메뉴 건너뛰기




Volumn 135, Issue 6, 2007, Pages 783-791

Therapeutical targets for revert liver fibrosis;Blancos terapéuticos potenciales para revertir la cirrosis hepática

Author keywords

Fatty liver; Fibrosis; Liver cirrhosis

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 34548301079     PISSN: 00349887     EISSN: 07176163     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (61)
  • 1
    • 0025364035 scopus 로고
    • Cellular sources of noncollagenous matrix proteins: Role of fat-storing cells in fibrogenesis
    • GRESSNER A, BACHEM M. Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis. Semin Liver Dis 1990; 10: 30-46.
    • (1990) Semin Liver Dis , vol.10 , pp. 30-46
    • GRESSNER, A.1    BACHEM, M.2
  • 2
    • 0029121317 scopus 로고
    • Molecular mechanism of liver fibrogenesis: A homage to the role of activated fat-storing cells
    • GRESSNER A, BACHEM M. Molecular mechanism of liver fibrogenesis: a homage to the role of activated fat-storing cells. Digestion 1995; 56: 335-46.
    • (1995) Digestion , vol.56 , pp. 335-346
    • GRESSNER, A.1    BACHEM, M.2
  • 3
    • 34548320166 scopus 로고    scopus 로고
    • SENTÍES-GÓMEZ D, GÁLVEZ- GASTELUM FJ, ARMENDÁRIZ-BORUNDA J. Fibrosis hepática: el papel de las metaloproteinasas y TGF-B. Gac Med Mex 2005; 141: 307-14.
    • SENTÍES-GÓMEZ D, GÁLVEZ- GASTELUM FJ, ARMENDÁRIZ-BORUNDA J. Fibrosis hepática: el papel de las metaloproteinasas y TGF-B. Gac Med Mex 2005; 141: 307-14.
  • 5
    • 0032211577 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrogenesis
    • OLASO E, FRIEDMAN S. Molecular regulation of hepatic fibrogenesis. J Hepatol 1998; 29: 836-47.
    • (1998) J Hepatol , vol.29 , pp. 836-847
    • OLASO, E.1    FRIEDMAN, S.2
  • 7
    • 0842301109 scopus 로고    scopus 로고
    • Structure and function of hepatic stellate cells
    • SENOO H. Structure and function of hepatic stellate cells. Med Electron Microsc 2004; 37: 3-15.
    • (2004) Med Electron Microsc , vol.37 , pp. 3-15
    • SENOO, H.1
  • 8
    • 1842531265 scopus 로고    scopus 로고
    • A significant proportion of myofibroblast are bone marrow origin in human liver fibrosis
    • FORBES S, RUSSO FP, REY V, BURRA P, RUGGE M, WRIGHT NA ET AL. A significant proportion of myofibroblast are bone marrow origin in human liver fibrosis. Gastroenterology 2004; 126: 955-64.
    • (2004) Gastroenterology , vol.126 , pp. 955-964
    • FORBES, S.1    RUSSO, F.P.2    REY, V.3    BURRA, P.4    RUGGE, M.5    WRIGHT, N.A.6    ET AL.7
  • 9
    • 1642450657 scopus 로고    scopus 로고
    • Commitment of bone marrow cells to hepatic stellate cells in mouse
    • BABASA S. Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol 2004; 40: 255-60.
    • (2004) J Hepatol , vol.40 , pp. 255-260
    • BABASA, S.1
  • 10
    • 0141595006 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in ral kupffer cells: Implications for liver fibrosis
    • TITOS E. Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in ral kupffer cells: implications for liver fibrosis. FASEB J 2003; 17: 1745-47.
    • (2003) FASEB J , vol.17 , pp. 1745-1747
    • TITOS, E.1
  • 11
    • 0034022483 scopus 로고    scopus 로고
    • Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: A pilot trial of interferon nonrespponders
    • NELSON D, LAUWERS G, IAU J. Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonrespponders. Gastroenterology 2000; 118: 655-60.
    • (2000) Gastroenterology , vol.118 , pp. 655-660
    • NELSON, D.1    LAUWERS, G.2    IAU, J.3
  • 12
    • 17144455384 scopus 로고    scopus 로고
    • Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy
    • SHIRATORI Y, IMAZEKI F, MORIYAMA M. Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med 2000; 132: 517-24.
