Genetic study of alcoholism and novel gene expression in the alcoholic brain

Addiction Biology

Volumn 9, Issue 1, 2004, Pages 11-18

  Fan, Li ^a,b   Bellinger, Frederick P ^a   Ge, Yong Liang ^b   Wilce, Peter A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL;

ALCOHOLISM; BRAIN REGION; DIFFERENTIAL DISPLAY; DNA MICROARRAY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INDUCTION; GENETIC ANALYSIS; HUMAN; MEDICAL INFORMATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; SUBTRACTIVE HYBRIDIZATION;

ALCOHOLISM; BRAIN; DNA-BINDING PROTEINS; GENE EXPRESSION; HUMANS; MEMBRANE PROTEINS; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLANT PROTEINS; POLYMERASE CHAIN REACTION;

EID: 2342615476     PISSN: 13556215     EISSN: None     Source Type: Journal    
DOI: 10.1080/13556210410001674040     Document Type: Review

References (76)

1. Diamond I, Gordon AS. Cellular and molecular neuroscience of alcoholism. Physiol Rev 1997;77: 1-20.
2. Nestler EJ, Hope BT, Widnell KL. Drug addiction: a model for the molecular basis of neural plasticity. Neuron 1993;11:995-1006.
3. Nestler EJ. Molecular neurobiology of addiction. Am J Addict 2001;10:201-17.
4. Koob GF, Sanna PP, Bloom FE. Neuroscience of addiction. Neuron 1998;21:467-76.
5. Lewohl JM, Wang L, Miles MF, Zhang L, Dodd PR, Harris RA. Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res 2000;24:1873-82.
6. Matsumoto I, Wilce PA, Buckley T, et al. Ethanol and gene expression in brain. Alcohol Clin Exp Res 2001;25(Suppl 5 ISBRA):S82-6.
7. Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 2002;81:802-13.
8. Carlen PL, Penn RD, Fornazzari L, Bennett J, Wilkinson DA, Wortzman G. Computerized tomographic scan assessment of alcoholic brain damage and its potential reversibility. Alcohol Clin Exp Res 1986;10:226-32.
9. Harper C, Kril J. Neuropathological changes in alcoholics. In: Hunt WA, Nixon SJ, editors. Alcohol-induced brain damage. Rockville, MD: National Institutes of Health, 1993; pp. 39-69.
10. Aschner M, Allen JW. Astrocytes in methylmercury, ammonia, methionine sulfoximine and alcohol-induced neurotoxicity. Neurotoxicology 2000; 21:573-9.
11. Charness ME. Brain lesions in alcoholics. Alcohol Clin Exp Res 1993;17:2-11.
12. Hunt WA. Role of acetaldehyde in the action of ethanol on the brain - a review. Alcohol 1996;13: 147-51.
13. Bora PS, Lange LG. Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl esters. Alcohol Clin Exp Res 1993;17:28-30.
14. Gustavsson L. Phosphatidylethanol formation: specific effects of ethanol mediated via phospholipase D. Alcohol Alcohol 1995;30:391-406.
15. Bleich S, Spilker K, Kurth C, et al. Oxidative stress and an altered methionine metabolism in alcoholism. Neurosci Lett 2000;293:171-74.
16. Freund G. Apoptosis and gene expression: perspectives on alcohol-induced brain damage. Alcohol 1994;11:385-7.
17. de la Monte SM, Ganju N, Banerjee K, Brown NV, Luong T, Wands JR. Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase. Alcohol Clin Exp Res 2000;24:716-26.
18. Wilce P, Beckmann A, Chen W, Davidson M, Hardy P, Shanley B. Adaptive changes in GABA and NMDA receptors underlie ethanol dependence and ethanol-induced brain damage following chronic exposure and withdrawal. Curr Top Neurochem 1997;1:133-9.
19. Littleton JM, Brennan C, Bouchenafa O. The role of calcium flux in the central nervous system actions of ethanol. Ann NY Acad Sci 1991;625: 388-94.
20. Tabakoff B, Nelson E, Yoshimura M, Hellevuo K, Hoffman PL. Phosphorylation cascades control the actions of ethanol on cell cAMP signalling. J Biomed Sci 2001;8:44-51.
21. Pandey SC, Saito T, Yoshimura M, Sohma H, Gotz ME. cAmp signaling cascade: a promising role in ethanol tolerance and dependence. Alcohol Clin Exp Res 2001;25(Suppl 5 ISBRA):S46-8.
