Phosphatidylethanol inhibits phosphatidylinositol-phospholipase C activity in a competitive manner with phosphatidylinositol-4,5-bisphosphate

Drug and Alcohol Dependence

Volumn 44, Issue 2-3, 1997, Pages 117-122

  Nishida, Akira ^a   Saito, Hiroshi ^a,b   Shimizu, Masami ^a   Zensho, Hidenobu ^a,b   Yamawaki, Shigeto ^b  

^a NATIONAL HOSPITAL ORGANIZATION KURE MEDICAL CENTER AND CHUGOKU CANCER CENTER   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Cerebrum; Ethanol; Phosphatidylethanol; Phospholipase C; Phospholipase D

Indexed keywords

ALCOHOL; ANTIBODY; CALCIUM ION; NEOMYCIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; PHOSPHOLIPID;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL MEMBRANE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030892988     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(96)01328-2     Document Type: Article

References (22)

1. Alling, C., Gustavsson, L., Månsson, J.-E., Benthin, G. and Änggård, E. (1984) Phosphatidylethanol formation in rat organs after ethanol treatment. Biochim. Biophys. Acta 793, 119-122.
2. Asaoka, Y., Kikkawa, U., Sekiguchi, K., Shearman, M.S., Kosaka, Y., Nakano, Y., Satoh, T. and Nishizuka, Y. (1988) Activation of brain specific protein kinase C subspecies in the presence of phosphatidylethanol. FEBS Lett. 231, 221-224.
3. Billah, M.M. and Anthes, J.C. (1990) The regulation and cellular functions of phospatidylcholine beakdown. Biochem. J. 269, 281-291.
4. Bondeson, J. and Sundler, R. (1987) Phosphatidylethanol counteracts calcium-induced membrane fusion but promotes protein fusion. Biochim. Biophys. Acta 899, 258-264.
5. Cockcroft, S. and Thomas, G.M. (1992) Inositol-lipid-specific phospholipase C isozymes and their differential regulation by receptors. Biochem. J. 288, 1-14.
6. Fisher, S.F., Heacock, A.M. and Agranoff, B.W. (1992) Inositol lipids and signal transduction in the nervous system: an update. J. Neurochem. 58, 18-38.
7. Fukuda, H., Nishida, A., Saito, H., Shimizu, M. and Yamawaki, S. (1994) Imipramine stimulates phospholipase C activity in rat brain. Neurochem. Int. 25, 567-571.
8. Gustavsson, L. and Alling, C. (1987) Formation of phosphatidylethanol in rat brain by phospholipase D. Biochem. Biophys. Res. Commun. 142, 958-963.
9. Gustavsson, L. (1995) Phosphatidylethanol formation: specific effect of ethanol mediated via phsopholipase D. Alcohol and Alcoholism, 30, 391-406.
10. Hoek, J. B., Thomas, A.P., Rooney, T.A., Higashi, K. and Rubin, E. (1992) Ethanol and signal transduction in the liver. FASEB J. 6, 2386-2396.
11. Klein, J., Chalifa, V., Liscovitch, M. and Löffelholz, K. (1995) Role of phospholipase D activation in nervous system: physiology and pathophysiology. J. Neurochem. 65, 1445-1455.
12. Kobayashi, M. and Kanfer, J.N. (1987) Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D. J. Neurochem. 48, 1597-1603.
13. Litosch, I., Sulkholutskaya, I. and Weng, C. (1993) G protein-mediated inhibition of phospholipase C activity in a solubilized membrane preparation. J. Biol. Chem. 268, 8692-8697.
14. Löffelholz, K. (1989) Receptor regulation of choline phospholipid hydrolysis: a novel source of diacylglycerol and phosphatidic acid. Biochem. Pharmacol. 38, 1543-1549.
15. Lundqvist, C., Rodriguez, F.D., Simonsson, P., Alling, C. and Gustavsson, L. (1993) Phosphatidylethanol affects inositol 1,4,5-trisphosphate levels in NG108-15 neuroblastom × glioma hybrid cells. J. Neurochem. 60, 738-744.
16. Lundqvist, C., Aradottir, S., Alling, C., Boyano-Adanez, M.C. and Gustavsson, L. (1994a) Phosphatidylethanol formation and degradation in brains of acutely and repeatedly ethanol-treated rats. Neurosci. Lett. 179, 127-131.
17. Lundqvist, C., Alling, C., Aradottir, S. and Gustavsson, L. (1994b) Agonist-stimulated and basal phosphatidylethanol formation in neutrophils from alcoholics. Alcohol. Clin. Exp. Res. 18, 580-586.
18. Mueller, G.C., Fleming, M.F., LeMahieu, M.A., Lybrand, G.S. and Barry, K.J. (1988) Synthesis of phosphatidylethanol-a potential marker for adult males at risk for alcoholism. Proc. Natl. Acad. Sci. 85, 9778-9782.
19. Omodeo-Salé, F., Lindi, C., Palestini, P. and Masserini, M. (1991) Role of Phosphatidylethanol in membranes: effects on membrane fluidity, tolerance to ethanol, and activity of membrane-bound enzymes. Biochemistry 30, 2477-2482.
20. Rhee, S.G. and Choi, K.D. (1992) Regulation of inositol phospholipidspecific phospholipase C isozymes. J. Biol. Chem. 267, 12393-12396.
21. Shukla, S.D. and Halenda, S.P. (1991) Phospholipase D in cell signaling and its regulation to phospholipase C. Life Sci. 48, 851-866.
22. Victorov, A.V., Janes, N., Moehren, G., Rubin, E., Taraschi, T.F. and Hoek, J.B. (1994) Rapid transbilayer movement of phosphatidylethanol in unilamellar phosphatidylcholine vesicles. J. Am. Chem. Soc. 116, 4050-4052.