Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy

Neuroscience

Volumn 91, Issue 2, 1999, Pages 429-438

  Baker, K G ^a,b   Harding, A J ^c   Halliday, G M ^c   Kril, J J ^a,b   Harper, C G ^a  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

Author keywords

Alcohol; Cerebellum; Human; Neurotoxicity; Pathology; Quantitation

Indexed keywords

ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CEREBELLUM; DIETARY INTAKE; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; GRAY MATTER; HUMAN; HUMAN TISSUE; NEUROTOXICITY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; STATISTICAL ANALYSIS; THIAMINE DEFICIENCY; WERNICKE KORSAKOFF SYNDROME;

EID: 0032909098     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)90664-9     Document Type: Article

References (28)

1. Andersen B.B., Korbo L., Pakkenberg B. A quantitative study of the human cerebellum using unbiased stereological techniques. J. comp. Neurol. 326:1992;549-560.
2. Baker K.G., Halliday G.M., Harper C.G. Effect of chronic alcohol consumption on the human locus coeruleus. Alcohol. clin. exp. Res. 18:1994;1491-1496.
3. Caine D., Halliday G.M., Kril J.J., Harper C.G. Operational criteria for the classification of chronic alcoholics: identification of Wernicke's encephalopathy. J. Neurol. Neurosurg. Psychiat. 62:1997;51-60.
4. Cavanagh J.B., Holton J.L., Nolan C.C. Selective damage to the cerebellar vermis in chronic alcoholism: a contribution from neurotoxicology to an old problem of selective vulnerability. Neuropath. appl. Neurobiol. 23:1997;355-363.
5. Ferrer I., Fabregues I., Pineda M., Gracia I., Ribalta T. A Golgi study of cerebellar atrophy in human chronic alcoholism. Neuropath. appl. Neurobiol. 10:1984;245-253.
6. Harding A.J., Halliday G.M., Cullen K. Practical considerations for the use of the optical disector in estimating neuronal number. J. Neurosci. Meth. 51:1994;83-89.
7. Harding A., Halliday G., Ng J., Harper C., Kril J. Loss of vasopressin-immunoreactive neurons in alcoholics is dose-related and time-dependent. Neuroscience. 72:1996;699-708.
8. Harding A.J., Wong A., Svoboda M., Kril J.J., Halliday G.M. Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus. 7:1997;78-87.
9. Harper C. Neuropathology of brain damage caused by alcohol. Med. J. Aust. 2:1982;277-282.
10. Harper C. G. and Kril J. J. (1993) Neuropathological changes in alcoholics. In Alcohol-induced Brain Damage: Research Monograph No. 22 (eds Hunt W. A. and Nixon S. J.), Vol. 22, pp. 39-69. National Institutes of Health, Rockville.
11. Harvey R.J., Napper R.M.A. Quantitative studies on the mammalian cerebellum. Prog. Neurobiol. 36:1991;437-463.
12. Johnson-Greene D., Adams K.M., Gilman S., Kluin K.J., Junck L., Martello S., Heumann M. Impaired upper limb coordination in alcoholic cerebellar degeneration. Archs Neurol. 54:1997;436-439.
13. Karhunen P.J., Erkinjuntti T., Laippala P. Moderate alcohol consumption and loss of cerebellar Purkinje cells. Br. med. J. 308:1994;1663-1667.
14. Kjellstrom C., Almstrom S., Conradi N. Decreased synapse-to-neuron ratio in rat locus ceruleus following chronic ethanol feeding. Alcohol. clin. exp. Res. 17:1993;406-410.
15. Kril J.J. Neuropathology of thiamine deficiency disorders. Metab. Brain Dis. 11:1996;9-17.
16. Mayhew T.M. Accurate prediction of Purkinje cell number from cerebellar weight can be achieved with the fractionator. J. comp. Neurol. 308:1991;162-168.
17. Nolte J. (1993) The Human Brain. Mosby Year Book, St Louis.
18. Palmer M., Wang Y., Fossom L., Spuhler K. Genetic correlation of ethanol-induced ataxia and cerebellar Purkinje neuron depression among inbred strains and selected lines of rats. Alcohol. clin. exp. Res. 11:1987;494-501.
19. Pentney R. J. (1993) Alterations in the structure of the cerebellum after long-term ethanol consumption. In Alcohol-induced Brain Damage: Research Monograph No. 22 (eds Hunt W. and Nixon S.), Vol. 22, pp. 249-276. National Institutes of Health, Rockville.
20. Phillips S., Harper C., Kril J. The contribution of Wernicke's encephalopathy to alcohol-related cerebellar damage. Drug Alcohol Rev. 9:1990;53-60.
21. Phillips S.C., Harper C.G., Kril J.J. A quantitative histological study of the cerebellar vermis in alcoholic patients. Brain. 110:1987;301-314.
22. Tavares M., Paula-Barbosa M. Alcohol-induced granule cell loss in the cerebellar cortex of the adult rat. Expl Neurol. 78:1982;574-582.
23. Tavares M.A., Paula-Barbosa M.M., Cadete-Leite A. Chronic alcohol consumption reduces the cortical layer volumes and the number of neurons of the rat cerebellar cortex. Alcohol. clin. exp. Res. 11:1987;315-319.
24. Torvik A., Torp S. The prevalence of alcoholic cerebellar atrophy. A morphometric and histological study of an autopsy material. J. neurol. Sci. 75:1986;43-51.
25. Victor M., Adams R. D. and Collins G. H. (1989) The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders Due to Alcoholism and Malnutrition. F. A. Davies, Philadelphia.
26. Victor M., Adams R.D., Mancall E.L. A restricted form of cerebellar cortical degeneration occurring in alcoholic patients. Archs Neurol. 1:1959;579-688.
27. Voogd J. The morphology of the cerebellum: the last 25 years. Eur. J. Morph. 30:1992;81-96.
28. Walker D. F., Barnes D. E., Riley J. N., Hunter B. E. and Zornetzer S. F. (1980) The neurotoxicity of chronic alcohol consumption: an animal model. In Psychopharmacology of Ethanol (ed. Sandler M.), pp. 17-31. Raven, New York.