    • (2000) Ann Intern Med , vol.132 , pp. 517-524
    • SHIRATORI, Y.1    IMAZEKI, F.2    MORIYAMA, M.3
  • 13
    • 0035825721 scopus 로고    scopus 로고
    • Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duc
    • HAMMEL P, COUVELARD A, O'TOOLE D. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duc. N Engl J Med 2001; 344: 418-23.
    • (2001) N Engl J Med , vol.344 , pp. 418-423
    • HAMMEL, P.1    COUVELARD, A.2    O'TOOLE, D.3
  • 14
    • 0022657973 scopus 로고
    • Histological course of alcoholic hepatitis. Influence of abstinence, sex and extent of hepatic damage
    • PARES A, CABALLERIA J, BRUGUERA M. Histological course of alcoholic hepatitis. Influence of abstinence, sex and extent of hepatic damage. J Hepatol 1986; 2: 3-42.
    • (1986) J Hepatol , vol.2 , pp. 3-42
    • PARES, A.1    CABALLERIA, J.2    BRUGUERA, M.3
  • 15
    • 0031054425 scopus 로고    scopus 로고
    • Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy
    • RAMM G, CRAWFORD D, POWELL L. Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy. J Hepatol 1997; 26: 584-92.
    • (1997) J Hepatol , vol.26 , pp. 584-592
    • RAMM, G.1    CRAWFORD, D.2    POWELL, L.3
  • 17
    • 0026670128 scopus 로고
    • Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis
    • PAROLA M, LEONARDUZZI G, BIASI F. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis. Hepatology 1992; 16: 1014-21.
    • (1992) Hepatology , vol.16 , pp. 1014-1021
    • PAROLA, M.1    LEONARDUZZI, G.2    BIASI, F.3
  • 18
    • 0028916565 scopus 로고    scopus 로고
    • DE LA MAZA M. Effects of long-term vitamin E supplementation in alcoholic cirrhotics. J Am Coll Nutr 1995; 14: 192-6.
    • DE LA MAZA M. Effects of long-term vitamin E supplementation in alcoholic cirrhotics. J Am Coll Nutr 1995; 14: 192-6.
  • 19
    • 0030014283 scopus 로고    scopus 로고
    • Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regresión
    • MA X, ZHAO J, LIEBER C. Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regresión. J Hepatol 1996; 24: 604-13.
    • (1996) J Hepatol , vol.24 , pp. 604-613
    • MA, X.1    ZHAO, J.2    LIEBER, C.3
  • 20
    • 0032404112 scopus 로고    scopus 로고
    • Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum
    • MIZOBUSHI Y, SHIMIZU I, YASUDA M. Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum. J Hepatol 1998; 29: 933-43.
    • (1998) J Hepatol , vol.29 , pp. 933-943
    • MIZOBUSHI, Y.1    SHIMIZU, I.2    YASUDA, M.3
  • 21
    • 0034065342 scopus 로고    scopus 로고
    • Deactivation of cultured human liver myofibroblast by transresveratrol, a grapevine-derived polyphenol
    • GODICHAUD S, KRISA S, COURONNE B. Deactivation of cultured human liver myofibroblast by transresveratrol, a grapevine-derived polyphenol. Hepatology 2000; 31: 922-31.
    • (2000) Hepatology , vol.31 , pp. 922-931
    • GODICHAUD, S.1    KRISA, S.2    COURONNE, B.3
  • 22
    • 0016802724 scopus 로고
    • Prednisone for chronic active liver disease: Dose tritration, standart dose, and combination with azathioprine compared
    • SUMMERSKILL W, KORMAN M, AMMON H. Prednisone for chronic active liver disease: dose tritration, standart dose, and combination with azathioprine compared. Gut 1975; 16: 876-83.
    • (1975) Gut , vol.16 , pp. 876-883
    • SUMMERSKILL, W.1    KORMAN, M.2    AMMON, H.3
  • 23
    • 0018843784 scopus 로고
    • Clinical features and prognosis of severe chronic active liver disease (CALD) after corticosteroid-induced remission
    • CZAJA A, AMMON H, SUMMESKILL W. Clinical features and prognosis of severe chronic active liver disease (CALD) after corticosteroid-induced remission. Gastroenterology 1980; 78: 518-23.
    • (1980) Gastroenterology , vol.78 , pp. 518-523
    • CZAJA, A.1    AMMON, H.2    SUMMESKILL, W.3
  • 24
    • 0021749087 scopus 로고
    • Development and prognosis of histologic cirrosis in corticosteroid-treated hepatitis B surface antigen-negative chronic active hepatitis
    • DAVIS G, CZAJA A, LUDWING J. Development and prognosis of histologic cirrosis in corticosteroid-treated hepatitis B surface antigen-negative chronic active hepatitis. Gastroenterology 1984; 87: 1222-27.
