MD, Cartwright H. The cerebral cortex is damaged in chronic alcoholics. Neuroscience 79(4), 983-998 (1997).
15. Jernigan TL, Butters N, DiTraglia G et al. Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging. Alcohol. Clin. Exp. Res. 15(3), 418-427 (1991).
16. Ferrer I, Fabregues I, Rairiz J, Galofre E. Decreased numbers of dendritic spines on cortical pyramidal neurons in human chronic alcoholism. Neurosci. Lett. 69(1), 115-119 (1986).
17. Harper C, Corbett D. Changes in the basal dendrites of cortical pyramidal cells from alcoholic patients - a quantitative Golgi study. J. Neurol. Neurosurg. Psychiatry 53(10), 856-861 (1990).
18. Dao-Castellana MH, Samson Y, Legault F et al. Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings. Psychol. Med. 28(5), 1039-1048 (1998).
19. Adams KM, Gilman S, Koeppe RA et al. Neuropsychological deficits are correlated with frontal hypometabolism in positron emission tomography studies of older alcoholic patients. Alcohol. Clin. Exp. Res. 17(2), 205-210 (1993).
20. Torvik A, Torp S. The prevalence of alcoholic cerebellar atrophy. A morphometric and histological study of an autopsy material. J. Neurol. Sci. 75(1), 43-51 (1986).
21. Pfefferbaum A, Rosenbloom M. In vivo imaging of morphological alterations associated with alcoholism. In: Alcohol-Induced Brain Damage. Hunt WA, Nixon SJ (Eds). US Department of Health and Human Services, Rockville, MD, USA 71-87 (1993).
22. Harper C. The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J. Neuropathol. Exp. Neurol. 57(2), 101-110 (1998).
23. Andersen BB. Reduction of Purkinje cell volume in cerebellum of alcoholics. Brain Res. 1007(1-2), 10-18 (2004).
24. Ferrer I, Fabregues I, Pineda M, Gracia I, Ribalta T. A Golgi study of cerebellar atrophy in human chronic alcoholism. Neuropathol. Appl. Neurobiol. 10(4), 245-253 (1984).
25. Pentney RJ. Quantitative analysis of ethanol effects on Purkinje cell dendritic tree. Brain Res. 249(2), 397-401 (1982).
26. Harper CG, Kril JJ. Neuropathological changes in alcoholics. In: Alcohol-Induced Brain Damage. Hunt WA, Nixon SJ (Eds). US Department of Health and Human Services, Rockville, MD, USA 39-69 (1993).
27. Baker KG, Harding AJ, Halliday GM, Kril J, Harper CG. Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy. Neuroscience 91(2), 429-438 (1999).
28. Parks MH, Dawant BM, Riddle WR et al. Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy. Alcohol. Clin. Exp. Res. 26(9), 1368-1380 (2002).
29. Martin PR, Singleton CK, Hiller-Sturmhofel S. The role of thiamine deficiency in alcoholic brain disease. Alcohol Res. Health 27(2), 134-142 (2003).
30. Schmahmann JD, Pandya DN. The cerebrocerebellar system. Int. Rev. Neurobiol. 41, 31-60 (1997).
31. Diamond A. Close interrelation of motor development and cognitive development and of the cerebellum and prefrontal cortex. Child Dev. 71(1), 44-56 (2000).
32. Sullivan EV. Compromised pontocerebellar and cerebellothalamocortical systems: speculations on their contributions to cognitive and motor impairment in nonamnesic alcoholism. Alcohol. Clin. Exp. Res. 27(9), 1409-1419 (2003).
33. Baynes K. Corpus callosum. In: Encyclopaedia of the Human Brain (Volume 2). Elsevier Science, St Louis, MO, USA 52 (2002).
34. Aboitiz F, Scheibel AB, Fisher RS, Zaidel E. Fiber composition of the human corpus callosum. Brain Res. 598(1-2), 143-153 (1992).
35. de Lacoste MC, Kirkpatrick JB, Ross ED. Topography of the human corpus callosum. J. Neuropathol. Exp. Neurol. 44(6), 578-591 (1985).
36. Lamantia AS, Rakic P. Cytological and quantitative characteristics of four cerebral commissures in the rhesus monkey. J. Comp. Neurol. 291(4), 520-537 (1990).
37. Gruber SA, Yurgelun-Todd DA. Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation. Brain Res. Cogn. Brain Res. 23(1), 107-118 (2005).
