TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells

Biochemical and Biophysical Research Communications

Volumn 341, Issue 1, 2006, Pages 239-244

  Wang, Yan Qing ^a,b   Luk, John M ^a   Chu, Andrew C ^a   Ikeda, Kazuo ^c   Man, Kwan ^a   Kaneda, Kenji ^c   Fan, Sheung Tat ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Activated hepatic stellate cells; Angiogenesis; COX 2; PDGF BB; TNP 470; VEGF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOOXYGENASE 2; FUMAGILLOL CHLOROACETYLCARBAMATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NIMESULIDE; PLATELET DERIVED GROWTH FACTOR BB; STRESS ACTIVATED PROTEIN KINASE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IN VITRO STUDY; LIVER CELL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; CELLS, CULTURED; CYCLOHEXANES; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA;

EID: 30944448391     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.175     Document Type: Article

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