    • (1984) Gastroenterology , vol.87 , pp. 1222-1227
    • DAVIS, G.1    CZAJA, A.2    LUDWING, J.3
  • 25
    • 33646141359 scopus 로고    scopus 로고
    • Efficacy and safety of prednisolone in patients with autoimmune hepatitis
    • YONEYAMA K. Efficacy and safety of prednisolone in patients with autoimmune hepatitis. Adv Ther 2006; 23: 74-91.
    • (2006) Adv Ther , vol.23 , pp. 74-91
    • YONEYAMA, K.1
  • 26
    • 0028209921 scopus 로고
    • An interleukin-1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver
    • MANZINI R, BENEDETTI A, JEZEQUEL A. An interleukin-1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver. Virchows Arch 1994; 424: 25-31.
    • (1994) Virchows Arch , vol.424 , pp. 25-31
    • MANZINI, R.1    BENEDETTI, A.2    JEZEQUEL, A.3
  • 27
    • 0031393744 scopus 로고    scopus 로고
    • The use of synthetic analogues of Arg-Gly-Asp (RGD) and soluble receptor of tumor necrosis factor to prevent acute and chronic experimental liver injury
    • BRUCK R, HERSHKOVIZ R, LIDER O. The use of synthetic analogues of Arg-Gly-Asp (RGD) and soluble receptor of tumor necrosis factor to prevent acute and chronic experimental liver injury. Yale J Biol Med 1997; 70: 391-402.
    • (1997) Yale J Biol Med , vol.70 , pp. 391-402
    • BRUCK, R.1    HERSHKOVIZ, R.2    LIDER, O.3
  • 28
    • 17344394012 scopus 로고    scopus 로고
    • The effect of malotilate on type III and type IV collagen, laminin and fibronectin metabolism in dimethylnitrosamine-induced liver fibrosis in the rat
    • RYHANEN L, STENBACK F, ALA-KOKKO L. The effect of malotilate on type III and type IV collagen, laminin and fibronectin metabolism in dimethylnitrosamine-induced liver fibrosis in the rat. J Hepatol 1996; 24: 238-45.
    • (1996) J Hepatol , vol.24 , pp. 238-245
    • RYHANEN, L.1    STENBACK, F.2    ALA-KOKKO, L.3
  • 29
    • 0032923588 scopus 로고    scopus 로고
    • Effects of Sho-saikoto, a Japanese herbal medicine, on hepatic fibrosis in rats
    • SHIMIZU I, MA Y, MIZOBUCHI Y. Effects of Sho-saikoto, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology 1999; 29: 149-60.
    • (1999) Hepatology , vol.29 , pp. 149-160
    • SHIMIZU, I.1    MA, Y.2    MIZOBUCHI, Y.3
  • 30
    • 0031962275 scopus 로고    scopus 로고
    • Effects of sho-saikoto extracts on fibrosis and regeneration of the liver in rats
    • MIYAMURA M, ONO M, KYOTANI S. Effects of sho-saikoto extracts on fibrosis and regeneration of the liver in rats. J Pharm Pharmacol 1998; 50: 97-105.
    • (1998) J Pharm Pharmacol , vol.50 , pp. 97-105
    • MIYAMURA, M.1    ONO, M.2    KYOTANI, S.3
  • 31
    • 2342627911 scopus 로고    scopus 로고
    • Amplified expression of dominant-negative transforming growth fatctorbeta type II receptor inhibits collagen type I production via reduced Smad-3 activity
    • HERNÁNDEZ-CAÑAVERAL I, GONZÁLEZ J, LÓPEZ-CASILLAS F, ARMENDARIZ-BORUNDA J. Amplified expression of dominant-negative transforming growth fatctorbeta type II receptor inhibits collagen type I production via reduced Smad-3 activity. J Gastroenterol Hepatol 2004; 19: 380-7.
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 380-387
    • HERNÁNDEZ-CAÑAVERAL, I.1    GONZÁLEZ, J.2    LÓPEZ-CASILLAS, F.3    ARMENDARIZ-BORUNDA, J.4
  • 33
    • 0032810213 scopus 로고    scopus 로고
    • Prolyl 4-hidroxylase inhibitor (HOE 077) prevents TIMP-1 gene expresión in rat liver fibrosis
    • SAKAIDA I, UCHIDA K, HIROKANA K. Prolyl 4-hidroxylase inhibitor (HOE 077) prevents TIMP-1 gene expresión in rat liver fibrosis. J Gastroenterol 1999; 34: 376-7.