38. Lim KO, Choi SJ, Pomara N, Wolkin A, Rotrosen JP. Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. Biol. Psychiatry 51(11), 890-895 (2002).
39. Matochik JA, Eldreth DA, Cadet JL, Bolla KI. Altered brain tissue composition in heavy marijuana users. Drug Alcohol Depend. 77(1), 23-30 (2005).
40. Pfefferbaum A, Sullivan EV. Disruption of brain white matter microstructure by excessive intracellular and extracellular fluid in alcoholism: evidence from diffusion tensor imaging. Neuropsychopharmacology 30(2), 423-432 (2005).
41. Ryabinin AE. Role of hippocampus in alcohol-induced memory impairment: implications from behavioral and immediate early gene studies. Psychopharmacology (Berl.) 139(1-2), 34-43 (1998).
42. Harding AJ, Wong A, Svoboda M, Kril JJ, Halliday GM. Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus 7(1), 78-87 (1997).
43. Korbo L. Glial cell loss in the hippocampus of alcoholics. Alcohol. Clin. Exp. Res. 23(1), 164-168 (1999).
44. Ikegami Y, Goodenough S, Inoue Y et al. Increased TUNEL positive cells in human alcoholic brains. Neurosci. Lett. 349(3), 201-205 (2003). • Interesting paper demonstrating possible genotoxicity in the human alcoholic brain.
45. Mayfield RD, Lewohl JM, Dodd PR et al. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J. Neurochem. 81(4), 802-813 (2002).
46. Flatscher-Bader T, van der Brug M, Hwang JW et al. Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. J. Neurochem. 93(2), 359-370 (2005).
47. Liu J, Lewohl JM, Dodd PR et al. Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. J. Neurochem. 90(5), 1050-1058 (2004).
48. Pierce RC, Kumaresan V. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neurosci. Biobehav. Rev. 30(2), 215-238 (2006). •• Important review paper describing the mesolimbic system as a center of drug addiction.
49. Robinson TE, Kolb B. Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J. Neurosci. 17(21), 8491-8497 (1997).
50. Robinson TE, Kolb B. Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur. J. Neurosci. 11(5), 1598-1604 (1999).
51. Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu. Rev. Neurosci. 29, 565-598 (2006).
52. Alexander-Kaufman K, Cordwell S, Harper C, Matsumoto I. A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Proteomics: Clinical Applications 1(1), 62-72 (2007). •• Our own paper investigating alcohol-induced changes in both gray and white matters of the prefrontal cortex. Proteins associated with thiamine deficiency were extracted in both matters.
53. Alexander-Kaufman K, Harper C, Wilce P, Matsumoto I. Cerebellar vermis proteome of chronic alcoholic individuals. Alcohol. Clin. Exp. Res. 31(8), 1286-1296 (2007).
54. Alexander-Kaufman K, James G, Sheedy D, Harper C, Matsumoto I. Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Mol. Psychiatry 11(1), 56-65 (2006). •• Our own paper investigating alcohol-induced changes in white matters of the prefrontal cortex. Proteins associated with thiamine deficiency were extracted and no hepatic effects were found on the brain proteome.
55. Beasley CL, Pennington K, Behan A et al. Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes. Proteomics 6(11), 3414-3425 (2006).
56. Choudhary J, Grant SG. Proteomics in postgenomic neuroscience: the end of the beginning. Nat. Neurosci. 7(5), 440-445 (2004).
57. Clark D, Dedova I, Cordwell S, Matsumoto I. A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Mol. Psychiatry 11(5), 459-470, 423 (2006).
58. Clark D, Dedova I, Cordwell S, Matsumoto I. Altered proteins of the anterior cingulate cortex white matter proteome in schizophrenia. Proteomics Clinical Applications 1(2), 157-166 (2007).
59. Iwazaki T, McGregor IS, Matsumoto I. Protein expression profile in the striatum of acute methamphetamine-treated rats. Brain Res. 1097(1), 19-25 (2006). •• Our own proteomics study demonstrating the changes of proteome in the dorsal striatum after acute methamphetamine (MAP) treatment. We have mainly identified the toxic effects of MAP in this study.
60. Iwazaki T, McGregor IS, Matsumoto I. Protein expression profile in the striatum of rats with methamphetamine-induced behavioral sensitsation. Proteomics 7(7), 1131-1139 (2007). •• Our own proteomics study demonstrating the proteome changes in the dorsal striatum after chronic MAP treatment. This chronic treatment induced the formation of drug sensitization. In contrast to acute treatment [59], more plasticity-related proteins were identified in the dorsal striatum indicating the structural modification of this region after chronic drug administration.