22. Pandey SC, Roy A, Mittal N. Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex. J Pharmacol Exp Ther 2001; 296:857-68.
23. Kalluri HS, Ticku MK. Ethanol-mediated inhibition of mitogen-activated protein kinase phosphorylation in mouse brain. Eur J Pharmacol 2002;439: 53-8.
24. Seiler AE, Henderson A, Rubin R. Ethanol inhibits insulin receptor tyrosine kinase. Alcohol Clin Exp Res 2000;24:1869-72.
25. Ball DM, Murray RM. Genetics of alcohol misuse. Br Med Bull 1994;50:18-35.
26. Goate AM, Edenberg HJ. The genetics of alcoholism. Curr Opin Genet Dev 1998;8:282-6.
27. Crabbe JC. Genetic contributions to addiction. Annu Rev Psychol 2002;53:435-62.
28. Crabbe JC, Belknap JK, Buck KJ. Genetic animal models of alcohol and drug abuse. Science 1994; 264:1715-23.
29. Crawley JK, Belknap JK, Collins A, et al. Behavioural phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 1997;132:107-24.
30. Melo JA, Shendure J, Pociask K, Silver LM. Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nature Genet 1996;13:147-53.
31. Buck KJ, Rademacher BS, Metten P, Crabbe JC. Mapping murine loci for physical dependence on ethanol. Psychopharmacology (Berl) 2002;160: 398-407.
32. Belknap JK, Richards SP, O'Toole LA, Helms ML, Phillips TJ. Short-term selective breeding as a tool for QTL mapping: alcohol preference drinking in mice. Behav Genet 1997;25:55-66.
33. McClearn GE, Tarantino LM, Rodriguez LA, Jones BC, Blizard DA, Plomin R. Genotype selection provides experimental confirmation for an alcohol consumption quantitative trait locus in mouse. Mol Psychiatry 1997;2:486-9.
34. Phillips TJ, Belknap JK, Buck KJ, Cunningham CL. Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Mamm Genome 1998;9:936-41.
35. Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 1997;17:3946-55.
36. Foroud T, Edenberg HJ, Goate A, et al. Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 2000;24:933-45.
37. Crabbe JC, Phillips TJ. Genetics of alcohol and other abused drugs. Drug Alcohol Depend 1998; 51:61-71.
38. Crews FT. Summary report of a symposium: genes and gene delivery for diseases of alcoholism. Alcohol Clin Exp Res 2001;25:1778-800.
39. Waterston RH, Lindblad-Toh K, Birney E, et al. Initial sequencing and comparative analysis of the mouse genome. Nature 2002;420:520-62.
40. Hoffman PL, Miles M, Edenberg HJ, et al. Gene expression in brain: a window on etnanol dependence, neuroadaptation, and preference. Alcohol Clin Exp Res 2003;27:155-68.
41. Devor EJ, Cloninger CR. Genetics of alcoholism. Annu Rev Genet 1989;23:19-36.
42. Merikangas KR. The genetic epidemiology of alcoholism. Psychol Med 1990;20:11-22.
43. Johnson EO, van den Bree MBM, Pickens RW. Subtypes of alcohol-dependent men: a typology based on relative genetic and environmental loading. Alcohol Clin Exp Res 1996;20:1472-80.
44. Reed T, Page WF, Viken RJ, Christian JC. Genetic predisposition to organ-specific endpoints of alcoholism. Alcohol Clin Exp Res 1996;20:1528-33.
45. True WR, Heath AC, Bucholz K, et al. Models of treatment seeking for alcoholism: the role of genes and environment. Alcohol Clin Exp Res 1996;20:1577-81.
46. Long JC, Knowler WC, Hanson RL, et al. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 1998;81:216-21.
47. Reich T, Edenberg HJ, Goate A, et al. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 1998;81:207-15.
48. Liang P, Pardee AB. Differential display of eukaryotic messenger RNA by mean of the polymerase chain reaction. Science 1992;257:967-71.
49. Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995;270:467-70.
50. Miles MF. Alcohol's effects on gene expression. Alcohol Health Res World 1995;19:237-43.