    • (1999) J Gastroenterol , vol.34 , pp. 376-377
    • SAKAIDA, I.1    UCHIDA, K.2    HIROKANA, K.3
  • 34
    • 0029923670 scopus 로고    scopus 로고
    • The prolilbb 4-hidroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expresión in rat liver fibrosis induced by choline-deficient L-amino acid-defined diet
    • SAKAIDA I, MATSUMURA Y, KUBOTA M. The prolilbb 4-hidroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expresión in rat liver fibrosis induced by choline-deficient L-amino acid-defined diet. Hepatology 1996; 23: 755-63.
    • (1996) Hepatology , vol.23 , pp. 755-763
    • SAKAIDA, I.1    MATSUMURA, Y.2    KUBOTA, M.3
  • 35
    • 17344372001 scopus 로고    scopus 로고
    • Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hidrocylase inhibitor
    • BICKEL M, BARINGHAUS K, GERL M. Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hidrocylase inhibitor. Hepatology 1998; 28: 404-11.
    • (1998) Hepatology , vol.28 , pp. 404-411
    • BICKEL, M.1    BARINGHAUS, K.2    GERL, M.3
  • 36
    • 0031975486 scopus 로고    scopus 로고
    • WANG Y, WANG S, BICKEL M. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol 1998; 152: 279-87.
    • WANG Y, WANG S, BICKEL M. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol 1998; 152: 279-87.
  • 37
    • 0033782394 scopus 로고    scopus 로고
    • The effect of halofuginone, an inhibitor of collagen type I synthesis, on urethral stricture formation: In vivo and in vitro study in a rat model
    • NAGLER A, GOFRIT O, OHANA M. The effect of halofuginone, an inhibitor of collagen type I synthesis, on urethral stricture formation: in vivo and in vitro study in a rat model. J Urol 2000; 164: 1776-80.
    • (2000) J Urol , vol.164 , pp. 1776-1780
    • NAGLER, A.1    GOFRIT, O.2    OHANA, M.3
  • 38
    • 0030759740 scopus 로고    scopus 로고
    • PINES M, KNOPOV V, GENINA O. Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine- induced liver cirrosis. J Hepatol 1997; 27: 391-8.
    • PINES M, KNOPOV V, GENINA O. Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine- induced liver cirrosis. J Hepatol 1997; 27: 391-8.
  • 39
    • 0015156115 scopus 로고
    • Effects of colchicines on collagenase in cultures of rheumatoid synovium
    • HARRIS E, KRANE S. Effects of colchicines on collagenase in cultures of rheumatoid synovium. Arthritis Rheum 1971; 14: 669-84.
    • (1971) Arthritis Rheum , vol.14 , pp. 669-684
    • HARRIS, E.1    KRANE, S.2
  • 40
    • 0015326077 scopus 로고
    • Inhibition of collagen secretion from bone and culture fibroblasts by microtubular disruptive drugs
    • DIEGELMANN R, PETERKOFFSKY B. Inhibition of collagen secretion from bone and culture fibroblasts by microtubular disruptive drugs. Proc Natl Acad Sci 1972; 69: 892-6.
    • (1972) Proc Natl Acad Sci , vol.69 , pp. 892-896
    • DIEGELMANN, R.1    PETERKOFFSKY, B.2
  • 41
    • 0016440066 scopus 로고
    • Effect of colchicine on collagen, albumin and transferrin sintesis by cirrhotic rat liver slices
    • ROJKIND M, KERSHENOBICH D. Effect of colchicine on collagen, albumin and transferrin sintesis by cirrhotic rat liver slices. Biochim Biophys Acta 1975; 378: 415-23.
    • (1975) Biochim Biophys Acta , vol.378 , pp. 415-423
    • ROJKIND, M.1    KERSHENOBICH, D.2
  • 42
    • 0023892140 scopus 로고    scopus 로고
    • KERSHENOBICH D, VARGAS F, GARCÍA- TSAO G. Colchicina in the treatment of cirrosis of the liver. N Engl J Med 1988; 318: 1709-13.
    • KERSHENOBICH D, VARGAS F, GARCÍA- TSAO G. Colchicina in the treatment of cirrosis of the liver. N Engl J Med 1988; 318: 1709-13.