61. Kashem MA, James G, Harper C, Wilce P, Matsumoto I. Differential protein expression in the corpus callosum (splenium) of human alcoholics: a proteomics study. Neurochem. Int. 50(2), 450-459, (2007). •• Our own study investigating the proteome in alcoholic corpus callosum. In this subregion of the corpus callosum (splenium), no effects of thiamine deficiency were identified while significant effects of hepatic complication were evident.
62. Matsuda-Matsumoto H, Iwazaki T, KashemMA, Harper C, Matsumoto I. Differential protein expression profiles in the hippocampus of human alcoholics. Neurochem. Int. (2007) (Epub ahead of print). •• Our own proteomics study investigating protein expression profiles in alcoholic hippocampus. We have identified the change in expression level of ammoniatrapping enzyme, glutamine synthetase, which is specifically localized in astrocytes. This may explain the abnormalities of astrocytes observed in the alcoholic hippocampus.
63. Mei J, Kolbin D, Kao HT, Porton B. Protein expression profiling of postmortem brain in schizophrenia. Schizophr. Res. 84(2-3), 204-213 (2006).
64. Novikova SI, He F, Cutrufello NJ, Lidow MS. Identification of protein biomarkers for schizophrenia and bipolar disorder in the postmortem prefrontal cortex using SELDI-TOF-MS ProteinChip profiling combined with MALDI-TOF-PSD-MS analysis. Neurobiol. Dis. 23(1), 61-76 (2006).
65. O'Brien E, Dedova I, Duffy L et al. Effects of chronic risperidone treatment on the striatal protein profiles in rats. Brain Res. 1113(1), 24-32 (2006).
66. Tannu N, Mash DC, Hemby SE. Cytosolic proteomic alterations in the nucleus accumbens of cocaine overdose victims. Mol. Psychiatry 12(1), 55-73 (2007).
67. Lewohl JM, Dodd PR, Mayfield RD, Harris RA. Application of DNA microarrays to study human alcoholism. J. Biomed. Sci. 8(1), 28-36 (2001).
68. Gygi SP, Rochon Y, Franza BR, Aebersold R. Correlation between protein and mRNA abundance in yeast. Mol. Cell Biol. 19(3), 1720-1730 (1999).
69. Anderson L, Seilhamer J. A comparison of selected mRNA and protein abundances in human liver. Electrophoresis 18(3-4), 533-537 (1997).
70. Sarris M, Garrick TM, Sheedy D, Harper CG. Banking for the future: an Australian experience in brain banking. Pathology 34(3), 225-229 (2002).
71. Harper C, Dixon G, Sheedy D, Garrick TM. Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 951-961 (2003). • Introduces the human brain bank system and how to access to human brain materials for research projects.
72. Hill C, Roberts S, Keks N et al. Diagnostic Instrument for Brain Studies: Psychoses and Mood Disorders (Version 3). NH & MRC Network for Brain Research into Mental Disorders. Mental Health Research Institute and Monash University, Mental Health Research Institute, Victoria, Australia 1-39 (2001).
73. Liu J, Lewohl JM, Harris RA et al. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31(7), 1574-1582 (2006).
74. Fan L, Jaquet V, Dodd PR, Chen W, Wilce PA. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. J. Neurochem. 76(5), 1275-1281 (2001).
75. Fan L, Bellinger F, Ge YL, Wilce P. Genetic study of alcoholism and novel gene expression in the alcoholic brain. Addict. Biol. 9(1), 11-18 (2004).
76. Depaz I, Ito M, Matsumoto I et al. Expression of hNP22 is altered in the frontal cortex and hippocampus of the alcoholic human brain. Alcohol. Clin. Exp. Res. 27(9), 1481-1488 (2003).
77. Lewohl JM, Van Dyk DD, Craft GE et al. The application of proteomics to the human alcoholic brain. Ann. NY Acad. Sci. 1025(14-26 (2004).
78. Butterworth RF. Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. Metab. Brain Dis. 10(1), 1-8 (1995).
79. Lavoie J, Butterworth RF. Reduced activities of thiamine-dependent enzymes in brains of alcoholics in the absence of Wernicke's encephalopathy. Alcohol. Clin. Exp. Res. 19(4), 1073-1077 (1995).
