메뉴 건너뛰기




Volumn 20, Issue 5, 2007, Pages 307-313

Antiangiogenic drugs currently used for colorectal cancer: What other pathways can we target to prolong responses?

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CELECOXIB; CETUXIMAB; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR; ERLOTINIB; FIBROBLAST GROWTH FACTOR; FLUOROURACIL; GEFITINIB; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; PANITUMUMAB; ROFECOXIB; THROMBOCYTE FACTOR 4; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN; VATALANIB;

EID: 34548370717     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2007.20.5.1120218     Document Type: Review
Times cited : (4)

References (70)
  • 3
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: Therapeutic implications. N Engl J Med 1971, 285: 1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 4
    • 0016430937 scopus 로고
    • Inhibition of tumor angiogenesis mediated by cartilage
    • Brem, H. and Folkman, J. Inhibition of tumor angiogenesis mediated by cartilage. J Exp Med 1975, 141: 427-39.
    • (1975) J Exp Med , vol.141 , pp. 427-439
    • Brem, H.1    Folkman, J.2
  • 5
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis
    • Fidler, I.J. and Ellis, L.M. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 1994, 79: 185-8.
    • (1994) Cell , vol.79 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 6
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995, 1: 27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 8
    • 0242624629 scopus 로고    scopus 로고
    • Molecular basis of angiogenesis and cancer
    • Tonini, T., Rossi, F. and Claudio, P.P. Molecular basis of angiogenesis and cancer. Oncogene 2003, 22: 6549-56.
    • (2003) Oncogene , vol.22 , pp. 6549-6556
    • Tonini, T.1    Rossi, F.2    Claudio, P.P.3
  • 9
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D. and Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86: 353-64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 10
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P. and Jain, R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407: 249-57.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 11
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain, R.K., Duda, D.G., Clark, J.W. and Loeffler, J.S. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006, 3: 24-40.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 12
    • 0042031680 scopus 로고    scopus 로고
    • Tumor microenvironment and the response to anticancer therapy
    • Brown, J.M. Tumor microenvironment and the response to anticancer therapy. Cancer Biol Ther 2002, 1: 453-8.
    • (2002) Cancer Biol Ther , vol.1 , pp. 453-458
    • Brown, J.M.1
  • 13
    • 0038146962 scopus 로고    scopus 로고
    • ATR ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • Hammond, E.M., Dorie, M.J. and Giaccia, A.J. ATR ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003, 278: 12207-13.
    • (2003) J Biol Chem , vol.278 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 14
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, R.K. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 2005, 307: 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 15
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler, F., Kozin, S.V., Tong, R.T. et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004, 6: 553-63.
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3
  • 16
    • 33644505462 scopus 로고    scopus 로고
    • DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response
    • Freiberg, R.A., Hammond, E.M., Dorie, M.J., Welford, S.M. and Giaccia, A.J. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol 2006, 26: 1598-609.
    • (2006) Mol Cell Biol , vol.26 , pp. 1598-1609
    • Freiberg, R.A.1    Hammond, E.M.2    Dorie, M.J.3    Welford, S.M.4    Giaccia, A.J.5
  • 17
    • 0029092846 scopus 로고
    • Effect of hypoxia and reoxygenation on the formation and release of reactive oxygen species by porcine pulmonary artery endothelial cells
    • Yang, W. and Block, E.R. Effect of hypoxia and reoxygenation on the formation and release of reactive oxygen species by porcine pulmonary artery endothelial cells. J Cell Physiol 1995, 164: 414-23.
    • (1995) J Cell Physiol , vol.164 , pp. 414-423
    • Yang, W.1    Block, E.R.2
  • 18
    • 0034629072 scopus 로고    scopus 로고
    • DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    • Hirao, A., Kong, Y.Y., Matsuoka, S. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 200, 287: 1824-7.
    • Science , vol.200 , Issue.287 , pp. 1824-1827
    • Hirao, A.1    Kong, Y.Y.2    Matsuoka, S.3
  • 19
    • 0034624718 scopus 로고    scopus 로고
    • hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
    • Lee, J.S., Collins, K.M., Brown, A.L., Lee, C.H. and Chung, J.H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 2000, 404: 201-4.
    • (2000) Nature , vol.404 , pp. 201-204
    • Lee, J.S.1    Collins, K.M.2    Brown, A.L.3    Lee, C.H.4    Chung, J.H.5
  • 20
    • 33144459287 scopus 로고    scopus 로고
    • VEGFR-1 and VEGFR-2: Two non-identical twins with a unique physiognomy
    • Rahimi, N. VEGFR-1 and VEGFR-2: Two non-identical twins with a unique physiognomy Front Biosci 2006, 11: 818-29.