  • 43
    • 0023875186 scopus 로고
    • Evaluation of colchicine therapy in primary biliary cirrosis
    • BODENHEIMER H, SCHAFFNER F, PEZZULLO J. Evaluation of colchicine therapy in primary biliary cirrosis. Gastroenterology 1988; 95: 124-9.
    • (1988) Gastroenterology , vol.95 , pp. 124-129
    • BODENHEIMER, H.1    SCHAFFNER, F.2    PEZZULLO, J.3
  • 44
    • 0022912599 scopus 로고
    • A prospective trial of colchicine for primary biliary cirrosis
    • KAPLAN M, ALLING D, ZIMMERMAN H. A prospective trial of colchicine for primary biliary cirrosis. N Engl J Med 1986; 315: 1448-54.
    • (1986) N Engl J Med , vol.315 , pp. 1448-1454
    • KAPLAN, M.1    ALLING, D.2    ZIMMERMAN, H.3
  • 45
    • 0023262886 scopus 로고
    • A controlled trial of colchicines in primary biliary cirrhosis. Trial design and preliminary report
    • WARNES T, SMITH A, LEE F. A controlled trial of colchicines in primary biliary cirrhosis. Trial design and preliminary report. J Hepatol 1987; 5: 1-7.
    • (1987) J Hepatol , vol.5 , pp. 1-7
    • WARNES, T.1    SMITH, A.2    LEE, F.3
  • 46
    • 0030795195 scopus 로고    scopus 로고
    • Pentoxifylline inhibits growth and collagen synthesis of cultured human hepatic myofibroblast-like cells
    • PREAUX A, MALLAT A, ROSENBAUM J. Pentoxifylline inhibits growth and collagen synthesis of cultured human hepatic myofibroblast-like cells. Hepatology 1997; 26: 315-22.
    • (1997) Hepatology , vol.26 , pp. 315-322
    • PREAUX, A.1    MALLAT, A.2    ROSENBAUM, J.3
  • 47
    • 0029958518 scopus 로고    scopus 로고
    • Inhibition by pentoxifylline of extra-cellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells
    • PINZANI M, MARRA F, CALIGIURI A. Inhibition by pentoxifylline of extra-cellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells. Br J Pharmacol 1996; 119: 1117-24.
    • (1996) Br J Pharmacol , vol.119 , pp. 1117-1124
    • PINZANI, M.1    MARRA, F.2    CALIGIURI, A.3
  • 48
    • 0030858931 scopus 로고    scopus 로고
    • Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis
    • WINDMEIER C, GRESSNER A. Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen Pharmacol 1997; 29: 181-96.
    • (1997) Gen Pharmacol , vol.29 , pp. 181-196
    • WINDMEIER, C.1    GRESSNER, A.2
  • 49
    • 0033031590 scopus 로고    scopus 로고
    • The Na+/H+ exchanger modulates the fibrogenic effect of oxidative stress in rat hapatic stellate cells
    • SVEGLIATI-BARONI G, DI SARIO A, CASINI A. The Na+/H+ exchanger modulates the fibrogenic effect of oxidative stress in rat hapatic stellate cells. J Hepatol 1999; 30: 868-75.
    • (1999) J Hepatol , vol.30 , pp. 868-875
    • SVEGLIATI-BARONI, G.1    DI SARIO, A.2    CASINI, A.3
  • 50
    • 3242751775 scopus 로고    scopus 로고
    • Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrosis
    • BORKHAM-KAMPHROST E, STOLL D, GRESSNER A, WEISKIRCHEN R. Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrosis. BBRC 2004; 321: 413-23.
    • (2004) BBRC , vol.321 , pp. 413-423
    • BORKHAM-KAMPHROST, E.1    STOLL, D.2    GRESSNER, A.3    WEISKIRCHEN, R.4
  • 51
    • 0032731750 scopus 로고    scopus 로고
    • The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrosis in rats
    • REIF S, WEIS B, AEED H. The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrosis in rats. J Hepatol 1999; 31: 1053-61.
    • (1999) J Hepatol , vol.31 , pp. 1053-1061
    • REIF, S.1    WEIS, B.2    AEED, H.3
  • 52
    • 0003454318 scopus 로고    scopus 로고
    • Angiotensin converting enzyme inhibition attenuates the development of hepatic fibrosis in the rat bile duct ligation model
    • JONSON J, CLOUSTON A, ANDO Y, KELEMER L, HORN M, ADAMSON M ET AL. Angiotensin converting enzyme inhibition attenuates the development of hepatic fibrosis in the rat bile duct ligation model. Hepatology 2000; 32: 191.