80. Majumdar SK. Chlormethiazole and utilization of vitamin B1 in chronic alcoholics. Eur. J. Clin. Pharmacol. 18(4), 361-362 (1980).
81. Majumdar SK, Shaw GK, Thomson AD. Vitamin utilization status in chronic alcoholics. Int. J. Vitam. Nutr. Res. 51(1), 54-58 (1981).
82. Harper CG, Giles M, Finlay-Jones R. Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J. Neurol. Neurosurg. Psychiatry 49(4), 341-345 (1986).
83. Goldstein RZ, Leskovjan AC, Hoff AL et al. Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex. Neuropsychologia 42(11), 1447-1458 (2004).
84. Alexander-Kaufman K, Harper C, Wilce P, Matsumoto I. The cerebellar vermis proteome of chronic alcoholics. Alcohol. Clin. Exp. Res. (2007) (Epub ahead of print). •• Our own paper investigating the proteome of alcoholic cerebellar vermis. In the cerebellar vermis, effects of both thiamine deficiency and hepatic complication on the brain proteome were identified.
85. Phillips SC, Harper CG, Kril JJ. The contribution of Wernicke's encephalopathy to alcohol-related cerebellar damage. Drug Alcohol Rev. 9(1), 53-60 (1990).
86. Phillips SC, Harper CG, Kril J. A quantitative histological study of the cerebellar vermis in alcoholic patients. Brain 110(Pt 2) 301-314 (1987).
87. Butterworth RF, Kril JJ, Harper CG. Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome. Alcohol. Clin. Exp. Res. 17(5), 1084-1088 (1993).
88. Gilman S, Adams K, Koeppe RA et al. Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomography. Ann. Neurol. 28(6), 775-785 (1990).
89. Gardner PR, Raineri I, Epstein LB, White CW. Superoxide radical and iron modulate aconitase activity in mammalian cells. J. Biol. Chem. 270(22), 13399-13405 (1995).
90. Yan LJ, Levine RL, Sohal RS. Oxidative damage during aging targets mitochondrial aconitase. Proc. Natl Acad. Sci. USA 94(21), 11168-11172 (1997).
91. Renis M, Calabrese V, Russo A et al. Nuclear DNA strand breaks during ethanol-induced oxidative stress in rat brain. FEBS Lett. 390(2), 153-156 (1996).
92. Wang Y, Floor E. Hydrogen peroxide inhibits the vacuolar H+-ATPase in brain synaptic vesicles at micromolar concentrations. J. Neurochem. 70(2), 646-652 (1998).
93. Wolosker H, Reis M, Assreuy J, de Meis L. Inhibition of glutamate uptake and proton pumping in synaptic vesicles by S-nitrosylation. J. Neurochem. 66(5), 1943-1948 (1996).
94. Felipo V, Butterworth RF. Neurobiology of ammonia. Prog. Neurobiol. 67(4), 259-279 (2002).
95. Lieber CS. Ethanol metabolism, cirrhosis and alcoholism. Clin. Chim. Acta 257(1), 59-84 (1997).
96. Sawara K, Kato A, Yoshioka Y, Suzuki K. Brain glutamine and glutamate levels in patients with liver cirrhosis: assessed by 3.0-T MRS. Hepatol. Res. 30(1), 18-23 (2004).
97. Chan H, Butterworth RF. Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain. Neurochem. Int. 43(4-5), 525-532 (2003).
98. Natarajan V, Taher MM, Roehm B et al. Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide. J. Biol. Chem. 268(2), 930-937 (1993).
99. Frohman MA, Sung TC, Morris AJ. Mammalian phospholipase D structure and regulation. Biochim. Biophys. Acta 1439(2), 175-186 (1999).
100. Nishida A, Saito H, Shimizu M, Zensho H, Yamawaki S. Phosphatidylethanol inhibits phosphatidylinositol-phospholipase C activity in a competitive manner with phosphatidylinositol-4,5-bisphosphate. Drug Alcohol Depend. 44(2-3), 117-122 (1997).
101. Hubbard KB, Hepler JR. Cell signalling diversity of the Gqα family of heterotrimeric G proteins. Cell. Signal. 18(2), 135-150 (2006).
102. Suarez I, Bodega G, Fernandez B. Glutamine synthetase in brain: effect of ammonia. Neurochem. Int. 41(2-3), 123-142 (2002).