    • (2006) Front Biosci , vol.11 , pp. 818-829
    • Rahimi, N.1
  • 21
    • 33748756029 scopus 로고    scopus 로고
    • Gampel, A., Moss, L., Jones, M.C., Brunton, V., Norman, J.C. and Mellor, H. VEGF regulates the mobilisation of VEGFR-2/KDR from an intracellular endothelial storage compartment. Blood 2006.
    • Gampel, A., Moss, L., Jones, M.C., Brunton, V., Norman, J.C. and Mellor, H. VEGF regulates the mobilisation of VEGFR-2/KDR from an intracellular endothelial storage compartment. Blood 2006.
  • 22
    • 0037443760 scopus 로고    scopus 로고
    • IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    • Li, A., Dubey, S.. Varney, M.L., Dave, B.J. and Singh, R.K. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 2003, 170: 3369-76.
    • (2003) J Immunol , vol.170 , pp. 3369-3376
    • Li, A.1    Dubey, S.2    Varney, M.L.3    Dave, B.J.4    Singh, R.K.5
  • 23
    • 33745976468 scopus 로고    scopus 로고
    • Current status of angiogenesis inhibitors combined with radiation therapy
    • Nieder, C., Wiedenmann, N., Andratschke, N. and Molls, M. Current status of angiogenesis inhibitors combined with radiation therapy. Cancer Treat Rev 2006, 32: 348-64.
    • (2006) Cancer Treat Rev , vol.32 , pp. 348-364
    • Nieder, C.1    Wiedenmann, N.2    Andratschke, N.3    Molls, M.4
  • 25
    • 27544479318 scopus 로고    scopus 로고
    • Role of tyrosine kinase inhibitors in cancer therapy
    • Arora, A. and Scholar, E.M. Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther 2005, 315: 971-9.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 971-979
    • Arora, A.1    Scholar, E.M.2
  • 26
    • 33646199298 scopus 로고    scopus 로고
    • Angiogenesis modifications related with cetuxirnab plus irinotecan as anticancer treatment in advanced colorectal cancer patients
    • Vincenzi, B., Santini, D., Russo, A. et al. Angiogenesis modifications related with cetuxirnab plus irinotecan as anticancer treatment in advanced colorectal cancer patients. Ann Oncol 2006, 17: 835-41.
    • (2006) Ann Oncol , vol.17 , pp. 835-841
    • Vincenzi, B.1    Santini, D.2    Russo, A.3
  • 27
    • 0038461104 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs
    • Ciardiello, F. and Tortora, G. Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. Eur J Cancer 2003, 39: 1348-54.
    • (2003) Eur J Cancer , vol.39 , pp. 1348-1354
    • Ciardiello, F.1    Tortora, G.2
  • 28
    • 33244473097 scopus 로고    scopus 로고
    • A phase III randomized, open-label, controlled trial of chemotherapy and bevacizumab with or without panitumumab in the first-line treatment of patients with metastatic colorectal cancer
    • Wainberg, Z. and Hecht, J.R. A phase III randomized, open-label, controlled trial of chemotherapy and bevacizumab with or without panitumumab in the first-line treatment of patients with metastatic colorectal cancer. Clin Colorectal Cancer 2006, 5: 363-7.
    • (2006) Clin Colorectal Cancer , vol.5 , pp. 363-367
    • Wainberg, Z.1    Hecht, J.R.2
  • 29
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung, K.Y., Shia, J., Kemeny, N.E. et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005, 23: 1803-10.
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3
  • 30
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell, P.H., Wiesener, M.S., Chang, G.W. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399: 271-5.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 31
    • 25144472027 scopus 로고    scopus 로고
    • Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells
    • Vengellur, A., Phillips, J.M., Hogenesch, J.B. and LaPres, J.J. Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells. Physiol Genomics 2005, 22: 308-18.
    • (2005) Physiol Genomics , vol.22 , pp. 308-318
    • Vengellur, A.1    Phillips, J.M.2    Hogenesch, J.B.3    LaPres, J.J.4
  • 32
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein, B. and Kinzler, K.W. Cancer genes and the pathways they control. Nat Med 2004, 10: 789-99.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 33
    • 0029165446 scopus 로고
    • Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability
    • Shima, D.T., Deutsch, U. and D'Amore, P.A. Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability. FEBS Lett 1995, 370: 203-8.
