Wild-type p53 reduces radiation hypermutability in p53-mutated human lymphoblast cells

Mutagenesis

Volumn 22, Issue 5, 2007, Pages 329-334

  Zhang, Qinming ^a   Liu, Yunfeng ^a   Zhou, Junqing ^a   Chen, Weihong ^a   Zhang, Ying ^a   Liber, Howard L ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; LYMPHOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION MUTAGENESIS; WILD TYPE;

CELL LINE, TUMOR; GAMMA RAYS; HUMANS; LYMPHOCYTES; MUTAGENESIS; MUTATION; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34548454906     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gem021     Document Type: Article

References (42)

1. De, B. V., Bennett, W. P., Greenblatt, M. S. and Harris, C. C. (1996) p53 tumor suppressor gene: implications for iatrogenic cancer and cancer therapy. Med. Pediatr. Oncol. Suppl., 1, 2-11.
2. Greenblatt, M. S., Bennett, W. P., Hollstein, M. and Harris, C. C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54, 4855-4878.
3. Olivier, M., Eeles, R., Hollstein, M., Khan, M. A., Harris, C. C. and Hainaut, P. (2002) The IARC TP53 database: new online mutation analysis and recommendations to users. Hum. Mutat., 19, 607-614.
4. Smith, M. L. and Fornace, A. J., Jr (1995) Genomic instability and the role of p53 mutations in cancer cells. Curr. Opin. Oncol., 7, 69-75.
5. Tainsky, M. A., Bischoff, F. Z. and Strong, L. C. (1995) Genomic instability due to germline p53 mutations drives preneoplastic progression toward cancer in human cells. Cancer Metastasis Rev., 14, 43-48.
6. Cherbonnel-Lasserre, C., Gauny, S. and Kronenberg, A. (1996) Suppression of apoptosis by Bcl-2 or Bcl-xL promotes susceptibility to mutagenesis. Oncogene, 13, 1489-1497.
7. Yu, Y., Li, C. Y. and Little, J. B. (1997) Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells. Oncogene, 14, 1661-1667.
8. Albrechtsen, N., Dornreiter, I., Grosse, F., Kim, E., Wiesmuller, L. and Deppert, W. (1999) Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53. Oncogene, 18, 7706-7717.
9. Bertrand, P., Rouillard, D., Boulet, A., Levalois, C., Soussi, T. and Lopez, B. S. (1997) Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein. Oncogene, 14, 1117-1122.
10. Bill, C. A., Yu, Y., Miselis, N. R., Little, J. B. and Nickoloff, J. A. (1997) A role for p53 in DNA end rejoining by human cell extracts. Mutat. Res., 385, 21-29.
11. Blander, G., Kipnis, J., Leal, J. F., Yu, C. E., Schellenberg, G. D. and Oren, M. (1999) Physical and functional interaction between p53 and the Werner's syndrome protein. J. Biol. Chem., 274, 29463-29469.
12. Dudenhoffer, C., Kurth, M., Janus, F., Deppert, W. and Wiesmuller, L. (1999) Dissociation of the recombination control and the sequence-specific transactivation function of P53. Oncogene, 18, 5773-5784.
13. Mathonnet, G., Leger, C., Desnoyers, J., Drouin, R., Therrien, J. P. and Drobetsky, E. A. (2003) UV wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells. Proc. Natl Acad. Sci. USA, 100, 7219-7224.
14. Mekeel, K. L., Tang, W., Kachnic, L. A., Luo, C. M., DeFrank, J. S. and Powell, S. N. (1997) Inactivation of p53 results in high rates of homologous recombination. Oncogene, 14, 1847-1857.
15. Romanova, L. Y., Willers, H., Blagosklonny, M. V. and Powell, S. N. (2004) The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene, 23, 9025-9033.
16. Saintigny, Y., Rouillard, D., Chaput, B., Soussi, T. and Lopez, B. S. (1999) Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint. Oncogene, 18, 3553-3563.
17. Sturzbecher, H. W., Donzelmann, B., Henning, W., Knippschild, U. and Buchhop, S. (1996) p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J., 15, 1992-2002.
18. Tang, W., Willers, H. and Powell, S. N. (1999) p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res., 59, 2562-2565.
19. Willers, H., McCarthy, E. E., Wu, B., Wunsch, H., Tang, W., Taghian, D. G., Xia, F. and Powell, S. N. (2000) Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control. Oncogene, 19, 632-639.
20. Zurer, I., Hofseth, L. J., Cohen, Y., Xu-Welliver, M., Hussain, S. P., Harris, C. C. and Rotter, V. (2004) The role of p53 in base excision repair following genotoxic stress. Carcinogenesis, 25, 11-19.