103. Girard G, Giguere JF, Butterworth RF. Region-selective reductions in activities of glutamine synthetase in rat brain following portacaval anastomosis. Metab. Brain Dis. 8(4), 207-215 (1993).
104. Lavoie J, Giguere JF, Layrargues GP, Butterworth RF. Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy. Metab. Brain Dis. 2(4), 283-290 (1987).
105. Franke H, Kittner H, Berger P, Wirkner K, Schramek J. The reaction of astrocytes and neurons in the hippocampus of adult rats during chronic ethanol treatment and correlations to behavioral impairments. Alcohol 14(5), 445-454 (1997).
106. Tagliaferro P, Vega MD, Evrard SG, Ramos AJ, Brusco A. Alcohol exposure during adulthood induces neuronal and astroglial alterations in the hippocampal CA-1 area. Ann. NY Acad. Sci. 965, 334-342 (2002).
107. Albertson DN, Pruetz B, Schmidt CJ et al. Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J. Neurochem. 88(5), 1211-1219 (2004).
108. Lehrmann E, Colantuoni C, Deep-Soboslay A et al. Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. PLoS ONE 1, E114 (2006).
109. Albertson DN, Schmidt CJ, Kapatos G, Bannon MJ. Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology 31(10), 2304-2312 (2006).
110. Lehrmann E, Oyler J, Vawter MP et al. Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 3(1), 27-40 (2003).
111. Ammon S, Mayer P, Riechert U, Tischmeyer H, Hollt V. Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal. Brain Res. Mol. Brain Res. 112(1-2), 113-125 (2003).
112. Yuferov V, Nielsen D, Butelman E, Kreek MJ. Microarray studies of psychostimulant-induced changes in gene expression. Addict Biol. 10(1), 101-118 (2005).
113. Graybiel AM, Moratalla R, Robertson HA. Amphetamine and cocaine induce drugspecific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc. Natl Acad. Sci. USA 87(17), 6912-6916 (1990).
114. Iwasa H, Kikuchi S, Hasegawa S, Suzuki K, Sato T. Alteration of G protein subclass mRNAs in methamphetamine-induced behavioral sensitization. Ann. NY Acad. Sci. 801, 110-115 (1996).
115. Ujike H, Takaki M, Kodama M, Kuroda S. Gene expression related to synaptogenesis, neuritogenesis, MAP kinase in behavioral sensitization to psychostimulants. Ann. NY Acad. Sci. 965, 55-67 (2002).
116. Kim SY, Chudapongse N, Lee SM et al. Proteomic analysis of phosphotyrosyl proteins in morphine-dependent rat brains. Brain Res. Mol. Brain Res. 133(1), 58-70 (2005).
117. Liao PC, Kuo YM, Hsu HC, Cherng CG, Yu L. Local proteins associated with methamphetamine-induced nigrostriatal dopaminergic neurotoxicity. J. Neurochem. 95(1), 160-168 (2005).
118. Freeman WM, Brebner K, Amara SG et al. Distinct proteomic profiles of amphetamine self-administration transitional states. Pharmacogenomics J. 5(3), 203-214 (2005).
119. Robinson TE, Berridge KC. The neural basis of drug craving: an incentivesensitization theory of addiction. Brain Res. Brain Res. Rev. 18(3), 247-291 (1993).
120. Robinson TE, Becker JB. Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res. 396(2), 157-198 (1986).
121. Nishikawa T, Mataga N, Takashima M, Toru M. Behavioral sensitization and relative hyperresponsiveness of striatal and limbic dopaminergic neurons after repeated methamphetamine treatment. Eur. J. Pharmacol. 88(2-3), 195-203 (1983).
122. Hamamura T, Akiyama K, Akimoto K et al. Co-administration of either a selective D1 or D2 dopamine antagonist with methamphetamine prevents methamphetamine-induced behavioral sensitization and neurochemical change, studied by in vivo intracerebral dialysis. Brain Res. 546(1), 40-46 (1991).
123. Nestler EJ. Molecular basis of long-term plasticity underlying addiction. Nat. Rev. Neurosci. 2(2), 119-128 (2001).
124. Lubec G, Krapfenbauer K, Fountoulakis M. Proteomics in brain research: potentials and limitations. Prog. Neurobiol. 69(3), 193-211 (2003).
125. Molloy MP, Herbert BR, Walsh BJ et al. Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis. Electrophoresis 19(5), 837-844 (1998).