    • (1995) FEBS Lett , vol.370 , pp. 203-208
    • Shima, D.T.1    Deutsch, U.2    D'Amore, P.A.3
  • 34
    • 0035029319 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease
    • Semenza, G.L. Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease. Pediatr Res 2001, 49: 614-7.
    • (2001) Pediatr Res , vol.49 , pp. 614-617
    • Semenza, G.L.1
  • 35
    • 24744438663 scopus 로고    scopus 로고
    • Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells
    • Mizukami, Y., Jo, W.S., Duerr, E.M. et al. Induction of interleukin-8 preserves the angiogenic response in HIF-1 alpha-deficient colon cancer cells. Nat Med 2005, 11: 992-7.
    • (2005) Nat Med , vol.11 , pp. 992-997
    • Mizukami, Y.1    Jo, W.S.2    Duerr, E.M.3
  • 36
    • 0026095795 scopus 로고
    • Structure and functional expression of a human interleukin-8 receptor
    • Holmes, W.E., Lee, J., Kuang, W.J., Rice, G.C. and Wood, W.I. Structure and functional expression of a human interleukin-8 receptor. Science 1991, 253: 1278-80.
    • (1991) Science , vol.253 , pp. 1278-1280
    • Holmes, W.E.1    Lee, J.2    Kuang, W.J.3    Rice, G.C.4    Wood, W.I.5
  • 37
    • 0030870251 scopus 로고    scopus 로고
    • Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells
    • Yang, S.K., Eckmann, L., Panja, A. and Kagnoff, M.F. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology 1997, 113: 1214-23.
    • (1997) Gastroenterology , vol.113 , pp. 1214-1223
    • Yang, S.K.1    Eckmann, L.2    Panja, A.3    Kagnoff, M.F.4
  • 38
    • 0034327812 scopus 로고    scopus 로고
    • The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity
    • Addison, C.L., Daniel, T.O., Burdick, M.D. et al. The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol 2000, 165: 5269-77.
    • (2000) J Immunol , vol.165 , pp. 5269-5277
    • Addison, C.L.1    Daniel, T.O.2    Burdick, M.D.3
  • 39
    • 0035266313 scopus 로고    scopus 로고
    • Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth
    • Nor, J.E., Christensen, J., Liu, J., Peters, M., Mooney, D.J., Strieter, R.M. and Polverini, P.J. Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res 2001, 61: 2183-8.
    • (2001) Cancer Res , vol.61 , pp. 2183-2188
    • Nor, J.E.1    Christensen, J.2    Liu, J.3    Peters, M.4    Mooney, D.J.5    Strieter, R.M.6    Polverini, P.J.7
  • 40
    • 0030772376 scopus 로고    scopus 로고
    • Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
    • Pierce, J.W., Schoenleber, R., Jesmok, G., Best, J., Moore, S.A., Collins, T. and Gerritsen, M.E. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 1997, 272: 21096-103.
    • (1997) J Biol Chem , vol.272 , pp. 21096-21103
    • Pierce, J.W.1    Schoenleber, R.2    Jesmok, G.3    Best, J.4    Moore, S.A.5    Collins, T.6    Gerritsen, M.E.7
  • 41
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV-1
    • Schreck, R., Rieber, P. and Baeuerle, P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV-1. Embo J 1991, 10: 2247-58.
    • (1991) Embo J , vol.10 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 42
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: A molecular target for colorectal cancer prevention
    • Brown, J.R. and DuBois, R.N. COX-2: A molecular target for colorectal cancer prevention. J Clin Oncol 2005, 23: 2840-55.
    • (2005) J Clin Oncol , vol.23 , pp. 2840-2855
    • Brown, J.R.1    DuBois, R.N.2
  • 43
    • 20644447818 scopus 로고    scopus 로고
    • Molecular determinants of cetuximab efficacy
    • Vallbohmer, D., Zhang, W., Gordon, M. et al. Molecular determinants of cetuximab efficacy. J Clin Oncol 2005, 23: 3536-44.
    • (2005) J Clin Oncol , vol.23 , pp. 3536-3544
    • Vallbohmer, D.1    Zhang, W.2    Gordon, M.3
  • 44
    • 2942522651 scopus 로고    scopus 로고
    • Monoclonal antibodies in the treatment of colorectal cancer
    • Veronese, M.L. and O'Dwyer, P.J. Monoclonal antibodies in the treatment of colorectal cancer. Eur J Cancer 2004, 40: 1292-301.