51. Chen W, Hardy P, Wilce PA. Differential expression of mitochondrial NADH dehydrogenase in ethanol-treated rat brain: revealed by differential display. Alcohol Clin Exp Res 1997;21:1053-6.
52. Fan L, van der Brug M, Chen W, et al. Increased expression of mitochondrial genes in human alcoholic brain revealed by differential display. Alcohol Clin Exp Res 1999;23:408-13.
53. Fan L, Jaquet V, Dodd PR, Chen W, Wilce PA. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. J Neurochem 2001;76:1275-81.
54. Thibault C, Lai C, Wilke N, et al. Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. Mol Pharmacol 2000;58:1593-600.
55. Lewohl JM, Dodd PR, Mayfield RD, Harris RA. Application of DNA microarrays to study human alcoholism. J Biomed Sci 2001;8:28-36.
56. Quackenbush J. Microarray data normalization and transformation. Nat Genet 2002;32(Suppl):496-501.
57. Dudoit S, Gentleman RC, Quackenbush J. Open source software for the analysis of microarray data. Biotechniques 2003;Suppl:45-51.
58. Miles MF. Microarrays: lost in a storm of data? Nat Rev Neurosci 2001;2:441-3.
59. Shanley BC, Wilce PA. Receptor changes associated with ethanol-induced brain damage. In: Hunt WA, Nixon SJ editors. Alcohol-induced brain damage. Rockville, MD: National Institutes of Health, 1993; pp. 299-324.
60. Tabakoff B, Hoffman PL. Alcohol addiction: an enigma among us. Neuron 1996;16:909-12.
61. Hayes G, Shine J. Dopamine receptor diversity. Today's Life Sci 1992;4:16-22.
62. Rimondini R, Arlinde C, Sommer W, Heilig M. Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J 2002;16:27-35.
63. Depaz I, Ito M, Matsumoto I, Niwa S, Kroon P, Wilce PA. Expression of hNP22 is altered in the frontal cortex and hippocampus of the alcoholic human brain. Alcohol Clin Exp Res 2003;27:1481-8.
64. Takahashi K, Nadal-Ginard B. Molecular cloning and sequence analysis of smooth muscle calponin. J Biol Chem 1991;266:13284-8.
65. Shapland C, Hsuan JJ, Totty NF, Lawson D. Purification and properties of transgelin: a transformation and shape change sensitive actin-gelling protein. J Cell Biol 1993;121:1065-73.
66. Lawson D, Harrison M, Shapland C. Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines. Cell Motil Cytoskeleton 1997;38:250-7.
67. De las Heras R, Leah J, Kroon PA, Wilce PA. Process formation induced by human neuronal protein of 22 kDa, hNP22. Proc Aust Neurosci Soc 2003;14:54.
68. Chandler LJ, Harris RA, Crews FT. Ethanol tolerance and synaptic plasticity. Trends Pharmacol Sci 1998;19:491-5.
69. Robinson TE, Kolb B. Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur J Neurosci 1999;11:1598-604.
70. Robinson TE, Gorny G, Savage VR, Kolb B. Widespread but regionally specific effects of experimenter- versus self-administered morphine on dendritic spines in the nucleus accumbens, hippocampus, and neocortex of adult rats. Synapse 2002;46:271-9.
71. Harris RA, McQuilkin SJ, Paylor R, Abeliovich A, Tonegawa S, Wehner JM. Mutant mice lacking the γ isoform of protein kinase C show decreased behavioural actions of ethanol and altered function of γ-aminobutyrate type A receptors. Proc Natl Acad Sci USA 1995;92:3658-62.
72. Hannon GJ. RNA interference. Nature 2002;418:244-51.
73. Dodd PR. Neural mechanisms of adaptation in chronic ethanol exposure and alcoholism. Alcohol Clin Exp Res 1996;20:A151-6.
74. George MS, Anton RF, Bloomer C, et al. Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues. Arch Gen Psychiatry 2001;58:345-52.
75. Schneider F, Habel U, Wagner M, et al. Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiatry 2001;158: 1075-83.
76. Mann K, Aganz I, Harper C, et al. Neuroimaging in alcoholism: ethanol and brain damage. Alcohol Clin Exp Res 2001;25(Suppl 5 ISBRA):S104-9.