    • (2000) Hepatology , vol.32 , pp. 191
    • JONSON, J.1    CLOUSTON, A.2    ANDO, Y.3    KELEMER, L.4    HORN, M.5    ADAMSON, M.6    ET AL.7
  • 53
    • 0001454995 scopus 로고
    • Pirfenidone: A novel pharmacologic agent for prevention and resolution (removal) of lung fibrosis
    • MARGOLIN S, LEFKOWITZ S. Pirfenidone: a novel pharmacologic agent for prevention and resolution (removal) of lung fibrosis. FASEB J 1994; 8: A117.
    • (1994) FASEB J , vol.8
    • MARGOLIN, S.1    LEFKOWITZ, S.2
  • 55
    • 1142275284 scopus 로고    scopus 로고
    • Improved effects of viral gene delivery of human uPA plus biliodigestive anastomosis induce recovery from experimental biliary cirrhosis
    • MIRANDA-DÍAZ A, RINCON AR, SALGADO S, VERA-CRUZ J, GÁLVEZ J, ISLAS MC ET AL. Improved effects of viral gene delivery of human uPA plus biliodigestive anastomosis induce recovery from experimental biliary cirrhosis. Mol Ther 2004; 9: 30-7.
    • (2004) Mol Ther , vol.9 , pp. 30-37
    • MIRANDA-DÍAZ, A.1    RINCON, A.R.2    SALGADO, S.3    VERA-CRUZ, J.4    GÁLVEZ, J.5    ISLAS, M.C.6    ET AL.7
  • 56
    • 0034567343 scopus 로고    scopus 로고
    • Liver cirrosis is reverted by urokinase-type plasminogen activator gene therapy
    • SALGADO S, GARCÍA J, VERA J, SILLER F, BUENO M, MIRANDA A ET AL. Liver cirrosis is reverted by urokinase-type plasminogen activator gene therapy. Mol Ther 2000; 2: 545-51.
    • (2000) Mol Ther , vol.2 , pp. 545-551
    • SALGADO, S.1    GARCÍA, J.2    VERA, J.3    SILLER, F.4    BUENO, M.5    MIRANDA, A.6    ET AL.7
  • 59
    • 85047698802 scopus 로고    scopus 로고
    • Cirrhotic rat livers with extensive fibrosis can be safety transduced with clinical grade adenoviral vectors. evidence of cirrhosis reversion
    • GARCÍA-BAÑUELOS J, SILLER-LÓPEZ F, MIRANDA A, AGUILAR LK, AGUILAR-CÓRDOVA E, ARMENDARIZ-BORUNDA J. Cirrhotic rat livers with extensive fibrosis can be safety transduced with clinical grade adenoviral vectors. evidence of cirrhosis reversion. Gen Ther 2002; 9: 127-34.
    • (2002) Gen Ther , vol.9 , pp. 127-134
    • GARCÍA-BAÑUELOS, J.1    SILLER-LÓPEZ, F.2    MIRANDA, A.3    AGUILAR, L.K.4    AGUILAR-CÓRDOVA, E.5    ARMENDARIZ-BORUNDA, J.6
  • 60
    • 33644895961 scopus 로고    scopus 로고
    • Molecular therapy for hepatic injury and fibrosis: Where are we?
    • PROSSER C, YEN RD, WU J. Molecular therapy for hepatic injury and fibrosis: where are we? World J Gastroenterol 2006; 12: 509-15.
    • (2006) World J Gastroenterol , vol.12 , pp. 509-515
    • PROSSER, C.1    YEN, R.D.2    WU, J.3
  • 61
    • 34548315066 scopus 로고    scopus 로고
    • Combined HUPA plus MMP8 gene therapy reverts cirrhosis and improves hepatic encephalopathy
    • GÁLVEZ-GASTELUM FJ, SEGURA A, GARCÍA J, BEAS C, ARMENDARIZ-BORUNDA J. Combined HUPA plus MMP8 gene therapy reverts cirrhosis and improves hepatic encephalopathy. Gut 2004; 53: A259-A260.
    • (2004) Gut , vol.53
    • GÁLVEZ-GASTELUM, F.J.1    SEGURA, A.2    GARCÍA, J.3    BEAS, C.4    ARMENDARIZ-BORUNDA, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.