    • (2004) Eur J Cancer , vol.40 , pp. 1292-1301
    • Veronese, M.L.1    O'Dwyer, P.J.2
  • 45
    • 0036468287 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo
    • Leahy, K.M., Ornberg, R.L., Wang, Y., Zweifel, B.S., Koki, A.T. and Masferrer, J.L. Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res 2002, 62: 625-31.
    • (2002) Cancer Res , vol.62 , pp. 625-631
    • Leahy, K.M.1    Ornberg, R.L.2    Wang, Y.3    Zweifel, B.S.4    Koki, A.T.5    Masferrer, J.L.6
  • 46
    • 27244432279 scopus 로고    scopus 로고
    • Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Wirth, L.J., Haddad, R.I., Lindeman, N.I. et al. Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2005, 23: 6976-81.
    • (2005) J Clin Oncol , vol.23 , pp. 6976-6981
    • Wirth, L.J.1    Haddad, R.I.2    Lindeman, N.I.3
  • 47
    • 30344439138 scopus 로고    scopus 로고
    • Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy
    • Ali, S., El-Rayes, B.F., Sarkar, F.H. and Philip, P.A. Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Mol Cancer Ther 2005, 4: 1943-51.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1943-1951
    • Ali, S.1    El-Rayes, B.F.2    Sarkar, F.H.3    Philip, P.A.4
  • 48
    • 33644971770 scopus 로고    scopus 로고
    • Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis
    • Soumaoro, L.T., Uetake, H., Takagi, Y. et al. Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. Dis Colon Rectum 2006, 49: 392-8.
    • (2006) Dis Colon Rectum , vol.49 , pp. 392-398
    • Soumaoro, L.T.1    Uetake, H.2    Takagi, Y.3
  • 49
    • 30944448391 scopus 로고    scopus 로고
    • TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells
    • Wang, Y.Q., Luk, J.M., Chu, A.C. et al. TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells. Biochem Biophys Res Commun 2006, 341: 239-44.
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 239-244
    • Wang, Y.Q.1    Luk, J.M.2    Chu, A.C.3
  • 50
    • 31644450227 scopus 로고    scopus 로고
    • Targeting angiogenesis in lung cancer
    • Sandler, A.B. Targeting angiogenesis in lung cancer. Semin Oncol 2005, 32: S16-22.
    • (2005) Semin Oncol , vol.32
    • Sandler, A.B.1
  • 51
    • 0037314662 scopus 로고    scopus 로고
    • Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer
    • Chen, J.J., Yao, P.L., Yuan, A. et al. Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res 2003, 9: 729-37.
    • (2003) Clin Cancer Res , vol.9 , pp. 729-737
    • Chen, J.J.1    Yao, P.L.2    Yuan, A.3
  • 52
    • 2942615257 scopus 로고    scopus 로고
    • The antiangiogenic basis of metronomic chemotherapy
    • Kerbel, R.S. and Kamen, B.A. The antiangiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004, 4: 423-36.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 53
    • 32944478170 scopus 로고    scopus 로고
    • Low-dose metronomic daily cyclo phosphamide and weekly tirapazamine: A well-tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia
    • Emmenegger, U., Morton, G.C., Francia, G. et al. Low-dose metronomic daily cyclo phosphamide and weekly tirapazamine: A well-tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia. Cancer Res 2006, 66: 1664-74.
    • (2006) Cancer Res , vol.66 , pp. 1664-1674
    • Emmenegger, U.1    Morton, G.C.2    Francia, G.3
  • 54
    • 33750693021 scopus 로고    scopus 로고
    • A novel metronomic chemotherapy regimen of weekly platinum and daily oral etoposide in high-risk non-small cell lung cancer patients
    • Correale, P., Cerretani, D., Remondo, C. et al. A novel metronomic chemotherapy regimen of weekly platinum and daily oral etoposide in high-risk non-small cell lung cancer patients. Oncol Rep 2006, 16: 133-40.
    • (2006) Oncol Rep , vol.16 , pp. 133-140
    • Correale, P.1    Cerretani, D.2    Remondo, C.3
  • 55
    • 0036152447 scopus 로고    scopus 로고
    • Differences in therapeutic indexes of combination metronomic chemotherapy and an and- VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts
    • Klement, G., Huang, P., Mayer, B. et al. Differences in therapeutic indexes of combination metronomic chemotherapy and an and- VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts. Clin Cancer Res 2002, 8: 221-32.