21. Levy, J. A., Virolainen, M. and Defendi, V. (1968) Human lymphoblastoid lines from lymph node and spleen. Cancer, 22, 517-524.
22. Benjamin, M. B., Potter, H., Yandell, D. W. and Little, J. B. (1991) A system for assaying homologous recombination at the endogenous human thymidine kinase gene. Proc. Natl Acad. Sci. USA, 88, 6652-6656.
23. Chuang, Y. Y., Chen, Q., Brown, J. P., Sedivy, J. M. and Liber, H. L. (1999) Radiation-induced mutations at the autosomal thymidine kinase locus are not elevated in p53-null cells. Cancer Res., 59, 3073-3076.
24. Skopek, T. R., Liber, H. L., Penman, B. W. and Thilly, W. G. (1978) Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay. Biochem. Biophys. Res. Commun., 84, 411-416.
25. Little, J. B., Nagasawa, H., Keng, P. C., Yu, Y. and Li, C. Y. (1995) Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status. J. Biol. Chem., 270, 11033-11036.
26. Xia, F., Wang, X., Wang, Y. H., Tsang, N. M., Yandell, D. W., Kelsey, K. T. and Liber, H. L. (1995) Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer Res., 55, 12-15.
27. Zhen, W., Denault, C. M., Loviscek, K., Walter, S., Geng, L. and Vaughan, A. T. (1995) The relative radiosensitivity of TK6 and WIL2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status. Mutat. Res., 346, 85-92.
28. Peng, Y., Zhang, Q., Nagasawa, H., Okayasu, R., Liber, H. L. and Bedford, J. S. (2002) Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Res., 62, 6400-6404.
29. Amundson, S. A., Xia, F., Wolfson, K. and Liber, H. L. (1993) Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor. Mutat. Res., 286, 233-241.
30. Xia, F. and Liber, H. L. (1997) The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line. Mutat. Res., 373, 87-97.
31. Liber, H. L. and Thilly, W. G. (1982) Mutation assay at the thymidine kinase locus in diploid human lymphoblasts. Mutat. Res., 94, 467-485.
32. Christophorou, M. A., Martin-Zanca, D., Soucek, L., Lawlor, E. R., Brown-Swigart, L., Verschuren, E. W. and Evan, G. I. (2005) Temporal dissection of p53 function in vitro and in vivo. Nat. Genet., 37, 718-726.
33. Essmann, F., Pohlmann, S., Gillissen, B., Daniel, P. T., Schulze-Osthoff, K. and Janicke, R. U. (2005) Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis. J. Biol. Chem., 280, 37169-37177.
34. Oancea, M., Mani, A., Hussein, M. A. and Almasan, A. (2004) Apoptosis of multiple myeloma. Int. J. Hematol., 80, 224-231.
35. Samuni, A. M., Kasid, U., Chuang, E. Y., Suy, S., Degraff, W., Krishna, M. C., Russo, A. and Mitchell, J. B. (2005) Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells. Cancer Res., 65, 579-586.
36. Zhang, Y., Lim, C. U., Williams, E. S., Zhou, J., Zhang, Q., Fox, M. H., Bailey, S. M. and Liber, H. L. (2005) NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells. Cancer Res., 65, 5544-5553.
37. Xia, F., Amundson, S. A., Nickoloff, J. A. and Liber, H. L. (1994) Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation. Mol. Cell. Biol., 14, 5850-5857.
38. Meyn, R. E., Stephens, L. C., Mason, K. A. and Medina, D. (1996) Radiation-induced apoptosis in normal and pre-neoplastic mammary glands in vivo: significance of gland differentiation and p53 status. Int. J. Cancer, 65, 466-472.
39. Spillare, E. A., Robles, A. I., Wang, X. W., Shen, J. C., Yu, C. E., Schellenberg, G. D. and Harris, C. C. (1999) p53-mediated apoptosis is attenuated in Werner syndrome cells. Genes Dev., 13, 1355-1360.
40. Yamabe, Y., Shimamoto, A., Goto, M., Yokota, J., Sugawara, M. and Furuichi, Y. (1998) Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53. Mol. Cell. Biol., 18, 6191-6200.
41. Brosh, R. M., Jr, Orren, D. K., Nehlin, J. O., Ravn, P. H., Kenny, M. K., Machwe, A. and Bohr, V. A. (1999) Functional and physical interaction between WRN helicase and human replication protein A. J. Biol. Chem., 274, 18341-18350.
42. Harmon, F. G., DiGate, R. J. and Kowalczykowski, S. C. (1999) RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination. Mol. Cell, 3, 611-620.