    • (2002) Clin Cancer Res , vol.8 , pp. 221-232
    • Klement, G.1    Huang, P.2    Mayer, B.3
  • 56
    • 0034032882 scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder, T., Butterfield, C.E., Kraling, B.M. et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 200, 60: 1878-86.
    • (1878) Cancer Res , vol.200 , pp. 60
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 57
    • 0041589524 scopus 로고    scopus 로고
    • Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
    • Bertolini, F., Paul, S., Mancuso, P. et al. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res 2003, 63: 4342-6.
    • (2003) Cancer Res , vol.63 , pp. 4342-4346
    • Bertolini, F.1    Paul, S.2    Mancuso, P.3
  • 58
    • 0036225350 scopus 로고    scopus 로고
    • Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: Antitumor activity and correlation with vascular endothelial growth factor levels
    • Colleoni, M., Rocca, A., Sandri, M.T. et al. Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: Antitumor activity and correlation with vascular endothelial growth factor levels. Ann Oncol 2002, 13: 73-80.
    • (2002) Ann Oncol , vol.13 , pp. 73-80
    • Colleoni, M.1    Rocca, A.2    Sandri, M.T.3
  • 59
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg, O. On respiratory impairment in cancer cells. Science 1956, 10: 269-70.
    • (1956) Science , vol.10 , pp. 269-270
    • Warburg, O.1
  • 60
    • 31144458716 scopus 로고    scopus 로고
    • How Avastin potentiates chemotherapeutic drugs: Action and reaction in antiangiogenic therapy
    • Blagosklonny, M.V. How Avastin potentiates chemotherapeutic drugs: Action and reaction in antiangiogenic therapy. Cancer Biol Ther 2005, 4: 1307-10.
    • (2005) Cancer Biol Ther , vol.4 , pp. 1307-1310
    • Blagosklonny, M.V.1
  • 61
    • 0038172576 scopus 로고    scopus 로고
    • Cancer: Out of air is not out of action
    • Bottaro, D.P. and Liotta, L.A. Cancer: Out of air is not out of action. Nature 2003, 423: 593-5.
    • (2003) Nature , vol.423 , pp. 593-595
    • Bottaro, D.P.1    Liotta, L.A.2
  • 62
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza, G.L. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 2000, 35: 71-103.
    • (2000) Crit Rev Biochem Mol Biol , vol.35 , pp. 71-103
    • Semenza, G.L.1
  • 63
    • 0037374289 scopus 로고    scopus 로고
    • Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
    • Krishnamachary, B., Berg-Dixon, S., Kelly, B. et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res 2003, 63: 1138-43.
    • (2003) Cancer Res , vol.63 , pp. 1138-1143
    • Krishnamachary, B.1    Berg-Dixon, S.2    Kelly, B.3
  • 65
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain, R.K. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy. Nat Med 2001, 7: 987-9.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 66
    • 0038235987 scopus 로고    scopus 로고
    • Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
    • Wildiers, H., Guetens, G., De Boeck, G. et al. Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer 2003, 88: 1979-86.
    • (2003) Br J Cancer , vol.88 , pp. 1979-1986
    • Wildiers, H.1    Guetens, G.2    De Boeck, G.3
  • 67
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong, R.T., Boucher, Y., Kozin, S.V., Winkler, F., Hicklin, D.J. and Jain, R.K. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res, 2004, 64: 3731-6.
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 68
    • 0036682284 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
    • Rapisarda, A., Uranchimeg, B., Scudiero, D.A., Selby, M., Sausville, E.A., Shoemaker, R.H. and Melillo, G. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 2002, 62: 4316-24.
    • (2002) Cancer Res , vol.62 , pp. 4316-4324
    • Rapisarda, A.1    Uranchimeg, B.2    Scudiero, D.A.3    Selby, M.4    Sausville, E.A.5    Shoemaker, R.H.6    Melillo, G.7
  • 69
    • 3242678017 scopus 로고    scopus 로고
    • Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy
    • Drevs, J., Fakler, J., Eisele, S. et al. Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. Anticancer Res 2004, 24: 1759-63.
    • (2004) Anticancer Res , vol.24 , pp. 1759-1763
    • Drevs, J.1    Fakler, J.2    Eisele, S.3
  • 70
    • 33644698562 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-negative colorectal cancer: Is there truly such an entity?
    • Saltz, L. Epidermal growth factor receptor-negative colorectal cancer: Is there truly such an entity? Clin Colorectal Cancer 2005, 5(Suppl 2): S98-100.
    • (2005) Clin Colorectal Cancer , vol.5 , Issue.SUPPL. 2
    • Saltz, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.